EP0238655A4 - Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells. - Google Patents

Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells.

Info

Publication number
EP0238655A4
EP0238655A4 EP19860906562 EP86906562A EP0238655A4 EP 0238655 A4 EP0238655 A4 EP 0238655A4 EP 19860906562 EP19860906562 EP 19860906562 EP 86906562 A EP86906562 A EP 86906562A EP 0238655 A4 EP0238655 A4 EP 0238655A4
Authority
EP
European Patent Office
Prior art keywords
polypeptides
processes
producing
stimulating factor
colony stimulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19860906562
Other languages
German (de)
French (fr)
Other versions
EP0238655A1 (en
Inventor
John Delamarter
Joachim F Ernst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Biogen NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen NV filed Critical Biogen NV
Publication of EP0238655A1 publication Critical patent/EP0238655A1/en
Publication of EP0238655A4 publication Critical patent/EP0238655A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP19860906562 1985-10-03 1986-10-03 Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells. Withdrawn EP0238655A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78341485A 1985-10-03 1985-10-03
US783414 1985-10-03

Publications (2)

Publication Number Publication Date
EP0238655A1 EP0238655A1 (en) 1987-09-30
EP0238655A4 true EP0238655A4 (en) 1989-09-11

Family

ID=25129176

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19860906562 Withdrawn EP0238655A4 (en) 1985-10-03 1986-10-03 Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells.

Country Status (5)

Country Link
EP (1) EP0238655A4 (en)
JP (1) JPS63502795A (en)
AU (2) AU606585B2 (en)
DK (1) DK282887A (en)
WO (1) WO1987002060A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104650A (en) * 1985-02-05 1992-04-14 Cetus Corporation Uses of recombinant colony stimulating factor-1
US5422105A (en) * 1985-02-05 1995-06-06 Cetus Oncology Corporation Use of recombinant colony stimulating factor 1
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
US5837229A (en) * 1985-02-05 1998-11-17 Chiron Corporation Uses of recombinant colony stimulating factor-1
US5242811A (en) * 1985-03-26 1993-09-07 Biogen, Inc. Production of human somatomedin C
DE3545568A1 (en) * 1985-12-21 1987-07-16 Hoechst Ag GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE
DE3712985A1 (en) * 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
EP0276846A3 (en) * 1987-01-29 1989-07-26 Zymogenetics, Inc. Colony-stimulating factor derivatives
JPS6420097A (en) * 1987-03-02 1989-01-24 Sumitomo Chemical Co Human granulocyte-macrophage colony stimulating factor
WO1988010310A1 (en) * 1987-06-25 1988-12-29 Immunex Corporation Bovine granulocyte-macrophage colony stimulating factor
IE63514B1 (en) * 1987-07-17 1995-05-03 Schering Biotech Corp Expression vectors for the production of human granulocyte-macrophage colony stimulation factor in a mammalian cell host
EP0391892A4 (en) * 1987-10-30 1990-11-28 Immunex Corporation Nonglycosylated analogs of human colony stimulating factors
GB2212159B (en) * 1987-11-13 1992-01-22 British Bio Technology Synthetic gene for human granulocyte/macrophage colony stimulating factor.
JPH03503897A (en) * 1988-04-21 1991-08-29 メドベット・サイエンス・プロプライアテリー・リミテッド Human GM-CSF variants
ZA893063B (en) * 1988-04-27 1990-01-31 Immunomedics Inc Improved radiotherapy
ATE89737T1 (en) * 1989-01-30 1993-06-15 Schering Corp TREATMENT OF LEUKOCYTE DISORDERS WITH GM-CSF.
WO1995023862A1 (en) * 1994-03-04 1995-09-08 Ludwig Institute For Cancer Research Animals with targeted gene disruption
RU2144083C1 (en) * 1998-03-13 2000-01-10 Государственный научный центр вирусологии и биотехнологии "Вектор" Method of industrial producing human recombinant granulocyte-macrophage colony-stimulating factor
US6979442B1 (en) 1998-08-17 2005-12-27 Pfizer Inc. Stabilized protein compositions
EP2042196B1 (en) 2001-10-10 2016-07-13 ratiopharm GmbH Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF)
PT2318029T (en) 2008-07-23 2018-01-10 Ambrx Inc MODIFIED BOVINE G-CSF POLYPEPTIDES AND THEIR UTILIZATIONS
TWI480288B (en) 2010-09-23 2015-04-11 Lilly Co Eli Formulations for bovine granulocyte colony stimulating factor and variants thereof
WO2018052142A1 (en) * 2016-09-16 2018-03-22 キッセイ薬品工業株式会社 Genetically-modified cells and method for producing same
CN119842769A (en) * 2025-01-21 2025-04-18 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) Prokaryotic expression plasmid of recombinant feline macrophage colony stimulating factor and construction method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0212914A2 (en) * 1985-08-06 1987-03-04 Immunex Corporation Amplifying the expression of recombinant DNA products
EP0228018A2 (en) * 1985-12-21 1987-07-08 Hoechst Aktiengesellschaft GM-CSF protein, its derivatives, preparation of such proteins and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6030654B2 (en) * 1980-12-31 1985-07-17 株式会社林原生物化学研究所 Method for producing human colony stimulating factor
NZ228031A (en) * 1984-07-06 1991-12-23 Sandoz Ltd Primate gm-csf and method of extraction
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene
IL77080A (en) * 1984-11-20 1998-02-08 Schering Biotech Corp Polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity, vectors and transformed cells for their production and pharmaceutical compositions comprising them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0212914A2 (en) * 1985-08-06 1987-03-04 Immunex Corporation Amplifying the expression of recombinant DNA products
EP0228018A2 (en) * 1985-12-21 1987-07-08 Hoechst Aktiengesellschaft GM-CSF protein, its derivatives, preparation of such proteins and their use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 82, no. 18, September 1985, pages 6250-6254, Washington, US; M.A. CANTRELL et al.: "Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor" *
See also references of WO8702060A1 *

Also Published As

Publication number Publication date
DK282887A (en) 1987-07-30
WO1987002060A1 (en) 1987-04-09
AU6578190A (en) 1991-01-10
DK282887D0 (en) 1987-06-02
AU606585B2 (en) 1991-02-14
AU6549386A (en) 1987-04-24
AU630516B2 (en) 1992-10-29
EP0238655A1 (en) 1987-09-30
JPS63502795A (en) 1988-10-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19870625

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: BIOGEN, INC.

A4 Supplementary search report drawn up and despatched

Effective date: 19890911

17Q First examination report despatched

Effective date: 19900920

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19921120

RIN1 Information on inventor provided before grant (corrected)

Inventor name: DELAMARTER, JOHN

Inventor name: ERNST, JOACHIM, F.