DK2416785T3 - Fremgangsmåde til behandling og forebyggelse af neuro-olfaktorisk udløste eller forværrede sygdomme eller relaterede tilstande - Google Patents
Fremgangsmåde til behandling og forebyggelse af neuro-olfaktorisk udløste eller forværrede sygdomme eller relaterede tilstande Download PDFInfo
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Claims (15)
1. Sammensætning til anvendelse ved en fremgangsmåde til behandling af i det mindste én af neuro-olfaktorisk udløste sygdomme og forværrede tilstande og tilstande relateret til neuro-olfaktorisk udløste sygdomme i et subjekt, hvilken sammensætning omfatter ét eller flere midler indrettet til at inducere et niveau af anosmi/hyposmi i subjektet, hvilket niveau af anosmi/hyposmi er tilstrækkeligt til i det væsentlige at mindske olfaktorisk sensorisk stimulation i subjektet og en neurologisk reaktion på stimuleringen, som er én eller begge af udløsning af og forværring af sygdommen eller tilstanden, hvor i det mindste ét af midlerne er et viskositetsforøgende middel, som forøger én eller begge af viskositeten og tykkelsen af et mukøst lag, som ligger over nasale olfaktoriske sensorer i subjektet, og som omfatter en naturlig eller syntetisk mucin, eller et polymert poly-saccharid; og hvilken fremgangsmåde omfatter trinnene med tilvejebringelse af sammensætningen og påføring af sammensætningen på et nasopharynx område på subjektet.
2. Sammensætning til anvendelsen ifølge krav 1, hvor det polymere polysaccharid vælges fra gruppen bestående af mikrokrystallinsk cellulose og vandopløselige cellulosederivater.
3. Sammensætning til anvendelsen ifølge krav 2, hvor de vandopløselige cellulosederivater vælges fra gruppen bestående af methylcellulose, hydroxy-ethylcellulose, hydroxypropylcellulose, carboxymethylcellulose og en alkalimetal-carboxyalkylcellulose.
4. Sammensætning til anvendelsen ifølge ethvert af kravene 1 til 3, hvor det viskositetsforøgende middel omfatter en blanding af mikrokrystallinsk cellulose og en alkalimetal-carboxyalkylcellulose, fortrinsvis natrium-carboxymethylcellulose.
5. Sammensætning til anvendelsen ifølge krav 4, hvor det viskositetsforøgende middel omfatter en blanding af 89 vægt% mikrokrystallinsk cellulose og 11 vægt% natrium-carboxymethylcellulose.
6. Sammensætning til anvendelsen ifølge krav 4 eller 5, hvor sammensætningen indeholder fra 2,5 vægt% til 10 vægt% af den nævnte blanding.
7. Sammensætning til anvendelsen ifølge krav 1, hvor ét eller flere af midlerne er et viskositetsforøgende middel indrettet til, individuelt eller i kombination med andre midler, at øge viskositeten af nasal mucus i subjektet til mere end 150 Poise.
8. Sammensætning til anvendelsen ifølge krav 1, hvor det ene eller flere midler, som påvirker anosmi/hyposmi, er GRAS-(Generally Recognized As Safe)-midler.
9. Sammensætning til anvendelsen ifølge krav 1, hvor trinnet med at påføre sammensætningen omfatter at subjektet sniffer sammensætningen.
10. Sammensætning til anvendelsen ifølge krav 1, hvor sammensætningen er i en næsesprayform, eller en næsedråbeform, eller i en topisk form.
11. Sammensætning til anvendelsen ifølge krav 1, hvor trinnet med påføring af sammensætningen omfatter påføring af sammensætningen til behandling af overvægt eller til behandling af multipel kemisk følsomhedssyndrom.
12. Sammensætning til anvendelsen ifølge krav 1, hvor trinnet med påføring af sammensætningen omfatter påføring af sammensætningen for behandling af én eller flere af en somatoform lidelse, kronisk træthedssyndrom, fibromyalgi, panisk lidelse, autisme, astma, epilepsi og posttraumatisk stresslidelse.
13. Sammensætning til anvendelsen ifølge krav 1, hvor trinnet med påføring af sammensætningen omfatter påføring af sammensætningen for undgåelse af normal fysiologisk reaktion eller følelse skabt ved udsættelsen for en normalt uacceptabel lugt.
14. Sammensætning til anvendelsen ifølge krav 1, hvor trinnet med påføring af sammensætningen eller trinnet med tilvejebringelse af sammensætningen ikke kræver en læges ordination.
15. Sammensætning til anvendelse ved en fremgangsmåde til forhindring af nauseocaptiv reaktion på lugte i et subjekt, hvor sammensætningen omfatter ét eller flere midler som angivet i et vilkårligt af kravene 1 til 8, indrettet til at inducere et niveau af anosmi/hyposmi i subjektet, hvilket niveau af anosmi/hyposmi er tilstrækkeligt til i det væsentlige at mindske olfaktorisk sensorisk stimulation i subjektet, hvilken sammensætning er i en form eller påføres, som defineret i et vilkårligt af kravene 9 til 14; og fremgangsmåden omfatter trinnene med at tilvejebringe sammensætningen og påføring af sammensætningen på subjektet periodisk i en mængde, som inducerer anosmi/hyposmi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16700509P | 2009-04-06 | 2009-04-06 | |
| PCT/US2010/030097 WO2010118028A1 (en) | 2009-04-06 | 2010-04-06 | Method of treating and preventing neuro-olfactory triggered or aggravated illnesses or related conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2416785T3 true DK2416785T3 (da) | 2016-04-11 |
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| DK10714402.4T DK2416785T3 (da) | 2009-04-06 | 2010-04-06 | Fremgangsmåde til behandling og forebyggelse af neuro-olfaktorisk udløste eller forværrede sygdomme eller relaterede tilstande |
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| EP (1) | EP2416785B1 (da) |
| DK (1) | DK2416785T3 (da) |
| ES (1) | ES2563047T3 (da) |
| WO (1) | WO2010118028A1 (da) |
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| WO2018213452A1 (en) * | 2017-05-19 | 2018-11-22 | Jackson Milton S | Appetite suppressant |
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| GB9218834D0 (en) | 1992-09-05 | 1992-10-21 | Procter & Gamble | Nasal spray products |
| US5976573A (en) | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
| DE29723959U1 (de) * | 1997-07-22 | 1999-07-22 | Zellner, Gerhard, Dr., 83435 Bad Reichenhall | Nasenspray-Flüssigkeit |
| US6565832B1 (en) | 2000-01-31 | 2003-05-20 | Schering-Plough Healthcare Products, Inc. | Spray composition with reduced dripping |
| WO2004084880A1 (en) * | 2003-03-21 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | METHODS FOR TREATING PAIN USING SMOOTH MUSCLE MODULATORS AND α2δ SUBUNIT CALCIUM CHANNEL MODULATORS |
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- 2010-04-06 DK DK10714402.4T patent/DK2416785T3/da active
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- 2010-04-06 EP EP10714402.4A patent/EP2416785B1/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| US20120093883A1 (en) | 2012-04-19 |
| EP2416785B1 (en) | 2016-02-10 |
| US9629868B2 (en) | 2017-04-25 |
| EP2416785A1 (en) | 2012-02-15 |
| ES2563047T3 (es) | 2016-03-10 |
| WO2010118028A1 (en) | 2010-10-14 |
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