DK3886834T3 - Processes for preparing nitrosylated propanediols, compositions comprising the same, and medical uses thereof - Google Patents

Processes for preparing nitrosylated propanediols, compositions comprising the same, and medical uses thereof Download PDF

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Publication number
DK3886834T3
DK3886834T3 DK19813750.7T DK19813750T DK3886834T3 DK 3886834 T3 DK3886834 T3 DK 3886834T3 DK 19813750 T DK19813750 T DK 19813750T DK 3886834 T3 DK3886834 T3 DK 3886834T3
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DK
Denmark
Prior art keywords
nitrosylated
propanediols
compositions
preparing
processes
Prior art date
Application number
DK19813750.7T
Other languages
English (en)
Inventor
Kristofer Bo Ingemar Nilsson
Anna Lena Elisabeth Minidis
Johan Salman Malmberg
Alexander Bogdan Emil Minidis
Leif Christofer Adding
Per Håkan Agvald
Original Assignee
Attgeno Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Attgeno Ab filed Critical Attgeno Ab
Application granted granted Critical
Publication of DK3886834T3 publication Critical patent/DK3886834T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/02—Formation or introduction of functional groups containing nitrogen of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/04—Preparation of esters of nitrous acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK19813750.7T 2018-11-27 2019-11-27 Processes for preparing nitrosylated propanediols, compositions comprising the same, and medical uses thereof DK3886834T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1819298.9A GB2579240B (en) 2018-11-27 2018-11-27 New processes, compositions and medical uses
PCT/EP2019/082800 WO2020109420A1 (en) 2018-11-27 2019-11-27 Processes for preparing nitrosylated propanediols, compositions comprising the same, and medical uses thereof

Publications (1)

Publication Number Publication Date
DK3886834T3 true DK3886834T3 (da) 2024-11-11

Family

ID=65024345

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19813750.7T DK3886834T3 (da) 2018-11-27 2019-11-27 Processes for preparing nitrosylated propanediols, compositions comprising the same, and medical uses thereof

Country Status (19)

Country Link
US (2) US12486216B2 (da)
EP (2) EP4450069A3 (da)
JP (1) JP7705346B2 (da)
KR (1) KR20210116450A (da)
CN (1) CN113164427B (da)
AU (1) AU2019390693B2 (da)
BR (1) BR112021010119A2 (da)
CA (1) CA3121045A1 (da)
DK (1) DK3886834T3 (da)
ES (1) ES2994492T3 (da)
FI (1) FI3886834T3 (da)
GB (1) GB2579240B (da)
HU (1) HUE069260T2 (da)
IL (1) IL283318B2 (da)
MX (1) MX2021006065A (da)
PL (1) PL3886834T3 (da)
PT (1) PT3886834T (da)
WO (1) WO2020109420A1 (da)
ZA (1) ZA202103286B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202007929D0 (en) * 2020-05-27 2020-07-08 Attgeno Ab New medical uses
GB202306258D0 (en) 2023-04-27 2023-06-14 Attgeno Ab New medical uses

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468416B (sv) 1991-09-27 1993-01-18 Lars Erik Gustafsson Saett att faststaella aktuell lungfunktion samt anordning foer att indikera naemnda lungfunktion
US5278192A (en) * 1992-07-02 1994-01-11 The Research Foundation Of State University Of New York Method of vasodilator therapy for treating a patient with a condition
US5646181A (en) 1992-07-02 1997-07-08 Research Foundation Of State University Of New York Method and compositions for treating impotence
AU6232794A (en) 1993-01-29 1994-08-15 Brigham And Women's Hospital The use of nitric oxide-delivering compounds for the treatment or prevention of alcoholic liver injury
ES2147236T3 (es) 1993-07-06 2000-09-01 Aerocrine Ab Un sistema para ser utilizado para la determinacion de niveles no en el aire exhalado y metodos de diagnostico para los trastornos relacionados con niveles anormales de no.
DE69617719D1 (de) 1995-10-20 2002-01-17 Air Liquide Pharmazeutische zusammensetzung von stickstoffmonoxid
DE19654895C2 (de) 1996-02-07 2000-07-27 Sanol Arznei Schwarz Gmbh Detektionsverfahren
GB0022084D0 (en) 2000-09-08 2000-10-25 Univ Aberdeen Treatment of multiply antibiotic-resistant organisms
DK1419134T3 (da) 2001-08-03 2008-11-10 Basf Se Fremgangsmåde til fremstilling af alkylnitriter og alkyldinitriter
SE0402221D0 (sv) 2004-09-14 2004-09-14 Aerocrine Ab Treatment of insufficient perfusion
WO2007106034A1 (en) * 2006-03-14 2007-09-20 Lars E Gustafsson New method for the manufacture of therapeutic compounds and compositions, compounds and compositions produced therewhith, and their use
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
GB202007929D0 (en) * 2020-05-27 2020-07-08 Attgeno Ab New medical uses

Also Published As

Publication number Publication date
MX2021006065A (es) 2021-08-11
GB2579240A (en) 2020-06-17
IL283318A (en) 2021-07-29
WO2020109420A1 (en) 2020-06-04
PT3886834T (pt) 2024-11-14
US20260070870A1 (en) 2026-03-12
ES2994492T3 (en) 2025-01-24
KR20210116450A (ko) 2021-09-27
IL283318B1 (en) 2025-05-01
FI3886834T3 (fi) 2024-11-06
JP7705346B2 (ja) 2025-07-09
JP2022513153A (ja) 2022-02-07
GB201819298D0 (en) 2019-01-09
EP3886834B1 (en) 2024-08-07
IL283318B2 (en) 2025-09-01
HUE069260T2 (hu) 2025-02-28
BR112021010119A2 (pt) 2021-09-28
PL3886834T3 (pl) 2025-02-10
US20220002223A1 (en) 2022-01-06
CN113164427B (zh) 2026-03-03
ZA202103286B (en) 2025-04-30
EP4450069A2 (en) 2024-10-23
CA3121045A1 (en) 2020-06-04
EP4450069A3 (en) 2025-02-12
CN113164427A (zh) 2021-07-23
AU2019390693B2 (en) 2025-04-10
GB2579240B (en) 2020-12-16
EP3886834A1 (en) 2021-10-06
AU2019390693A1 (en) 2021-06-03
US12486216B2 (en) 2025-12-02

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