EP0270632A4 - Body powder in liquid form, body powder containing active ingredients and method of preparing thereof - Google Patents

Body powder in liquid form, body powder containing active ingredients and method of preparing thereof

Info

Publication number
EP0270632A4
EP0270632A4 EP19870903964 EP87903964A EP0270632A4 EP 0270632 A4 EP0270632 A4 EP 0270632A4 EP 19870903964 EP19870903964 EP 19870903964 EP 87903964 A EP87903964 A EP 87903964A EP 0270632 A4 EP0270632 A4 EP 0270632A4
Authority
EP
European Patent Office
Prior art keywords
lbs
composition
liquid powder
potato starch
powder composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19870903964
Other versions
EP0270632A1 (en
Inventor
Garry D. Fields
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0270632A1 publication Critical patent/EP0270632A1/en
Publication of EP0270632A4 publication Critical patent/EP0270632A4/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/12—Face or body powders for grooming, adorning or absorbing

Definitions

  • the present invention relates to body powders. More * specifically, this invention relates to a body powder in ⁇ 5 liquid form which can be used by itself or as a carrier for active ingredients intended for topical and mucous tissue application to animals, including humans. This invention also relates to a method of preparing a liquid body powder having optimal characteristics for applying to the skin in 10 terms of its smoothness, adherence, consistency and rate of evaporation after application.
  • the liquid powders of this invention are useful for many purposes including to improve the smoothness of the skin, prevent irritation, absorb perspiration and deliver active ingredients to the human and 15 animal body.
  • the above and other objects of the invention are attained by forming an aqueous solution or suspension of ingredients comprising a substantial quantity of potato starch in accordance with a specific procedure and temperature regime.
  • the product obtained is a stable liquid product having a desirable thickness for easy application and general stability which assures a long shelf life..
  • various other components can be added to the potato starch.
  • Preferred components are veegum, cetyl alcohol, stearic acid, glycerin, and optionally Peg-8-oleate.
  • the variation of the amounts of these components in the liquid powder composition results in a final product which may be in the form of a liquid lotion, of heavy lotion, a gel-like preparation, a light cream or a heavy cream, among others.
  • the amount of water contained in the composition also contributes to and helps determine the final consistency of the liquid powder product.
  • This liquid powder composition finds a remarkable use as an oil-free wet lubricant which leaves no excess residues encountered in talcum powders or oil-based lubricants used by the prior art.
  • This composition is also useful for its skin soothing characteristics and for use in prostheses and orthotics.
  • As a water-based composition it will not clog valves, makes no mess on clothing articles, is ideal for attaining complete contact with suction sockets and helping control sweating and can be washed off easily at the end of the day.
  • a liquid powder composition comprising per 400 lbs. of composition a ou - s., po a o s arc ; about 1-12 lbs.; veegum; about 3.6-12 lbs., cetyl alcohol; about 2-10 lbs., stearic acid; about 3-10 lbs., glycerin; about 0.5 lbs., Peg-8 oleate; and the remainder, water.
  • the above-described liquid powder composition further comprises an agent selected from about .0.005-100 parts of an active agent; and about 0.005-1 parts of a fragrance per 100 parts of the carrier composition.
  • An even more preferred embodiment of the above-described composition comprises about 1-10 parts of an active ingredient, or about 0.1-0.3 parts of a fragrance per 100 parts of the carrier composition.
  • a process for obtaining a liquid powder composition comprising (1) adding together about 1-12 lbs. veegum, about 3.6-12 lbs. cetyl alcohol, about 2-10 lbs. stearic acid, about 3-10
  • a more preferred way of conducting the above process involves adding a first portion of between about 12 and 48 lbs. of potato starch and a second portion of between, about 40 and 52 lbs. of potato starch.
  • an agent selected from an active ingredient and a fragrance can be added to the liquid powder composition.
  • These ingredients are added to the composition preferably subsequent to step (5) of the above process at a temperature at which they remain stable.
  • the liquid powder composition comprises per 400 lbs. of composition about 52-100 lbs. of potato starch, about 2-6 lbs. of veegum, about 4-6 lbs. of cetyl alcohol, about 2-6 lbs. of stearic acid, about 7-9 lbs. of glycerin, about 1.6-4 lbs. of Peg-8-oleate; and the remainder water.
  • the liquid powder composition may additionally contain a fragrance which can be selected from any fragrances known in the art, such as perfumes, essences, and the like.
  • fragrances While a variety of fragrances can be employed, a preferred fragrance which is utilized to prepare the The fragrance is preferably added to the liquid powder composition in an amount of about 0.005 to 1 parts per 100 parts of the composition. A still more preferred amount of fragrance is between about 0.1 and 0.3 parts per 100 parts of the composition.
  • E eressence ⁇ 1160 (Emery Chemicals, Cincinnati, OH) can be used in the composition of the invention.
  • the composition may additionally contain an active ingredient.
  • the basic liquid powder composition acts as a carrier for the active ingredient.
  • active ingredients are contemplated within the confines of this invention. For all practical matters, any ingredient which would be applied to the skin of humans or animals or to mucous tissues thereof can be utilized with the present composition.
  • Suitable active ingredients for the liquid powder composition of this invention are anti-itch, anti-inflammatory, antimicrobial, antiviral, antibacterial, antifungal, antiperspirant, analgesic, wound-healing, antihistiminic, antiemetic and skin improving agents, herbs, plant parts, extracts thereof and mixtures thereof, among others.
  • active ingredients can be added to the liquid powder composition in amounts known in the art and can be administered to animals, including humans in a preventative manner or as a means for treating a condition requiring the administration of the ingredient thereof.
  • various of the active ingredients and/or fragrances may be combined in a single composition.
  • the components are added in amounts known in the art and within the ranges disclosed herein.
  • Preferred amounts for the addition of the active ingredients are about 0.005 to 100 parts of the active ingredient per 100 parts of the composition. A more preferred range is between about 1 and 10 parts of the active ingredient per 100 parts of the composition.
  • the liquid powder composition containing an active ingredient is intended for cutaneous, intravaginal, intranasal, intrauterine and intralesional use, among others in animals including humans, and for intramammary use in animals.
  • any compounds, plant parts, herbs, extracts thereof and mixtures thereof known in the art for having a medicinal or pharmaceutical use, among others, are suitable for use in the present composition.
  • active agents can be cited: cortical steroids as an anti-inflammatory, amirozglycosides as an antibiotic, corticosteroids as an
  • TM anti-itch Emery Industries, Mauldin, SC
  • Wickenol 340 and Germeben R II Sutton Labs, Inc., Chatham, NJ
  • acetyl salicylic as an analgesic
  • teramicin as a wound-healing agent
  • certain herbs as a skin improving agent, among others.
  • herbs and plant part that can be utilized are as follows: aloe, comfrey, calendula and other herbal preparations with properties known to give specific beneficial results to the user of the product.
  • the extracts of the herbs and plant parts are prepared as is known in the art and the extracted preparations are then added to the liquid powder carrier of the invention.
  • Example 1 A most preferred composition for the liquid powder composition of the invention is described in Example 1 hereinbelow.
  • the process for obtaining the liquid powder composition the Cetyl alcohol and the stearic acid can be melted together by heating these ingredients to their melting points or approximately 140 ⁇ F.
  • the glycerin and the Peg-8 Oleate are then added at room temperature to the melted ingredients, then raising the temperature first up to about 145 ⁇ F and then up to about
  • the ingredients and the water are mixed for a period of time sufficient to allow cooling to a temperature between about 145 ⁇ F and 150 ⁇ F.
  • the first portion of the potato starch is added at this point and the admixture is homogenized until the preparation cools to below about 135 ⁇ F.
  • the remaining amount of potato starch is added at this point while the preparation cools to about room temperature and the composition is then homogenized to obtain a product in the form of a lotion, a gel or a cream. At this point the liquid powder composition is in condition for packaging.
  • the veegum can be added at the time of the second addition of potato starch instead of being incorporated with the Cetyl alcohol, stearic acid, glycerin Peg-8 oleate and water.
  • the agent selected from the active ingredient and the fragrance can be added to the composition as soon as the * temperature is lowered to below about 135 ⁇ F.
  • the active ingredient and/or the fragrance are added prior to the last addition of potato starch to the composi ⁇ tion in amounts between about 0.005 and 100 parts of the active ingredient and about 0.005 and 1 parts of the frag ⁇ rance per 100 parts of the composition.
  • the mixing of the veegum, Cetyl alcohol, stearic acid, glycerin and Peg-8 oleate with the water is conducted at about 145 ⁇ -150 ⁇ F for between about 15 minutes and 75 minutes, preferably between 30 minutes and 60 minutes.
  • the admixture is homogenized at a temperature of below about 135 ⁇ F, typically for a period of between about 1 hour to 3 hours, preferably between 1.5 and 2.5 hours.
  • the admixing of the last portion of the potato starch to the rest of the ingredients and cooling of the composition to ambient temperature is typically conducted for about 1 hour to 4 hours, preferably 1.5 hours to 3.5 hours.
  • Homogenization subsequent to the addition of the potato starch to the mixture is typically conducted at about room temperature for between about 0.5 hours and 1.5 hours.
  • the above-described steps can be conducted for different periods of time as suitable for various purposes, such as attaining a specific consistency of the product.
  • the composition when the liquid powder composition is prepared by adding an active ingredient and/or a fragrance, the composition can be homogenized immediately after such addition and prior to the subsequent addition of the last portion of the potato starch.
  • This homogenization __ is typically conducted for between about 0.5 hours and 3 hours, preferably between about 0.5 hours and 1.5 hours.
  • the cooling of the preparation occurring during steps (5) and (6) can be aided and accelerated by conducting the process in a cooling tank provided with a refrigerating system.
  • composition of this exemplary formulation is as follows.
  • the cetyl alcohol and stearic acid were melted together by heating them to approximately 170 ⁇ F which is approximately the melting point of these ingredients.
  • the glycerin and Peg-8 oleate, both initially at room temperature were then added to, and mixed with, the melted ingredients, and the resulting mixture was then reheated to 170 ⁇ F.
  • all the water, preheated to 150 ⁇ F, was added to the initial mixture and, with the temperature maintained at 150 ⁇ F, the Germeben II and the fragrance, both of which were initially at room temperature, were added to the aqueous mixture.
  • the mixture is then permitted to cool to 145*F, and 24 lbs. of the potato starch, initially at room temperature, were added. The mixture was then permitted to cool while mixing and homogenizing, and it thickened. After the temperature of the resulting mixture dropped below 120°F, the remaining starch and the veegum which were initially at room temperature, were added and the entire mixture was then stirred in order to attain complete homogenization. This latter step can take place at a temperature between 120 ⁇ F and room temperature, although a temperature close to 120°F facilitates the homogenization.
  • a liquid powder composition of this exemplary formulation is as follows.
  • Example 2 A composition as that described in Example 2 was prepared and 8 lbs. of Germeben II TM were added thereto. Various amounts of Magnabrite brand veegum were added as follows.
  • Example 2 Three samples were prepared according to the formulation of Example 2, also containing Germeben II TM 8 lbs. The amount of glycerin was varied to contain 7, 8 and 9 lbs. of glycerin. All three yielded satisfactory results with the preparation containing 8 lbs. of glycerin being the best.
  • Example 5 The amounts of stearic acid and Cetyl alcohol were varied in the composition of Example 2 also containing 8
  • the initial amount of starch was varied in the composi ⁇ tion described in Example 2 also containing 8 lbs. of Germeben II TM. Potato starch was added in amounts of 12, 24,

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

A liquid powder composition comprising per 400 lbs. of composition 40-150 lbs. potato starch; 1-12 lbs. veegum; 3.6-12 lbs. cetyl alcohol; 2-10 lbs. stearic acid; 3-10 lbs. glycerin; 0.5 lbs. Peg-8 oleate and the remainder water. This liquid powder composition can be used as a carrier, for prostheses and orthoptics and in general as an oil-free wet lubricant which leaves no excess residue as do talcum powders and oil-based lubricants. This composition is prepared by a process comprising in the following order the steps of adding together the veegum, the cetyl alcohol, the stearic acid, the glycerin and the Peg-8 oleate and raising the temperature first to 145 DEG F and then to 175 DEG F; adding the heated ingredients to the water preheated to 130 to 200 DEG F, mixing the ingredients and the water while allowing to cool to a temperature of 145 DEG F-150 DEG F, admixing thereto 10-50 lbs. potato starch, homogenizing the admixture while allowing to cool to a temperature below 135 DEG F, admixing thereto 30-100 lbs. potato starch while allowing to cool to ambient temperature, and homogenizing the admixture to obtain the liquid powder in the form of a lotion, a gel or a cream. The liquid powder composition may further comprise an active ingredient and/or a fragrance.

Description

FORM , BODY POWDER CONTAINING ACTIVE INGREDIENTS AND METHOD OF PREPARING THEREOF
BACKGROUND OF THE INVENTION Field of the Invention
The present invention relates to body powders. More * specifically, this invention relates to a body powder in ^ 5 liquid form which can be used by itself or as a carrier for active ingredients intended for topical and mucous tissue application to animals, including humans. This invention also relates to a method of preparing a liquid body powder having optimal characteristics for applying to the skin in 10 terms of its smoothness, adherence, consistency and rate of evaporation after application. The liquid powders of this invention are useful for many purposes including to improve the smoothness of the skin, prevent irritation, absorb perspiration and deliver active ingredients to the human and 15 animal body.
Description of the Background
Typically, products intended for the above uses are manufactured and sold in powder form. This medium is known to have certain disadvantages, particularly that during each 20 application a certain quantity of the powder is dispersed "into the air in a wasteful manner and also produces a detrimental inhalation thereof. Accordingly, there still is a need for an improved body powder having excellent dispersion, adherence and smoothness while lacking the drawbacks accounted by the prior art products.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide an oil-free wet lubricant lacking the excess residue deposited by talcum powders or oil-based lubricants.
It is another object of the present invention to provide a product which is packaged and applied in liquid form, the liquid components evaporating rapidly after application leaving a layer of material in powder form at a desired location on the skin or mucous tissues of an animal, including humans. It is also an object of the present invention to provide a process for preparing an oil-free wet lubricant in the form of a heavy lotion which can be used by itself or as a carrier for active agents to be applied topically to the skin or to mucous tissues of animals, including humans. The above and other objects of the invention are attained by forming an aqueous solution or suspension of ingredients comprising a substantial quantity of potato starch in accordance with a specific procedure and temperature regime. The product obtained is a stable liquid product having a desirable thickness for easy application and general stability which assures a long shelf life..
Other objects, advantages and features of the present
• * invention will become apparent to those skilled in the art t 5 from the following discussion.
DESCRIPTION OF THE INVENTION Applicant has further discovered that in order for the product to be given an appropriate thickness and stability, various other components can be added to the potato starch. Preferred components are veegum, cetyl alcohol, stearic acid, glycerin, and optionally Peg-8-oleate. The variation of the amounts of these components in the liquid powder composition results in a final product which may be in the form of a liquid lotion, of heavy lotion, a gel-like preparation, a light cream or a heavy cream, among others. The amount of water contained in the composition also contributes to and helps determine the final consistency of the liquid powder product.
This liquid powder composition finds a remarkable use as an oil-free wet lubricant which leaves no excess residues encountered in talcum powders or oil-based lubricants used by the prior art. This composition is also useful for its skin soothing characteristics and for use in prostheses and orthotics. As a water-based composition, it will not clog valves, makes no mess on clothing articles, is ideal for attaining complete contact with suction sockets and helping control sweating and can be washed off easily at the end of the day.
In one embodiment of this invention, it is provided a liquid powder composition comprising per 400 lbs. of composition a ou - s., po a o s arc ; about 1-12 lbs.; veegum; about 3.6-12 lbs., cetyl alcohol; about 2-10 lbs., stearic acid; about 3-10 lbs., glycerin; about 0.5 lbs., Peg-8 oleate; and the remainder, water.
In yet another preferred embodiment of the invention, the above-described liquid powder composition further comprises an agent selected from about .0.005-100 parts of an active agent; and about 0.005-1 parts of a fragrance per 100 parts of the carrier composition.
An even more preferred embodiment of the above-described composition comprises about 1-10 parts of an active ingredient, or about 0.1-0.3 parts of a fragrance per 100 parts of the carrier composition.
In another aspect of this invention, it is provided a process for obtaining a liquid powder composition comprising (1) adding together about 1-12 lbs. veegum, about 3.6-12 lbs. cetyl alcohol, about 2-10 lbs. stearic acid, about 3-10
s. g ycer ne, an a ou - s. eg- - ea e w e ra s ng the temperature from about 145 βF up to about 175 °F,
(2) adding the heated ingredients to about 350.4 to 201 lbs. of water preheated to between about 130 βF to 200 βF, (3) mixing the ingredients and the water for a period of time sufficient to allow cooling to a temperature between about 145 βF and 150 βF,
(4) admixing thereto about 10-50 lbs. potato starch,
(5) homogenizing the admixture for a period of time sufficient to allow cooling to a temperature below about
135 βF,
(6) admixing thereto about 30-100 lbs. potato starch for a period of time sufficient to allow cooling to ambient temperature, and (7) homogenizing the admixture to obtain the liquid powder in the form of a lotion, a gel or a cream.
A more preferred way of conducting the above process involves adding a first portion of between about 12 and 48 lbs. of potato starch and a second portion of between, about 40 and 52 lbs. of potato starch.
In still another aspect of the process, an agent selected from an active ingredient and a fragrance can be added to the liquid powder composition. These ingredients are added to the composition preferably subsequent to step (5) of the above process at a temperature at which they remain stable. Other o ects, a vantages and features of the present invention will become apparent to those skilled in the art from the following detailed discussion.
DESCRIPTION OF THE PREFERRED EMBODIMENTS As noted above, a principal ingredient of the liquid powder composition according to the present invention is potato starch. In effect, applicant has discovered that the use of potato starch makes possible the manufacture of a product having the above-described properties. In a preferred aspect of the invention, the liquid powder composition comprises per 400 lbs. of composition about 52-100 lbs. of potato starch, about 2-6 lbs. of veegum, about 4-6 lbs. of cetyl alcohol, about 2-6 lbs. of stearic acid, about 7-9 lbs. of glycerin, about 1.6-4 lbs. of Peg-8-oleate; and the remainder water.
In another aspect of the invention the liquid powder composition may additionally contain a fragrance which can be selected from any fragrances known in the art, such as perfumes, essences, and the like.
While a variety of fragrances can be employed, a preferred fragrance which is utilized to prepare the The fragrance is preferably added to the liquid powder composition in an amount of about 0.005 to 1 parts per 100 parts of the composition. A still more preferred amount of fragrance is between about 0.1 and 0.3 parts per 100 parts of the composition. By means of example, E eressence^ 1160 (Emery Chemicals, Cincinnati, OH) can be used in the composition of the invention.
In still another aspect of the present invention, the composition may additionally contain an active ingredient. In this case, the basic liquid powder composition acts as a carrier for the active ingredient. A variety of active ingredients are contemplated within the confines of this invention. For all practical matters, any ingredient which would be applied to the skin of humans or animals or to mucous tissues thereof can be utilized with the present composition.
Suitable active ingredients for the liquid powder composition of this invention are anti-itch, anti-inflammatory, antimicrobial, antiviral, antibacterial, antifungal, antiperspirant, analgesic, wound-healing, antihistiminic, antiemetic and skin improving agents, herbs, plant parts, extracts thereof and mixtures thereof, among others. These active ingredients can be added to the liquid powder composition in amounts known in the art and can be administered to animals, including humans in a preventative manner or as a means for treating a condition requiring the administration of the ingredient thereof.
In yet another aspect of the invention, various of the active ingredients and/or fragrances may be combined in a single composition. The components are added in amounts known in the art and within the ranges disclosed herein.
Preferred amounts for the addition of the active ingredients are about 0.005 to 100 parts of the active ingredient per 100 parts of the composition. A more preferred range is between about 1 and 10 parts of the active ingredient per 100 parts of the composition.
The liquid powder composition containing an active ingredient is intended for cutaneous, intravaginal, intranasal, intrauterine and intralesional use, among others in animals including humans, and for intramammary use in animals.
Any compounds, plant parts, herbs, extracts thereof and mixtures thereof known in the art for having a medicinal or pharmaceutical use, among others, are suitable for use in the present composition. As examples of active agents can be cited: cortical steroids as an anti-inflammatory, amirozglycosides as an antibiotic, corticosteroids as an
TM anti-itch, Emercide 1199 (Emery Industries, Mauldin, SC), Wickenol 340 and GermebenR II (Sutton Labs, Inc., Chatham, NJ) as antimicrobials, preservatives, germicides and antifungals, sodium aluminum lactate as an antiperspirant. acetyl salicylic as an analgesic, teramicin as a wound-healing agent, and certain herbs as a skin improving agent, among others.
Examples of herbs and plant part that can be utilized are as follows: aloe, comfrey, calendula and other herbal preparations with properties known to give specific beneficial results to the user of the product.
The extracts of the herbs and plant parts are prepared as is known in the art and the extracted preparations are then added to the liquid powder carrier of the invention.
A most preferred composition for the liquid powder composition of the invention is described in Example 1 hereinbelow.
In another aspect of the invention, the process for obtaining the liquid powder composition the Cetyl alcohol and the stearic acid can be melted together by heating these ingredients to their melting points or approximately 140βF.
The glycerin and the Peg-8 Oleate are then added at room temperature to the melted ingredients, then raising the temperature first up to about 145βF and then up to about
175βF. All the ingredients are then added to the water including the Veegum, which was preheated to between about
130βF and 200βF and the ingredients and the water are mixed for a period of time sufficient to allow cooling to a temperature between about 145βF and 150βF. The first portion of the potato starch is added at this point and the admixture is homogenized until the preparation cools to below about 135βF.
The remaining amount of potato starch is added at this point while the preparation cools to about room temperature and the composition is then homogenized to obtain a product in the form of a lotion, a gel or a cream. At this point the liquid powder composition is in condition for packaging.
In yet another aspect of the process, the veegum can be added at the time of the second addition of potato starch instead of being incorporated with the Cetyl alcohol, stearic acid, glycerin Peg-8 oleate and water.
In yet another aspect of the inventive process, the agent selected from the active ingredient and the fragrance can be added to the composition as soon as the* temperature is lowered to below about 135βF. In a preferred form of the process, the active ingredient and/or the fragrance are added prior to the last addition of potato starch to the composi¬ tion in amounts between about 0.005 and 100 parts of the active ingredient and about 0.005 and 1 parts of the frag¬ rance per 100 parts of the composition.
Typically, the mixing of the veegum, Cetyl alcohol, stearic acid, glycerin and Peg-8 oleate with the water is conducted at about 145β-150βF for between about 15 minutes and 75 minutes, preferably between 30 minutes and 60 minutes. Once the first addition of the potato starch to the veegum, Cetyl alcohol, stearic acid, glycerin, Peg-8 oleate and water has occurred, the admixture is homogenized at a temperature of below about 135βF, typically for a period of between about 1 hour to 3 hours, preferably between 1.5 and 2.5 hours.
The admixing of the last portion of the potato starch to the rest of the ingredients and cooling of the composition to ambient temperature is typically conducted for about 1 hour to 4 hours, preferably 1.5 hours to 3.5 hours.
Homogenization subsequent to the addition of the potato starch to the mixture is typically conducted at about room temperature for between about 0.5 hours and 1.5 hours. However, the above-described steps can be conducted for different periods of time as suitable for various purposes, such as attaining a specific consistency of the product.
In another aspect of the process, when the liquid powder composition is prepared by adding an active ingredient and/or a fragrance, the composition can be homogenized immediately after such addition and prior to the subsequent addition of the last portion of the potato starch. This homogenization __ is typically conducted for between about 0.5 hours and 3 hours, preferably between about 0.5 hours and 1.5 hours.
In another aspect of this process, the cooling of the preparation occurring during steps (5) and (6) can be aided and accelerated by conducting the process in a cooling tank provided with a refrigerating system. Having now generally described this invention, the same will be better understood by reference to certain specific examples, which are included herein for purposes of illustration only and are not intended to be limiting of the invention or any embodiment thereof, unless so specified.
EXAMPLES
Example 1
The following description while provided by way of example relates to a formulation which has been perfected and which is presently considered to be the preferred formulation. The composition of this exemplary formulation is as follows.
Table 1: Composition of Example 1
Initial
Ingredient Source & Type Designation Form Quantity
Water Liquid 559 lb.
Magnebrite brand
Veegum —. AC-590A-03 Powder 6.6 lb. Germeben IIAn GB7 120 Liquid 8 lb.
Glycerin Emery 912-1601 Liquid 8 lb.
Stearic acid Emery Powder 4 lb.
Cetyl Alcohol Pg 33120 G73C95 Powder 7.2 lb.
Peg-8 oleate Witro 09-H-2555 Liquid 3.2 lb.
Fragrance Global j223 Liquid 0.4 lb.
Potato starch Simplot Powder 203.6 lb. 14
To produce the liquid product, the cetyl alcohol and stearic acid were melted together by heating them to approximately 170βF which is approximately the melting point of these ingredients. The glycerin and Peg-8 oleate, both initially at room temperature were then added to, and mixed with, the melted ingredients, and the resulting mixture was then reheated to 170βF. Then all the water, preheated to 150βF, was added to the initial mixture and, with the temperature maintained at 150βF, the Germeben II and the fragrance, both of which were initially at room temperature, were added to the aqueous mixture.
The mixture is then permitted to cool to 145*F, and 24 lbs. of the potato starch, initially at room temperature, were added. The mixture was then permitted to cool while mixing and homogenizing, and it thickened. After the temperature of the resulting mixture dropped below 120°F, the remaining starch and the veegum which were initially at room temperature, were added and the entire mixture was then stirred in order to attain complete homogenization. This latter step can take place at a temperature between 120βF and room temperature, although a temperature close to 120°F facilitates the homogenization.
The product was then permitted to cool to room temperature, at which time it is ready to be packaged. Example 2
A liquid powder composition of this exemplary formulation is as follows.
Table 2: Composition of Example 2
Initial
Ingredient Source & Type Designation Form Quantity
Water Liquid remainder up to 800 lbs.
Magnebrite brand
Veegum AC-590A-03 Powder 8 lbs.
Glycerin Emery 912-1601 Liquid 8 lbs.
Stearic acid Emery Powder 4 lbs.
Cetyl Alcohol Pg 33120 G73C95 Powder 7.2 lbs.
Peg-8 oleate Witro 09-H-2555 Liquid 3.2 lbs.
Fragrance Global j223 Liquid 0.4 lbs.
Potato starch Simplot Powder 203.6 lbs.
To this composition the following three active ingredients were added.
(a) Emercide 1199 produced by
Emery Chemical 8 lbs.
(b) Wickenol 340 Sodium Aluminum
Lactate by Wickhen Products 8 lbs.
(c) Germeben II by Sutton Labs 8 lbs
All three antibacterial agents were effective when tested. Germeben II gave the best results due to its high compatibility with the lotion and the fact that it has a broad spectrum of preservative characteristics. Example 3
A composition as that described in Example 2 was prepared and 8 lbs. of Germeben II TM were added thereto. Various amounts of Magnabrite brand veegum were added as follows.
(a) 0.5% (4 lbs.)
(b) 0.75% (6 lbs.)
(c) 1.0% (8 lbs.)
Although there were some signs of separation, all three proportions of veegum were satisfactory. In general, the best results were attained with the 1.0% veegum as the carrier.
Example 4
Three samples were prepared according to the formulation of Example 2, also containing Germeben II TM 8 lbs. The amount of glycerin was varied to contain 7, 8 and 9 lbs. of glycerin. All three yielded satisfactory results with the preparation containing 8 lbs. of glycerin being the best.
Example 5 The amounts of stearic acid and Cetyl alcohol were varied in the composition of Example 2 also containing 8
TM lbs. of Germeben II . The best results were attained with 7.2 lbs. of stearic acid and 9.0 lbs. of Cetyl alcohol. When the amount Peg-8 oleate was varied in the composition of Example 2 also containing 8 lbs. of Germeben II , added in amounts of 0, 2.0 and 3.2 lbs. gave satisfactory results. The best results were obtained with 3.2 lbs. of Peg-8 oleate.
Example 7
The initial amount of starch was varied in the composi¬ tion described in Example 2 also containing 8 lbs. of Germeben II TM. Potato starch was added in amounts of 12, 24,
28 and 32 lbs. at a temperature of 145-150°F. All four samples gave satisfactory results, with the one having a first addition of 28 lbs. of potato starch yielding the best consistency to hold the remaining starch to the skin. It will be understood that the above description of the present invention is susceptible to various modifications, changes, and adaptations, and the same are intended to be comprehended within the meaning and range of equivalents of the appended claims.

Claims

WHAT IS CLAIMED IS:
1. A liquid powder composition comprising per 400 lbs. of the mixture about 40-150 lbs. potato starch; about 1-12 lbs. veegum; about 3.6-12 lbs. cetyl alcohol; about 2-10 lbs. stearic acid; about 3-10 lbs. glycerin; about 0.5 lbs. Peg-8 oleate the remainder water.
2. The liquid powder composition of claim 1 comprising per 400 lbs. of composition about 52-100 lbs. potato starch; about 2-6 lbs. veegum; about 4-6 lbs. Cetyl alcohol; about 2-6 lbs. stearic acid; about 7-9 lbs. glycerin; about 1.6-4 lbs. Peg-8 oleate; and the remainder water.
3. The liquid powder composition of claim 2, further comprising an agent selected from the group consisting of
_ about 0.005-100 parts of an active ingredient and about 0.005-1 part fragrance per 100 parts of the composition or mixtures thereof. 4. The liquid powder composition of claim 3, wherein the active ingredient is present in an amount between about 1 and 10 parts.
5. The liquid powder composition of claim 3, wherein the fragrance is present in an amount between about
0.1 and 0.3 parts.
6. The liquid powder composition of claim 3, wherein the active ingredient is selected from the group consisting of anti-itch, anti-inflammatory, antimicrobial, antibacterial, antifungal, antiperspirant, analgesic, wound-healing, antihistaminic, antiemetic and skin improving agents, herbs, plant parts, extracts thereof and mixtures thereof.
7. The liquid powder composition of claim 1 in the form of a lotion, a gel or a cream.
8. The liquid powder composition of claim 7 for cutaneous, intravaginal, intrauterine, intranasal, intralesional or intramammary use.
9. A process for obtaining a liquid powder composition, comprising in the following order the steps of
(1) adding together — about 1-12 lbs. veegum; about 3.6-12 lbs. cetyl alcohol; about 2-10 lbs. stearic acid; about 3-10 lbs. glycerin; and about 0-5 lbs. Peg-8 oleate; and raising the temperature first up to about 145βF and then up to about to 175βF,
(2) adding the heated ingredients to about 350.4 to 201 lbs. of water preheated to between about 130βF to 200βF,
(3) mixing the ingredients and the water for a period of time sufficient to allow cooling to a temperature between about 145βF and 150βF,
(4) admixing thereto about 10-50 lbs. potato starch,
(5) homogenizing the admixture for a period of time sufficient to allow cooling to a temperature below about 135°F,
(6) admixing thereto about 30-100 lbs. potato starch for a period of time sufficient to allow cooling to ambient temperature, and
(7) homogenizing the admixture to obtain the liquid powder in the form of a lotion, a gel or a cream.
10. The process of claim 9, wherein between about 12 and 48 lbs. of potato starch are added in Step (4) and between about 25 and 52 lbs. of potato starch are added in Step (6) .
11. The process of claim 9, wherein step (1) comprises _ melting together the cetyl alcohol and stearic
.acid, and adding thereto the veegum, the glycerin and the Peg-8 oleate while raising the temperature first up to about 145βF and then up to about 175βF. 12. The process of claim 9 further comprising between steps (5) and (6) admixing an agent selected from the group consisting of about 0.005-100 parts of an active ingredient, about 0.005-1 part of a fragrance per 100 parts of the composition and mixtures thereof; and homogenizing the admixture.
13. The process of claim 9 wherein the veegum is added in step (6) .
14. The process of claim 9, wherein step (3) is conducted for between about 15 minutes to 75 minutes.
15. The process of claim 9, wherein step (5) is conducted for between about 1 hour and 3 hours.
16. The process of claim 9, wherein step (6) is conducted for between about 1 hour to 4 hours.
17. The process of claim 9, wherein steps (5) and (6) are conducted in a cooling tank.
EP19870903964 1986-05-30 1987-05-29 Body powder in liquid form, body powder containing active ingredients and method of preparing thereof Withdrawn EP0270632A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86854386A 1986-05-30 1986-05-30
US868543 1986-05-30
US91673586A 1986-10-08 1986-10-08
US916735 1986-10-08

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EP0270632A4 true EP0270632A4 (en) 1991-04-17

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JP (1) JPH01501147A (en)
AU (1) AU7514987A (en)
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ATE293432T1 (en) * 1999-01-20 2005-05-15 Stada Arzneimittel Ag COSMETIC OR PHARMACEUTICAL PREPARATIONS FOR TOPICAL ADMINISTRATION WITH IMPROVED STABILITY
JP3783104B2 (en) * 2004-03-31 2006-06-07 小林製薬株式会社 Antifungal composition for external use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3726M (en) * 1964-01-15 1965-12-06 Andre David Garson New composition has various uses.
GB1357731A (en) * 1970-02-12 1974-06-26 Ethichem Ltd Free flowing powder compositions and ointments containing them'

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838440A (en) * 1953-10-29 1958-06-10 Rohm & Haas Dusting powder of carboxylic cationexchange resin and powder base
US4137302A (en) * 1976-04-02 1979-01-30 Lever Brothers Company Cosmetic composition
US4302443A (en) * 1980-02-21 1981-11-24 Terry Corporation Non-irritating antiperspirant
US4568539A (en) * 1983-08-03 1986-02-04 Johnson & Johnson Baby Products Company Body powder compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3726M (en) * 1964-01-15 1965-12-06 Andre David Garson New composition has various uses.
GB1357731A (en) * 1970-02-12 1974-06-26 Ethichem Ltd Free flowing powder compositions and ointments containing them'

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8707139A1 *

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NZ220364A (en) 1990-04-26
AU7514987A (en) 1987-12-22
WO1987007139A1 (en) 1987-12-03
EP0270632A1 (en) 1988-06-15

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