DK159450C - 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin b og farmaceutisk acceptable syreadditionssalte deraf samt 9-deoxo-9a-aza-9a-homoerythromycin b til anvendelse som mellemprodukt ved fremstilling deraf - Google Patents

9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin b og farmaceutisk acceptable syreadditionssalte deraf samt 9-deoxo-9a-aza-9a-homoerythromycin b til anvendelse som mellemprodukt ved fremstilling deraf

Info

Publication number: DK159450C
Authority: DK; Denmark
Prior art keywords: deoxo; aza; homoerythromycin; methyl; homoerythromycine
Prior art date: 1983-09-06

Application number

DK423084A

Other languages

Danish (da)

English (en)

Other versions

DK423084A (da

DK423084D0 (da

DK159450B (da

Inventor

Gene Michael Bright

James Robert Hauske

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-06

Filing date

1984-09-05

Publication date

1991-03-18

1984-09-05 Application filed by Pfizer filed Critical Pfizer

1984-09-05 Publication of DK423084D0 publication Critical patent/DK423084D0/da

1985-03-07 Publication of DK423084A publication Critical patent/DK423084A/da

1990-10-15 Publication of DK159450B publication Critical patent/DK159450B/da

1991-03-18 Application granted granted Critical

1991-03-18 Publication of DK159450C publication Critical patent/DK159450C/da

Links

239000002253 acid Substances 0.000 title 1
IDRYSCOQVVUBIJ-UHFFFAOYSA-N Erythromycin-B Natural products CC1C(OC2C(C(CC(C)O2)N(C)C)O)C(C)(O)CC(C)C(=O)C(C)C(O)C(C)C(CC)OC(=O)C(C)C1OC1CC(C)(OC)C(O)C(C)O1 IDRYSCOQVVUBIJ-UHFFFAOYSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
IDRYSCOQVVUBIJ-PPGFLMPOSA-N erythromycin B Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@H]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)C)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 IDRYSCOQVVUBIJ-PPGFLMPOSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK423084A 1983-09-06 1984-09-05 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin b og farmaceutisk acceptable syreadditionssalte deraf samt 9-deoxo-9a-aza-9a-homoerythromycin b til anvendelse som mellemprodukt ved fremstilling deraf DK159450C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52982783A	1983-09-06	1983-09-06
US52982783		1983-09-06

Publications (4)

Publication Number	Publication Date
DK423084D0 DK423084D0 (da)	1984-09-05
DK423084A DK423084A (da)	1985-03-07
DK159450B DK159450B (da)	1990-10-15
DK159450C true DK159450C (da)	1991-03-18

Family

ID=24111404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK423084A DK159450C (da)	1983-09-06	1984-09-05	9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin b og farmaceutisk acceptable syreadditionssalte deraf samt 9-deoxo-9a-aza-9a-homoerythromycin b til anvendelse som mellemprodukt ved fremstilling deraf

Country Status (9)

Country	Link
EP (1)	EP0136831B1 (fr)
JP (1)	JPS6072896A (fr)
AT (1)	ATE38519T1 (fr)
CA (1)	CA1239398A (fr)
DE (1)	DE3475073D1 (fr)
DK (1)	DK159450C (fr)
ES (1)	ES535624A0 (fr)
GR (1)	GR80277B (fr)
IE (1)	IE57632B1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5075289A (en) *	1988-06-07	1991-12-24	Abbott Laboratories	9-r-azacyclic erythromycin antibiotics
US5912331A (en) *	1991-03-15	1999-06-15	Merck & Co., Inc.	Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) *	1992-03-26	1999-11-16	Merck & Co., Inc.	Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) *	1992-04-02	1993-02-23	Merck & Co., Inc.	8a-AZA-8a-homoerythromycin cyclic iminoethers
US5215980A (en) *	1992-01-17	1993-06-01	Merck & Co., Inc.	10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) *	1992-08-26	1993-05-11	Merck & Co., Inc.	Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) *	1993-04-14	1994-07-26	Merck & Co., Inc.	Process of producing 8A- and 9A-azalide antibiotics
US6407074B1 (en)	1997-06-11	2002-06-18	Pfizer Inc	C-4″-substituted macrolide derivatives
HN1998000074A (es) *	1997-06-11	1999-01-08	Pfizer Prod Inc	Derivados de macrolidos c-4 sustituidos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI7910768A8 (en) *	1979-04-02	1996-06-30	Pliva Pharm & Chem Works	Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) *	1982-03-01	1983-05-03	Pfizer Inc.	4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
US4496546A (en) *	1982-04-12	1985-01-29	Pfizer Inc.	Erythromycin D and esters thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) *	1982-11-15	1986-03-04	Pfizer	Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof

1984
- 1984-09-03 DE DE8484306009T patent/DE3475073D1/de not_active Expired
- 1984-09-03 AT AT84306009T patent/ATE38519T1/de not_active IP Right Cessation
- 1984-09-03 GR GR80277A patent/GR80277B/el unknown
- 1984-09-03 EP EP84306009A patent/EP0136831B1/fr not_active Expired
- 1984-09-04 CA CA000462343A patent/CA1239398A/fr not_active Expired
- 1984-09-04 ES ES535624A patent/ES535624A0/es active Granted
- 1984-09-05 IE IE2267/84A patent/IE57632B1/en not_active IP Right Cessation
- 1984-09-05 DK DK423084A patent/DK159450C/da not_active IP Right Cessation
- 1984-09-06 JP JP59187244A patent/JPS6072896A/ja active Pending

Also Published As

Publication number	Publication date
EP0136831B1 (fr)	1988-11-09
ATE38519T1 (de)	1988-11-15
DK423084A (da)	1985-03-07
EP0136831A2 (fr)	1985-04-10
IE57632B1 (en)	1993-02-10
DK423084D0 (da)	1984-09-05
ES8603506A1 (es)	1985-12-16
JPS6072896A (ja)	1985-04-24
EP0136831A3 (en)	1986-03-19
DE3475073D1 (en)	1988-12-15
GR80277B (en)	1985-01-04
ES535624A0 (es)	1985-12-16
IE842267L (en)	1985-03-06
DK159450B (da)	1990-10-15
CA1239398A (fr)	1988-07-19

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Legal Events

Date	Code	Title	Description
2004-08-23	PBP	Patent lapsed	Country of ref document: DK