DK1255558T3 - Anti-april antistoffer og hybridomaceller - Google Patents
Anti-april antistoffer og hybridomacellerInfo
- Publication number
- DK1255558T3 DK1255558T3 DK00983773T DK00983773T DK1255558T3 DK 1255558 T3 DK1255558 T3 DK 1255558T3 DK 00983773 T DK00983773 T DK 00983773T DK 00983773 T DK00983773 T DK 00983773T DK 1255558 T3 DK1255558 T3 DK 1255558T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- april
- hybridoma cells
- taci
- bcma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18293800P | 2000-02-16 | 2000-02-16 | |
| US22698600P | 2000-08-22 | 2000-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1255558T3 true DK1255558T3 (da) | 2006-10-23 |
Family
ID=26878566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00983773T DK1255558T3 (da) | 2000-02-16 | 2000-11-28 | Anti-april antistoffer og hybridomaceller |
| DK05025025.7T DK1666052T3 (da) | 2000-02-16 | 2000-11-28 | Anti-APRIL monoklonalt antistof og dets anvendelse til behandling af en immum-relateret sygdom eller cancer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05025025.7T DK1666052T3 (da) | 2000-02-16 | 2000-11-28 | Anti-APRIL monoklonalt antistof og dets anvendelse til behandling af en immum-relateret sygdom eller cancer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060073146A1 (fr) |
| EP (2) | EP1666052B1 (fr) |
| JP (1) | JP5062606B2 (fr) |
| AT (2) | ATE329610T1 (fr) |
| AU (1) | AU2048501A (fr) |
| CA (1) | CA2396793A1 (fr) |
| CY (1) | CY1105212T1 (fr) |
| DE (1) | DE60028830T2 (fr) |
| DK (2) | DK1255558T3 (fr) |
| ES (1) | ES2267593T3 (fr) |
| IL (1) | IL150755A0 (fr) |
| PT (1) | PT1255558E (fr) |
| WO (1) | WO2001060397A1 (fr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7217788B2 (en) | 1996-03-14 | 2007-05-15 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta polypeptides |
| US6541224B2 (en) | 1996-03-14 | 2003-04-01 | Human Genome Sciences, Inc. | Tumor necrosis factor delta polypeptides |
| US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| UA75049C2 (uk) | 1999-08-17 | 2006-03-15 | Байоджен Айдек Ма Інк. | Фармацевтична композиція, що містить поліпептид, який являє собою білковий фактор дозрівання в-клітин (всма), що зв'язується з фактором активації в-клітин (baff), спосіб інгібування росту в-клітин, спосіб лікування аутоімунного захворювання, спосіб лікування гіпертонії, спосіб інгібування запалення та спосіб модулювання імунної відповіді у ссавця за допомогою всма |
| UA74798C2 (uk) * | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| US20040013674A1 (en) * | 2001-04-27 | 2004-01-22 | Christine Ambrose | Taci as an anti-tumor agent |
| US7371388B1 (en) | 2000-05-04 | 2008-05-13 | Human Genome Sciences, Inc. | Treatment of Sjogren's syndrome by administration of TR18 polypeptides |
| US20020086018A1 (en) * | 2000-05-12 | 2002-07-04 | Theill Lars Eyde | Methods and compositions of matter concerning APRIL/G70, BCMA, BLYS/AGP-3, and TACI |
| AU2001268427B2 (en) | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| WO2002016411A2 (fr) | 2000-08-18 | 2002-02-28 | Human Genome Sciences, Inc. | Polypeptides de fixation et procedes associes |
| US20030012783A1 (en) | 2001-02-20 | 2003-01-16 | Wayne Kindsvogel | Antibodies that bind both BCMA and TACI |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| JP2004537290A (ja) | 2001-05-24 | 2004-12-16 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 腫瘍壊死因子δ(APRIL)に対する抗体 |
| US7256015B2 (en) | 2001-09-21 | 2007-08-14 | Amgen Inc. | TALL-1 receptor molecules and uses thereof |
| EP1456347A4 (fr) * | 2001-11-16 | 2006-08-02 | Human Genome Sciences Inc | Anticorps se liant a blys selon un mode immunospecifique |
| WO2003041730A1 (fr) * | 2001-11-16 | 2003-05-22 | Genset S.A. | Agonistes et antagonistes de ditacine utilises pour traiter des troubles du metabolisme |
| PT1946776T (pt) | 2002-02-27 | 2017-03-17 | Immunex Corp | Composição de tnfr-fc estabilizada compreendendo arginina |
| CN1692127A (zh) * | 2002-07-25 | 2005-11-02 | 健泰科生物技术公司 | Taci抗体及其用途 |
| EP1558278B1 (fr) * | 2002-10-11 | 2009-09-02 | ZymoGenetics, Inc. | Production de proteines hybrides homo-trimeriques |
| PL1631313T3 (pl) * | 2003-06-05 | 2015-08-31 | Genentech Inc | Terapia skojarzona zaburzeń z komórek B |
| CA2554526A1 (fr) * | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants du domaine extracellulaire de bcma et utilisations de ceux-ci |
| WO2006067210A1 (fr) | 2004-12-23 | 2006-06-29 | Laboratoires Serono S.A. | Polypeptides bcma et leurs utilisations |
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| EP1922079A2 (fr) * | 2005-08-09 | 2008-05-21 | ZymoGenetics, Inc. | Procedes pour le traitement et la prevention de proliferation cellulaire anormale par le biais de molecules de fusion taci |
| US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| EA015860B1 (ru) | 2005-10-13 | 2011-12-30 | Хьюман Дженом Сайенсиз, Инк. | Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа |
| WO2007062090A2 (fr) | 2005-11-23 | 2007-05-31 | Genentech, Inc. | Procedes et compositions lies a des analyses de lymphocytes b |
| US8211649B2 (en) | 2006-03-31 | 2012-07-03 | Human Genome Sciences, Inc. | Methods of diagnosing and prognosing hodgkin's lymphoma |
| JP2009537563A (ja) | 2006-05-15 | 2009-10-29 | アレス トレーディング ソシエテ アノニム | Taci融合分子を使用する自己免疫疾患を治療するための方法 |
| JP5426531B2 (ja) * | 2007-03-27 | 2014-02-26 | ザイモジェネティクス, インコーポレイテッド | 自己免疫疾患の治療のためのBLyS阻害および/またはAPRIL阻害ならびに免疫抑制剤の組み合わせ |
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| JP2011503036A (ja) * | 2007-11-12 | 2011-01-27 | アレス トレーディング ソシエテ アノニム | 再発性多発性硬化症治療のためのtaci−免疫グロブリン融合タンパク質 |
| WO2009062960A1 (fr) * | 2007-11-12 | 2009-05-22 | Ares Trading S.A. | Formulations pour protéines hybrides taci-immunoglobuline |
| WO2009062916A1 (fr) * | 2007-11-12 | 2009-05-22 | Ares Trading S.A. | Protéines de fusion taci-immunoglobuline pour le traitement d'une névrite optique |
| CA2919467C (fr) * | 2009-03-02 | 2018-04-17 | Jan Paul Medema | Anticorps contre le ligand a induisant la proliferation (april) |
| AU2015201974B2 (en) * | 2009-03-02 | 2016-12-15 | Aduro Biotech Holdings, Europe B.V. | Antibodies against a proliferating inducing ligand (APRIL) |
| EP2406284B9 (fr) | 2009-03-10 | 2017-03-01 | Biogen MA Inc. | Anticorps anti-bcma |
| EP2488200A4 (fr) * | 2009-10-14 | 2013-06-12 | Merck Sharp & Dohme | Antagonistes d'april et méthodes d'utilisation |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| UA112434C2 (uk) | 2011-05-27 | 2016-09-12 | Ґлаксо Ґруп Лімітед | Антигензв'язувальний білок, який специфічно зв'язується з всма |
| WO2013171296A1 (fr) | 2012-05-16 | 2013-11-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Diagnostic et traitement de la sarcoïdose |
| US9688767B2 (en) | 2013-03-15 | 2017-06-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method of predicting survival time in myocardial infarction patients by measuring BAFF levels |
| NL2011406C2 (en) | 2013-09-06 | 2015-03-10 | Bionovion Holding B V | Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides. |
| WO2015100246A1 (fr) | 2013-12-24 | 2015-07-02 | Ossianix, Inc. | Composés à liaison sélective baff et procédés associés |
| JP6556156B2 (ja) | 2014-02-27 | 2019-08-07 | ユーシーエル ビジネス ピーエルシー | Aprilバリアント |
| NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
| DK3380522T5 (da) | 2015-11-25 | 2024-09-30 | Visterra Inc | Antistofmolekyler til april og anvendelser deraf |
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| CN111655280B (zh) * | 2017-09-01 | 2025-01-14 | 达纳-法伯癌症研究所股份有限公司 | 用于治疗癌症的bcma和taci抗原特异的免疫原性肽 |
| JP7748393B2 (ja) | 2020-05-08 | 2025-10-02 | アルパイン イミューン サイエンシズ インコーポレイテッド | Aprilおよびbaff阻害免疫調節タンパク質、ならびにその使用方法 |
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| WO2022131889A1 (fr) * | 2020-12-16 | 2022-06-23 | 주식회사 굳티셀 | Utilisation de protéine taci |
| US12605537B2 (en) | 2022-02-15 | 2026-04-21 | Biogen Ma Inc. | Implantable medical device for use with or having recording electrode |
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-
2000
- 2000-11-28 CA CA002396793A patent/CA2396793A1/fr not_active Abandoned
- 2000-11-28 AU AU20485/01A patent/AU2048501A/en not_active Abandoned
- 2000-11-28 DE DE60028830T patent/DE60028830T2/de not_active Expired - Lifetime
- 2000-11-28 ES ES00983773T patent/ES2267593T3/es not_active Expired - Lifetime
- 2000-11-28 WO PCT/US2000/032378 patent/WO2001060397A1/fr not_active Ceased
- 2000-11-28 EP EP05025025A patent/EP1666052B1/fr not_active Expired - Lifetime
- 2000-11-28 PT PT00983773T patent/PT1255558E/pt unknown
- 2000-11-28 IL IL15075500A patent/IL150755A0/xx unknown
- 2000-11-28 EP EP00983773A patent/EP1255558B1/fr not_active Expired - Lifetime
- 2000-11-28 AT AT00983773T patent/ATE329610T1/de active
- 2000-11-28 AT AT05025025T patent/ATE511857T1/de active
- 2000-11-28 DK DK00983773T patent/DK1255558T3/da active
- 2000-11-28 JP JP2001559493A patent/JP5062606B2/ja not_active Expired - Lifetime
- 2000-11-28 DK DK05025025.7T patent/DK1666052T3/da active
-
2005
- 2005-02-28 US US11/069,473 patent/US20060073146A1/en not_active Abandoned
-
2006
- 2006-09-06 CY CY20061101276T patent/CY1105212T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001060397A9 (fr) | 2002-12-05 |
| IL150755A0 (en) | 2003-02-12 |
| PT1255558E (pt) | 2006-11-30 |
| EP1666052A1 (fr) | 2006-06-07 |
| DK1666052T3 (da) | 2011-09-12 |
| WO2001060397A1 (fr) | 2001-08-23 |
| HK1093674A1 (en) | 2007-03-09 |
| DE60028830D1 (de) | 2006-07-27 |
| AU2048501A (en) | 2001-08-27 |
| ATE329610T1 (de) | 2006-07-15 |
| JP2003522800A (ja) | 2003-07-29 |
| ATE511857T1 (de) | 2011-06-15 |
| EP1255558B1 (fr) | 2006-06-14 |
| EP1255558A1 (fr) | 2002-11-13 |
| ES2267593T3 (es) | 2007-03-16 |
| DE60028830T2 (de) | 2007-01-18 |
| US20060073146A1 (en) | 2006-04-06 |
| EP1666052B1 (fr) | 2011-06-08 |
| JP5062606B2 (ja) | 2012-10-31 |
| CA2396793A1 (fr) | 2001-08-23 |
| CY1105212T1 (el) | 2010-03-03 |
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