DK174095B1 - Anvendelse af et humant rhinovirus (HRV)-hovedreceptorpræparat til fremstilling af et lægemiddel til inhibering af initieringen eller spredningen af rhino-virusinfektion - Google Patents

Anvendelse af et humant rhinovirus (HRV)-hovedreceptorpræparat til fremstilling af et lægemiddel til inhibering af initieringen eller spredningen af rhino-virusinfektion Download PDF

Info

Publication number
DK174095B1
DK174095B1 DK198904312A DK431289A DK174095B1 DK 174095 B1 DK174095 B1 DK 174095B1 DK 198904312 A DK198904312 A DK 198904312A DK 431289 A DK431289 A DK 431289A DK 174095 B1 DK174095 B1 DK 174095B1
Authority
DK
Denmark
Prior art keywords
receptor
hrv
protein
icam
cells
Prior art date
Application number
DK198904312A
Other languages
Danish (da)
English (en)
Other versions
DK431289D0 (da
DK431289A (da
Inventor
Jeffrey Greve
Alan Mcclelland
Gary Davis
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK431289D0 publication Critical patent/DK431289D0/da
Publication of DK431289A publication Critical patent/DK431289A/da
Application granted granted Critical
Publication of DK174095B1 publication Critical patent/DK174095B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70525ICAM molecules, e.g. CD50, CD54, CD102
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
DK198904312A 1988-09-01 1989-08-31 Anvendelse af et humant rhinovirus (HRV)-hovedreceptorpræparat til fremstilling af et lægemiddel til inhibering af initieringen eller spredningen af rhino-virusinfektion DK174095B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US23957188A 1988-09-01 1988-09-01
US23957188 1988-09-01
US26242888A 1988-10-25 1988-10-25
US26242888 1988-10-25
US39066289A 1989-08-10 1989-08-10
US39066289 1989-08-10

Publications (3)

Publication Number Publication Date
DK431289D0 DK431289D0 (da) 1989-08-31
DK431289A DK431289A (da) 1990-03-02
DK174095B1 true DK174095B1 (da) 2002-06-10

Family

ID=27399251

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198904312A DK174095B1 (da) 1988-09-01 1989-08-31 Anvendelse af et humant rhinovirus (HRV)-hovedreceptorpræparat til fremstilling af et lægemiddel til inhibering af initieringen eller spredningen af rhino-virusinfektion

Country Status (15)

Country Link
US (1) US7132395B1 (de)
EP (1) EP0362531B1 (de)
JP (1) JP3253064B2 (de)
AT (1) ATE186552T1 (de)
AU (1) AU637324B2 (de)
CA (1) CA1339193C (de)
DE (1) DE68929096T2 (de)
DK (1) DK174095B1 (de)
ES (1) ES2141076T3 (de)
FI (1) FI894065A7 (de)
GR (1) GR3032456T3 (de)
IL (1) IL91454A (de)
NO (1) NO893373L (de)
NZ (1) NZ230474A (de)
PT (1) PT91570B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0303692A4 (en) * 1987-02-26 1990-12-05 Dana Farber Cancer Institute Cloning of lfa-1
US5151267A (en) * 1988-07-15 1992-09-29 University Of Saskatchewan Bovine herpesvirus type 1 polypeptides and vaccines
US5585264A (en) * 1988-07-15 1996-12-17 University Of Saskatchewan Nucleotide sequences encoding recombinant bovine herpesvirus type-1 GI, GIII and GIV polypeptides
ES2141076T3 (es) 1988-09-01 2000-03-16 Bayer Ag Proteina del receptor de rinovirus humano que inhibe la infectividad del virus.
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
NO900155L (no) * 1989-01-24 1990-07-25 Molecular Therapeutics Inc Et opploeselig molekyl som er relatert til, men forskjellig fra icam-1.
JPH04505009A (ja) * 1989-03-09 1992-09-03 ダナ・ファーバー・キャンサー・インスティチュート クローニングlfa―1
ATE219838T1 (de) * 1989-03-16 2002-07-15 Blood Res Center Verwendung von funktionellen derivaten des interzellulär-adhäsions-moleküls icam-1 in einer antivirus-therapie
WO1991018010A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of viral infection using intercellular adhesion molecule-1-like peptides and/or analogues thereof
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
ES2134762T3 (es) * 1990-07-20 1999-10-16 Bayer Ag Formas multimericas de proteinas receptoras de rinovirus humanos.
US6130202A (en) * 1990-07-20 2000-10-10 Bayer Corporation Antiviral methods
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5288854A (en) * 1990-11-28 1994-02-22 Center For Blood Research, Inc. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1
US5629162A (en) * 1991-06-11 1997-05-13 The Center For Blood Research Method of identifying agents which modulate ICAM-3 binding to LFA-1
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US5811517A (en) * 1992-01-27 1998-09-22 Icos Corporation ICAM-related protein variants
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
WO1993014776A1 (en) * 1992-01-27 1993-08-05 Icos Corporation Icam-related protein
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
AU710965B2 (en) * 1992-06-22 1999-09-30 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
WO1994011400A1 (en) * 1992-11-18 1994-05-26 Helsinki University Licensing Ltd. Oy Peptides from human icam-2 and from human icam-1 and their analogs for use in therapy and diagnosis
GB9414966D0 (en) * 1994-07-26 1994-09-14 Danbiosyst Uk Pharmaceutical compositions for the nasal administration of antiviral agents
US5879712A (en) 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
DE69722594T2 (de) * 1996-03-06 2004-04-29 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Pulverförmiges arzneimittel enthaltend interzelluläres adhäsionsmolekül
US6391452B1 (en) 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
CA2544678C (en) 2003-11-05 2013-12-31 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
DK2444079T3 (en) 2005-05-17 2017-01-30 Sarcode Bioscience Inc Compositions and Methods for the Treatment of Eye Diseases
ES2830024T3 (es) 2007-10-19 2021-06-02 Novartis Ag Composiciones y métodos para el tratamiento del edema macular
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
KR20200108932A (ko) 2012-07-25 2020-09-21 에스에이알코드 바이오사이언스 인코포레이티드 Lfa-1 저해제 및 그의 다형체
EP3419629A4 (de) 2016-02-25 2019-10-30 Applied Biological Laboratories, Inc. Zusammensetzungen und verfahren zum schutz gegen luftbürtige pathogene und reizmittel
US12447166B2 (en) 2016-02-25 2025-10-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171365A (en) 1977-08-05 1979-10-16 Sterling Drug Inc. Antiviral aryloxyalkylpyrazoles
US4209526A (en) 1977-08-05 1980-06-24 Sterling Drug Inc. Antiviral arylenedioxyalkyl substituted pyrazoles
US4261928A (en) 1977-08-05 1981-04-14 Sterling Drug Inc. 2-Benzoyl-8-(2-chloro-4-methoxyphenoxy)-1-phenyl-1-octanone
FR2432170A1 (fr) 1978-06-12 1980-02-22 Corning Glass Works Procede de mesure de recepteurs d'antigene sur des membranes de cellules
US4234725A (en) 1979-10-24 1980-11-18 Sterling Drug Inc. 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-[4-(4-morpholinyl)-1-oxobutyl]-1H-pyrazole
US4232161A (en) 1979-10-24 1980-11-04 Sterling Drug Inc. 4-[6-(2-Chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1-(2-pyridinyl)-1H-pyrazole
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4427653A (en) 1981-01-26 1984-01-24 President And Fellows Of Harvard College Method of making monoclonal antibodies
US4372976A (en) 1981-08-07 1983-02-08 Sterling Drug Inc. Novel aryl-aliphatic ketone and its use as an antiviral agent
US4451476A (en) 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents
US4843087A (en) 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
EP0169146A3 (de) * 1984-07-20 1988-07-20 Merck & Co. Inc. Monoklonale Antikörper gegen den Rezeptor des menschlichen Rhinovirus
JPS6181798A (ja) 1984-07-23 1986-04-25 ベクトン・デイツキンソン・アンド・カンパニ− 細胞リセプタ−の回収
DE3505148A1 (de) 1985-02-15 1986-10-30 Boehringer Ingelheim International GmbH, 6507 Ingelheim Polypeptide des rhinovirusstammes hrv2 sowie die hierfuer codierenden dna-molekuele
CA1280753C (en) 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
EP0227604A3 (de) 1985-12-23 1989-01-18 Sandoz Ag Verwendung von Oligopeptiden in der Behandlung von viralen Infektionen
EP0261403A3 (de) 1986-08-23 1988-04-13 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Polypeptide des Rhinovirusstammes HRV89 sowie die hierfür codierenden DNA-Moleküle
DE3886237T2 (de) 1987-02-26 1994-05-05 Dana Farber Cancer Inst Inc Reinigung von LFA-3.
EP0303692A4 (en) 1987-02-26 1990-12-05 Dana Farber Cancer Institute Cloning of lfa-1
US5304636A (en) 1987-04-14 1994-04-19 Boehringer Ingelheim International Gmbh Receptor for the human rhinovirus minor group
DE3712678A1 (de) 1987-04-14 1988-10-27 Boehringer Ingelheim Int Rezeptor der kleinen rhinovirus rezeptor gruppe
US5603932A (en) 1987-04-14 1997-02-18 Boehringer Ingelheim International Gmbh Receptor of the minor human rhinovirus receptor group
US5831036A (en) 1987-05-04 1998-11-03 Dana Farber Cancer Institute Soluble fragments of human intercellular adhesion molecule-1
US5284931A (en) 1987-05-04 1994-02-08 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
AU629189B2 (en) 1987-05-04 1992-10-01 Dana-Farber Cancer Institute Intercellular adhesion molecules and their binding ligands
ES2080044T3 (es) * 1987-05-04 1996-02-01 Dana Farber Cancer Inst Inc Moleculas de adhesion intercelular y sus ligandos de fijacion.
US4956281A (en) 1987-06-03 1990-09-11 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3
US5109123A (en) 1988-06-14 1992-04-28 Dana Farber Cancer Institute Alteration of ability of soluble CD4 fragments to bind HIV
DE3852374T2 (de) 1987-11-02 1995-05-04 Baylor College Medicine Verwendung von ICAM-1 oder ihre funktionelle Derivate zur Behandlung unspezifischer Entzündungen.
US5081228A (en) 1988-02-25 1992-01-14 Immunex Corporation Interleukin-1 receptors
CA1341055C (en) * 1987-12-08 2000-07-18 Alan Mcclelland Transfectant cell lines which express the major human rhinovirus receptor
US5395929A (en) 1987-12-15 1995-03-07 Dana Farber Cancer Institute Isolated nucleic acid encoding the alpha subunit of the human leukocyte adhesion receptor
EP0372056A4 (en) 1988-05-04 1991-05-15 Dana Farber Cancer Institute Protein micelles
DE68923048T2 (de) 1988-08-23 1995-11-16 Dana Farber Cancer Inst Inc Alpha-Subeinheit des LFA-1-Leukocyt-Adhäsions-Rezeptors.
US6514936B1 (en) * 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US6143298A (en) 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ZA896668B (en) 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6051231A (en) 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
ES2141076T3 (es) 1988-09-01 2000-03-16 Bayer Ag Proteina del receptor de rinovirus humano que inhibe la infectividad del virus.
ES2201052T3 (es) 1988-09-28 2004-03-16 Dana Farber Cancer Institute Moleculas de adhesion intercelular y sus ligandos de union.
AU4412889A (en) 1988-09-28 1990-04-18 Dana-Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
US5372933A (en) 1988-10-03 1994-12-13 The Scripps Research Institute Polypeptides that mimic receptor-induced binding sites, and methods of using same
US5235049A (en) 1989-01-24 1993-08-10 Molecular Therapeutics, Inc. Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1
NO900155L (no) 1989-01-24 1990-07-25 Molecular Therapeutics Inc Et opploeselig molekyl som er relatert til, men forskjellig fra icam-1.
PT92900A (pt) 1989-01-24 1990-07-31 Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos
CA2008368C (en) 1989-01-24 2003-04-08 Jeffrey Greve Soluble molecule related to but distinct from icam-1
ZA901842B (en) 1989-03-09 1990-12-28 Boehringer Ingelheim Pharma Use of intercellular adhesion molecules,and their binding ligans in the treatment of asthma
JPH04505009A (ja) 1989-03-09 1992-09-03 ダナ・ファーバー・キャンサー・インスティチュート クローニングlfa―1
ES2035668T3 (es) 1989-03-09 1993-04-16 Boehringer Ingelheim Pharmaceuticals Inc. Uso de moleculas de adherencia intercelular y sus ligandos de union en el tratamiento del asma.
HU217792B (hu) 1989-03-16 2000-04-28 Dana Farber Cancer Institute Eljárás intercelluláris adhéziós molekula (ICAM-1) oldható származékai és ezeket tartalmazó gyógyszerkészítmények előállítására
ATE219838T1 (de) 1989-03-16 2002-07-15 Blood Res Center Verwendung von funktionellen derivaten des interzellulär-adhäsions-moleküls icam-1 in einer antivirus-therapie
ZA903223B (en) 1989-04-28 1991-02-27 Baylor College Medicine Dissemination of hiv-1 infected cells
US5324510A (en) 1989-09-01 1994-06-28 Boehringer Ingelheim Pharmaceuticals, Inc. Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma
GB9009549D0 (en) 1990-04-27 1990-06-20 Celltech Ltd Recombinant antibody and method
GB9009548D0 (en) 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
WO1991018010A1 (en) 1990-05-15 1991-11-28 Swinburne Limited Inhibition of viral infection using intercellular adhesion molecule-1-like peptides and/or analogues thereof
WO1991018011A1 (en) 1990-05-15 1991-11-28 Swinburne Limited Inhibition of cell adhesion using intercellular adhesion molecule-1-like peptides and/or analogues thereof
EP0459577A3 (en) 1990-06-01 1992-08-05 Merck & Co. Inc. Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors
US5349053A (en) 1990-06-01 1994-09-20 Protein Design Labs, Inc. Chimeric ligand/immunoglobulin molecules and their uses
JPH06504186A (ja) 1990-07-13 1994-05-19 ザ ジェネラル ホスピタル コーポレイション Cd53細胞表面抗原とその使用
US5686581A (en) 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US5686582A (en) 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US6130202A (en) * 1990-07-20 2000-10-10 Bayer Corporation Antiviral methods
US6107461A (en) 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
ES2134762T3 (es) 1990-07-20 1999-10-16 Bayer Ag Formas multimericas de proteinas receptoras de rinovirus humanos.
WO1992003473A1 (en) 1990-08-27 1992-03-05 Cetus Corporation Cd18 peptide medicaments for the treatment of disease
WO1992006119A1 (en) 1990-10-03 1992-04-16 Boehringer Ingelheim Pharmaceuticals, Inc. Method for treating inflammation using anti-idiotypic antibodies
US5288854A (en) 1990-11-28 1994-02-22 Center For Blood Research, Inc. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1
WO1992010591A1 (en) 1990-12-14 1992-06-25 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
US5709859A (en) 1991-01-24 1998-01-20 Bristol-Myers Squibb Company Mixed specificity fusion proteins
EP0510483A1 (de) 1991-04-22 1992-10-28 Boehringer Ingelheim Pharmaceuticals Inc. Verfahren zum Nachweis von Viren
US5223396A (en) 1991-05-03 1993-06-29 Boehringer Ingelheim Pharmaceuticals, Inc. Method for detecting organ transplant rejection
US5240694A (en) 1991-09-23 1993-08-31 University Of Virginia Combined antiviral and antimediator treatment of common colds
WO1993006842A1 (en) 1991-10-02 1993-04-15 Boehringer Ingelheim Pharmaceuticals, Inc. Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma
AU2797892A (en) 1991-10-03 1993-05-03 Center For Blood Research, The (plasmodium falciparum)-infected erythrocytes binding to icam-1 and cd36
DE69229275T2 (de) 1991-10-04 1999-12-30 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville Herstellung eines arzneimittels zur behandlung von augenentzündung durch blockierung von zelladhäsionsmolekulen
US5861151A (en) 1991-12-20 1999-01-19 Bristol-Myers Squibb Co Soluble fusion molecules with binding specificity for cell adhesion molecules
US5525487A (en) 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US5532127A (en) 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
WO1993014776A1 (en) 1992-01-27 1993-08-05 Icos Corporation Icam-related protein
DK0566554T3 (da) 1992-03-13 2000-08-07 Monsanto Co Fremstilling af rekombinante proteiner ved anvendelse af herpesviruspromotorer og VP16-transaktivatorer
JPH06510208A (ja) 1992-06-22 1994-11-17 マイルス・インコーポレーテツド 多量体形態のヒトライノウイルスレセプタ蛋白質
JPH06510673A (ja) 1992-07-08 1994-12-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ヒトライノウイルスに対する結合部位を有する受容体誘導体
US5580969A (en) 1992-07-24 1996-12-03 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ICAM-I RNA
WO1994011400A1 (en) 1992-11-18 1994-05-26 Helsinki University Licensing Ltd. Oy Peptides from human icam-2 and from human icam-1 and their analogs for use in therapy and diagnosis
EP0757697A4 (de) 1994-04-12 2000-05-17 Boehringer Ingelheim Pharma Verwendung von agentien, die die interzellülare wechselwirkung inhibieren, in der behandlung von viralen infektionen des atemweges
WO1995028170A1 (en) 1994-04-19 1995-10-26 The University Of Kansas Icam-1/lfa-1 short-chain peptides and method of using same
GB9414966D0 (en) 1994-07-26 1994-09-14 Danbiosyst Uk Pharmaceutical compositions for the nasal administration of antiviral agents
AU3159595A (en) 1994-08-30 1996-03-22 Hyal Pharmaceutical Corporation Hyaluronic acid and derivatives for modulation of cellular activity
US5733540A (en) 1995-03-08 1998-03-31 Lee; Peter Poon-Hang Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria
US5695760A (en) 1995-04-24 1997-12-09 Boehringer Inglehiem Pharmaceuticals, Inc. Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
US5879712A (en) 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
ES2222775B1 (es) 2002-01-31 2006-12-16 Laboratorios Indas, S.A. Procedimiento para la deteccion de una predisposicion a una enfermedad cardiovascular.
AUPS161102A0 (en) 2002-04-08 2002-05-16 Industrial Engineering Technology Pty Ltd Improved gas burner

Also Published As

Publication number Publication date
FI894065A0 (fi) 1989-08-30
JP3253064B2 (ja) 2002-02-04
NO893373L (no) 1990-03-02
JPH02238892A (ja) 1990-09-21
PT91570B (pt) 1995-05-31
NO893373D0 (no) 1989-08-22
FI894065L (fi) 1990-03-02
AU4027189A (en) 1990-03-08
AU637324B2 (en) 1993-05-27
DK431289D0 (da) 1989-08-31
EP0362531B1 (de) 1999-11-10
US7132395B1 (en) 2006-11-07
PT91570A (pt) 1990-03-30
GR3032456T3 (en) 2000-05-31
ES2141076T3 (es) 2000-03-16
DE68929096D1 (de) 1999-12-16
IL91454A (en) 1995-08-31
EP0362531A1 (de) 1990-04-11
DE68929096T2 (de) 2000-05-11
ATE186552T1 (de) 1999-11-15
NZ230474A (en) 1993-03-26
DK431289A (da) 1990-03-02
FI894065A7 (fi) 1990-03-02
IL91454A0 (en) 1990-04-29
CA1339193C (en) 1997-08-05

Similar Documents

Publication Publication Date Title
DK174095B1 (da) Anvendelse af et humant rhinovirus (HRV)-hovedreceptorpræparat til fremstilling af et lægemiddel til inhibering af initieringen eller spredningen af rhino-virusinfektion
JP3166854B2 (ja) 細胞間粘着分子の官能性誘導体を用いた抗ウィルス剤
JP2997053B2 (ja) ヒトリンパ球により生成されるタンパク質、それらのタンパク質をコードするdna配列及びそれらの医薬及び生物学的使用
US5589453A (en) Human rhinovirus receptor protein (ICAM-1) that inhibits rhinovirus attachment and infectivity
DE69131564T2 (de) Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins
EP0670369A2 (de) An menschliches programmiertes Zelltod relatiertes Peptid, und dessen kodierende DNA
JPH0335781A (ja) キメラcd4イムノグロブリンポリペプチド類
AU624789B2 (en) Purified platelet-derived growth factor and methods for purification thereof
JP2003159088A (ja) 組換えトロンビンレセプターおよびそれに関連した薬剤
JPH05501398A (ja) 組換え産生したヒト細胞膜補助因子タンパク(mcp)
US5674982A (en) Multimeric form of human rhinovirus receptor protein
EA006423B1 (ru) Олигопептид, обладающий биологической активностью модулятора рецептора тромбопоэтина, и способы его применения
US6051231A (en) Antiviral methods and prepations
US6326004B1 (en) Antiviral methods using fragments of human rhinovirus receptor (ICAM-1)
Lineberger et al. Antibodies that block rhinovirus attachment map to domain 1 of the major group receptor
Wengler et al. The isolation of the ectodomain of the alphavirus E1 protein as a soluble hemagglutinin and its crystallization
US5512442A (en) Detection of vascular adhesion protein-1 (VAP-1)
US5175255A (en) Methods for purification of platelet-derived growth factor
JPH06510208A (ja) 多量体形態のヒトライノウイルスレセプタ蛋白質
PT88783B (pt) Processo de purificacao de proteina t4 soluvel e de producao da mesma
JPH06502541A (ja) フォン・ウィルブランド因子の治療断片
HK1003104B (en) Use of functional derivatives of the intercellular adhesion molecule icam-1 in anti-viral therapy

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired