DK2648621T3 - Generering af en egnet model til estimering af patientstrålingsdosis som følge af medicinske billeddannelsesscanninger - Google Patents

Generering af en egnet model til estimering af patientstrålingsdosis som følge af medicinske billeddannelsesscanninger Download PDF

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DK2648621T3
DK2648621T3 DK11846200.1T DK11846200T DK2648621T3 DK 2648621 T3 DK2648621 T3 DK 2648621T3 DK 11846200 T DK11846200 T DK 11846200T DK 2648621 T3 DK2648621 T3 DK 2648621T3
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James Couch
Gregory Couch
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Bayer Healthcare Llc
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    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
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Claims (14)

1. Computerimplementeret fremgangsmåde (400) til generering at en billeddannelsesmodel, der svarer til en første person (120), hvilken fremgangsmåde omfatter: valg af (405) et indledende matematisk fantom for den første person, der får foretaget en billeddannelsesscanning, hvor valget er baseret på den første persons alder og køn; modtagelse af et eller flere arbejdsbilleder (410) af den første person; valg (415) blandt billeder opnået fra flere personer af et referencesæt af ledebilleder med en kropsgeometri, størrelse og positionering, der er et tæt match med det indledende matematiske fantom; bestemmelse af (420) en transformation mellem mindst ét af ledebillederne og mindst ét af arbejdsbillederne af den første person; og deformering af det indledende matematiske fantom på basis af transformationen, hvorved et deformeret matematisk fantom, der opnås ved transformationen, er et bedre match (425) med hensyn til størrelsen, formen og organplaceringer for den første person.
2. Computerimplementeret fremgangsmåde ifølge krav 1, hvor bestemmelse af en transformation mellem mindst ét af ledebillederne og mindst ét af arbejdsbillederne af den første person omfatter udførelse af en billedregistreringsproces, der kortlægger et sæt af punkter i ét af ledebillederne til et tilsvarende sæt af punkter i ét af arbejdsbillederne af personen.
3. Computerimplementeret fremgangsmåde ifølge krav 1, hvor billeddannelsesscanningen er en computertomografi (CT)-scanning udført ved hjælp af en CT-scanner.
4. Computerimplementeret fremgangsmåde til generering af en billeddannelsesmodel, der svarer til en person (120), hvilken fremgangsmåde omfatter: valg af et indledende matematisk fantom for en person (120), der får foretaget en billeddannelsesscanning, der udføres ved hjælp af et billedscanningsapparat (105); segmentering af en referencescanning, der er forbundet med personen, til identificering af et tredimensionelt (3D) volumen af en flerhed af anatomiske pejlemærker hos personen, der er til stede i referencescanningen; for mindst ét af flerheden af anatomiske pejlemærker bestemmelse af et geometrisk tyngdepunkt for det respektive 3D-volumen; matchning af et eller flere af de identificerede anatomiske pejlemærker i den segmenterede referencescanning til tilsvarende anatomiske pejlemærker i det indledende matematiske fantom; og deformering af det indledende matematiske fantom på basis af de matchede anatomiske pejlemærker, hvor deformering af det indledende matematiske fantom omfatter; bestemmelse af et tredimensionelt forskydningskort, der viser forskydning fra mindst ét geometrisk tyngdepunkt for de identificerede anatomiske pejlemærker til geometriske tyngdepunkter for de tilsvarende anatomiske pejlemærker for det indledende matematiske fantom; voxelering af den indledende billeddannelsesscanning; transformering af det voxelerede indledende matematiske fantom, så det matcher det tredimensionelle forskydningskort; og bestemmelse af om to eller flere af de tilsvarende anatomiske pejlemærker for det indledende matematiske fantom overlapper i det samme fysiske volumen i det transformerede, voxelerede indledende matematiske fantom.
5. Fremgangsmåde ifølge krav 1 eller 4, der yderligere omfatter: modtagelse af et sæt af parametre, der beskriver billeddannelsesscanningen og billedscanningsapparater, der anvendes til udførelse af billeddannelsesscanningen; simulering af billeddannelsesscanningen ved anvendelse af det deformerede matematiske fantom og det modtagne sæt af parametre; og estimering på basis af simuleringen af mængder af stråling, der er absorberet af personen som følge af udførelse af billeddannelsesscanningen.
6. System, der omfatter; en processor; og en hukommelse, der lagrer et applikationsprogram, der er konfigureret til at udføre en operation til generering af en billeddannelsesmodel, der svarer til en første person, hvilken operation omfatter: valg af et indledende matematisk fantom for den første person, der får foretaget en billeddannelsesscanning, hvilket valg er baseret på den første persons alder og køn, modtagelse af et eller flere arbejdsbilleder af den første person, valg blandt billeder opnået fra flere personer af et referencesæt af ledebilleder med en kropsgeometri, størrelse og positionering, der er et tæt match med det indledende matematiske fantom; bestemmelse af en transformation mellem mindst ét af ledebillederne og mindst ét af arbejdsbillederne af den første person, og deformering af det indledende matematiske fantom på basis af transformationen, hvorved et deformeret matematisk fantom, der opnås ved transformationen, er et bedre match (425) med hensyn til størrelsen, formen og organplaceringer for den første person.
7. System (125, 130), der omfatter; en processor (205, 305); og en hukommelse (220, 320), der lagrer et applikationsprogram (232), der er konfigureret til at udføre en operation til generering af en billeddannelsesmodel, der svarer til en person, hvilken operation omfatter: valg af et indledende matematisk fantom for personen, der får foretaget en computtomografi (CT)-scanning, segmentering (610) af en reference-CT-scanning, der er forbundet med personen, til identificering (615) af et tredimensionelt (3D)-volumen af en flerhed af anatomiske pejlemærker hos personen, der er til stede i reference-CT-scanningen, for mindst ét af flerheden af anatomiske pejlemærker bestemmelse af et geometrisk tyngdepunkt for det respektive 3D-volumen; matchning (620) af et eller flere af de identificerede anatomiske pejlemærker i den segmenterede reference-CT- scanning til tilsvarende anatomiske pejlemærker i det indledende matematiske fantom og deformering af det indledende matematiske fantom på basis af de matchede anatomiske pejlemærker, hvor deformering af det indledende matematiske fantom på basis af de matchede anatomiske pejlemærker omfatter; bestemmelse (625) af et tredimensionelt forskydningskort, der viser forskydning fra det mindst ene geometriske tyngdepunkt for de identificerede anatomiske pejlemærker til geometriske tyngdepunkter for de tilsvarende anatomiske pejlemærker for det indledende matematiske fantom; voxelering af den indledende billeddannelsesscanning; transformering (630) af det voxelerede indledende matematiske fantom, så det matcher det tredimensionelle forskydningskort; og bestemmelse af om to eller flere af de tilsvarende anatomiske pejlemærker for det indledende matematiske fantom overlapper i det samme fysiske volumen i det transformerede, voxelerede indledende matematiske fantom.
8. Computerimplementeret fremgangsmåde ifølge krav 3, der yderligere omfatter: modtagelse af et sæt af parametre, der beskriver billeddannelsesscanningen og CT-scanningsapparatet (105), der anvendes til udførelse af CT-scanningen af den første person (120) ; opnåelse af adgang til et simuleringsbibliotek (335), der omfatter en flerhed af tidligere udførte simuleringer til estimering af strålingsdosisabsorption, der svarer til den ene eller de flere andre personer; evaluering (328) af flerheden af tidligere udførte simuleringer til estimering af strålingsdosisabsorption, der svarer til den ene eller de flere andre personer; tilvejebringelse af realtidssøgning på basis af evalueringen efter én af flerheden af tidligere udførte simuleringer i simuleringsbiblioteket (335), der har et sæt af parametre, der matcher med et specificeret tolerancemål, det modtagne sæt af parametre og det deformerede matematiske fantom; og bestemmelse (1030) af estimatet for strålingsdosisabsorption, der er forbundet med den ene af de tidligere udførte simuleringer, der er søgt i simuleringsbiblioteket, som estimatet for strålingsdosis absorberet af den første person.
9. Computerimplementeret fremgangsmåde ifølge krav 8, hvor estimatet for strålingsdosis absorberet af den første person tilvejebringer estimater for en organabsorberet dosis for et eller flere organer hos den første person.
10. Computerimplementeret fremgangsmåde ifølge krav 8, der yderligere omfatter lagring af sættet af parametre og estimatet for strålingsdosis absorberet af den første person i simuleringsbiblioteket.
11. Computerimplementeret fremgangsmåde ifølge krav 3, hvor opnåelsen af et eller flere arbejdsbilleder af den første person omfatter: optagelse af en todimensionel (2D)-projektion af den første person ved anvendelse af CT-scanneren (105) og før udførelse af CT-scanningen.
12. Computerimplementeret fremgangsmåde ifølge krav 1, hvor bestemmelse af transformationen mellem mindst ét af arbejdsbillederne af den første person og det mindst ene af ledebillederne omfatter: udførelse af en billedregistreringsproces, der kortlægger et sæt af punkter i ét af ledebillederne til et tilsvarende sæt af punkter i ét af arbejdsbillederne af den første person.
13. Computerimplementeret fremgangsmåde ifølge krav 1, hvor det indledende matematiske fantom omfatter et sæt af NURB'er (non-uniform rational basis splines).
14. Computerimplementeret fremgangsmåde ifølge krav 1, der yderligere omfatter valg af mindst ét af ledebillederne på basis af, hvor tæt det matcher med det indledende matematiske fantom i et område, der skal afbildes i billeddannelsesscanningen, der udføres på den første person, hvor transformationen bestemmes mellem det valgte mindst ene af ledebillederne og mindst ét af arbejdsbillederne af den første person.
DK11846200.1T 2010-12-08 2011-12-08 Generering af en egnet model til estimering af patientstrålingsdosis som følge af medicinske billeddannelsesscanninger DK2648621T3 (da)

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DK16192895.7T DK3150126T3 (da) 2010-12-08 2011-12-08 Frembringelse af en egnet model til estimering af patientgivet strålingsdosis, der resulterer fra medicinske billedscanninger
DK19164751.0T DK3524159T3 (da) 2010-12-08 2011-12-08 Frembringelse af en egnet model til estimering af strålingsdosis modtaget af patient under scanninger til medicinsk billeddannelse
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DK16192895.7T DK3150126T3 (da) 2010-12-08 2011-12-08 Frembringelse af en egnet model til estimering af patientgivet strålingsdosis, der resulterer fra medicinske billedscanninger
DK19164751.0T DK3524159T3 (da) 2010-12-08 2011-12-08 Frembringelse af en egnet model til estimering af strålingsdosis modtaget af patient under scanninger til medicinsk billeddannelse

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