DK1633702T3 - Proteaseinhibitorer - Google Patents

Proteaseinhibitorer

Info

Publication number: DK1633702T3
Authority: DK; Denmark
Prior art keywords: disease; syndrome; protease inhibitors; monoacyl; chagas
Prior art date: 2003-05-30

Application number

DK04734996T

Other languages

Danish (da)

English (en)

Inventor

Lars Naerum

Jon Bondebjerg

Henrik Fuglsang

Original Assignee

Prozymex As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-30

Filing date

2004-05-27

Publication date

2008-11-10

2004-05-27 Application filed by Prozymex As filed Critical Prozymex As

2008-11-10 Application granted granted Critical

2008-11-10 Publication of DK1633702T3 publication Critical patent/DK1633702T3/da

Links

229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
102000003902 Cathepsin C Human genes 0.000 abstract 3
108090000267 Cathepsin C Proteins 0.000 abstract 3
208000024827 Alzheimer disease Diseases 0.000 abstract 1
206010001935 American trypanosomiasis Diseases 0.000 abstract 1
208000024699 Chagas disease Diseases 0.000 abstract 1
206010012438 Dermatitis atopic Diseases 0.000 abstract 1
208000028132 Haim-Munk syndrome Diseases 0.000 abstract 1
208000023105 Huntington disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
208000007279 Papillon-Lefevre Disease Diseases 0.000 abstract 1
208000035884 Papillon-Lefèvre syndrome Diseases 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
206010061603 Respiratory syncytial virus infection Diseases 0.000 abstract 1
206010040047 Sepsis Diseases 0.000 abstract 1
210000001744 T-lymphocyte Anatomy 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
208000024693 gingival disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
206010022000 influenza Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
201000001245 periodontitis Diseases 0.000 abstract 1
208000030925 respiratory syncytial virus infectious disease Diseases 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)

DK04734996T 2003-05-30 2004-05-27 Proteaseinhibitorer DK1633702T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US47442403P	2003-05-30	2003-05-30
DKPA200300810		2003-05-30
DKPA200301365		2003-09-19
PCT/DK2004/000371 WO2004106289A1 (en)	2003-05-30	2004-05-27	Protease inhibitors

Publications (1)

Publication Number	Publication Date
DK1633702T3 true DK1633702T3 (da)	2008-11-10

Family

ID=46045482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04734996T DK1633702T3 (da)	2003-05-30	2004-05-27	Proteaseinhibitorer

Country Status (6)

Country	Link
US (1)	US20070155803A1 (de)
EP (2)	EP1633702B1 (de)
AT (1)	ATE399763T1 (de)
DK (1)	DK1633702T3 (de)
ES (1)	ES2308181T3 (de)
WO (1)	WO2004106289A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060241051A1 (en)	2002-12-26	2006-10-26	Chieko Kitada	Metastin derivatives and use thereof
WO2004080479A1 (ja)	2003-03-12	2004-09-23	Takeda Pharmaceutical Company Limited	性腺機能改善剤
AR049938A1 (es)	2004-06-25	2006-09-13	Takeda Pharmaceutical	Derivados de metastina y utilizacion de los mismos
JP2008531706A (ja) *	2005-03-02	2008-08-14	グラクソグループリミテッド	新規なカテプシンｃ阻害剤およびその使用
GB0521512D0 (en) *	2005-10-21	2005-11-30	Novartis Ag	Organic compounds
US8404643B2 (en)	2005-12-22	2013-03-26	Takeda Pharmaceutical Company Limited	Metastin derivatives and use thereof
TWI386417B (zh) *	2005-12-22	2013-02-21	Takeda Pharmaceutical	轉移抑素衍生物及其用途
TWI404726B (zh)	2006-10-25	2013-08-11	Takeda Pharmaceutical	腫瘤轉移抑制素衍生物及其用途
EP2108960A1 (de)	2008-04-07	2009-10-14	Arena Pharmaceuticals, Inc.	Verfahren zur Verwendung eines A G Protein-gekoppelten Rezeptors zur Identifikation von Peptid YY (PYY) Sekretagoga und nützliche Verbindungen zur Behandlung von durch (PYY) Sekretagoga modulierten Zuständen und nützliche Verbindungen zur Behandlung von Zuständen durch PYY
JP5370957B2 (ja) *	2008-08-20	2013-12-18	学校法人日本大学	アポトーシス抑制剤
CN102596321B (zh) *	2009-10-29	2014-11-19	詹森药业有限公司	可用作dpp-1抑制剂的炔基衍生物
US8552032B2 (en)	2009-12-18	2013-10-08	Janssen Pharmaceutica Nv	Bicyclic derivatives useful as inhibitors of DPP-1
US8481547B2 (en) *	2009-12-18	2013-07-09	Janssen Pharmaceutica Nv	Substituted benzothiazole and benzoxazole derivatives useful as inhibitors of DPP-1
NO2699580T3 (de)	2014-01-24	2018-02-24
WO2018043399A1 (ja) *	2016-08-31	2018-03-08	Ｊｃｒファーマ株式会社	新規糖尿病治療剤
KR20250002710A (ko)	2018-03-01	2025-01-07	아스트라제네카 에이비이	(2s)-n-｛(1s)-1-시아노-2-[4-(3-메틸-2-옥소-2,3-디하이드로-1,3-벤족사졸-5-일)페닐]에틸｝-1,4-옥사제판-2-카복스아미드를포함하는 약학 조성물
AU2019306532A1 (en)	2018-07-17	2021-03-04	Insmed Incorporated	Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating Lupus Nephritis
US20210252015A1 (en) *	2018-07-17	2021-08-19	Insmed Incorporated	Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating inflammatory bowel disease
US11883461B2 (en)	2019-05-09	2024-01-30	The Feinstein Institutes For Medical Research	HMGB1 antagonist treatment of severe sepsis
IL287617B2 (en) *	2019-05-09	2024-11-01	Feinstein Institutes For Medical Research	Hmgb1 antagonist
EP4646265A1 (de)	2023-01-06	2025-11-12	Insmed Incorporated	Neuartige reversible dpp1-inhibitoren und verwendungen davon

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB992961A (en) *	1960-07-28	1965-05-26	Ciba Ltd	Process for the manufacture of amino acid derivatives
NZ183712A (en) *	1976-04-08	1979-10-25	Ici Ltd	Polypeptide analogues of enkephalins, and pharmaceutical compositions
FR2488253A1 (fr) *	1980-08-08	1982-02-12	Roques Bernard	Nouveaux peptides et leur application en therapeutique
ATE16495T1 (de) *	1981-06-22	1985-11-15	Ici Plc	Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.
EP0083849B1 (de) *	1982-01-12	1985-08-28	Imperial Chemical Industries Plc	Dimere von Peptidamiden
US5326875A (en) *	1991-01-24	1994-07-05	Hoechst Aktiengesellschaft	Alkylation of azaglycine derivatives
US5602102A (en)	1992-05-29	1997-02-11	Board Of Regents, The Univ. Of Tx System	Dipeptidyl peptidase-I inhibitors and uses thereof
SK56798A3 (en) *	1995-10-30	1998-12-02	Smithkline Beecham Corp	Protease inhibitors, pharmaceutical composition containing them and their use
US5952294A (en) *	1996-07-31	1999-09-14	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Peptidyl prodrugs and methods of making and using the same
CA2332492A1 (en) *	1998-05-21	1999-11-25	Stacie Marie Halbert	Protease inhibitors
DE60131423T2 (de) *	2000-09-08	2009-03-19	Prozymex A/S	Ratten-spezifische cathepsin, dipeptidyl peptidase i (dppi): kristallstruktur, hemmstoffe und deren anwendungen
DE10143840A1 (de)	2001-09-06	2003-03-27	Probiodrug Ag	Neue Inhibitoren der Dipeptidylpeptidase I

2004
- 2004-05-27 AT AT04734996T patent/ATE399763T1/de not_active IP Right Cessation
- 2004-05-27 DK DK04734996T patent/DK1633702T3/da active
- 2004-05-27 ES ES04734996T patent/ES2308181T3/es not_active Expired - Lifetime
- 2004-05-27 EP EP04734996A patent/EP1633702B1/de not_active Expired - Lifetime
- 2004-05-27 EP EP08159362A patent/EP1975153A3/de not_active Withdrawn
- 2004-05-27 WO PCT/DK2004/000371 patent/WO2004106289A1/en not_active Ceased
- 2004-05-27 US US10/558,782 patent/US20070155803A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1975153A3 (de)	2010-03-31
ES2308181T3 (es)	2008-12-01
EP1975153A2 (de)	2008-10-01
EP1633702A1 (de)	2006-03-15
US20070155803A1 (en)	2007-07-05
WO2004106289A1 (en)	2004-12-09
EP1633702B1 (de)	2008-07-02
ATE399763T1 (de)	2008-07-15

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ATE399763T1 (de)	2008-07-15	Proteasehemmer
DE60232797D1 (de)	2009-08-13	Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsynthese
DE602004008098D1 (de)	2007-09-20	Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
AR051778A2 (es)	2007-02-07	Derivados del acido dimetilaminocrotonico y procesos para supreparacion
ECSP088367A (es)	2008-06-30	Derivados de bifenilo y su uso en el tratamiento de la hepatitis c
NO20044744L (no)	2004-11-02	Karbaminsyreforbindelser omfattende et piperazinledd som HDASinbibitorer
DK0931788T3 (da)	2002-11-25	Metalloproteasehæmmere
EA200400361A1 (ru)	2004-08-26	Производные алкинарилнафтиридин-4(1h)-онов в качестве ингибитора фосфодиэстеразы типа iv
DK1477472T3 (da)	2009-04-06	Substituerede phenylalkansyrederivater og anvendelse deraf
NO20081582L (no)	2008-05-06	Benzamidforbindelser anvendbare som histon-deacetylaseinhibitorer
EP1508570A4 (de)	2007-08-15	Neue physiologisch aktive substanzen
NO20071222L (no)	2007-05-31	Benzamidforbindelser.
EP1314712A4 (de)	2004-12-15	Substituierte benzoesäurederivate als nf-kappa-b-inhibitoren
ATE303384T1 (de)	2005-09-15	1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
DE60027144D1 (de)	2006-05-18	Hydroxamsäure-derivate
NO981250D0 (no)	1998-03-19	Nye derivater av cyklodepsipeptid PF1022-substans
EA200702058A1 (ru)	2008-02-28	Новые фармацевтические соединения
EA200701810A1 (ru)	2008-02-28	Производное изоксазолина и новый способ его получения
NO20054787L (no)	2005-11-14	Indenderivater som farmasotiske midler
BR0212899A (pt)	2004-11-03	Compostos orgânicos
EP1640380A4 (de)	2006-08-23	Histondeacetylaseinhibitor und verfahren zu dessen herstellung
ES2189080T3 (es)	2003-07-01	Derivados de creatina para el asma.
BR0110255A (pt)	2003-01-07	Cromenilmetil pirimidinadiaminas como agentes antibacterianos
FI20002525A0 (fi)	2000-11-17	Tulehduksenvastaisia aineita
WO2008154905A3 (de)	2009-08-27	Modifikationen des histondeacetylase-inhibitors suberoylanilidhydroxamsäure