DK2167039T3 - Forbedrede depotformuleringer - Google Patents
Forbedrede depotformuleringer Download PDFInfo
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- DK2167039T3 DK2167039T3 DK08767765.4T DK08767765T DK2167039T3 DK 2167039 T3 DK2167039 T3 DK 2167039T3 DK 08767765 T DK08767765 T DK 08767765T DK 2167039 T3 DK2167039 T3 DK 2167039T3
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
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- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
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- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biological Depolymerization Polymers (AREA)
Claims (12)
1. Formulering, der omfatter: (i) sucroseacetatisobutyrat (SAIB); (ii) fra 15 til 45 vægt-%, baseret på formuleringens samlede vægt, af et lineært poly(lactid-co-glycolid), der har en vægtmiddelmolekylvægt på mindre end eller lig med 15.000 Dalton, og som har et forhold R mellem lactid-repeat-enheder og samlede repeat-enheder, hvor R opfylder følgende: 0,55 < R < 0,95; og (iii) N-methylpyrrolidon, hvor N-methylpyrrolidon er til stede i en mængde, der er større end 20 vægt-%, baseret på formuleringens samlede vægt, når 0,55 < R < 0,85 and hvor the N-methylpyrrolidon er til stede i en mængde, der er større end eller lig med 10 vægt-%, baseret på formuleringens samlede vægt, når 0,85 < R < 0,95.
2. Formulering ifølge krav 1, hvor poly(lactid-co-glycolid) er til stede i en mængde på fra 15 til 35 vægt-% baseret på formuleringens samlede vægt.
3. Formulering ifølge krav 1 eller 2, hvor R er fra 0,55 til 0,85.
4. Formulering ifølge krav 1 eller 2, hvor R er fra større end 0,85 til 0,95.
5. Formulering ifølge et hvilket som helst af de foregående krav, hvor N- methylpyrrolidon er til stede i en mængde, der er større end eller lig med 25 vægt-% baseret på formuleringens samlede vægt.
6. Formulering ifølge krav 3, hvor N-methylpyrrolidon er til stede i en mængde, der er større end eller lig med 35 vægt-% baseret på formuleringens samlede vægt.
7. Farmaceutisk sammensætning, der omfatter en formulering som defineret i et hvilket som helst af de foregående krav og et biologisk aktivt stof.
8. Sammensætning ifølge krav 7, hvor det biologisk aktive stof omfatter et atypisk antipsykotikum.
9. Sammensætning ifølge krav8, hvor det atypiske antipsykotikum omfatter risperidon eller et farmaceutisk acceptabelt salt eller en polymorf deraf.
10. Sammensætning ifølge et hvilket som helst af kravene 7 til 9, hvor det biologisk aktive stof er til stede i en mængde, der ligger i intervallet fra 1 vægt-% til 20 vægt-% baseret på formuleringens samlede vægt.
11. Sammensætning ifølge et hvilket som helst af kravene 7 til 10, hvor det biologisk aktive stof er til stede i en mængde, der ligger i intervallet fra 2 vægt-% til 20 vægt-% baseret på formuleringens samlede vægt.
12. Sammensætning ifølge et hvilket som helst af kravene 7 til 11, hvor det biologisk aktive stof er til stede i en mængde, der ligger i intervallet fra 2 vægt-% til 10 vægt-% baseret på formuleringens samlede vægt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93073907P | 2007-05-18 | 2007-05-18 | |
| PCT/US2008/006320 WO2008143992A2 (en) | 2007-05-18 | 2008-05-16 | Improved depot formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2167039T3 true DK2167039T3 (da) | 2017-01-09 |
Family
ID=39708928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08767765.4T DK2167039T3 (da) | 2007-05-18 | 2008-05-16 | Forbedrede depotformuleringer |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US20080287464A1 (da) |
| EP (2) | EP2167039B1 (da) |
| JP (4) | JP5599705B2 (da) |
| CN (2) | CN103007288B (da) |
| AU (1) | AU2008254538B2 (da) |
| CA (1) | CA2686137C (da) |
| DK (1) | DK2167039T3 (da) |
| ES (1) | ES2606951T3 (da) |
| HU (1) | HUE030789T2 (da) |
| IL (1) | IL202181A (da) |
| PL (1) | PL2167039T3 (da) |
| WO (1) | WO2008143992A2 (da) |
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| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| BRPI0809995A2 (pt) * | 2007-04-03 | 2015-07-21 | Trimeris Inc | Composição, e, métodos para a liberação prolongada de um peptídeo em um paciente e para melhorar um sintoma associado com uma infecção por hiv |
| DK2167039T3 (da) | 2007-05-18 | 2017-01-09 | Durect Corp | Forbedrede depotformuleringer |
| EP2152315B1 (en) | 2007-05-25 | 2016-01-06 | Indivior UK Limited | Sustained delivery formulations of risperidone compounds |
| US8524267B2 (en) | 2008-04-18 | 2013-09-03 | Warsaw Orthopedic, Inc. | Dexamethasone formulations in a biodegradable material |
| US10285936B2 (en) | 2010-05-31 | 2019-05-14 | Laboratorios Farmacéuticos Rovi, S.A. | Injectable composition with aromatase inhibitor |
| US10335366B2 (en) | 2010-05-31 | 2019-07-02 | Laboratorios Farmacéuticos Rovi, S.A. | Risperidone or paliperidone implant formulation |
| US10350159B2 (en) | 2010-05-31 | 2019-07-16 | Laboratories Farmacéuticos Rovi, S.A. | Paliperidone implant formulation |
| US10463607B2 (en) | 2010-05-31 | 2019-11-05 | Laboratorios Farmaceutics Rofi S.A. | Antipsychotic Injectable Depot Composition |
| US10881605B2 (en) | 2010-05-31 | 2021-01-05 | Laboratorios Farmaceuticos Rovi, S.A. | Methods for the preparation of injectable depot compositions |
| LT2394664T (lt) * | 2010-05-31 | 2016-09-26 | Laboratorios Farmaceuticos Rovi, S.A. | Antipsichozinė injekcinė depozitinė kompozicija |
| PT2394663T (pt) | 2010-05-31 | 2021-11-26 | Farm Rovi Lab Sa | Composições para implantes biodegradáveis injectáveis |
| JP2013543898A (ja) * | 2010-11-24 | 2013-12-09 | デュレクト コーポレイション | 生体分解性薬物送達組成物 |
| LT2529756T (lt) * | 2011-05-31 | 2021-07-26 | Laboratorios Farmaceuticos Rovi, S.A. | Risperidono ir (arba) paliperidono implantų kompozicija |
| US20140294977A1 (en) | 2011-11-23 | 2014-10-02 | Durect Corporation | Radiation-Sterilized Biodegradable Drug Delivery Composition |
| HK1220628A1 (zh) * | 2013-03-11 | 2017-05-12 | Durect Corporation | 包含高粘度液体载体的可注射控制释放组合物 |
| US20140308352A1 (en) * | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| TWI731853B (zh) | 2015-03-18 | 2021-07-01 | 日商參天製藥股份有限公司 | 徐放性醫藥組成物及其安定化方法 |
| US10682340B2 (en) | 2016-06-30 | 2020-06-16 | Durect Corporation | Depot formulations |
| KR20190025635A (ko) | 2016-06-30 | 2019-03-11 | 듀렉트 코퍼레이션 | 데포 제형 |
| PE20210047A1 (es) | 2018-06-12 | 2021-01-08 | Farm Rovi Lab Sa | Composicion inyectable |
| WO2021011891A1 (en) * | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| EP3999046A4 (en) * | 2019-07-18 | 2023-08-09 | Durect Corporation | LONG-ACTING FORMULATIONS AND VEHICLES |
| JP2023515918A (ja) | 2020-01-13 | 2023-04-17 | デュレクト コーポレーション | 不純物が低減された徐放性薬物送達システム及び関連の方法 |
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