DK1317564T3 - Screeningsfremgangsmåder til at identificere G-proteiner og andre forbindelser, som modulerer phosphodiesterase (PDE)-aktiviteten - Google Patents

Screeningsfremgangsmåder til at identificere G-proteiner og andre forbindelser, som modulerer phosphodiesterase (PDE)-aktiviteten

Info

Publication number
DK1317564T3
DK1317564T3 DK01979243T DK01979243T DK1317564T3 DK 1317564 T3 DK1317564 T3 DK 1317564T3 DK 01979243 T DK01979243 T DK 01979243T DK 01979243 T DK01979243 T DK 01979243T DK 1317564 T3 DK1317564 T3 DK 1317564T3
Authority
DK
Denmark
Prior art keywords
proteins
identify
compounds
relates
pde
Prior art date
Application number
DK01979243T
Other languages
English (en)
Inventor
Robert Margolskee
Joseph Beavo
Original Assignee
Sinai School Medicine
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine, Univ Washington filed Critical Sinai School Medicine
Application granted granted Critical
Publication of DK1317564T3 publication Critical patent/DK1317564T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01979243T 2000-09-14 2001-09-14 Screeningsfremgangsmåder til at identificere G-proteiner og andre forbindelser, som modulerer phosphodiesterase (PDE)-aktiviteten DK1317564T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23255200P 2000-09-14 2000-09-14
PCT/US2001/028663 WO2002022649A2 (en) 2000-09-14 2001-09-14 Screening methods to identify g-proteins and other compounds which modulate phosphodiesterase (pde) activity

Publications (1)

Publication Number Publication Date
DK1317564T3 true DK1317564T3 (da) 2007-12-03

Family

ID=22873601

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01979243T DK1317564T3 (da) 2000-09-14 2001-09-14 Screeningsfremgangsmåder til at identificere G-proteiner og andre forbindelser, som modulerer phosphodiesterase (PDE)-aktiviteten

Country Status (9)

Country Link
US (1) US7179614B2 (da)
EP (1) EP1317564B1 (da)
AT (1) ATE368750T1 (da)
AU (1) AU2002211228A1 (da)
CA (1) CA2421938A1 (da)
DE (1) DE60129719T2 (da)
DK (1) DK1317564T3 (da)
ES (1) ES2291362T3 (da)
WO (1) WO2002022649A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002086079A2 (en) * 2001-04-20 2002-10-31 Mount Sinai School Of Medicine T1r3 a novel taste receptor
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
US20050260258A1 (en) 2003-12-18 2005-11-24 The Texas A&M University System Use of vitelline protein B as a microencapsulating additive
EP2742350B1 (en) 2011-08-08 2019-10-30 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
WO2014169087A2 (en) * 2013-04-10 2014-10-16 The Trustees Of Columbia University In The City Of New York Treatment of proximal spinal muscular atrophy

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168062A (en) * 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
IL92124A (en) 1988-10-28 1996-10-31 Sidney Pestka Recombinant proteins modified to contain post-phosphorylation that do not occur in nature
DK0460323T3 (da) * 1990-06-06 1993-12-27 Propper Mfg Co Inc Biologisk sterilisationstestpakning
US5783682A (en) * 1990-07-27 1998-07-21 Isis Pharmaceuticals, Inc. Oligonucleotide mimics having nitrogen-containing linkages
US5792844A (en) * 1990-07-27 1998-08-11 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent nitrogen atoms
US5677437A (en) * 1990-07-27 1997-10-14 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
WO1992005263A1 (en) 1990-09-25 1992-04-02 Cantab Pharmaceuticals Research Limited Viral defective vaccine produced by transcomplementing cell line
US5217889A (en) * 1990-10-19 1993-06-08 Roninson Igor B Methods and applications for efficient genetic suppressor elements
DE69233785D1 (de) * 1991-04-19 2010-07-08 Univ Washington diert
US5817759A (en) * 1992-04-09 1998-10-06 Linguagen Corporation Gustducin polypeptides and fragments
US6008000A (en) * 1992-04-09 1999-12-28 Linguagen Corporation Gustducin materials and methods
US5281400A (en) * 1992-09-30 1994-01-25 Carr Metal Products Plastic autoclave tray and lid combination
EP0689603A1 (en) 1993-03-19 1996-01-03 Cantab Pharmaceuticals Research Limited Defective mutant non-retroviral virus (e.g. hsv) as vaccine
ES2333691T3 (es) * 1993-05-27 2010-02-26 Board Of Regents Of The University Of Washington Union a gmp ciclica, materiales de fosfodiesterasa especificos a gmp ciclicos y metodos.
US5637684A (en) * 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
WO1995028494A1 (en) 1994-04-15 1995-10-26 Targeted Genetics Corporation Gene delivery fusion proteins
US6001553A (en) * 1994-04-26 1999-12-14 Cadus Pharmaceutical Corporation Functional expression of mammalian adenylyl cyclase in yeast
CA2135253A1 (en) * 1994-11-07 1996-05-08 Michael Dennis Compound screening based on a window of chemical-messenger-independent activity
AU7286696A (en) * 1995-10-13 1997-05-07 F. Hoffmann-La Roche Ag Antisense oligomers
US5814500A (en) * 1996-10-31 1998-09-29 The Johns Hopkins University School Of Medicine Delivery construct for antisense nucleic acids and methods of use
WO1998053301A2 (en) * 1997-05-23 1998-11-26 Becton Dickinson And Company Automated microbiological testing apparatus and methods therefor
US6815206B2 (en) * 1997-09-19 2004-11-09 Ethicon, Inc. Container monitoring system
US5834313A (en) * 1997-09-19 1998-11-10 Johnson & Johnson Medical, Inc. Container monitoring system
US6355448B1 (en) * 1998-06-02 2002-03-12 3M Innovative Properties Company Sterilization indicator with chemically stabilized enzyme
WO2000027861A1 (en) * 1998-11-12 2000-05-18 The Board Of Trustees Of The Leland Stanford Junior University Novel phosphodiesterase interacting proteins
GB9927331D0 (en) * 1999-11-18 2000-01-12 Fluorescience Ltd Assay for measuring enzyme activity in vivo
EP1309700A2 (en) * 2000-06-22 2003-05-14 Incyte Genomics, Inc. Human phosphodiesterases
WO2003034830A1 (en) * 2001-10-24 2003-05-01 Rock-Tenn Company System and method for packaging meat products in low oxygen environment

Also Published As

Publication number Publication date
WO2002022649A2 (en) 2002-03-21
DE60129719T2 (de) 2008-06-05
DE60129719D1 (de) 2007-09-13
EP1317564A2 (en) 2003-06-11
US7179614B2 (en) 2007-02-20
ATE368750T1 (de) 2007-08-15
EP1317564A4 (en) 2005-01-19
WO2002022649A3 (en) 2002-05-30
CA2421938A1 (en) 2002-03-21
EP1317564B1 (en) 2007-08-01
US20040063148A1 (en) 2004-04-01
AU2002211228A1 (en) 2002-03-26
ES2291362T3 (es) 2008-03-01

Similar Documents

Publication Publication Date Title
DK1100811T3 (da) Nucleinsyrer, som koder for en G-protein-koblet receptor involveret i sensorisk transduktion
DE69926248D1 (de) Test zum nachweis von prionen-proteinen die in einer mit krankheit assoziierten konformationen vorliegen
DE60231651D1 (de) Proteinreinigungsverfahren
EP1229047A3 (en) IL-1 Receptor fusion proteins used as antagonists and methods of making and using
MXPA04001287A (es) Ensayo de receptor unido a proteina g.
ATE398676T2 (de) Antagonistische selektive bindungsagenzien des osteoprotegerin-bindungsproteins
WO2000021987A3 (en) A method of identifying modulators of cell surface membrane receptors useful in the treatment of disease
WO2003006996A3 (en) Natural ligand of gpcr chemr23 and uses thereof
ATE343591T1 (de) Antagonist für die multimerisierung von hiv-1 vif-protein
GB0226729D0 (en) Intracellular antibodies
DE60324331D1 (de) Millisekunden-aktivationsschalter für 7-transmembran-proteine
DK1864131T3 (da) Naturlig ligand af G protein koblet receptor RCC356 og anvendelser deraf
DK1317564T3 (da) Screeningsfremgangsmåder til at identificere G-proteiner og andre forbindelser, som modulerer phosphodiesterase (PDE)-aktiviteten
ATE407951T1 (de) Rezeptor der edb-fibronektin-domäne (ii)
ATE288589T1 (de) Verfahren zur analyse von proteinen
AU5722499A (en) G protein-coupled receptor agonists or antagonists
WO2002042458A3 (en) G protein coupled receptors
WO2002000719A3 (en) Human and mouse g-protein couipled receptors
DK0979410T3 (da) Fremgangsmåde til bestemmelse af cytokinreceptoraktivering ved anvendelse af et antistof
WO2004009770A3 (en) Methods and compositions for modulating agonist-induced downregulation of g protein-coupled receptors
ATE412187T1 (de) Screening test
DK1208213T3 (da) Fremgangsmåde til fremstilling af proteiner i værtsceller under anvendelse af chaperoniner
NO20011511L (no) Nukleinsyrer som koder for en G-protein gammasubenhet som er involvert i sensorisk transduksjon
DK1263787T3 (da) G-proteinkoblet receptor
WO2005040820A3 (en) Methods for selecting compounds using antibodies with activity as antagonist, antagonist or allosteric modulators