EA202190244A3 - Сверхэкспрессия регуляторов пути n-гликозилирования для модуляции гликозилирования рекомбинантных белков - Google Patents

Сверхэкспрессия регуляторов пути n-гликозилирования для модуляции гликозилирования рекомбинантных белков

Info

Publication number: EA202190244A3
Authority: EA; Eurasian Patent Office
Prior art keywords: glycosylation; overexpression; modulation; recombinant proteins; path regulators
Prior art date: 2014-01-29

Application number

EA202190244A

Other languages

English (en)

Russian (ru)

Other versions

EA202190244A2 (ru

Inventor

Шивани Гупта

Сохие Канг

Original Assignee

Эмджен Инк.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-01-29

Filing date

2014-12-11

Publication date

2021-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53757626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA202190244(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-12-11 Application filed by Эмджен Инк. filed Critical Эмджен Инк.

2021-05-31 Publication of EA202190244A2 publication Critical patent/EA202190244A2/ru

2021-08-31 Publication of EA202190244A3 publication Critical patent/EA202190244A3/ru

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01101—Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (2.4.1.101)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01094—Protein N-acetylglucosaminyltransferase (2.4.1.94)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01143—Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (2.4.1.143)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

EA202190244A 2014-01-29 2014-12-11 Сверхэкспрессия регуляторов пути n-гликозилирования для модуляции гликозилирования рекомбинантных белков EA202190244A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201461933137P	2014-01-29	2014-01-29

Publications (2)

Publication Number	Publication Date
EA202190244A2 EA202190244A2 (ru)	2021-05-31
EA202190244A3 true EA202190244A3 (ru)	2021-08-31

Family

ID=53757626

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EA202190244A EA202190244A3 (ru)	2014-01-29	2014-12-11	Сверхэкспрессия регуляторов пути n-гликозилирования для модуляции гликозилирования рекомбинантных белков
EA201691532A EA037565B1 (ru)	2014-01-29	2014-12-11	Способ снижения содержания высокоманнозных гликоформ рекомбинантного белка

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EA201691532A EA037565B1 (ru)	2014-01-29	2014-12-11	Способ снижения содержания высокоманнозных гликоформ рекомбинантного белка

Country Status (14)

Country	Link
US (3)	US10227627B2 (2)
EP (1)	EP3099806A1 (2)
JP (4)	JP6474420B2 (2)
KR (3)	KR102410393B1 (2)
CN (2)	CN106170554B (2)
AU (3)	AU2014380174C1 (2)
BR (1)	BR112016017606A2 (2)
CA (1)	CA2938079C (2)
CL (1)	CL2016001900A1 (2)
EA (2)	EA202190244A3 (2)
IL (3)	IL282517B (2)
MX (2)	MX377780B (2)
SG (1)	SG10201912081RA (2)
WO (1)	WO2015116315A1 (2)

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CN109576212B (zh) *	2018-12-14	2021-06-22	杭州奕安济世生物药业有限公司	高密度接种培养中种子细胞的培养方法及其应用
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CN113684322B (zh) *	2021-09-09	2024-01-23	上海药明生物技术有限公司	一种降低抗体类蛋白高聚甘露糖型水平的方法
CN114525252B (zh) *	2022-03-10	2023-12-01	广州源井生物科技有限公司	一种提高mda-mb-231单细胞克隆形成率的单克隆增强培养基与培养方法及其应用
TW202426485A (zh)	2022-10-26	2024-07-01	美商安進公司	抗ｔｓｌｐ抗體組成物及其用途

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2014
- 2014-12-11 JP JP2016549077A patent/JP6474420B2/ja active Active
- 2014-12-11 EA EA202190244A patent/EA202190244A3/ru unknown
- 2014-12-11 CA CA2938079A patent/CA2938079C/en active Active
- 2014-12-11 MX MX2016009911A patent/MX377780B/es active IP Right Grant
- 2014-12-11 CN CN201480074585.XA patent/CN106170554B/zh active Active
- 2014-12-11 BR BR112016017606A patent/BR112016017606A2/pt not_active Application Discontinuation
- 2014-12-11 CN CN202110902965.XA patent/CN113774084B/zh active Active
- 2014-12-11 AU AU2014380174A patent/AU2014380174C1/en active Active
- 2014-12-11 KR KR1020217028516A patent/KR102410393B1/ko active Active
- 2014-12-11 EA EA201691532A patent/EA037565B1/ru unknown
- 2014-12-11 KR KR1020227019897A patent/KR102519540B1/ko active Active
- 2014-12-11 KR KR1020167021676A patent/KR102301034B1/ko active Active
- 2014-12-11 SG SG10201912081RA patent/SG10201912081RA/en unknown
- 2014-12-11 EP EP14821424.0A patent/EP3099806A1/en active Pending
- 2014-12-11 IL IL282517A patent/IL282517B/en unknown
- 2014-12-11 WO PCT/US2014/069744 patent/WO2015116315A1/en not_active Ceased
2016
- 2016-07-24 IL IL246914A patent/IL246914B/en active IP Right Grant
- 2016-07-26 CL CL2016001900A patent/CL2016001900A1/es unknown
- 2016-07-29 MX MX2020012356A patent/MX2020012356A/es unknown
2018
- 2018-09-13 US US16/130,879 patent/US10227627B2/en active Active
- 2018-11-15 AU AU2018264100A patent/AU2018264100C1/en active Active
2019
- 2019-01-28 JP JP2019011871A patent/JP6797950B2/ja active Active
- 2019-01-29 US US16/261,311 patent/US10655156B2/en active Active
- 2019-11-24 IL IL270861A patent/IL270861B/en active IP Right Grant
2020
- 2020-05-15 US US16/875,832 patent/US10907186B2/en active Active
- 2020-09-23 AU AU2020239681A patent/AU2020239681C1/en active Active
- 2020-11-17 JP JP2020190707A patent/JP7034236B2/ja active Active
2022
- 2022-02-28 JP JP2022029077A patent/JP7788307B2/ja active Active

Also Published As

Publication number	Publication date
AU2018264100A1 (en)	2018-12-06
AU2020239681B2 (en)	2022-06-23
JP7034236B2 (ja)	2022-03-11
JP2021040638A (ja)	2021-03-18
CN106170554B (zh)	2021-08-17
US10655156B2 (en)	2020-05-19
US20200277642A1 (en)	2020-09-03
AU2014380174C1 (en)	2025-06-05
EA202190244A2 (ru)	2021-05-31
AU2018264100C1 (en)	2025-06-05
EP3099806A1 (en)	2016-12-07
IL270861B (en)	2021-05-31
AU2020239681A1 (en)	2020-10-15
US20190010532A1 (en)	2019-01-10
MX2020012356A (es)	2021-01-29
JP2017505620A (ja)	2017-02-23
CN113774084B (zh)	2024-04-16
CA2938079A1 (en)	2015-08-06
IL282517B (en)	2022-07-01
CN106170554A (zh)	2016-11-30
AU2014380174B2 (en)	2018-08-30
AU2014380174A1 (en)	2016-08-11
MX377780B (es)	2025-03-11
IL282517A (en)	2021-06-30
JP6474420B2 (ja)	2019-02-27
KR102519540B1 (ko)	2023-04-10
KR20210114549A (ko)	2021-09-23
JP6797950B2 (ja)	2020-12-09
AU2018264100B2 (en)	2020-07-23
KR102301034B1 (ko)	2021-09-13
WO2015116315A1 (en)	2015-08-06
CA2938079C (en)	2022-10-11
JP2019088305A (ja)	2019-06-13
KR20160111943A (ko)	2016-09-27
CL2016001900A1 (es)	2017-05-12
EA037565B1 (ru)	2021-04-14
IL270861A (en)	2020-01-30
US10227627B2 (en)	2019-03-12
US20190153496A1 (en)	2019-05-23
KR20220086703A (ko)	2022-06-23
BR112016017606A2 (pt)	2017-10-10
JP2022068365A (ja)	2022-05-09
KR102410393B1 (ko)	2022-06-16
JP7788307B2 (ja)	2025-12-18
IL246914B (en)	2019-12-31
EA201691532A1 (ru)	2017-01-30
MX2016009911A (es)	2016-10-28
CN113774084A (zh)	2021-12-10
US10907186B2 (en)	2021-02-02
SG10201912081RA (en)	2020-02-27
IL246914A0 (en)	2016-09-29
AU2020239681C1 (en)	2025-06-05

Publication	Publication Date	Title
EA202190244A2 (ru)	2021-05-31	Сверхэкспрессия регуляторов пути n-гликозилирования для модуляции гликозилирования рекомбинантных белков
CY1121217T1 (el)	2020-05-29	Μεθοδοι για συγκομιδη καλλιεργειων κυτταρου θηλαστικων
MX2023011785A (es)	2023-10-11	Metodos y composiciones para produccion de proteina de clara de huevo.
MX2023008559A (es)	2023-08-08	Proteínas de fusión fc heterodiméricas il15/il15ra.
PH12018501280A1 (en)	2019-01-28	Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
MX2023001834A (es)	2023-03-13	Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso.
EP3912998A3 (en)	2022-02-23	Binding molecules that inhibit cancer growth
EA201891709A1 (ru)	2019-01-31	Антигенсвязывающие белки, связывающие pd-l1
EP3294774C0 (en)	2024-08-28	AFUCOSYLATED PROTEINS, CELL EXPRESSING THIS PROTEIN AND RELATED METHODS
EA202090931A3 (ru)	2020-10-30	Композиции и способы перепрограммирования tcr с помощью гибридных белков
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