EP0503050A4 - Hybrid growth factors - Google Patents

Hybrid growth factors

Info

Publication number: EP0503050A4
Authority: EP; European Patent Office
Prior art keywords: growth factors; hybrid growth; hybrid; factors; growth
Prior art date: 1990-09-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19910918221

Other versions

EP0503050A1 (en

Inventor

Jonathan I Rosen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ortho Pharmaceutical Corp

Original Assignee

Ortho Pharmaceutical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-28

Filing date

1991-09-26

Publication date

1994-07-06

1991-09-26 Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp

1992-09-16 Publication of EP0503050A1 publication Critical patent/EP0503050A1/en

1994-07-06 Publication of EP0503050A4 publication Critical patent/EP0503050A4/en

Status Withdrawn legal-status Critical Current

Links

239000003102 growth factor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

EP19910918221 1990-09-28 1991-09-26 Hybrid growth factors Withdrawn EP0503050A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58995890A	1990-09-28	1990-09-28
US589958		1990-09-28

Publications (2)

Publication Number	Publication Date
EP0503050A1 EP0503050A1 (en)	1992-09-16
EP0503050A4 true EP0503050A4 (en)	1994-07-06

Family

ID=24360286

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19910918221 Withdrawn EP0503050A4 (en)	1990-09-28	1991-09-26	Hybrid growth factors

Country Status (8)

Country	Link
EP (1)	EP0503050A4 (en)
JP (1)	JPH05502463A (en)
AU (2)	AU8735991A (en)
CA (1)	CA2069746A1 (en)
IE (1)	IE913426A1 (en)
PT (1)	PT99107A (en)
WO (1)	WO1992006116A1 (en)
ZA (1)	ZA917766B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5718893A (en) *	1984-04-15	1998-02-17	Foster; Preston F.	Use of G-CSF to reduce acute rejection
DK0546124T4 (en) *	1990-08-29	2003-05-19	Inst Genetics Llc	Multiple-domain hematopoiesis stimulators
EP0672145B1 (en) *	1992-11-24	2003-04-23	G.D. Searle & Co.	Interleukin-3 (il-3) multiple mutation polypeptides
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6153183A (en)	1992-11-24	2000-11-28	G. D. Searle & Company	Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US5501962A (en) *	1993-06-21	1996-03-26	G. D. Searle & Co.	Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US5536495A (en) *	1994-04-15	1996-07-16	Foster; Preston F.	Use of G-CSF to reduce acute rejection
WO1995028427A1 (en) *	1994-04-15	1995-10-26	Imclone Systems Incorporated	Chimeric interleukin-3/mutein interleukin-6 lymphokine
ITFI940106A1 (en) *	1994-05-27	1995-11-27	Menarini Ricerche Sud Spa	HYBRID MOLECULE OF GM-CSF-L-EPO OR EPO-L-GM-CSF FORMULA FOR ERYTHROPOIETIC STIMULATION
IT1271688B (en) *	1994-08-04	1997-06-04	Menarini Ricerche Sud Spa	HYBRID MOLECULES FOR ANTI-CANCER TREATMENT THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS
AU705064B2 (en) *	1995-04-26	1999-05-13	Kyowa Hakko Kogyo Co. Ltd.	Novel polypeptides
US6066318A (en) *	1995-10-05	2000-05-23	G.D. Searle & Co.	Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
WO1998012558A1 (en) *	1996-09-20	1998-03-26	Ortho Mcneil Pharmaceutical, Inc.	Methods for in vitro determination of erythropoietin bioactivity
NZ335382A (en) *	1996-10-25	2001-03-30	Searle & Co	Multi-functional chimeric hematopoietic polypeptides of IL-3, GCSF, Flt3L, EPO, stem cell factor, cmpl link with or without linker group consisting of Alanine, Glycine and/or Serine for treating autoimmune and tumour related diseases
BR9712675A (en) *	1996-10-25	1999-10-19	Searle & Co	Circularly exchanged erythropoietin receptor agonists.
US6967092B1 (en)	1996-10-25	2005-11-22	Mc Kearn John P	Multi-functional chimeric hematopoietic receptor agonists
US6187564B1 (en) *	1997-07-10	2001-02-13	Beth Israel Deaconess Medical Center	DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
US6165476A (en) *	1997-07-10	2000-12-26	Beth Israel Deaconess Medical Center	Fusion proteins with an immunoglobulin hinge region linker
ES2208798T3 (en) *	1997-09-01	2004-06-16	Aventis Pharma Deutschland Gmbh	RECOMBINANT HUMAN ERYTHROPOYETIN WITH AN ADVANTAGE GLICOSILATION PROFILE.
WO1999041382A2 (en) *	1998-02-17	1999-08-19	Hyseq, Inc.	A novel interleukin-3 and uses thereof
BR9917606A (en) *	1998-11-06	2002-12-31	Bio Sidus S A	Procedure for the purification of recombinant human erythropoietin from cell culture supernatants and recombinant human erythropoietin obtained with such procedure
PL219131B1 (en)	2000-05-15	2015-03-31	Hoffmann La Roche	Novel pharmaceutical composition
US7220407B2 (en)	2003-10-27	2007-05-22	Amgen Inc.	G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
US20060153799A1 (en)	2004-11-05	2006-07-13	Northwestern University	Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders
WO2011109556A2 (en)	2010-03-04	2011-09-09	Pfenex Inc.	Method for producing soluble recombinant interferon protein without denaturing
NZ603033A (en)	2010-04-01	2014-06-27	Pfenex Inc	Methods for g-csf production in a pseudomonas host cell
EP2881414B1 (en)	2012-07-31	2018-07-11	Asahi Kasei Kabushiki Kaisha	Epoxy resin composition and cured article
LT6161B (en)	2013-09-27	2015-06-25	Uab Profarma	Fused proteins of granulocyte colony-stimulating factor with other partners of growh factor, preferably with stem cell factor, and method of preparation thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990001039A1 (en) *	1988-07-20	1990-02-08	Immunex Corporation	Nonglycosylated human interleukin-3 compositions
WO1990012874A2 (en) *	1989-04-21	1990-11-01	Genetics Institute, Inc.	Cysteine added variants of polypeptides and chemical modifications thereof
WO1991002754A1 (en) *	1989-08-22	1991-03-07	Immunex Corporation	Fusion proteins comprising gm-csf and il-3
WO1991007988A1 (en) *	1989-12-01	1991-06-13	Amgen Inc.	Megakaryocyte production
WO1992004455A1 (en) *	1990-08-29	1992-03-19	Genetics Institute, Inc.	Multidomain hematopoiesis stimulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1983003971A1 (en) *	1982-05-12	1983-11-24	President And Fellows Of Harvard College	Hybrid proteins
US4935352A (en) *	1985-10-21	1990-06-19	Takeda Chemical Industries, Ltd.	Expression vector for animal cell line and use thereof
US4935233A (en) *	1985-12-02	1990-06-19	G. D. Searle And Company	Covalently linked polypeptide cell modulators
DE3751664T2 (en) *	1986-08-01	1996-06-05	Commw Scient Ind Res Org	RECOMBINANT VACCINE
JPH04501808A (en) *	1989-07-06	1992-04-02	セラジェン・インコーポレーテッド	hybrid molecule
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3

1991
- 1991-09-26 CA CA002069746A patent/CA2069746A1/en not_active Abandoned
- 1991-09-26 WO PCT/US1991/007053 patent/WO1992006116A1/en not_active Ceased
- 1991-09-26 AU AU87359/91A patent/AU8735991A/en not_active Abandoned
- 1991-09-26 EP EP19910918221 patent/EP0503050A4/en not_active Withdrawn
- 1991-09-26 JP JP3517013A patent/JPH05502463A/en active Pending
- 1991-09-27 IE IE342691A patent/IE913426A1/en not_active Application Discontinuation
- 1991-09-27 ZA ZA917766A patent/ZA917766B/en unknown
- 1991-09-27 PT PT99107A patent/PT99107A/en not_active Application Discontinuation
1995
- 1995-02-06 AU AU11576/95A patent/AU1157695A/en not_active Abandoned

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990001039A1 (en) *	1988-07-20	1990-02-08	Immunex Corporation	Nonglycosylated human interleukin-3 compositions
WO1990012874A2 (en) *	1989-04-21	1990-11-01	Genetics Institute, Inc.	Cysteine added variants of polypeptides and chemical modifications thereof
WO1991002754A1 (en) *	1989-08-22	1991-03-07	Immunex Corporation	Fusion proteins comprising gm-csf and il-3
WO1991007988A1 (en) *	1989-12-01	1991-06-13	Amgen Inc.	Megakaryocyte production
WO1992004455A1 (en) *	1990-08-29	1992-03-19	Genetics Institute, Inc.	Multidomain hematopoiesis stimulators

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
S. TANIKAWA ET AL: "Effects of recombinant granulocyte colony-stimulatinfg-factor (rG-CSF) and recombinant granulocyte-macrophage colony-stimulating-factor (rGM-CSF) on acute radiation hematopoietic injury in mice", EXPERIMENTAL HEMATOLOGY, vol. 17, 1989, pages 883 - 888 *
See also references of WO9206116A1 *

Also Published As

Publication number	Publication date
CA2069746A1 (en)	1992-03-29
AU1157695A (en)	1995-04-13
WO1992006116A1 (en)	1992-04-16
PT99107A (en)	1992-08-31
AU8735991A (en)	1992-04-28
IE913426A1 (en)	1992-04-08
ZA917766B (en)	1993-03-29
JPH05502463A (en)	1993-04-28
EP0503050A1 (en)	1992-09-16

Legal Events

Date	Code	Title	Description
1992-07-31	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1992-09-16	17P	Request for examination filed	Effective date: 19920430
1992-09-16	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1994-05-25	RHK1	Main classification (correction)	Ipc: C12N 15/62
1994-07-06	A4	Supplementary search report drawn up and despatched
1994-07-06	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1996-01-10	17Q	First examination report despatched	Effective date: 19951123
1996-09-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1996-10-30	18D	Application deemed to be withdrawn	Effective date: 19960405

Publication	Publication Date	Title
EP0503050A4 (en)	1994-07-06	Hybrid growth factors
IL103684A0 (en)	1993-04-04	Novel hybrid transforming growth factors
IL96048A0 (en)	1991-07-18	Crystalline polyimidesiloxanes
EP0364481A4 (en)	1992-01-22	Growth factors
EP0466854A4 (en)	1993-03-31	T cell growth factor
GB9004679D0 (en)	1990-04-25	Semiconductor growth
GB9119571D0 (en)	1991-10-23	Day surgery trolley
GB9225928D0 (en)	1993-02-03	Growth factor
GB9009540D0 (en)	1990-06-20	Floral arrangement
GB9016571D0 (en)	1990-09-12	Trolley aid
GB9006147D0 (en)	1990-05-16	Polypropylene
AU325P (en)	1994-04-27	Ausblush Rosa hybrid
AU170P (en)	1992-06-18	MEIXTRAFLO Rosa hybrid
AU77P (en)	1990-10-04	SCHOBITET Rosa hybrid
AU76P (en)	1990-10-04	MEIGOVIN Rosa hybrid
AU75P (en)	1990-10-04	MEIBARKE Rosa hybrid
AU326P (en)	1994-04-27	Auscot Rosa hybrid
AU79P (en)	1990-10-04	MEIRUTRAL Rosa hybrid
AU239P (en)	1993-01-20	NOATRAUM Rosa hybrid
AU78P (en)	1990-10-04	MEIPONAL Rosa hybrid
AU197P (en)	1992-10-12	COCDESTIN Rosa hybrid
AU171P (en)	1992-06-18	KEITAIBU Rosa hybrid
AU80P (en)	1990-10-04	MEITIFRAN Rosa hybrid
AU169P (en)	1992-06-18	MEIFRONY Rosa hybrid
AU168P (en)	1992-06-18	KEINOUMI Rosa hybrid