DK2164964T3 - Dehydrerede chitosanpartikler - Google Patents

Dehydrerede chitosanpartikler

Info

Publication number
DK2164964T3
DK2164964T3 DK08758308.4T DK08758308T DK2164964T3 DK 2164964 T3 DK2164964 T3 DK 2164964T3 DK 08758308 T DK08758308 T DK 08758308T DK 2164964 T3 DK2164964 T3 DK 2164964T3
Authority
DK
Denmark
Prior art keywords
nanoparticles
dehydrated
particles
nucleic acid
chitosan particles
Prior art date
Application number
DK08758308.4T
Other languages
English (en)
Inventor
Ja Rgen Kjems
Morten A Stergaard Andersen
Kenneth Alan Howard
Flemming Besenbacher
Original Assignee
Univ Aarhus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Aarhus filed Critical Univ Aarhus
Application granted granted Critical
Publication of DK2164964T3 publication Critical patent/DK2164964T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity
    • C12N2320/51Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK08758308.4T 2007-07-06 2008-07-04 Dehydrerede chitosanpartikler DK2164964T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200701004 2007-07-06
PCT/DK2008/050171 WO2009006905A1 (en) 2007-07-06 2008-07-04 Dehydrated chitosan nanoparticles

Publications (1)

Publication Number Publication Date
DK2164964T3 true DK2164964T3 (da) 2011-12-05

Family

ID=39790018

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08758308.4T DK2164964T3 (da) 2007-07-06 2008-07-04 Dehydrerede chitosanpartikler

Country Status (7)

Country Link
US (1) US20110033547A1 (da)
EP (1) EP2164964B1 (da)
AT (1) ATE523592T1 (da)
CA (1) CA2729923A1 (da)
DK (1) DK2164964T3 (da)
ES (1) ES2376200T3 (da)
WO (1) WO2009006905A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100272813A1 (en) 2007-07-23 2010-10-28 Aarhus Universitet Nanoparticle-mediated treatment for inflammatory diseases
JP5804453B2 (ja) * 2009-05-14 2015-11-04 国立大学法人 東京大学 結晶性ポリオール微粒子及びその調製方法
CA2849378A1 (en) * 2011-09-21 2013-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nano delivery systems for sirna
EP2591770B1 (en) * 2011-11-14 2016-03-16 Silenseed Ltd Compositions for siRNA delivery and methods of manufacturing and using same
CN104039356B (zh) 2012-01-27 2018-08-17 弗·哈夫曼-拉罗切有限公司 用于靶向递送的、与小分子整联蛋白拮抗剂共价连接的壳聚糖
GB201220675D0 (en) * 2012-11-16 2013-01-02 Univ Singapore Process and materials for medical applications
AU2014280796A1 (en) * 2013-06-10 2016-01-28 Polyvalor, Societe En Commandite Freeze-dried polyelectrolyte complexes that maintain size and biological activity
JP6721514B2 (ja) * 2014-02-20 2020-07-15 オルト リジェネレイティヴ テクノロジーズ インク.Ortho Regenerative Technologies Inc. 多血小板血漿と混合し、組織修復のためのインプラントを形成するための凍結乾燥ポリマー組成物及び/又は治療用関節内注射のための組成物
CN105031746B (zh) * 2015-09-10 2017-11-03 李健 一种壳聚糖携载siRNA涂层血管支架及其制备方法
GB201520600D0 (en) 2015-11-23 2016-01-06 Univ Leuven Kath Treatment of central nervous tumours
US10973774B2 (en) 2016-04-26 2021-04-13 Viaqua Therapeutics Ltd. Compositions and methods for treating viral infections in shrimps
WO2018156935A1 (en) 2017-02-24 2018-08-30 The Regents Of The University Of California Particle-drop structures and methods for making and using the same
CN107875400B (zh) * 2017-11-20 2020-10-30 南通大学 一种壳-核结构的siRNA仿病毒递送系统及应用
CA3215070A1 (en) 2021-04-14 2022-10-20 Joseph DE RUTTE Nanoscale reaction chambers and methods of using the same
US20250108067A1 (en) 2021-11-09 2025-04-03 Viaqua Therapeutics Ltd. Compositions for aquaculturing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT986404E (pt) * 1996-07-10 2002-09-30 West Pharm Serv Drug Res Ltd Sistema de entrega de terapia genica com alvo no endotelio
JP2003265171A (ja) * 2002-03-15 2003-09-24 Koike Kagaku Kk 遺伝子ドライパウダー及びその調製方法並びに遺伝子ドライパウダーの調製装置
CA2610723A1 (en) * 2005-06-03 2007-05-03 Biohesion, Inc. Gold surfaces coated with a thermostable, chemically resistant polypeptide layer and applications thereof
US20070299043A1 (en) * 2005-10-03 2007-12-27 Hunter William L Anti-scarring drug combinations and use thereof
DOP2006000268A (es) * 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
JP2007224012A (ja) * 2006-01-30 2007-09-06 Fujifilm Corp 酵素架橋したタンパク質ナノ粒子
CA2652530A1 (en) * 2006-05-24 2007-11-29 Advanced In Vitro Cell Technologies, S.L. Nanoparticles of chitosan and hyaluronan for the administration of active molecules
US20100092572A1 (en) * 2007-01-29 2010-04-15 Peter Kaeuper Chitosan-based colloidal particles for rna delivery

Also Published As

Publication number Publication date
US20110033547A1 (en) 2011-02-10
EP2164964A1 (en) 2010-03-24
ES2376200T3 (es) 2012-03-09
ATE523592T1 (de) 2011-09-15
EP2164964B1 (en) 2011-09-07
WO2009006905A1 (en) 2009-01-15
CA2729923A1 (en) 2009-01-15

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