DK2305654T3 - Terapeutisk middel mod cancersmerter - Google Patents
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- DK2305654T3 DK2305654T3 DK09746375.6T DK09746375T DK2305654T3 DK 2305654 T3 DK2305654 T3 DK 2305654T3 DK 09746375 T DK09746375 T DK 09746375T DK 2305654 T3 DK2305654 T3 DK 2305654T3
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- 229960000779 irinotecan hydrochloride Drugs 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
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- 201000007270 liver cancer Diseases 0.000 description 1
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- 239000003589 local anesthetic agent Substances 0.000 description 1
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- 239000000314 lubricant Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
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- 159000000003 magnesium salts Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 208000008013 morphine dependence Diseases 0.000 description 1
- 229960005195 morphine hydrochloride Drugs 0.000 description 1
- XELXKCKNPPSFNN-BJWPBXOKSA-N morphine hydrochloride trihydrate Chemical compound O.O.O.Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O XELXKCKNPPSFNN-BJWPBXOKSA-N 0.000 description 1
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- 208000025189 neoplasm of testis Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- BPGXUIVWLQTVLZ-OFGSCBOVSA-N neuropeptide y(npy) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 BPGXUIVWLQTVLZ-OFGSCBOVSA-N 0.000 description 1
- 210000000929 nociceptor Anatomy 0.000 description 1
- 108091008700 nociceptors Proteins 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
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- 239000006201 parenteral dosage form Substances 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000001044 sensory neuron Anatomy 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (6)
1. A 1,5-benzodiazepinderivat repræsenteret ved formel (1):
(i) (hvori R1 betegner en Ci-6-alkylgruppe, R2 betegner en phenylgruppe eller en cyclohexylgruppe, og Y betegner en enkeltbinding eller en Ci_4 alkylen-gruppe) eller et farmaceutisk acceptabelt salt deraf, til anvendelse ved behandling eller forebyggelse af cancersmerter i en peroral daglig dosis til en voksen på 50 til 600 mg.
2.
1,5-benzodiazepinderivat til anvendelse ifølge krav 1, hvor, i formel (1), R1 er en tert-butylgruppe, R2 er en cyclohexylgruppe, og Y er en enkeltbinding.
3.
1,5-benzodiazepinderivat til anvendelse ifølge krav 1, hvor et aktivt stof er (R)-(-)-3-[3-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)ureido]benzoesyre eller et farmaceutisk acceptabelt salt deraf.
4. 1,5-benzodiazepinderivat til anvendelse ifølge krav 1, hvor et aktivt stof er (R)-(-)-3-[3-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)ureido]benzoesyre eller et kalciumsalt deraf. 5.1,5-benzodiazepinderivat til anvendelse ifølge et hvilket som helst af kravene 1 til 4, ved behandling eller forebyggelse af cancersmerter i en peroral daglig dosis til en voksen på 180 til 500 mg. 6. 1,5-benzodiazepinderivat til anvendelse ifølge et hvilket som helst af kravene 1 til 5 i kombination med et andet smertestillende middel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008128735 | 2008-05-15 | ||
| PCT/JP2009/002109 WO2009139168A1 (ja) | 2008-05-15 | 2009-05-14 | 疼痛治療薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2305654T3 true DK2305654T3 (da) | 2016-01-11 |
Family
ID=41318543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09746375.6T DK2305654T3 (da) | 2008-05-15 | 2009-05-14 | Terapeutisk middel mod cancersmerter |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20110059956A1 (da) |
| EP (1) | EP2305654B1 (da) |
| JP (1) | JP5533649B2 (da) |
| KR (1) | KR101614966B1 (da) |
| CN (1) | CN102026987B (da) |
| AU (1) | AU2009247440B2 (da) |
| BR (1) | BRPI0911961A2 (da) |
| CA (1) | CA2723623C (da) |
| DK (1) | DK2305654T3 (da) |
| ES (1) | ES2550790T3 (da) |
| HU (1) | HUE026358T2 (da) |
| MX (1) | MX2010012425A (da) |
| PT (1) | PT2305654E (da) |
| RU (1) | RU2486900C2 (da) |
| SG (2) | SG10201502377RA (da) |
| TW (1) | TWI459948B (da) |
| WO (1) | WO2009139168A1 (da) |
| ZA (1) | ZA201007839B (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103374000B (zh) * | 2012-04-13 | 2015-11-11 | 中国科学院广州生物医药与健康研究院 | 嘧啶并二氮杂卓类化合物及其药用组合物和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484917A (en) * | 1993-06-16 | 1996-01-16 | Pfizer Inc. | Substituted tetrahydrobenzazepinones |
| JP3999819B2 (ja) * | 1996-12-10 | 2007-10-31 | ゼリア新薬工業株式会社 | １，５―ベンゾジアセピン誘導体 |
| TWI288747B (en) * | 1999-12-02 | 2007-10-21 | Zeria Pharm Co Ltd | Calcium salts of a 1,5-benzodiazepine derivative, a process for preparing the same, and drugs containing the same as the active ingredient |
| DE602006013094D1 (de) * | 2005-01-19 | 2010-05-06 | Zeria Pharm Co Ltd | Krebsmittel |
-
2009
- 2009-05-13 TW TW098115909A patent/TWI459948B/zh not_active IP Right Cessation
- 2009-05-14 WO PCT/JP2009/002109 patent/WO2009139168A1/ja not_active Ceased
- 2009-05-14 RU RU2010151433/15A patent/RU2486900C2/ru not_active IP Right Cessation
- 2009-05-14 ES ES09746375.6T patent/ES2550790T3/es active Active
- 2009-05-14 AU AU2009247440A patent/AU2009247440B2/en not_active Ceased
- 2009-05-14 HU HUE09746375A patent/HUE026358T2/en unknown
- 2009-05-14 KR KR1020107025219A patent/KR101614966B1/ko not_active Expired - Fee Related
- 2009-05-14 JP JP2010511888A patent/JP5533649B2/ja not_active Expired - Fee Related
- 2009-05-14 CA CA2723623A patent/CA2723623C/en not_active Expired - Fee Related
- 2009-05-14 EP EP09746375.6A patent/EP2305654B1/en not_active Not-in-force
- 2009-05-14 CN CN200980117150.8A patent/CN102026987B/zh not_active Expired - Fee Related
- 2009-05-14 SG SG10201502377RA patent/SG10201502377RA/en unknown
- 2009-05-14 DK DK09746375.6T patent/DK2305654T3/da active
- 2009-05-14 BR BRPI0911961A patent/BRPI0911961A2/pt not_active Application Discontinuation
- 2009-05-14 MX MX2010012425A patent/MX2010012425A/es active IP Right Grant
- 2009-05-14 SG SG2013031281A patent/SG189814A1/en unknown
- 2009-05-14 US US12/991,179 patent/US20110059956A1/en not_active Abandoned
- 2009-05-14 PT PT97463756T patent/PT2305654E/pt unknown
-
2010
- 2010-11-02 ZA ZA2010/07839A patent/ZA201007839B/en unknown
-
2014
- 2014-09-24 US US14/495,047 patent/US20150038495A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SG189814A1 (en) | 2013-05-31 |
| EP2305654B1 (en) | 2015-10-14 |
| KR20110021763A (ko) | 2011-03-04 |
| SG10201502377RA (en) | 2015-05-28 |
| CA2723623C (en) | 2016-01-19 |
| ES2550790T3 (es) | 2015-11-12 |
| PT2305654E (pt) | 2016-02-04 |
| JP5533649B2 (ja) | 2014-06-25 |
| JPWO2009139168A1 (ja) | 2011-09-15 |
| CA2723623A1 (en) | 2009-11-19 |
| KR101614966B1 (ko) | 2016-04-22 |
| AU2009247440A1 (en) | 2009-11-19 |
| HUE026358T2 (en) | 2016-06-28 |
| US20110059956A1 (en) | 2011-03-10 |
| US20150038495A1 (en) | 2015-02-05 |
| TW200946122A (en) | 2009-11-16 |
| AU2009247440B2 (en) | 2013-09-26 |
| CN102026987A (zh) | 2011-04-20 |
| BRPI0911961A2 (pt) | 2015-10-13 |
| EP2305654A4 (en) | 2012-03-21 |
| TWI459948B (zh) | 2014-11-11 |
| RU2010151433A (ru) | 2012-06-20 |
| CN102026987B (zh) | 2014-03-12 |
| MX2010012425A (es) | 2010-12-17 |
| RU2486900C2 (ru) | 2013-07-10 |
| EP2305654A1 (en) | 2011-04-06 |
| WO2009139168A1 (ja) | 2009-11-19 |
| ZA201007839B (en) | 2012-02-29 |
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