DK1636561T3 - Kombinatorisk proteinbiblioteksscreening ved hjælp af periplasmatisk ekspression - Google Patents

Kombinatorisk proteinbiblioteksscreening ved hjælp af periplasmatisk ekspression

Info

Publication number
DK1636561T3
DK1636561T3 DK03817832.3T DK03817832T DK1636561T3 DK 1636561 T3 DK1636561 T3 DK 1636561T3 DK 03817832 T DK03817832 T DK 03817832T DK 1636561 T3 DK1636561 T3 DK 1636561T3
Authority
DK
Denmark
Prior art keywords
library screening
protein library
periplasmic expression
combinatorial protein
bacillus anthracis
Prior art date
Application number
DK03817832.3T
Other languages
English (en)
Inventor
Barrett R Harvey
George Georgiou
Brent I Iverson
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of DK1636561T3 publication Critical patent/DK1636561T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK03817832.3T 2002-07-15 2003-07-15 Kombinatorisk proteinbiblioteksscreening ved hjælp af periplasmatisk ekspression DK1636561T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39605802P 2002-07-15 2002-07-15
PCT/US2003/021928 WO2005019409A2 (en) 2002-07-15 2003-07-15 Combinatorial protein library screening by periplasmic expression

Publications (1)

Publication Number Publication Date
DK1636561T3 true DK1636561T3 (da) 2011-05-16

Family

ID=34215743

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03817832.3T DK1636561T3 (da) 2002-07-15 2003-07-15 Kombinatorisk proteinbiblioteksscreening ved hjælp af periplasmatisk ekspression

Country Status (9)

Country Link
US (2) US6916474B2 (da)
EP (1) EP1636561B1 (da)
JP (1) JP4570565B2 (da)
AT (1) ATE497774T1 (da)
AU (2) AU2003304195B8 (da)
CA (1) CA2501188C (da)
DE (1) DE60336023D1 (da)
DK (1) DK1636561T3 (da)
WO (1) WO2005019409A2 (da)

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US7094571B2 (en) * 2000-10-27 2006-08-22 The Board Of Regents Of The University Of Texas System Combinatorial protein library screening by periplasmic expression
US7083945B1 (en) 2000-10-27 2006-08-01 The Board Of Regents Of The University Of Texas System Isolation of binding proteins with high affinity to ligands
CA2465891C (en) * 2001-11-05 2012-05-15 Board Of Regents, The University Of Texas System Recombinant antibodies for the detection and neutralization of anthrax toxin
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US6916474B2 (en) * 2002-07-15 2005-07-12 Board Of Regents, The University Of Texas System Antibodies with increased affinities for anthrax antigens
US7611866B2 (en) * 2002-07-15 2009-11-03 Board Of Regents, The University Of Texas System Selection of bacterial inner-membrane anchor polypeptides
US20060246079A1 (en) 2003-11-14 2006-11-02 Morrow Phillip R Neutralizing human antibodies to anthrax toxin
WO2005103074A2 (en) * 2004-03-18 2005-11-03 Board Of Regents, The University Of Texas System Combinatorial protein library screening by periplasmic expression
WO2006137938A2 (en) * 2004-11-08 2006-12-28 The University Of Texas At Austin Antibody fragments for protection from pathogen infection and methods of use thereof
US7794732B2 (en) * 2006-05-12 2010-09-14 Oklahoma Medical Research Foundation Anthrax compositions and methods of use and production
ATE527339T1 (de) 2006-06-30 2011-10-15 Univ Georgia Anthrax-kohlenhydrate sowie synthese und verwendungen davon
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Also Published As

Publication number Publication date
AU2003304195B8 (en) 2008-08-28
EP1636561A4 (en) 2008-05-28
AU2008243161B2 (en) 2010-11-04
CA2501188A1 (en) 2005-03-03
WO2005019409A3 (en) 2007-07-12
EP1636561B1 (en) 2011-02-09
AU2003304195A1 (en) 2005-09-08
US20050106647A1 (en) 2005-05-19
AU2008243161A1 (en) 2008-12-04
DE60336023D1 (de) 2011-03-24
US7902344B2 (en) 2011-03-08
ATE497774T1 (de) 2011-02-15
AU2003304195B2 (en) 2008-08-07
US20050267294A1 (en) 2005-12-01
WO2005019409A2 (en) 2005-03-03
US6916474B2 (en) 2005-07-12
JP4570565B2 (ja) 2010-10-27
CA2501188C (en) 2012-05-15
EP1636561A2 (en) 2006-03-22
JP2006515514A (ja) 2006-06-01

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