DK2793954T3 - 18f-fluciclovin-sammensætninger i citratbuffere - Google Patents

18f-fluciclovin-sammensætninger i citratbuffere Download PDF

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Publication number
DK2793954T3
DK2793954T3 DK12806500.0T DK12806500T DK2793954T3 DK 2793954 T3 DK2793954 T3 DK 2793954T3 DK 12806500 T DK12806500 T DK 12806500T DK 2793954 T3 DK2793954 T3 DK 2793954T3
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DK
Denmark
Prior art keywords
fluciclovin
compositions
citrate buffers
citrate
buffers
Prior art date
Application number
DK12806500.0T
Other languages
English (en)
Inventor
Kristine Romoren
Olav Ryan
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Priority claimed from PCT/EP2012/076689 external-priority patent/WO2013093025A1/en
Application granted granted Critical
Publication of DK2793954T3 publication Critical patent/DK2793954T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0404Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B9/00General methods of preparing halides
    • C01B9/08Fluorides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001Acyclic or carbocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK12806500.0T 2010-12-29 2012-12-21 18f-fluciclovin-sammensætninger i citratbuffere DK2793954T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061427839P 2010-12-29 2010-12-29
PCT/EP2011/073670 WO2012089594A1 (en) 2010-12-29 2011-12-21 Eluent solution
PCT/EP2012/076689 WO2013093025A1 (en) 2011-12-21 2012-12-21 18f - fluciclovine compositions in citrate buffers

Publications (1)

Publication Number Publication Date
DK2793954T3 true DK2793954T3 (da) 2021-01-04

Family

ID=45495902

Family Applications (3)

Application Number Title Priority Date Filing Date
DK11808853.3T DK2658831T3 (da) 2010-12-29 2011-12-21 Elueringsopløsning
DK12806500.0T DK2793954T3 (da) 2010-12-29 2012-12-21 18f-fluciclovin-sammensætninger i citratbuffere
DK20196030.9T DK3766522T3 (da) 2010-12-29 2012-12-21 Automatiseret fremgangsmåde til fremstillingen af 18f-fluciclovin-sammensætninger

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11808853.3T DK2658831T3 (da) 2010-12-29 2011-12-21 Elueringsopløsning

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK20196030.9T DK3766522T3 (da) 2010-12-29 2012-12-21 Automatiseret fremgangsmåde til fremstillingen af 18f-fluciclovin-sammensætninger

Country Status (16)

Country Link
US (3) US11504430B2 (da)
EP (2) EP2658831B1 (da)
JP (1) JP6018581B2 (da)
KR (3) KR102218263B1 (da)
CN (2) CN108218650A (da)
AU (1) AU2011351550B2 (da)
BR (2) BR112013015396B1 (da)
CA (1) CA2823063C (da)
DK (3) DK2658831T3 (da)
ES (2) ES2621950T3 (da)
MX (1) MX363538B (da)
PL (2) PL2658831T3 (da)
PT (2) PT2793954T (da)
RU (1) RU2608932C2 (da)
SG (1) SG10201805198TA (da)
WO (1) WO2012089594A1 (da)

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GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
KR20140102700A (ko) * 2011-12-21 2014-08-22 지이 헬쓰케어 리미티드 시트레이트 완충제 내 18f―플루시클로빈 조성물
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
GB201221266D0 (en) 2012-11-27 2013-01-09 Ge Healthcare Ltd Aldehyde compositions
GB201305687D0 (en) * 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
ES3005832T3 (en) * 2013-11-13 2025-03-17 Ge Healthcare Ltd Dual run cassette for the synthesis of 18f-labelled compounds
US9988336B2 (en) * 2014-03-18 2018-06-05 Mayo Foundation For Medical Education And Research Gaseous F-18 technologies
NL2014828B1 (en) * 2015-05-20 2017-01-31 Out And Out Chemistry S P R L Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method.
JP6827709B2 (ja) * 2016-04-25 2021-02-10 日本メジフィジックス株式会社 2−[18f]フルオロ−2−デオキシ−d−グルコースの製造方法
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
JP7148121B2 (ja) * 2018-08-31 2022-10-05 国立大学法人北海道大学 放射性核種18fの精製方法
GB202005282D0 (en) * 2020-04-09 2020-05-27 Blue Earth Diagnostics Ltd Pharmaceutical Formulations
KR20230092982A (ko) * 2020-10-22 2023-06-26 니혼 메디피직스 가부시키가이샤 방사성 지르코늄 착체의 제조 방법
JP7127164B2 (ja) * 2021-01-19 2022-08-29 日本メジフィジックス株式会社 2-[18f]フルオロ-2-デオキシ-d-グルコースの製造方法
CN113372399A (zh) * 2021-06-04 2021-09-10 江苏华益科技有限公司 一种氟[18f]脱氧葡糖注射液的合成方法
CN119591463B (zh) * 2024-11-27 2025-12-09 遵义医科大学 一种 [18f] 三氟甲基末端烯烃的放射性标记方法

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EP1356827A1 (en) 2002-04-24 2003-10-29 Mallinckrodt Inc. Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG)-solution
ES2347535T3 (es) 2002-11-05 2010-11-02 Ion Beam Applications S.A. Estabilizacion de composiciones acuosas de 2-fluoro-2-desoxi-d-glucosa marcada con el isotopo 18f con etanol.
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CA2823063C (en) * 2010-12-29 2020-08-11 Ge Healthcare Limited A method for preparation of f for use in a radiofluorination reaction
GB201214220D0 (en) * 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis

Also Published As

Publication number Publication date
AU2011351550A1 (en) 2013-07-25
US20190192660A1 (en) 2019-06-27
US20130324715A1 (en) 2013-12-05
AU2011351550B2 (en) 2017-02-02
BR112014015042B1 (pt) 2021-10-26
ES2621950T3 (es) 2017-07-05
RU2608932C2 (ru) 2017-01-26
CN108218650A (zh) 2018-06-29
PT3766522T (pt) 2022-06-14
MX363538B (es) 2019-03-27
BR112013015396B1 (pt) 2021-11-03
MX2013007699A (es) 2013-08-15
US20230068052A1 (en) 2023-03-02
KR102218263B1 (ko) 2021-02-22
PL3766522T3 (pl) 2022-07-04
KR20190008994A (ko) 2019-01-25
EP3766522A1 (en) 2021-01-20
PT2793954T (pt) 2021-01-06
WO2012089594A1 (en) 2012-07-05
CA2823063A1 (en) 2012-07-05
CA2823063C (en) 2020-08-11
KR20130132892A (ko) 2013-12-05
ES2917875T3 (es) 2022-07-12
CN103270004A (zh) 2013-08-28
DK2658831T3 (da) 2017-04-24
SG10201805198TA (en) 2018-07-30
KR102137348B1 (ko) 2020-07-23
DK3766522T3 (da) 2022-06-13
KR20190119673A (ko) 2019-10-22
JP2014508731A (ja) 2014-04-10
US11504430B2 (en) 2022-11-22
BR112014015042A8 (pt) 2017-07-04
BR112014015042A2 (pt) 2017-06-13
EP2658831B1 (en) 2017-02-15
JP6018581B2 (ja) 2016-11-02
EP3766522B1 (en) 2022-03-23
BR112013015396A2 (pt) 2016-09-20
PL2658831T3 (pl) 2017-07-31
RU2013126979A (ru) 2015-03-20
EP2658831A1 (en) 2013-11-06

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