EA201400120A1 - Кристаллический (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'н-спиро[циклогексан-1,1'-пирано[3,4,в]индол]-4-амин - Google Patents

Кристаллический (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'н-спиро[циклогексан-1,1'-пирано[3,4,в]индол]-4-амин

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Publication number
EA201400120A1
EA201400120A1 EA201400120A EA201400120A EA201400120A1 EA 201400120 A1 EA201400120 A1 EA 201400120A1 EA 201400120 A EA201400120 A EA 201400120A EA 201400120 A EA201400120 A EA 201400120A EA 201400120 A1 EA201400120 A1 EA 201400120A1
Authority
EA
Eurasian Patent Office
Prior art keywords
spiro
dihydro
fluoro
dimethyl
phenyl
Prior art date
Application number
EA201400120A
Other languages
English (en)
Other versions
EA026750B1 (ru
Inventor
Михаэль Грусс
Штефан Клуге
Штефан Прюс
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201400120A1 publication Critical patent/EA201400120A1/ru
Publication of EA026750B1 publication Critical patent/EA026750B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Настоящее изобретение относится к кристаллическим формам (1r,4r)-6'-фтор-N,N-диметил-4-фенил-4',9'-дигидро-3'Н-спиро[циклогексан-1,1'-пирано[3,4,b]индол]-4-амина, фармацевтическим композициям и лекарственным средствам, которые содержат эти модификации, применению этих модификаций, а также к способу их обогащения.
EA201400120A 2011-07-08 2012-07-06 КРИСТАЛЛИЧЕСКИЙ (1R,4R)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН EA026750B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (2)

Publication Number Publication Date
EA201400120A1 true EA201400120A1 (ru) 2014-06-30
EA026750B1 EA026750B1 (ru) 2017-05-31

Family

ID=46717800

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400120A EA026750B1 (ru) 2011-07-08 2012-07-06 КРИСТАЛЛИЧЕСКИЙ (1R,4R)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН

Country Status (23)

Country Link
US (2) US8618156B2 (ru)
EP (2) EP3235821B1 (ru)
JP (2) JP6276689B2 (ru)
CN (2) CN106939005A (ru)
AR (1) AR087081A1 (ru)
AU (2) AU2012283449B2 (ru)
BR (1) BR112014000358A2 (ru)
CA (1) CA2841032C (ru)
CY (1) CY1120525T1 (ru)
DK (2) DK2729470T3 (ru)
EA (1) EA026750B1 (ru)
ES (1) ES2641299T3 (ru)
HR (1) HRP20170968T1 (ru)
HU (1) HUE033043T2 (ru)
IL (1) IL230331B (ru)
LT (1) LT2729470T (ru)
MX (1) MX2014000297A (ru)
PL (1) PL2729470T3 (ru)
PT (1) PT2729470T (ru)
RS (1) RS56343B1 (ru)
SI (1) SI2729470T1 (ru)
TW (1) TWI585092B (ru)
WO (1) WO2013007361A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106939005A (zh) * 2011-07-08 2017-07-11 格吕伦塔尔有限公司 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺
CA2974578C (en) 2015-01-23 2020-11-17 Grunenthal Gmbh Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function
ES2713960T3 (es) 2015-02-02 2019-05-24 Ratiopharm Gmbh Composición que comprende cebranopadol en forma disuelta
JP7373904B2 (ja) 2016-02-29 2023-11-06 パーク・セラピューティクス・インコーポレイテッド セブラノパドールの滴定
WO2020233588A1 (zh) * 2019-05-21 2020-11-26 江苏众强药业有限公司 曲前列尼尔钠盐新晶型及制备方法
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
JP2026506102A (ja) 2023-02-15 2026-02-20 アドニューリス・セラピューティクス・インコーポレーテッド 疼痛緩和に有用なレジメンおよび組成物
WO2026035694A1 (en) 2024-08-05 2026-02-12 Adneuris Therapeutics, Inc. Cebranopadol useful for preventing or reducing opioid induced respiratory depression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
PE20131096A1 (es) * 2010-08-04 2013-10-10 Gruenenthal Chemie Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico
CN106939005A (zh) * 2011-07-08 2017-07-11 格吕伦塔尔有限公司 晶态的（1r,4r）‑6’‑氟‑N,N‑二甲基‑4‑苯基‑4’,9’‑二氢‑3’H‑螺[环己烷‑1,1’‑吡喃并[3,4,b]吲哚]‑4‑胺

Also Published As

Publication number Publication date
WO2013007361A8 (en) 2013-04-04
HUE033043T2 (hu) 2017-11-28
WO2013007361A9 (en) 2013-12-27
EP3235821A1 (en) 2017-10-25
AU2017204572B2 (en) 2018-05-24
JP2017081981A (ja) 2017-05-18
JP6559165B2 (ja) 2019-08-14
AU2017204572A1 (en) 2017-07-27
AU2012283449A8 (en) 2014-03-27
AU2012283449B2 (en) 2017-04-06
JP2014518226A (ja) 2014-07-28
CN103649094B (zh) 2017-05-24
MX2014000297A (es) 2014-01-31
EA026750B1 (ru) 2017-05-31
CN106939005A (zh) 2017-07-11
DK3235821T3 (da) 2020-04-20
CY1120525T1 (el) 2019-07-10
PL2729470T3 (pl) 2017-11-30
WO2013007361A1 (en) 2013-01-17
LT2729470T (lt) 2017-08-25
US20130012563A1 (en) 2013-01-10
PT2729470T (pt) 2017-10-02
US8618156B2 (en) 2013-12-31
ES2641299T3 (es) 2017-11-08
CN103649094A (zh) 2014-03-19
AU2012283449A1 (en) 2014-02-20
EP2729470B1 (en) 2017-06-21
AR087081A1 (es) 2014-02-12
TW201311694A (zh) 2013-03-16
US20130231381A1 (en) 2013-09-05
RS56343B1 (sr) 2017-12-29
JP6276689B2 (ja) 2018-02-07
HRP20170968T1 (hr) 2017-09-22
EP3235821B1 (en) 2020-04-08
BR112014000358A2 (pt) 2017-01-10
EP2729470A1 (en) 2014-05-14
CA2841032A1 (en) 2013-01-17
SI2729470T1 (sl) 2017-10-30
CA2841032C (en) 2020-12-15
TWI585092B (zh) 2017-06-01
IL230331B (en) 2018-11-29
DK2729470T3 (en) 2017-09-11
US8765800B2 (en) 2014-07-01

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU