EP0442878A4 - Derivatives of tryptophan as cck antagonists - Google Patents

Derivatives of tryptophan as cck antagonists

Info

Publication number
EP0442878A4
EP0442878A4 EP19890905266 EP89905266A EP0442878A4 EP 0442878 A4 EP0442878 A4 EP 0442878A4 EP 19890905266 EP19890905266 EP 19890905266 EP 89905266 A EP89905266 A EP 89905266A EP 0442878 A4 EP0442878 A4 EP 0442878A4
Authority
EP
European Patent Office
Prior art keywords
tryptophan
derivatives
cck antagonists
cck
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890905266
Other versions
EP0442878A1 (en
Inventor
James F. Kerwin, Jr.
Alex M. Nadzan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP0442878A1 publication Critical patent/EP0442878A1/en
Publication of EP0442878A4 publication Critical patent/EP0442878A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP19890905266 1988-04-05 1989-04-04 Derivatives of tryptophan as cck antagonists Withdrawn EP0442878A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17771588A 1988-04-05 1988-04-05
US177715 1988-04-05

Publications (2)

Publication Number Publication Date
EP0442878A1 EP0442878A1 (en) 1991-08-28
EP0442878A4 true EP0442878A4 (en) 1991-10-23

Family

ID=22649698

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19890905266 Withdrawn EP0442878A4 (en) 1988-04-05 1989-04-04 Derivatives of tryptophan as cck antagonists
EP19890105864 Pending EP0336356A3 (en) 1988-04-05 1989-04-04 Derivatives of tryptophan as cck antagonists

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19890105864 Pending EP0336356A3 (en) 1988-04-05 1989-04-04 Derivatives of tryptophan as cck antagonists

Country Status (3)

Country Link
EP (2) EP0442878A4 (en)
JP (1) JPH03503650A (en)
WO (1) WO1989010355A1 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1326108C (en) * 1988-04-12 1994-01-11 Sun Hyuk Kim Cck antagonists
US5631281A (en) * 1989-06-29 1997-05-20 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
US5278316A (en) * 1989-06-29 1994-01-11 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
US5580896A (en) * 1989-06-29 1996-12-03 Warner-Lambert Company Treatment of pain and colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives
IE902295A1 (en) * 1989-07-07 1991-01-16 Abbott Lab Amino acid analog cck antagonists
FR2667066B2 (en) * 1990-03-07 1993-06-25 Rhone Poulenc Sante N-HETEROCYCLYL GLYCINAMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
JPH05504968A (en) * 1990-03-07 1993-07-29 ローン―プーラン・ロレ・ソシエテ・アノニム Glycinamide derivatives, their production and pharmaceuticals containing them
US5264419A (en) * 1990-08-31 1993-11-23 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
US5244915A (en) * 1990-08-31 1993-09-14 Warner-Lambert Company Amico acid derivatives cyclized at the c-terminal
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
US5340825A (en) * 1990-08-31 1994-08-23 Warner-Lambert Company Pro drugs for CCK antagonists
CA2088980C (en) * 1990-08-31 2002-04-16 David C. Horwell Pro-drugs for cck antagonists
CA2088195A1 (en) * 1990-08-31 1992-03-01 David C. Horwell Cholecystokinin antagonists, their preparation and therapeutic use
US5244905A (en) * 1990-08-31 1993-09-14 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives
US5075313A (en) * 1990-09-13 1991-12-24 Eli Lilly And Company 3-aryl-4(3H)quinazolinone CCK antagonists and pharmaceutical formulations thereof
FR2694006A1 (en) * 1992-07-22 1994-01-28 Esteve Labor Dr New amide derivs. of benzo-hetero cyclic cpds. - for treating gastrointestinal disorders, including ulcers and gastric hypersecretion
CA2140640A1 (en) * 1992-08-13 1994-03-03 David C. Horwell Tachykinin antagonists
JP3419539B2 (en) 1993-02-17 2003-06-23 中外製薬株式会社 Indoline-2-one derivatives
US6403577B1 (en) 1993-11-17 2002-06-11 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
US6869957B1 (en) 1993-11-17 2005-03-22 Eli Lilly And Company Non-peptide tachykinin receptor antagonists
ATE184593T1 (en) * 1994-01-24 1999-10-15 Fujisawa Pharmaceutical Co AMINO ACID DERIVATIVES AND THEIR USE AS PHOSPHOLIPASE A2 INHIBITORS
EP0693055B1 (en) * 1994-02-08 1997-05-21 Alcon Laboratories, Inc. Novel process for preparation of clonidine derivatives
GB9409150D0 (en) * 1994-05-09 1994-06-29 Black James Foundation Cck and gastrin receptor ligands
GB2303369B (en) * 1994-05-09 1998-05-27 Black James Foundation Cck and gastrin receptor ligands
DE69523154T2 (en) * 1994-06-06 2002-06-06 Warner-Lambert Co., Morris Plains TACHYKININ (NK1) RECEPTOR ANTAGONISTS
JPH08325263A (en) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd Novel 2-amino-3-phenylpropionic acid derivative
KR100241643B1 (en) 1995-06-06 2000-03-02 디. 제이. 우드 Substituted N- (indole-2-carbonyl) -β-alanimamide and its derivatives for treating diabetes
US6297269B1 (en) 1995-06-06 2001-10-02 Pfizer Inc. Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors
MX9709875A (en) * 1995-06-06 1998-03-31 Pfizer Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors.
CA2360740A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
RU2227144C2 (en) * 2001-11-15 2004-04-20 Научно-исследовательский институт фармакологии РАМН Substituted tryptophan-containing dipeptides with cholecystokinin-negative or cholecystokinin-positive activity
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20100222316A1 (en) 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US7880001B2 (en) 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
KR101496190B1 (en) 2005-01-05 2015-02-26 애브비 인코포레이티드 Adamantyl derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
CA2594116A1 (en) 2005-01-05 2006-07-13 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8198331B2 (en) 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
JP5736098B2 (en) 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド Pharmaceutical composition for treating central nervous system disorders
JP5213961B2 (en) * 2008-09-18 2013-06-19 日本臓器製薬株式会社 Amino acid derivatives
PL228037B1 (en) * 2009-03-23 2018-02-28 Marciniak Agnieszka Maria Application of kynurenic acid and its derivatives in preventing or treatment of pancreas diseases
CN102020588B (en) * 2009-09-16 2014-01-29 深圳微芯生物科技有限责任公司 Tricyclic compound with histone deacetylases inhibition activity and preparation method and application thereof
US9453014B2 (en) * 2011-12-22 2016-09-27 Connexios Life Sciences Pvt. Ltd. Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof
EP2994142A4 (en) * 2013-05-08 2017-03-29 Colorado Seminary, Which Owns and Operates The University of Denver Antibiotic and anti-parasitic agents that modulate class ii fructose 1,6-bisphosphate aldolase
CN104628616B (en) * 2015-02-12 2016-06-01 佛山市赛维斯医药科技有限公司 Containing N-diamantane amides, the Preparation Method And The Use of p-nitrophenyl
CN104628617B (en) * 2015-02-12 2016-04-06 佛山市赛维斯医药科技有限公司 N-diamantane amides glucokinase activators, preparation method and its usage
CN104628615B (en) * 2015-02-12 2016-04-06 佛山市赛维斯医药科技有限公司 N-adamantane amide compounds containing halogenated benzene, its preparation method and use
CN104693084B (en) * 2015-02-12 2016-03-16 佛山市赛维斯医药科技有限公司 The N-diamantane amides of nitrile group-containing phenyl, Preparation Method And The Use
US11584740B2 (en) 2017-09-13 2023-02-21 Syngenta Participations Ag Microbiocidal quinoline (thio)carboxamide derivatives
ES2904910T3 (en) * 2017-09-13 2022-04-06 Syngenta Participations Ag Microbiocidal quinoline (thio)carboxamide derivatives
WO2021032933A1 (en) * 2019-08-21 2021-02-25 Kalvista Pharmaceuticals Limited Enzyme inhibitors

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2224130A1 (en) * 1971-05-18 1972-11-30 Rotta Research Laboratorium S.P.A., San Fruttuoso Di Monza, Mailand (Italien) Tryptophan derivatives
DE2726276A1 (en) * 1976-10-12 1978-04-13 Ici Ltd POLYPEPTIDE
DE3236484A1 (en) * 1981-10-02 1983-04-21 Richter Gedeon Vegyészeti Gyár R.T., 1103 Budapest TRIPEPTIDES, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THEM
US4472305A (en) * 1983-05-17 1984-09-18 Sterling Drug Inc. Hexapeptide amides
EP0230151A2 (en) * 1985-12-31 1987-07-29 Biomeasure, Inc. Cholecystokinin antagonists
EP0250148A2 (en) * 1986-06-16 1987-12-23 Merck & Co. Inc. Amino acid analogs as CCK-antagonists

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US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
US4642315A (en) * 1982-11-18 1987-02-10 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4604402A (en) * 1984-03-30 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxy substituted ureido amino and imino acids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2224130A1 (en) * 1971-05-18 1972-11-30 Rotta Research Laboratorium S.P.A., San Fruttuoso Di Monza, Mailand (Italien) Tryptophan derivatives
DE2726276A1 (en) * 1976-10-12 1978-04-13 Ici Ltd POLYPEPTIDE
DE3236484A1 (en) * 1981-10-02 1983-04-21 Richter Gedeon Vegyészeti Gyár R.T., 1103 Budapest TRIPEPTIDES, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THEM
US4472305A (en) * 1983-05-17 1984-09-18 Sterling Drug Inc. Hexapeptide amides
EP0230151A2 (en) * 1985-12-31 1987-07-29 Biomeasure, Inc. Cholecystokinin antagonists
EP0250148A2 (en) * 1986-06-16 1987-12-23 Merck & Co. Inc. Amino acid analogs as CCK-antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO8910355A1 *

Also Published As

Publication number Publication date
EP0336356A2 (en) 1989-10-11
WO1989010355A1 (en) 1989-11-02
EP0442878A1 (en) 1991-08-28
JPH03503650A (en) 1991-08-15
EP0336356A3 (en) 1991-09-25

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