DK1252163T3 - 4-Pyridyl- og 2,4-pyrimidinyl-substituerede pyrrolderivater og deres anvendelse i farmacien - Google Patents

4-Pyridyl- og 2,4-pyrimidinyl-substituerede pyrrolderivater og deres anvendelse i farmacien

Info

Publication number
DK1252163T3
DK1252163T3 DK01902370T DK01902370T DK1252163T3 DK 1252163 T3 DK1252163 T3 DK 1252163T3 DK 01902370 T DK01902370 T DK 01902370T DK 01902370 T DK01902370 T DK 01902370T DK 1252163 T3 DK1252163 T3 DK 1252163T3
Authority
DK
Denmark
Prior art keywords
pyrimidyl
pyridyl
alkyl
inhibitor
1beta
Prior art date
Application number
DK01902370T
Other languages
English (en)
Inventor
Karola Tollmann
Hans-Guenter Striegel
Stefan Laufer
Susanne Tries
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Application granted granted Critical
Publication of DK1252163T3 publication Critical patent/DK1252163T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK01902370T 2000-02-01 2001-01-31 4-Pyridyl- og 2,4-pyrimidinyl-substituerede pyrrolderivater og deres anvendelse i farmacien DK1252163T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10004157A DE10004157A1 (de) 2000-02-01 2000-02-01 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
PCT/EP2001/001011 WO2001057042A2 (de) 2000-02-01 2001-01-31 4-pyridyl- und 2,4-pyrimidinyl-substituierte pyrrolderivate und ihre anwendung in der pharmazie

Publications (1)

Publication Number Publication Date
DK1252163T3 true DK1252163T3 (da) 2004-01-19

Family

ID=7629335

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01902370T DK1252163T3 (da) 2000-02-01 2001-01-31 4-Pyridyl- og 2,4-pyrimidinyl-substituerede pyrrolderivater og deres anvendelse i farmacien

Country Status (16)

Country Link
US (1) US6867211B2 (da)
EP (1) EP1252163B1 (da)
JP (1) JP2003525227A (da)
KR (1) KR20030005176A (da)
CN (1) CN1206230C (da)
AT (1) ATE250608T1 (da)
AU (1) AU2001230219A1 (da)
CA (1) CA2398111C (da)
DE (2) DE10004157A1 (da)
DK (1) DK1252163T3 (da)
ES (1) ES2208548T3 (da)
MX (1) MXPA02007403A (da)
NO (1) NO323246B1 (da)
PT (1) PT1252163E (da)
TR (1) TR200301898T4 (da)
WO (1) WO2001057042A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10001166A1 (de) 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
CN1549711A (zh) * 2001-08-30 2004-11-24 ��Ĭ���� 稠合的吡咯化合物在治疗关节软骨或软骨下骨组织退化中的用途
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US20050043331A1 (en) * 2002-09-27 2005-02-24 Bullington James L. Substituted 3-(2,5-disubstituted)pyridyl-4-aryl pyrroles for treating inflammatory diseases
ATE426605T1 (de) * 2003-06-12 2009-04-15 Merck & Co Inc Inhibitoren von mitotischem kinesin
GB0520958D0 (en) * 2005-10-14 2005-11-23 Cyclacel Ltd Compound
EP1884239A1 (en) * 2006-07-28 2008-02-06 Merckle Gmbh Annellated pyrrole compounds for cancer management
GB0816759D0 (en) * 2008-09-12 2008-10-22 Selcia Ltd Compounds
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920672A (en) 1974-08-22 1975-11-18 Syntex Inc Thiacycl (2.2.2.)azine carboxylic acids
JPS56100784A (en) 1980-01-16 1981-08-12 Yoshitomi Pharmaceut Ind Ltd Indolizine derivative
US4536512A (en) 1982-10-08 1985-08-20 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
FR2539417A1 (fr) 1983-01-13 1984-07-20 Rhone Poulenc Sante Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent
AU562833B2 (en) * 1983-01-13 1987-06-18 Rhone-Poulenc Sante Ortho-fused pyrrole derivatives
US4560699A (en) 1983-01-17 1985-12-24 Syntex (U.S.A.) Inc. 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
FR2557111B1 (fr) 1983-12-21 1986-04-11 Rhone Poulenc Sante Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent
US4719218A (en) 1985-12-12 1988-01-12 Smithkline Beckman Corporation Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor
US4873340A (en) * 1986-05-29 1989-10-10 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates
FR2617484B1 (fr) 1987-07-02 1989-10-20 Rhone Poulenc Sante Procede de preparation de l'acide (pyridyl-3)-3 1h-3h-pyrrolo (1,2-c) thiazolecarboxylique-7 dextrogyre
DE3732135A1 (de) 1987-09-24 1989-04-13 Deutsche Forsch Luft Raumfahrt Entladungskanal fuer hochleistungslaser
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
US5260451A (en) 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
WO1991000093A1 (en) 1989-06-26 1991-01-10 The Research Foundation Of State University Of New York Bis-acyloxymethyl derivatives
JP3135917B2 (ja) * 1991-07-17 2001-02-19 アボツト・ラボラトリーズ 血小板活性化因子拮抗剤
JPH05289267A (ja) 1992-04-07 1993-11-05 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
DE69419327D1 (de) 1993-01-21 1999-08-12 Konishiroku Photo Ind Ein farbphotographisches Silberhalogenidmaterial
DE4419246A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419315A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419247A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie
US5552422A (en) 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
DE19845446A1 (de) 1998-10-02 2000-04-06 Merckle Gmbh Antiinflammatorische Oxo- und Hydroxyderivate von Pyrrolizinen und deren Verwendung in der Pharmazie
AU5091100A (en) 1999-06-24 2001-01-31 Varco I/P Inc. A screen, a panel for a screen, a shale shaker and a method of screening
US7640571B1 (en) 1999-07-15 2009-12-29 General Instrument Corporation Method and apparatus for preventing disruptions in set-top terminal function due to the download of updated programming or data to the set-top terminal
US6878738B1 (en) 1999-11-23 2005-04-12 Merckle Gmbh Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use
DE10001166A1 (de) * 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung

Also Published As

Publication number Publication date
CA2398111A1 (en) 2001-08-09
JP2003525227A (ja) 2003-08-26
CA2398111C (en) 2008-08-12
PT1252163E (pt) 2004-02-27
ATE250608T1 (de) 2003-10-15
US20030153558A1 (en) 2003-08-14
CN1206230C (zh) 2005-06-15
AU2001230219A1 (en) 2001-08-14
EP1252163B1 (de) 2003-09-24
KR20030005176A (ko) 2003-01-17
NO20023634D0 (no) 2002-07-31
NO20023634L (no) 2002-09-25
US6867211B2 (en) 2005-03-15
WO2001057042A3 (de) 2001-12-27
CN1396923A (zh) 2003-02-12
ES2208548T3 (es) 2004-06-16
TR200301898T4 (tr) 2004-01-21
DE50100678D1 (de) 2003-10-30
EP1252163A2 (de) 2002-10-30
DE10004157A1 (de) 2001-08-02
MXPA02007403A (es) 2004-04-05
WO2001057042A2 (de) 2001-08-09
NO323246B1 (no) 2007-02-12

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