EA200000700A3 - НОВЫЕ β- КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИХ - Google Patents

НОВЫЕ β- КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИХ

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Publication number
EA200000700A3
EA200000700A3 EA200000700A EA200000700A EA200000700A3 EA 200000700 A3 EA200000700 A3 EA 200000700A3 EA 200000700 A EA200000700 A EA 200000700A EA 200000700 A EA200000700 A EA 200000700A EA 200000700 A3 EA200000700 A3 EA 200000700A3
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EA
Eurasian Patent Office
Prior art keywords
group
cor
beta
preparation
description
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Application number
EA200000700A
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English (en)
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EA004140B1 (ru
EA200000700A2 (ru
Inventor
Соло Гольдстейн
Гийом Пуассонне
Жан-Жилль Парментье
Жан-Даниель Брион
Марк Миллан
Анн Декейн
Жан Бутэн
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Адир Э Компани
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Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200000700A2 publication Critical patent/EA200000700A2/ru
Publication of EA200000700A3 publication Critical patent/EA200000700A3/ru
Publication of EA004140B1 publication Critical patent/EA004140B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Соединения формулы (I)в которойпредставляет простую или двойную связь,Rпредставляет атом водорода, алкильную группу, -R-арильную группу, -R-циклоалкильную группу, -R-гетероцикл, -COR, -CORили -CONHR, где R, Rи Rопределены в описании изобретения;Rпредставляет цианогруппу, моно- или диалкиламино-алкиламинокарбонильную группу, или -COR, -CONHR, -NRR, -NHCORили -COR, где R, Rи Rопределены в описании изобретения,Rи R, взятые вместе, образуют (С-С)циклоалкильную группу,Rпредставляет атом водорода, или алкильную группу, или арилалкильную группу,каждый из Ra, Rb, Rc и Rd, которые могут быть одинаковыми или различными, независимо представляет группу, определенную в описании изобретения,их изомеры, а также их аддитивные соли с фармацевтически приемлемой кислотой или фармацевтически приемлемым основанием. Лекарственные препараты.
EA200000700A 1999-07-23 2000-07-21 β-КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ИХ СОДЕРЖАЩАЯ EA004140B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9909576A FR2796644B1 (fr) 1999-07-23 1999-07-23 Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200000700A2 EA200000700A2 (ru) 2001-02-26
EA200000700A3 true EA200000700A3 (ru) 2001-04-23
EA004140B1 EA004140B1 (ru) 2004-02-26

Family

ID=9548447

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000700A EA004140B1 (ru) 1999-07-23 2000-07-21 β-КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ИХ СОДЕРЖАЩАЯ

Country Status (16)

Country Link
US (1) US6350757B1 (ru)
EP (1) EP1070716A1 (ru)
JP (1) JP2001072679A (ru)
KR (1) KR20010049859A (ru)
CN (1) CN1282743A (ru)
AU (1) AU762958B2 (ru)
BR (1) BR0003105A (ru)
CA (1) CA2314473A1 (ru)
EA (1) EA004140B1 (ru)
FR (1) FR2796644B1 (ru)
HU (1) HUP0002843A3 (ru)
MX (1) MXPA00007058A (ru)
NO (1) NO20003764L (ru)
NZ (1) NZ505903A (ru)
PL (1) PL341549A1 (ru)
ZA (1) ZA200003702B (ru)

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UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US20040253891A1 (en) * 2000-09-12 2004-12-16 Schierenbeck Alan W. Composite structure for protective garment
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
WO2004096802A2 (en) * 2003-04-29 2004-11-11 Oscient Pharmaceuticals ANTIBIOTIC TETRAHYDRO-β-CARBOLINE DERIVATIVES
ES2427166T3 (es) 2003-06-23 2013-10-29 Ono Pharmaceutical Co., Ltd. Compuesto heterocíclico tricíclico novedoso
US20050137220A1 (en) * 2003-07-23 2005-06-23 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
CN1910183A (zh) 2004-01-23 2007-02-07 希龙公司 四氢咔啉化合物作为抗癌药
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
MXPA06010543A (es) 2004-03-15 2007-03-26 Ptc Therapeutics Inc Derivados de carbolina utiles en la inhibicion de la angiogenesis.
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
WO2006068164A1 (ja) 2004-12-22 2006-06-29 Ono Pharmaceutical Co., Ltd. 三環式化合物およびその用途
FR2901795A1 (fr) * 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
FR2908768A1 (fr) * 2006-06-19 2008-05-23 Fourtillan Snc DERIVES DE 3H,11H-OXAZOLO (3',4':1,2)PYRIDO(3,4-b)INDOLE ET LEUR UTILISATION EN THERAPEUTIQUE
FR2912405A1 (fr) * 2007-02-08 2008-08-15 Fourtillan Snc Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique
AU2008302751A1 (en) * 2007-09-20 2009-03-26 D2E, Llc Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
EP2225250A2 (en) * 2007-11-30 2010-09-08 Biota Scientific Management Pty Ltd Bicyclic ppat inhibitors as antibacterial agents
JP5611846B2 (ja) * 2008-03-12 2014-10-22 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 置換ヘテロ環縮合ガンマ−カルボリン類固体
TWI443098B (zh) 2008-03-24 2014-07-01 Medivation Technologies Inc 吡啶并〔３，４－ｂ〕吲哚及使用方法
DE102008025893B4 (de) * 2008-05-26 2014-09-18 Technische Universität Dresden Verfahren zur Herstellung von Fettsäureamiden mit gesättigten, ungesättigten oder Hydroxy-Fettsäuren
WO2011038163A1 (en) * 2009-09-23 2011-03-31 Medivation Technologies, Inc. Pyrido[3,4-b]indoles and methods of use
EP2480079A4 (en) * 2009-09-23 2015-04-08 Medivation Technologies Inc PYRIDO- (3,4-B-) INDOLE AND USE METHOD THEREFOR
CN103476417A (zh) 2011-02-18 2013-12-25 梅迪维新技术公司 治疗糖尿病的化合物和方法
ES2587856T3 (es) 2011-03-18 2016-10-27 Ono Pharmaceutical Co., Ltd. Derivado de tetrahidrocarbolina
KR101534523B1 (ko) * 2013-04-30 2015-07-09 경희대학교 산학협력단 1,2,3,4-테트라히드로-6-메톡시-1-옥소-베타-카르볼린을 포함하는 피부 미백용 화장료 조성물
TWI653235B (zh) * 2013-05-28 2019-03-11 阿斯特捷利康公司 作為抗癌劑之吲哚衍生物
CN112654354A (zh) * 2018-08-16 2021-04-13 菲尼克思药业股份有限公司 1,3,4,9-四氢-2H-吡啶并[3,4-b]吲哚衍生物化合物及其用途
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US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof
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Also Published As

Publication number Publication date
FR2796644A1 (fr) 2001-01-26
HUP0002843A3 (en) 2001-07-30
AU4876900A (en) 2001-01-25
HU0002843D0 (en) 2000-09-28
FR2796644B1 (fr) 2001-09-07
EA004140B1 (ru) 2004-02-26
HUP0002843A2 (hu) 2001-04-28
EA200000700A2 (ru) 2001-02-26
NO20003764L (no) 2001-01-24
KR20010049859A (ko) 2001-06-15
NO20003764D0 (no) 2000-07-21
ZA200003702B (en) 2001-05-21
CA2314473A1 (fr) 2001-01-23
NZ505903A (en) 2001-08-31
CN1282743A (zh) 2001-02-07
PL341549A1 (en) 2001-01-29
EP1070716A1 (fr) 2001-01-24
MXPA00007058A (es) 2002-04-24
JP2001072679A (ja) 2001-03-21
AU762958B2 (en) 2003-07-10
BR0003105A (pt) 2001-03-13
US6350757B1 (en) 2002-02-26

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