EE200200462A - Piperidiini ja piperasiiniga asendatud N-hüdroksüformamiidid kui metalloproteinaaside inhibiitorid - Google Patents

Piperidiini ja piperasiiniga asendatud N-hüdroksüformamiidid kui metalloproteinaaside inhibiitorid

Info

Publication number: EE200200462A
Authority: EE; Estonia
Prior art keywords: hydroxyformamides; metalloproteinases; piperazine; piperidine; inhibitors
Prior art date: 2000-02-21

Application number

EEP200200462A

Other languages

English (en)

Estonian (et)

Inventor

Christophe Barlaam Bernard

Ian Dowell Robert

Raymond Verschoyle Finlay Maurice

John Newcombe Nicholas

Tucker Howard

Waterson David

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-21

Filing date

2001-02-15

Publication date

2003-12-15

2001-02-15 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-12-15 Publication of EE200200462A publication Critical patent/EE200200462A/xx

Links

GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
102000005741 Metalloproteases Human genes 0.000 title 1
108010006035 Metalloproteases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
KDGKTJGPFXIBEB-UHFFFAOYSA-N n-hydroxyformamide Chemical group ONC=O KDGKTJGPFXIBEB-UHFFFAOYSA-N 0.000 title 1
125000003386 piperidinyl group Chemical group 0.000 title 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200200462A 2000-02-21 2001-02-15 Piperidiini ja piperasiiniga asendatud N-hüdroksüformamiidid kui metalloproteinaaside inhibiitorid EE200200462A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00400467		2000-02-21
PCT/GB2001/000624 WO2001062742A1 (en)	2000-02-21	2001-02-15	Piperidine- and piperazine substituted n-hydroxyformamides as inhibitors of metalloproteinases

Publications (1)

Publication Number	Publication Date
EE200200462A true EE200200462A (et)	2003-12-15

Family

ID=8173564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200462A EE200200462A (et)	2000-02-21	2001-02-15	Piperidiini ja piperasiiniga asendatud N-hüdroksüformamiidid kui metalloproteinaaside inhibiitorid

Country Status (29)

Country	Link
US (3)	US6734183B2 (uk)
EP (1)	EP1261590B1 (uk)
JP (1)	JP4256095B2 (uk)
KR (1)	KR20020073594A (uk)
CN (1)	CN1247547C (uk)
AR (1)	AR029657A1 (uk)
AT (1)	ATE553097T1 (uk)
AU (1)	AU783284B2 (uk)
BG (1)	BG65276B1 (uk)
BR (1)	BR0108501A (uk)
CA (1)	CA2396965C (uk)
CO (1)	CO5241356A1 (uk)
CZ (1)	CZ20022828A3 (uk)
EE (1)	EE200200462A (uk)
HU (1)	HUP0302723A3 (uk)
IL (1)	IL150806A0 (uk)
IS (1)	IS6507A (uk)
MX (1)	MXPA02008111A (uk)
MY (1)	MY128164A (uk)
NO (1)	NO323765B1 (uk)
NZ (1)	NZ520104A (uk)
PL (1)	PL365909A1 (uk)
RU (1)	RU2283306C2 (uk)
SA (1)	SA01220167B1 (uk)
SG (1)	SG127737A1 (uk)
SK (1)	SK287071B6 (uk)
TW (1)	TWI276632B (uk)
UA (1)	UA73155C2 (uk)
WO (1)	WO2001062742A1 (uk)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0119474D0 (en)	2001-08-09	2001-10-03	Astrazeneca Ab	Compounds
GB0119472D0 (en) *	2001-08-09	2001-10-03	Astrazeneca Ab	Compounds
GB0119473D0 (en) *	2001-08-09	2001-10-03	Astrazeneca	Compounds
DE60230781D1 (en)	2001-09-07	2009-02-26	Kaken Pharma Co Ltd	Reverse hydroxamsäurederivate
SE0301922D0 (sv)	2003-06-27	2003-06-27	Astrazeneca Ab	Novel compounds
JP4866610B2 (ja)	2003-08-18	2012-02-01	富士フイルムファインケミカルズ株式会社	ピリジルテトラヒドロピリジン類およびピリジルピペリジン類
SE0401762D0 (sv) *	2004-07-05	2004-07-05	Astrazeneca Ab	Novel compounds
GB0427403D0 (en)	2004-12-15	2005-01-19	Astrazeneca Ab	Novel compounds I
EP1951687B1 (en) *	2005-11-24	2011-08-24	Merck Serono SA	N-hydroxyamide derivatives and use thereof
GB0617367D0 (en) *	2006-09-02	2006-10-11	Astrazeneca Ab	Novel process
AU2009241365B2 (en)	2008-04-28	2015-01-22	Revalesio Corporation	Compositions and methods for treating multiple sclerosis
DK2597084T3 (en) *	2010-07-08	2016-08-15	Kaken Pharma Co Ltd	N-HYDROXYFORMAMIDE DERIVATIVE AND MEDICINAL CONTAINING SAME
CA2941581C (en)	2014-03-12	2018-07-24	Chong Kun Dang Pharmaceutical Corp.	Novel compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same
EP3860608A1 (en)	2018-10-04	2021-08-11	INSERM (Institut National de la Santé et de la Recherche Médicale)	Egfr inhibitors for treating keratodermas

Family Cites Families (14)

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UA19045A (uk) *	1988-02-24	1997-12-25	Ф.Хофманн - Ля Рош Аг	Спосіб одержаhhя похідhих стильбеhу
HU218480B (hu) *	1995-06-15	2000-09-28	BIOREX Kutató és Fejlesztő Rt.	Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
AU743901B2 (en)	1996-10-16	2002-02-07	Wyeth Holdings Corporation	Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors
US6376506B1 (en)	1997-01-23	2002-04-23	Syntex (U.S.A.) Llc	Sulfamide-metalloprotease inhibitors
ID22849A (id) *	1997-01-23	1999-12-09	Hoffmann La Roche	Penghambat-penghambat sulmafida-metaloprotease
ZA98376B (en)	1997-01-23	1998-07-23	Hoffmann La Roche	Sulfamide-metalloprotease inhibitors
US6482827B1 (en)	1997-07-10	2002-11-19	Pharmacia & Upjohn S.P.A.	Matrix metalloproteinase inhibitors
AU8858398A (en) *	1997-07-10	1999-02-08	Pharmacia & Upjohn S.P.A.	Matrix metalloproteinase inhibitors
US6294573B1 (en)	1997-08-06	2001-09-25	Abbott Laboratories	Reverse hydroxamate inhibitors of matrix metalloproteinases
US6235786B1 (en)	1997-08-06	2001-05-22	Abbott Laboratories	Reverse hydroxamate inhibitors of matrix metalloproteinases
US6130220A (en)	1997-10-16	2000-10-10	Syntex (Usa) Inc.	Sulfamide-metalloprotease inhibitors
PL200418B1 (pl)	1998-01-30	2009-01-30	Darwin Discovery Ltd	Pochodna N-hydroksyformamidu, zawierający ją środek farmaceutyczny i jej zastosowanie
EP1107953A1 (en)	1998-08-29	2001-06-20	British Biotech Pharmaceuticals Limited	Hydroxamic acid derivatives as proteinase inhibitors
GB9919776D0 (en) *	1998-08-31	1999-10-27	Zeneca Ltd	Compoujnds

2001
- 2001-02-15 PL PL01365909A patent/PL365909A1/xx not_active Application Discontinuation
- 2001-02-15 CN CNB018053920A patent/CN1247547C/zh not_active Expired - Fee Related
- 2001-02-15 BR BR0108501-8A patent/BR0108501A/pt not_active Application Discontinuation
- 2001-02-15 CZ CZ20022828A patent/CZ20022828A3/cs unknown
- 2001-02-15 HU HU0302723A patent/HUP0302723A3/hu unknown
- 2001-02-15 IL IL15080601A patent/IL150806A0/xx not_active IP Right Cessation
- 2001-02-15 SK SK1197-2002A patent/SK287071B6/sk not_active IP Right Cessation
- 2001-02-15 WO PCT/GB2001/000624 patent/WO2001062742A1/en not_active Ceased
- 2001-02-15 EE EEP200200462A patent/EE200200462A/xx unknown
- 2001-02-15 KR KR1020027010762A patent/KR20020073594A/ko not_active Ceased
- 2001-02-15 AT AT01905885T patent/ATE553097T1/de active
- 2001-02-15 EP EP01905885A patent/EP1261590B1/en not_active Expired - Lifetime
- 2001-02-15 MX MXPA02008111A patent/MXPA02008111A/es active IP Right Grant
- 2001-02-15 NZ NZ520104A patent/NZ520104A/en unknown
- 2001-02-15 AU AU33855/01A patent/AU783284B2/en not_active Ceased
- 2001-02-15 UA UA2002075698A patent/UA73155C2/uk unknown
- 2001-02-15 CA CA2396965A patent/CA2396965C/en not_active Expired - Fee Related
- 2001-02-15 SG SG200404773A patent/SG127737A1/en unknown
- 2001-02-15 JP JP2001562524A patent/JP4256095B2/ja not_active Expired - Fee Related
- 2001-02-15 RU RU2002118301/04A patent/RU2283306C2/ru not_active IP Right Cessation
- 2001-02-19 MY MYPI20010723A patent/MY128164A/en unknown
- 2001-02-20 CO CO01013250A patent/CO5241356A1/es not_active Application Discontinuation
- 2001-02-21 AR ARP010100790A patent/AR029657A1/es not_active Application Discontinuation
- 2001-02-21 US US09/788,687 patent/US6734183B2/en not_active Expired - Fee Related
- 2001-02-27 TW TW090104516A patent/TWI276632B/zh not_active IP Right Cessation
- 2001-06-23 SA SA01220167A patent/SA01220167B1/ar unknown
2002
- 2002-08-14 BG BG107003A patent/BG65276B1/bg unknown
- 2002-08-16 IS IS6507A patent/IS6507A/is unknown
- 2002-08-20 NO NO20023956A patent/NO323765B1/no not_active IP Right Cessation
2004
- 2004-02-26 US US10/787,813 patent/US7122551B2/en not_active Expired - Fee Related
2006
- 2006-08-24 US US11/509,490 patent/US20060287338A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HUP0302723A2 (hu)	2003-11-28
AU3385501A (en)	2001-09-03
US20060287338A1 (en)	2006-12-21
CZ20022828A3 (cs)	2002-11-13
HUP0302723A3 (en)	2007-09-28
UA73155C2 (en)	2005-06-15
WO2001062742A1 (en)	2001-08-30
US20040176386A1 (en)	2004-09-09
NZ520104A (en)	2004-10-29
BG107003A (en)	2003-04-30
SK11972002A3 (sk)	2002-12-03
ATE553097T1 (de)	2012-04-15
CA2396965C (en)	2010-03-16
US6734183B2 (en)	2004-05-11
US20020022628A1 (en)	2002-02-21
KR20020073594A (ko)	2002-09-27
PL365909A1 (en)	2005-01-10
EP1261590A1 (en)	2002-12-04
IL150806A0 (en)	2003-02-12
MXPA02008111A (es)	2002-11-29
SG127737A1 (en)	2006-12-29
BR0108501A (pt)	2003-04-29
CA2396965A1 (en)	2001-08-30
TWI276632B (en)	2007-03-21
EP1261590B1 (en)	2012-04-11
MY128164A (en)	2007-01-31
IS6507A (is)	2002-08-16
NO20023956D0 (no)	2002-08-20
NO323765B1 (no)	2007-07-02
CN1418197A (zh)	2003-05-14
NO20023956L (no)	2002-10-07
JP4256095B2 (ja)	2009-04-22
CO5241356A1 (es)	2003-01-31
AU783284B2 (en)	2005-10-13
US7122551B2 (en)	2006-10-17
AR029657A1 (es)	2003-07-10
SA01220167B1 (ar)	2006-11-25
SK287071B6 (sk)	2009-11-05
JP2003524005A (ja)	2003-08-12
CN1247547C (zh)	2006-03-29
RU2283306C2 (ru)	2006-09-10
BG65276B1 (bg)	2007-11-30

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