DK3431590T3 - Fremgangsmåde til fremstilling af aktiveret hepatocytvækstfaktor (hgf) - Google Patents
Fremgangsmåde til fremstilling af aktiveret hepatocytvækstfaktor (hgf) Download PDFInfo
- Publication number
- DK3431590T3 DK3431590T3 DK17766718.5T DK17766718T DK3431590T3 DK 3431590 T3 DK3431590 T3 DK 3431590T3 DK 17766718 T DK17766718 T DK 17766718T DK 3431590 T3 DK3431590 T3 DK 3431590T3
- Authority
- DK
- Denmark
- Prior art keywords
- hepatocy
- hgf
- procedure
- growth factor
- preparing activated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21034—Plasma kallikrein (3.4.21.34)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016054128 | 2016-03-17 | ||
| PCT/JP2017/010355 WO2017159722A1 (ja) | 2016-03-17 | 2017-03-15 | 活性型肝細胞増殖因子（ｈｇｆ）の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3431590T3 true DK3431590T3 (da) | 2021-10-11 |
Family
ID=59850449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17766718.5T DK3431590T3 (da) | 2016-03-17 | 2017-03-15 | Fremgangsmåde til fremstilling af aktiveret hepatocytvækstfaktor (hgf) |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11548926B2 (da) |
| EP (1) | EP3431590B1 (da) |
| JP (1) | JP6861201B2 (da) |
| KR (1) | KR102275262B1 (da) |
| CN (1) | CN109196099B (da) |
| AU (1) | AU2017232582B2 (da) |
| CA (1) | CA3014567C (da) |
| DK (1) | DK3431590T3 (da) |
| ES (1) | ES2894477T3 (da) |
| HU (1) | HUE055414T2 (da) |
| IL (1) | IL261066B (da) |
| LT (1) | LT3431590T (da) |
| MX (1) | MX395311B (da) |
| RU (1) | RU2747977C2 (da) |
| SG (1) | SG11201806843UA (da) |
| WO (1) | WO2017159722A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2894477T3 (es) | 2016-03-17 | 2022-02-14 | Eisai R&D Man Co Ltd | Método para producir factor de crecimiento de hepatocitos (HGF) activo |
| CN110607304A (zh) * | 2019-07-25 | 2019-12-24 | 广州凌腾生物医药有限公司 | 肝细胞生长因子的重组表达方法 |
| CN110606883A (zh) * | 2019-07-25 | 2019-12-24 | 广州凌腾生物医药有限公司 | 肝细胞生长因子的制备方法 |
| WO2024096038A1 (ja) * | 2022-11-01 | 2024-05-10 | クリングルファーマ株式会社 | 活性型ｈｇｆの製造方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2564486B2 (ja) | 1986-07-14 | 1996-12-18 | 修治 橋本 | 肝細胞増殖因子 |
| NZ232813A (en) | 1989-03-10 | 1992-08-26 | Snow Brand Milk Products Co Ltd | Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons |
| JP2706704B2 (ja) | 1989-06-05 | 1998-01-28 | 敏一 中村 | 組換ヒト肝実質細胞増殖因子 |
| JP3036782B2 (ja) | 1990-04-03 | 2000-04-24 | 三菱化学株式会社 | ヒト肝実質細胞増殖因子の生産方法および該因子を産生する形質転換体 |
| JP2577091B2 (ja) | 1989-08-11 | 1997-01-29 | 三菱化学株式会社 | 肝実質細胞増殖因子及びそれをコードする遺伝子 |
| JP2777678B2 (ja) | 1990-06-11 | 1998-07-23 | 敏一 中村 | 組換ヒト肝実質細胞増殖因子及びその製造方法 |
| JP3072628B2 (ja) | 1990-11-19 | 2000-07-31 | 敏一 中村 | ヒト肝実質細胞増殖因子をコードする染色体ｄｎａ |
| JP3213985B2 (ja) * | 1991-10-18 | 2001-10-02 | 三菱化学株式会社 | 新規なタンパク質 |
| JP3232714B2 (ja) * | 1992-11-20 | 2001-11-26 | 三菱化学株式会社 | 新規なタンパク質およびそれをコードする遺伝子 |
| CA2102463A1 (en) * | 1992-11-05 | 1994-05-06 | Mitsubishi Chemical Corporation | Protein and gene encoding said protein |
| DE69426292T2 (de) | 1993-02-23 | 2001-05-17 | Genentech, Inc. | Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff |
| JP2577091Y2 (ja) | 1993-06-23 | 1998-07-23 | 賢一 片山 | 分流装置の合成樹脂製サドル |
| JP3680114B2 (ja) * | 1993-09-17 | 2005-08-10 | 敏一 中村 | 脳神経障害治療剤 |
| JP2747979B2 (ja) | 1994-08-19 | 1998-05-06 | 雪印乳業株式会社 | ヒト由来の糖蛋白質からなる生理活性因子を有効成分とする医薬 |
| JP3927248B2 (ja) | 1995-07-11 | 2007-06-06 | 第一製薬株式会社 | Ｈｇｆ凍結乾燥製剤 |
| JP2859577B2 (ja) | 1996-03-27 | 1999-02-17 | 三菱化学株式会社 | 肝実質細胞増殖因子 |
| JP4463885B2 (ja) | 1996-12-05 | 2010-05-19 | 敏一 中村 | 劇症肝炎疾患治療剤 |
| JP2980888B2 (ja) | 1998-07-09 | 1999-11-22 | 三菱化学株式会社 | 肝実質細胞増殖因子をコードする遺伝子 |
| KR100767473B1 (ko) | 1999-05-31 | 2007-10-17 | 미쯔비시 가가꾸 가부시끼가이샤 | 간실질세포 증식인자 동결건조 제제 |
| JP3072628U (ja) | 2000-02-17 | 2000-10-24 | 輝夫 尾形 | ステンドグラス製文字入り記念楯 |
| JP4090236B2 (ja) * | 2000-12-05 | 2008-05-28 | 三菱化学株式会社 | 活性型肝細胞増殖因子アクティベーターに対する特異的抗体とその使用法 |
| US7045602B2 (en) * | 2000-12-05 | 2006-05-16 | Mitsubishi Chemical Corporation | Specific antibody directed to active hepatocyte growth factor activator and method for using the same |
| DE10204792A1 (de) | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
| AU2005269463B2 (en) * | 2004-07-26 | 2011-08-18 | Genentech, Inc. | Methods and compositions for modulating hepatocyte growth factor activation |
| US7741096B2 (en) * | 2004-12-10 | 2010-06-22 | Genentech, Inc. | Crystal structure of hepatocyte growth factor activator complexed with Kunitz domain inhibitor |
| EP1954714A2 (en) * | 2005-11-10 | 2008-08-13 | Receptor Biologix, Inc. | Hepatocyte growth factor intron fusion proteins |
| EP2014676B1 (en) | 2006-04-20 | 2012-03-07 | Kringle Pharma Inc. | Hgf precursor protein mutant and activated form thereof |
| WO2008078189A2 (en) | 2006-12-20 | 2008-07-03 | Bayer Healthcare Llc | Factor vii and viia compositions |
| WO2008102452A1 (ja) | 2007-02-22 | 2008-08-28 | Kringle Pharma Inc. | Ｈｇｆ製剤 |
| EP2362767B1 (en) | 2008-10-29 | 2017-12-06 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
| CN101649320B (zh) * | 2009-09-15 | 2011-06-15 | 上海交通大学医学院附属仁济医院 | 重组人源hgf激活因子及其应用 |
| US8759491B2 (en) * | 2009-10-19 | 2014-06-24 | Genentech, Inc. | Modulators of hepatocyte growth factor activator |
| WO2011102845A1 (en) | 2010-02-18 | 2011-08-25 | Transtech Pharma, Inc. | Rage fusion protein compositions and methods of use |
| JP2012051822A (ja) | 2010-08-31 | 2012-03-15 | Institute Of Physical & Chemical Research | 肺癌診断用ポリペプチド、肺癌の検出方法、および治療効果の評価方法 |
| US9272018B2 (en) | 2011-04-18 | 2016-03-01 | Kyoto University | Acute hepatic insufficiency depressant and method for evaluating drug efficacy thereof |
| US20130071931A1 (en) | 2011-08-02 | 2013-03-21 | National Cancer Center | Process for hepatic differentiation from induced hepatic stem cells, and induced hepatic progenitor cells differentiated thereby |
| AU2013201422B2 (en) * | 2012-01-23 | 2015-04-09 | Ablynx Nv | Sequences directed against hepatocyte growth factor (HFG) and polypeptides comprising the same for the treatment of cancers and/or tumors |
| CN105209074A (zh) | 2012-10-20 | 2015-12-30 | 得克萨斯大学体系董事会 | 癌细胞陷阱 |
| RU2506946C1 (ru) | 2012-11-28 | 2014-02-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации | Технология лиофилизации обогащенной тромбоцитами плазмы с сохранением жизнеспособности факторов tgf pdgf vegf |
| US11547743B2 (en) | 2014-04-28 | 2023-01-10 | Eisai R&D Management Co., Ltd. | Lyophilized formulation of HGF |
| ES2894477T3 (es) | 2016-03-17 | 2022-02-14 | Eisai R&D Man Co Ltd | Método para producir factor de crecimiento de hepatocitos (HGF) activo |
| US20200341014A1 (en) | 2016-03-18 | 2020-10-29 | Eisai R&D Management Co., Ltd. | PD Marker of Hepatocyte Growth Factor (HGF) |
| CN208371461U (zh) | 2017-08-21 | 2019-01-15 | 潍坊鸿旺工贸有限公司 | 一种晾衣架用连接构件及晾衣架 |
-
2017
- 2017-03-15 ES ES17766718T patent/ES2894477T3/es active Active
- 2017-03-15 US US16/078,568 patent/US11548926B2/en active Active
- 2017-03-15 JP JP2018505972A patent/JP6861201B2/ja active Active
- 2017-03-15 SG SG11201806843UA patent/SG11201806843UA/en unknown
- 2017-03-15 AU AU2017232582A patent/AU2017232582B2/en active Active
- 2017-03-15 LT LTEPPCT/JP2017/010355T patent/LT3431590T/lt unknown
- 2017-03-15 RU RU2018130530A patent/RU2747977C2/ru active
- 2017-03-15 KR KR1020187024470A patent/KR102275262B1/ko active Active
- 2017-03-15 DK DK17766718.5T patent/DK3431590T3/da active
- 2017-03-15 CN CN201780013057.7A patent/CN109196099B/zh active Active
- 2017-03-15 WO PCT/JP2017/010355 patent/WO2017159722A1/ja not_active Ceased
- 2017-03-15 MX MX2018010283A patent/MX395311B/es unknown
- 2017-03-15 EP EP17766718.5A patent/EP3431590B1/en active Active
- 2017-03-15 HU HUE17766718A patent/HUE055414T2/hu unknown
- 2017-03-15 CA CA3014567A patent/CA3014567C/en active Active
-
2018
- 2018-08-08 IL IL261066A patent/IL261066B/en unknown
-
2022
- 2022-05-05 US US17/737,343 patent/US20220267393A1/en not_active Abandoned
-
2024
- 2024-02-01 US US18/429,738 patent/US12384824B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018010283A (es) | 2019-01-31 |
| US20240218035A1 (en) | 2024-07-04 |
| LT3431590T (lt) | 2021-09-10 |
| ES2894477T3 (es) | 2022-02-14 |
| MX395311B (es) | 2025-03-25 |
| KR102275262B1 (ko) | 2021-07-12 |
| JP6861201B2 (ja) | 2021-04-21 |
| IL261066B (en) | 2021-08-31 |
| AU2017232582B2 (en) | 2022-07-14 |
| AU2017232582A1 (en) | 2018-08-30 |
| RU2018130530A3 (da) | 2020-08-13 |
| SG11201806843UA (en) | 2018-09-27 |
| CN109196099A (zh) | 2019-01-11 |
| US20190062390A1 (en) | 2019-02-28 |
| WO2017159722A1 (ja) | 2017-09-21 |
| US20220267393A1 (en) | 2022-08-25 |
| CA3014567A1 (en) | 2017-09-21 |
| CN109196099B (zh) | 2022-01-11 |
| RU2018130530A (ru) | 2020-04-17 |
| KR20180127322A (ko) | 2018-11-28 |
| RU2747977C2 (ru) | 2021-05-18 |
| US11548926B2 (en) | 2023-01-10 |
| EP3431590B1 (en) | 2021-07-28 |
| HUE055414T2 (hu) | 2021-11-29 |
| EP3431590A1 (en) | 2019-01-23 |
| CA3014567C (en) | 2024-02-20 |
| JPWO2017159722A1 (ja) | 2019-01-24 |
| IL261066A (en) | 2018-10-31 |
| EP3431590A4 (en) | 2019-11-20 |
| US12384824B2 (en) | 2025-08-12 |
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