EP0494992A4 - Methods and apparatus for treating disease states using oxidized lipoproteins - Google Patents

Methods and apparatus for treating disease states using oxidized lipoproteins

Info

Publication number: EP0494992A4
Authority: EP; European Patent Office
Prior art keywords: methods; disease states; treating disease; oxidized lipoproteins; lipoproteins
Prior art date: 1989-10-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19900916422

Other versions

EP0494992A1 (en

Inventor

Eric T. Fossel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beth Israel Deaconess Medical Center Inc

Original Assignee

Beth Israel Deaconess Medical Center Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-06

Filing date

1990-10-04

Publication date

1993-03-31

1990-10-04 Application filed by Beth Israel Deaconess Medical Center Inc filed Critical Beth Israel Deaconess Medical Center Inc

1992-07-22 Publication of EP0494992A1 publication Critical patent/EP0494992A1/en

1993-03-31 Publication of EP0494992A4 publication Critical patent/EP0494992A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Developmental Biology & Embryology (AREA)
Immunology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
External Artificial Organs (AREA)
Lighting Device Outwards From Vehicle And Optical Signal (AREA)

EP19900916422 1989-10-06 1990-10-04 Methods and apparatus for treating disease states using oxidized lipoproteins Withdrawn EP0494992A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41838289A	1989-10-06	1989-10-06
US418382		1989-10-06

Publications (2)

Publication Number	Publication Date
EP0494992A1 EP0494992A1 (en)	1992-07-22
EP0494992A4 true EP0494992A4 (en)	1993-03-31

Family

ID=23657894

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP19910901910 Withdrawn EP0495014A4 (en)	1989-10-06	1990-10-04	Novel oxidized lipoproteins and methods for their preparation
EP19900916422 Withdrawn EP0494992A4 (en)	1989-10-06	1990-10-04	Methods and apparatus for treating disease states using oxidized lipoproteins

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
EP19910901910 Withdrawn EP0495014A4 (en)	1989-10-06	1990-10-04	Novel oxidized lipoproteins and methods for their preparation

Country Status (7)

Country	Link
EP (2)	EP0495014A4 (en)
JP (2)	JPH05500963A (en)
AU (2)	AU7045291A (en)
BR (2)	BR9007721A (en)
CA (2)	CA2067356A1 (en)
FI (2)	FI921431L (en)
WO (2)	WO1991004744A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2674753B1 (en) *	1991-04-02	1995-03-10	Jean Berque	NEW THERAPEUTIC INDICATIONS, PARTICULARLY FOR THE TREATMENT OF AIDS, OF AN ALREADY EXISTING MEDICINAL PRODUCT FROM A DENIMOUS MOLECULE OF CONTRAINDICATIONS AND ADVERSE REACTIONS.
WO1994023302A1 (en) *	1993-04-07	1994-10-13	The Australian National University	Immunological assay of oxidatively modified human low density lipoproteins in plasma
AP2781A (en) *	2000-10-20	2013-10-31	Hamburger Stiftung Zur Forderung Van Wissenschaft Und Kultur	Oxidized proteins, their biological activity, and therapeutic and diagnostic measures, which are derived from the active mechansim, from the use of these porteins or from the inhibition thereof
US20060079440A1 (en) *	2003-04-25	2006-04-13	Kehrel Beate E	Treatment of hi-virus infections with oxidised blood proteins
WO2006059082A1 (en) *	2004-11-30	2006-06-08	Trigen Limited	Oxidised lipids as reversal agents for boronic acid drugs
US9551768B2 (en)	2013-03-15	2017-01-24	East Carolina University	NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
US10775458B2 (en)	2018-03-05	2020-09-15	Texas Tech University System	Method and system for non-invasive measurement of metabolic health

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2095338A (en) *	1927-08-20	1937-10-12	Ig Farbenindustrie Ag	Process for oxidizing organic substances in the liquid phase and apparatus therefor
US2095388A (en) *	1935-08-03	1937-10-12	Bendix Radio Corp	Electrical regulator apparatus
US3655700A (en) *	1970-02-02	1972-04-11	Zoecon Corp	Oxygenated unsaturated aliphatic carboxylic acids and esters
US4226713A (en) *	1978-04-24	1980-10-07	Goldberg Jack M	Diagnostic agents
JPS5810056A (en) *	1981-07-10	1983-01-20	株式会社クラレ	Blood purifying apparatus
DD243714A1 (en) *	1985-10-08	1987-03-11	Akad Wissenschaften Ddr	PROCESS FOR STABILIZING IMMOBILIZED GLUCOSE OXIDASE

1990
- 1990-10-04 JP JP3502153A patent/JPH05500963A/en active Pending
- 1990-10-04 WO PCT/US1990/005680 patent/WO1991004744A1/en not_active Ceased
- 1990-10-04 AU AU70452/91A patent/AU7045291A/en not_active Abandoned
- 1990-10-04 AU AU70400/91A patent/AU7040091A/en not_active Abandoned
- 1990-10-04 FI FI921431A patent/FI921431L/en not_active Application Discontinuation
- 1990-10-04 CA CA002067356A patent/CA2067356A1/en not_active Abandoned
- 1990-10-04 BR BR909007721A patent/BR9007721A/en not_active Application Discontinuation
- 1990-10-04 WO PCT/US1990/005679 patent/WO1991005536A2/en not_active Ceased
- 1990-10-04 JP JP2515223A patent/JPH05501258A/en active Pending
- 1990-10-04 EP EP19910901910 patent/EP0495014A4/en not_active Withdrawn
- 1990-10-04 BR BR909007725A patent/BR9007725A/en not_active Application Discontinuation
- 1990-10-04 CA CA002067364A patent/CA2067364A1/en not_active Abandoned
- 1990-10-04 FI FI921430A patent/FI921430L/en not_active Application Discontinuation
- 1990-10-04 EP EP19900916422 patent/EP0494992A4/en not_active Withdrawn

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS vol. 148, no. 1, 14 October 1987, DULUTH, MINNESOTA US pages 260 - 266 A.W. BERNHEIMER ET AL. 'TOXICITY OF ENZYMATICALLY-OXIDIZED LOW-DENSITY LIPOPROTEIN' *
BIOLOGICAL ABSTRACTS vol. 84 , 1987, Philadelphia, PA, US; abstract no. 12154, K. KOSUGI ET AL. 'Toxicity of oxidized low-density lipoprotein to cultured fibroblasts is selective for S phase of the cell cycle' *
MANUFACTURING CHEMIST vol. 59, no. 11, November 1988, LONDON, GB page 44 'DRUG DELIVERY AMBITIONS' *
N. ENGL. J. MED. vol. 316, no. 6, 5 February 1987, BOSTON, MASS., US pages 297 - 303 R. EDELSON ET AL. 'TREATMENT OF CUTANEOUS T-CELL LYMPHOMA BY EXTRACORPOREAL PHOTOCHEMOTHERAPY' *
PROC. AM. ASSOC. CANCER RES. ANNU. MEET., ABSTR.NO. 975 vol. 31, no. 0, March 1990, page 164 E.T. FOSSEL ET J. MCDONAGH 'EVIDENCE FOR PLASMA LIPOPROTEIN LIPID PEROXIDATION IN PATIENTS WITH CANCER' *
See also references of WO9104744A1 *

Also Published As

Publication number	Publication date
AU7045291A (en)	1991-05-16
FI921431A7 (en)	1992-04-01
CA2067356A1 (en)	1991-04-07
CA2067364A1 (en)	1991-04-07
WO1991005536A2 (en)	1991-05-02
WO1991005536A3 (en)	1991-08-08
FI921430A7 (en)	1992-04-01
EP0495014A1 (en)	1992-07-22
WO1991004744A1 (en)	1991-04-18
JPH05500963A (en)	1993-02-25
JPH05501258A (en)	1993-03-11
BR9007725A (en)	1992-08-18
FI921431A0 (en)	1992-04-01
EP0495014A4 (en)	1993-07-28
BR9007721A (en)	1992-08-18
FI921430A0 (en)	1992-04-01
AU7040091A (en)	1991-04-28
FI921431L (en)	1992-04-01
FI921430L (en)	1992-04-01
EP0494992A1 (en)	1992-07-22

Legal Events

Date	Code	Title	Description
1992-06-05	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1992-07-22	17P	Request for examination filed	Effective date: 19920430
1992-07-22	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1993-03-31	A4	Supplementary search report drawn up and despatched	Effective date: 19930208
1993-03-31	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1995-02-08	17Q	First examination report despatched	Effective date: 19941223
1995-09-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1995-11-15	18D	Application deemed to be withdrawn	Effective date: 19950501

Publication	Publication Date	Title
PL279972A1 (en)	1989-12-27	Apparatus for diagnosing and treating rhinopathies
GB2241786B (en)	1993-06-16	Electroencephalic neurofeedback apparatus and method
GB8910566D0 (en)	1989-06-21	Imaging apparatus and method
EP0429191A3 (en)	1992-06-10	Imaging apparatus and methods
KR960016175B1 (en)	1996-12-04	Exposing method and apparatus thereof
EP0454873A4 (en)	1992-05-06	Drying method and apparatus therefor
ZW9090A1 (en)	1992-03-11	Emulsification method and apparatus
GB9027707D0 (en)	1991-02-13	Method and apparatus for blood sampling
ZW14888A1 (en)	1989-07-19	Emulsification method and apparatus
EP0412657A3 (en)	1991-05-29	Imaging apparatus and methods
EP0436352A3 (en)	1991-09-25	Solid imaging method and apparatus
GB9026382D0 (en)	1991-01-23	Process and apparatus for incineration
EP0418832A3 (en)	1991-10-16	Control method and apparatus
GB2233710B (en)	1992-05-06	Method and apparatus for detecting stalls
EP0422525A3 (en)	1991-11-13	Exposing method and apparatus
GB8912240D0 (en)	1989-07-12	Apparatus and method
GB2238740B (en)	1994-02-16	Sand treatment method and apparatus
GB2233882B (en)	1993-02-10	Cleaning apparatus and method
EP0414622A3 (en)	1992-07-29	Copying method and apparatus
EP0428391A3 (en)	1992-08-05	Method and apparatus for beautificating drawings
EP0411768A3 (en)	1991-08-28	Radiographic apparatus and methods
GB9025071D0 (en)	1991-01-02	Method and apparatus
IL93665A0 (en)	1990-12-23	Method and apparatus for slit radiography
IL93871A0 (en)	1990-12-23	Skimming apparatus and method
GB2230698B (en)	1992-01-22	Explosive-screening apparatus and method