DK3639829T3 - Anvendelse af isovalerylspiramycin i eller iii ved fremstilling af lægemiddel til behandling og/eller forebyggelse af tumor samt lægemiddel - Google Patents
Anvendelse af isovalerylspiramycin i eller iii ved fremstilling af lægemiddel til behandling og/eller forebyggelse af tumor samt lægemiddel Download PDFInfo
- Publication number
- DK3639829T3 DK3639829T3 DK18827765.1T DK18827765T DK3639829T3 DK 3639829 T3 DK3639829 T3 DK 3639829T3 DK 18827765 T DK18827765 T DK 18827765T DK 3639829 T3 DK3639829 T3 DK 3639829T3
- Authority
- DK
- Denmark
- Prior art keywords
- medicines
- tumors
- prevention
- iii
- manufacture
- Prior art date
Links
- ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 title 1
- -1 ISOVALERYL Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 239000004187 Spiramycin Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 229960001294 spiramycin Drugs 0.000 title 1
- 229930191512 spiramycin Natural products 0.000 title 1
- 235000019372 spiramycin Nutrition 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710537958 | 2017-07-04 | ||
| CN201711497546 | 2017-12-27 | ||
| CN201711450396 | 2017-12-27 | ||
| CN201711450300 | 2017-12-27 | ||
| PCT/CN2018/094504 WO2019007368A1 (zh) | 2017-07-04 | 2018-07-04 | 异戊酰螺旋霉素i、ii和/或iii在制备治疗和/或预防肿瘤药物方面的应用和药物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3639829T3 true DK3639829T3 (da) | 2022-05-16 |
Family
ID=64950608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18827765.1T DK3639829T3 (da) | 2017-07-04 | 2018-07-04 | Anvendelse af isovalerylspiramycin i eller iii ved fremstilling af lægemiddel til behandling og/eller forebyggelse af tumor samt lægemiddel |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20200163984A1 (da) |
| EP (1) | EP3639829B1 (da) |
| JP (1) | JP7060631B2 (da) |
| KR (1) | KR102375444B1 (da) |
| CN (1) | CN110869027B (da) |
| AU (1) | AU2018298187A1 (da) |
| CA (1) | CA3068921A1 (da) |
| DK (1) | DK3639829T3 (da) |
| ES (1) | ES2912734T3 (da) |
| MX (1) | MX390755B (da) |
| RU (1) | RU2766176C2 (da) |
| WO (1) | WO2019007368A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110051845A (zh) * | 2018-01-19 | 2019-07-26 | 沈阳福洋医药科技有限公司 | 一种mTOR抑制剂、药物组合物及其应用 |
| MX2020007627A (es) | 2018-01-19 | 2020-11-24 | Shenyang Fuyang Pharmaceutical Tech Co Ltd | Uso de la carrimicina o de sus ingredientes activos. |
| KR20220008895A (ko) * | 2019-05-16 | 2022-01-21 | 쉔양 푸양 파마슈티컬 테크놀로지 컴퍼니 리미티드 | 섬유증을 예방, 완화 및/또는 치료하는 약물, 복합 제품 및 이의 응용 |
| US11351185B2 (en) | 2020-03-11 | 2022-06-07 | Asclea Corporation | Use of isovalerylspiramycins as anti-cancer agents to inhibit metastasis |
| CN113577086B (zh) * | 2020-04-30 | 2023-05-02 | 沈阳福洋医药科技有限公司 | 异戊酰螺旋霉素类化合物或其组合物在制备治疗免疫失调的药物中的应用 |
| CN113372397A (zh) * | 2021-06-22 | 2021-09-10 | 天方药业有限公司 | 一种己二酸螺旋霉素的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1540397A (en) * | 1976-12-08 | 1979-02-14 | May & Baker Ltd | Spiramycin esters |
| CA2127578A1 (en) * | 1993-07-08 | 1995-01-09 | Keiichi Ajito | 16-membered macrolide derivatives and process for producing the same |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| DE602007006663D1 (de) | 2006-06-12 | 2010-07-01 | Univ Ramot | Verfahren zur behandlung von krebs |
| CN101362784A (zh) | 2008-10-06 | 2009-02-11 | 山东大学 | 埃博霉素苷类化合物和以其为活性成分的组合物及其应用 |
| CN101785779B (zh) | 2010-03-09 | 2014-03-05 | 沈阳同联集团有限公司 | 异戊酰螺旋霉素ii的分离制备 |
| CN101785778A (zh) * | 2010-03-09 | 2010-07-28 | 沈阳同联集团有限公司 | 异戊酰螺旋霉素i的分离制备及其应用 |
| CN101773510B (zh) | 2010-03-09 | 2013-06-05 | 沈阳同联集团有限公司 | 异戊酰螺旋霉素iii的分离制备 |
| CA2800019C (en) | 2010-05-25 | 2015-05-26 | Shenyang Tonglian Group Co., Ltd. | Levocarrimycin, pharmaceutical compositions, preparation methods and uses thereof |
| CN102229634B (zh) * | 2010-05-25 | 2014-05-28 | 沈阳同联集团有限公司 | 左旋异戊酰螺旋霉素i、其制剂、制备方法及应用 |
| EP2578595B1 (en) * | 2010-05-25 | 2017-04-19 | Shenyang Fuyang Pharmaceutical Technology Co., Ltd. | Crystalline levoisovalerylspiramycin i |
| RU2746047C1 (ru) * | 2017-04-06 | 2021-04-06 | Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. | Применение карримицина и его фармацевтически приемлемой соли для производства медикаментов для лечения и/или профилактики опухоли |
-
2018
- 2018-07-04 RU RU2020102713A patent/RU2766176C2/ru active
- 2018-07-04 AU AU2018298187A patent/AU2018298187A1/en not_active Abandoned
- 2018-07-04 CN CN201880019070.8A patent/CN110869027B/zh active Active
- 2018-07-04 EP EP18827765.1A patent/EP3639829B1/en active Active
- 2018-07-04 ES ES18827765T patent/ES2912734T3/es active Active
- 2018-07-04 KR KR1020207002990A patent/KR102375444B1/ko active Active
- 2018-07-04 WO PCT/CN2018/094504 patent/WO2019007368A1/zh not_active Ceased
- 2018-07-04 DK DK18827765.1T patent/DK3639829T3/da active
- 2018-07-04 MX MX2019015676A patent/MX390755B/es unknown
- 2018-07-04 CA CA3068921A patent/CA3068921A1/en active Pending
- 2018-07-04 JP JP2019571958A patent/JP7060631B2/ja active Active
- 2018-07-04 US US16/627,102 patent/US20200163984A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR102375444B1 (ko) | 2022-03-17 |
| JP2020528047A (ja) | 2020-09-17 |
| EP3639829B1 (en) | 2022-02-09 |
| US20200163984A1 (en) | 2020-05-28 |
| KR20200024280A (ko) | 2020-03-06 |
| RU2020102713A (ru) | 2021-08-04 |
| CN110869027A (zh) | 2020-03-06 |
| EP3639829A1 (en) | 2020-04-22 |
| MX390755B (es) | 2025-03-21 |
| RU2766176C2 (ru) | 2022-02-08 |
| ES2912734T3 (es) | 2022-05-27 |
| RU2020102713A3 (da) | 2021-08-04 |
| CN110869027B (zh) | 2023-09-08 |
| EP3639829A4 (en) | 2020-06-24 |
| JP7060631B2 (ja) | 2022-04-26 |
| CA3068921A1 (en) | 2019-01-10 |
| AU2018298187A1 (en) | 2020-02-06 |
| WO2019007368A1 (zh) | 2019-01-10 |
| MX2019015676A (es) | 2022-03-17 |
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