EA200901295A1 - Кристаллический 1-(циклогексилоксикарбонилокси)этил-1-((2`-цианодифенил-4-ил)метил)-2-этокси-1н-бензо[d]имидазол-7-карбоксилат и способ его получения - Google Patents

Кристаллический 1-(циклогексилоксикарбонилокси)этил-1-((2`-цианодифенил-4-ил)метил)-2-этокси-1н-бензо[d]имидазол-7-карбоксилат и способ его получения

Info

Publication number
EA200901295A1
EA200901295A1 EA200901295A EA200901295A EA200901295A1 EA 200901295 A1 EA200901295 A1 EA 200901295A1 EA 200901295 A EA200901295 A EA 200901295A EA 200901295 A EA200901295 A EA 200901295A EA 200901295 A1 EA200901295 A1 EA 200901295A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzo
imidazole
carboxylate
ethyl
methyl
Prior art date
Application number
EA200901295A
Other languages
English (en)
Inventor
Сильво Зупанциц
Матей Смрколи
Рената Осольник
Миха Врбинц
Original Assignee
Крка, Д.Д. Ново Место
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Крка, Д.Д. Ново Место filed Critical Крка, Д.Д. Ново Место
Publication of EA200901295A1 publication Critical patent/EA200901295A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к 1-(циклогексилоксикарбонилокси)этил-1-((2'-цианобифенил-4-ил)метил)-2-этокси-1Н-бензо[d]имидазол-7-карбоксилату в кристаллической форме и способу его получения, который является промежуточной стадией в получении кандесартана цилексетила. Настоящее изобретение также относится к получению кандесартана цилексетила и фармацевтической композиции, содержащей кандесартан цилексетил.
EA200901295A 2007-04-24 2008-04-24 Кристаллический 1-(циклогексилоксикарбонилокси)этил-1-((2`-цианодифенил-4-ил)метил)-2-этокси-1н-бензо[d]имидазол-7-карбоксилат и способ его получения EA200901295A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200700100A SI22488A (sl) 2007-04-24 2007-04-24 Kristalni 1-(cikloheksiloksikarboniloksi)etil 1-((2'-cianobifenil-4-il)metil) - 2-etoksi-1h-benz(d)imidazol -7-karboksilat in proces za njegovo pripravo
PCT/EP2008/054997 WO2008129077A2 (en) 2007-04-24 2008-04-24 Crystalline 1-(cyclohexyloxycarbonyloxy) ethyl 1-((2'-cyanobiphenyl-4-yl)methyl)-2-ethoxy-1h-benzo[d]imidazole-7-carboxylate and a process for its preparation

Publications (1)

Publication Number Publication Date
EA200901295A1 true EA200901295A1 (ru) 2010-04-30

Family

ID=39671465

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901295A EA200901295A1 (ru) 2007-04-24 2008-04-24 Кристаллический 1-(циклогексилоксикарбонилокси)этил-1-((2`-цианодифенил-4-ил)метил)-2-этокси-1н-бензо[d]имидазол-7-карбоксилат и способ его получения

Country Status (9)

Country Link
EP (1) EP2139866B1 (ru)
CN (1) CN101679300A (ru)
AT (1) ATE495160T1 (ru)
DE (1) DE602008004486D1 (ru)
EA (1) EA200901295A1 (ru)
PL (1) PL2139866T3 (ru)
SI (2) SI22488A (ru)
UA (1) UA98140C2 (ru)
WO (1) WO2008129077A2 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103073537A (zh) * 2013-02-01 2013-05-01 武汉工程大学 坎地沙坦酯的合成工艺
CN103724277A (zh) * 2014-01-20 2014-04-16 华润赛科药业有限责任公司 一种阿齐沙坦中间体的制备方法
CN104788429B (zh) * 2015-03-06 2018-07-06 浙江美诺华药物化学有限公司 一种通过脱除三苯甲基保护基制备沙坦类药物的方法
CN107089972B (zh) * 2017-06-23 2021-05-18 浙江华海药业股份有限公司 一种坎地沙坦酯的制备方法
CN113456601A (zh) * 2021-05-26 2021-10-01 江苏宇锐医药科技有限公司 一种坎地沙坦酯氢氯噻嗪复方片剂的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
CN1204125C (zh) * 2000-12-27 2005-06-01 中国科学院上海药物研究所 坎地沙坦酯的合成新路线
CN1425654A (zh) * 2003-01-07 2003-06-25 江苏省药物研究所 一种2－烷氧基苯并咪唑类化合物的制备方法
TWI346108B (en) * 2004-08-23 2011-08-01 Bristol Myers Squibb Co A method for preparing irbesartan and intermediates thereof
EP1764365A1 (en) * 2005-09-20 2007-03-21 KRKA, D.D., Novo Mesto A process for the preparation of sartan derivates and intermediates useful in such process

Also Published As

Publication number Publication date
ATE495160T1 (de) 2011-01-15
WO2008129077A2 (en) 2008-10-30
SI2139866T1 (sl) 2011-04-29
DE602008004486D1 (de) 2011-02-24
WO2008129077A3 (en) 2009-01-29
SI22488A (sl) 2008-10-31
UA98140C2 (ru) 2012-04-25
EP2139866B1 (en) 2011-01-12
EP2139866A2 (en) 2010-01-06
PL2139866T3 (pl) 2011-04-29
CN101679300A (zh) 2010-03-24

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