DK2401383T3 - Fremgangsmåder til udvælgelse af eukaryote celler, som udtrykker et heterologt protein - Google Patents
Fremgangsmåder til udvælgelse af eukaryote celler, som udtrykker et heterologt proteinInfo
- Publication number
- DK2401383T3 DK2401383T3 DK10709687.7T DK10709687T DK2401383T3 DK 2401383 T3 DK2401383 T3 DK 2401383T3 DK 10709687 T DK10709687 T DK 10709687T DK 2401383 T3 DK2401383 T3 DK 2401383T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- cells expressing
- eukaryotic cells
- heterologous protein
- selecting eukaryotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09154000 | 2009-02-27 | ||
| PCT/EP2010/001223 WO2010097239A1 (en) | 2009-02-27 | 2010-02-26 | Methods for selecting eukaryotic cells expressing a heterologous protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2401383T3 true DK2401383T3 (da) | 2013-12-16 |
Family
ID=40451117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10709687.7T DK2401383T3 (da) | 2009-02-27 | 2010-02-26 | Fremgangsmåder til udvælgelse af eukaryote celler, som udtrykker et heterologt protein |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8962274B2 (da) |
| EP (1) | EP2401383B1 (da) |
| JP (2) | JP5745431B2 (da) |
| KR (1) | KR101706399B1 (da) |
| CN (1) | CN102333875B (da) |
| AU (1) | AU2010219088B2 (da) |
| BR (1) | BRPI1008762B8 (da) |
| CA (1) | CA2753813C (da) |
| DK (1) | DK2401383T3 (da) |
| ES (1) | ES2440321T3 (da) |
| IL (1) | IL214620A (da) |
| MX (1) | MX2011009023A (da) |
| PL (1) | PL2401383T3 (da) |
| PT (1) | PT2401383E (da) |
| RU (1) | RU2551229C2 (da) |
| SG (1) | SG173457A1 (da) |
| WO (1) | WO2010097239A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5745431B2 (ja) * | 2009-02-27 | 2015-07-08 | ノバルティス アーゲー | 異種タンパク質を発現する真核生物細胞の選択方法 |
| CA2753814C (en) | 2009-02-27 | 2018-07-31 | Novartis Ag | Novel selection vectors and methods of selecting eukaryotic host cells |
| SG2014008809A (en) * | 2011-09-21 | 2014-04-28 | Hoffmann La Roche | Co2 profile cultivation |
| PT3027646T (pt) | 2013-07-31 | 2018-10-16 | Novartis Ag | Novos vetores e métodos de seleção de células hospedeiras eucarióticas |
| SG11201706617SA (en) * | 2015-04-03 | 2017-09-28 | Selexis Sa | Use of vitamins and vitamin metabolic genes and proteins for recombinant protein production in mammalian cells |
| UY37758A (es) | 2017-06-12 | 2019-01-31 | Novartis Ag | Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2585532B2 (ja) | 1986-05-10 | 1997-02-26 | 三井東圧化学株式会社 | 動物細胞の形質転換体及びそれを得る方法並びにその形質転換体を用いてｔ−ＰＡを生産する方法 |
| WO1991003554A1 (en) * | 1989-09-01 | 1991-03-21 | Genentech, Inc. | Cells transfected with nucleic acid encoding gtp |
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| AR008077A1 (es) | 1996-07-26 | 1999-12-09 | Talarico Salinas Laura Beatriz | Un polipeptido de fusion o una sal del mismo, su uso, un proceso para prepararlos, una composicion farmaceutica que los comprende, y un vector. |
| JP4031154B2 (ja) * | 1999-07-30 | 2008-01-09 | 独立行政法人科学技術振興機構 | 遺伝子増幅細胞の迅速選択法 |
| ATE427318T1 (de) | 2000-09-14 | 2009-04-15 | Beth Israel Hospital | Modulierung von il-2 und il-15 vermittelten t zellantworten |
| HUP0402226A2 (hu) * | 2001-11-28 | 2005-02-28 | Sandoz Ag. | Eljárás sejttenyésztésre |
| US7384744B2 (en) * | 2002-11-29 | 2008-06-10 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products |
| TW200513351A (en) * | 2003-07-17 | 2005-04-16 | Availvs Corp | High pressure water jet surface cutting device and cutting method |
| EP1533617A1 (en) | 2003-11-19 | 2005-05-25 | RMF Dictagene S.A. | Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer |
| EP1953222A1 (en) | 2007-01-24 | 2008-08-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Improvement of cell growth |
| KR20140001229A (ko) | 2007-03-30 | 2014-01-06 | 아보트 러보러터리즈 | 숙주 세포에서 재조합 단백질의 발현을 증강시키기 위한 재조합 발현 벡터 요소(ｒＥＶＥ) |
| JP5745431B2 (ja) * | 2009-02-27 | 2015-07-08 | ノバルティス アーゲー | 異種タンパク質を発現する真核生物細胞の選択方法 |
-
2010
- 2010-02-26 JP JP2011551443A patent/JP5745431B2/ja active Active
- 2010-02-26 RU RU2011139183/10A patent/RU2551229C2/ru active
- 2010-02-26 KR KR1020117022540A patent/KR101706399B1/ko active Active
- 2010-02-26 ES ES10709687.7T patent/ES2440321T3/es active Active
- 2010-02-26 PL PL10709687T patent/PL2401383T3/pl unknown
- 2010-02-26 EP EP10709687.7A patent/EP2401383B1/en active Active
- 2010-02-26 PT PT107096877T patent/PT2401383E/pt unknown
- 2010-02-26 AU AU2010219088A patent/AU2010219088B2/en active Active
- 2010-02-26 SG SG2011054087A patent/SG173457A1/en unknown
- 2010-02-26 DK DK10709687.7T patent/DK2401383T3/da active
- 2010-02-26 WO PCT/EP2010/001223 patent/WO2010097239A1/en not_active Ceased
- 2010-02-26 MX MX2011009023A patent/MX2011009023A/es active IP Right Grant
- 2010-02-26 CN CN201080009517.7A patent/CN102333875B/zh active Active
- 2010-02-26 BR BRPI1008762A patent/BRPI1008762B8/pt active IP Right Grant
- 2010-02-26 US US13/203,546 patent/US8962274B2/en active Active
- 2010-02-26 CA CA2753813A patent/CA2753813C/en active Active
-
2011
- 2011-08-11 IL IL214620A patent/IL214620A/en active IP Right Grant
-
2014
- 2014-02-06 US US14/174,228 patent/US9315844B2/en active Active
- 2014-12-24 JP JP2014261016A patent/JP2015107120A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2440321T3 (es) | 2014-01-28 |
| CA2753813C (en) | 2018-12-11 |
| EP2401383B1 (en) | 2013-09-18 |
| US20140154739A1 (en) | 2014-06-05 |
| KR101706399B1 (ko) | 2017-02-13 |
| JP2012518991A (ja) | 2012-08-23 |
| KR20110123783A (ko) | 2011-11-15 |
| US20110306095A1 (en) | 2011-12-15 |
| BRPI1008762A2 (pt) | 2015-08-25 |
| PL2401383T3 (pl) | 2014-02-28 |
| AU2010219088B2 (en) | 2012-11-01 |
| IL214620A0 (en) | 2011-09-27 |
| US8962274B2 (en) | 2015-02-24 |
| CN102333875B (zh) | 2014-04-16 |
| RU2011139183A (ru) | 2013-04-10 |
| JP5745431B2 (ja) | 2015-07-08 |
| US9315844B2 (en) | 2016-04-19 |
| AU2010219088A1 (en) | 2011-08-18 |
| CN102333875A (zh) | 2012-01-25 |
| BRPI1008762B8 (pt) | 2021-05-25 |
| MX2011009023A (es) | 2011-09-28 |
| IL214620A (en) | 2016-02-29 |
| SG173457A1 (en) | 2011-09-29 |
| CA2753813A1 (en) | 2010-09-02 |
| EP2401383A1 (en) | 2012-01-04 |
| WO2010097239A1 (en) | 2010-09-02 |
| BRPI1008762B1 (pt) | 2020-10-27 |
| PT2401383E (pt) | 2013-12-16 |
| RU2551229C2 (ru) | 2015-05-20 |
| JP2015107120A (ja) | 2015-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3159001T3 (da) | Hidtil ukendt fremgangsmåde til fremstilling af differentierede celler | |
| DK3287525T3 (da) | RNA-præparater omfattende oprenset modificeret RNA til omprogrammering af celler | |
| DK4306158T3 (da) | Klapprotese til udskiftning af mitralklap | |
| DK2569129T3 (da) | Fremgangsmåde til styring af en automatiseret arbejdscelle | |
| BRPI1009416A2 (pt) | célula solar. | |
| DK2510843T4 (da) | System, kapsel og fremgangsmåde til fremstilling af en drikkevare | |
| BR112012000107A2 (pt) | receptores de células t. | |
| DK2429486T4 (da) | Fremgangsmåde til fremstilling af en tværbundet gel | |
| DK2348215T3 (da) | Fremgangsmåde til planering af ujævnheder af havbunden | |
| DK2451643T3 (da) | Foliefrit emballagelaminat, fremgansgmåde til fremstilling af emballagelaminat og emballagebeholder deraf | |
| DK3363878T3 (da) | Fremgangsmåde til fremstilling af en hydrobearbejdningskatalysator | |
| BR112012003386A2 (pt) | método para comunicação com um nó correspondente, e, nó hospedeiro. | |
| BRPI1009795A2 (pt) | separador centrífugo, e, método em um separador centrífugo. | |
| IL245535B (en) | Method of engrafting cells from solid tissues | |
| DK2432975T3 (da) | Fremgangsmåde til at generere elektrisk energi, og anvendelse af et arbejdsmedium | |
| DK2569130T3 (da) | Fremgangsmåde til styring af en automatiseret arbejdscelle | |
| BRPI0924664A2 (pt) | eletrodo ,e ,método para construir um eletrodo. | |
| DK2497592T3 (da) | Skærende værktøj, fremgangsmåde til fremstilling af et formværktøj | |
| BRPI1013889A2 (pt) | Célula de levedura, e, método para gerar uma célula de levedura. | |
| BRPI1007317A2 (pt) | corrente para gerador eólico troposférico. | |
| DK2385248T3 (da) | Leje, især til en vindturbine | |
| DK2469081T3 (da) | Kontrolsystem, vindmøllepark og metoder til optimering af driften af en vindmølle | |
| DK2401383T3 (da) | Fremgangsmåder til udvælgelse af eukaryote celler, som udtrykker et heterologt protein | |
| DK2472055T3 (da) | Værktøj til tilvejebringelse af kunstigt løft | |
| DK2417152T3 (da) | Fremgangsmåde til isolering af linaclotid |