EP0552373A4 - Apoptosis regulator - Google Patents

Apoptosis regulator

Info

Publication number: EP0552373A4
Authority: EP; European Patent Office
Prior art keywords: apoptosis regulator; apoptosis; regulator
Prior art date: 1991-07-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP19920914177

Other versions

EP0552373A1 (en

EP0552373B1 (en

Inventor

Satoru Nakai

Koutoku Aihara

Hitomi Mori

Michiaki Tominaga

Masakazu Adachi

Hiroyuki Ichikawa

Seiji Akamatsu

Fumio Saito

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Otsuka Pharmaceutical Co Ltd

Original Assignee

Otsuka Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-03

Filing date

1992-07-02

Publication date

1993-09-22

1992-07-02 Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd

1993-07-28 Publication of EP0552373A1 publication Critical patent/EP0552373A1/en

1993-09-22 Publication of EP0552373A4 publication Critical patent/EP0552373A4/en

1999-10-13 Application granted granted Critical

1999-10-13 Publication of EP0552373B1 publication Critical patent/EP0552373B1/en

2012-07-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000006907 apoptotic process Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP92914177A 1991-07-03 1992-07-02 Apoptosis regulator Expired - Lifetime EP0552373B1 (en)

Applications Claiming Priority (13)

Application Number	Priority Date	Filing Date	Title
JP16258791		1991-07-03
JP16258791		1991-07-03
JP162587/91		1991-07-03
JP3346992		1992-02-20
JP3346992		1992-02-20
JP33469/92		1992-02-20
JP45718/92		1992-03-03
JP4571892		1992-03-03
JP4571892		1992-03-03
JP10058592		1992-03-25
JP10058592		1992-03-25
JP100585/92		1992-03-25
PCT/JP1992/000841 WO1993000902A1 (en)	1991-07-03	1992-07-02	Apoptosis regulator

Publications (3)

Publication Number	Publication Date
EP0552373A1 EP0552373A1 (en)	1993-07-28
EP0552373A4 true EP0552373A4 (en)	1993-09-22
EP0552373B1 EP0552373B1 (en)	1999-10-13

Family

ID=27459795

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92914177A Expired - Lifetime EP0552373B1 (en)	1991-07-03	1992-07-02	Apoptosis regulator

Country Status (11)

Country	Link
US (5)	US5672603A (en)
EP (1)	EP0552373B1 (en)
KR (1)	KR100196368B1 (en)
AU (1)	AU648690B2 (en)
CA (1)	CA2090876A1 (en)
DE (1)	DE69230131T2 (en)
DK (1)	DK0552373T3 (en)
ES (1)	ES2138971T3 (en)
MX (1)	MX9203950A (en)
TW (1)	TW229157B (en)
WO (1)	WO1993000902A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU666577B2 (en) *	1992-08-19	1996-02-15	Otsuka Pharmaceutical Co., Ltd.	Apoptosis regulator
WO1994020107A1 (en) *	1993-03-02	1994-09-15	Otsuka Pharmaceutical Co., Ltd.	Rejection inhibitor for transplants and il-1 production inhibitor
GB9311132D0 (en)	1993-05-28	1993-07-14	Eisai London Res Lab Ltd	Control of cell death
DK0674515T3 (en) *	1993-10-21	1999-12-20	Otsuka Pharma Co Ltd	Use of Carbostyril Derivatives for the Preparation of a Drug for Inhibition of Interleukin-8
US5504093A (en) *	1994-08-01	1996-04-02	Otsuka Pharmaceutical Co., Ltd.	Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
WO1996021449A1 (en) *	1995-01-11	1996-07-18	Otsuka Pharmaceutical Co., Ltd.	Pharmaceutical composition of indene derivatives for regulating apoptosis
WO1998046229A1 (en) *	1995-06-21	1998-10-22	Otsuka Pharmaceutical Co., Ltd.	Il-8 and mcaf production inhibitors
JPH0971532A (en) *	1995-09-06	1997-03-18	Otsuka Pharmaceut Co Ltd	Carcinogenesis suppressing agent
US5700803A (en) *	1995-12-12	1997-12-23	Otsuka Pharmaceutical Co., Ltd.	Method for reducing infarct size in subjects afflicted with ischemic heart disease
AU6854398A (en) *	1997-04-25	1998-11-24	Otsuka Pharmaceutical Co., Ltd.	Hyaluronate synthesis inhibitors
US6008209A (en) *	1997-04-28	1999-12-28	Hoffmann-La Roche Inc.	Method of using vitamin D3 analogs with bis C-20 side chains
US6544972B1 (en)	1997-09-25	2003-04-08	Regents Of The University Of Minnesota	Methods of limiting apoptosis of cells
US6281191B1 (en)	1997-12-29	2001-08-28	Vladimir I. Slesarev	Compositions and methods for treating hepatitis-C
FR2774289B1 (en) *	1998-02-03	2002-05-24	Goemar Lab Sa	MEDICINE FOR THE TREATMENT OF APOPTOSIS DISORDERS
ATE276763T1 (en)	1998-07-13	2004-10-15	Univ Texas	USE OF ANTIBODIES TO AMINOPHOSPHOLIPIDES FOR CANCER TREATMENT
SI1107795T1 (en)	1998-09-04	2003-06-30	The Regents Of The University Of Michigan	Thiomolybdate associated with at least one carbohydrate, and its use for preventing or treating diseases characterized by aberrant vascularization, such as cancer, wet type macular degeneration, rheumatoid arthritis
US6277974B1 (en)	1999-12-14	2001-08-21	Cogent Neuroscience, Inc.	Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death
US20030044413A1 (en) *	2000-08-15	2003-03-06	Regents Of The University Of Minnesota	Methods of limiting apoptosis of cells
AU2002360665A1 (en) *	2001-12-20	2003-07-09	Cogent Neuroscience, Inc.	Methods for treating conditions, disorders, or diseases involving cell death
EP2357009A1 (en)	2002-07-15	2011-08-17	Board of Regents, The University of Texas System	Duramycin peptide binding to anionic phospholipids and aminophospholipids conjugates and their use in treating viral infections
AU2003275495A1 (en) *	2002-11-07	2004-06-03	Walter C. Low	Methods of treating injuries of the nervous system associated with hemorrhage
US8431396B2 (en)	2003-03-21	2013-04-30	The Cleveland Clinic Foundation	Anti-angiogenic peptides
US20060204481A1 (en) *	2003-04-02	2006-09-14	Steer Clifford J	Methods of promoting cell viability
ES2809302T3 (en)	2004-01-22	2021-03-03	Univ Miami	Coenzyme Q10 formulations to treat solid tumors by intravenous administration
WO2006086452A1 (en) *	2005-02-10	2006-08-17	Regents Of The University Of Minnesota	Methods for treating visual disorders
ES2572356T3 (en)	2007-11-09	2016-05-31	Peregrine Pharmaceuticals Inc	Compositions of antibodies directed against VEGF and procedures

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5430184A (en) *	1977-08-10	1979-03-06	Otsuka Pharmaceut Co Ltd	3,4-dihydrocarbostyril derivative
JPS6038384B2 (en) *	1978-03-24	1985-08-31	大塚製薬株式会社	Thiosemicarbazone derivatives
JPS5777676A (en) *	1980-10-31	1982-05-15	Otsuka Pharmaceut Co Ltd	Carbostyril derivative
JPS5793962A (en) *	1980-12-01	1982-06-11	Otsuka Pharmaceut Co Ltd	Carbostyryl derivative
JPS62135423A (en) *	1985-12-09	1987-06-18	Otsuka Pharmaceut Co Ltd	Improver for hypoxia

1992
- 1992-07-02 CA CA002090876A patent/CA2090876A1/en not_active Abandoned
- 1992-07-02 AU AU22317/92A patent/AU648690B2/en not_active Ceased
- 1992-07-02 DE DE69230131T patent/DE69230131T2/en not_active Expired - Fee Related
- 1992-07-02 DK DK92914177T patent/DK0552373T3/en active
- 1992-07-02 WO PCT/JP1992/000841 patent/WO1993000902A1/en not_active Ceased
- 1992-07-02 ES ES92914177T patent/ES2138971T3/en not_active Expired - Lifetime
- 1992-07-02 KR KR1019930700644A patent/KR100196368B1/en not_active Expired - Fee Related
- 1992-07-02 EP EP92914177A patent/EP0552373B1/en not_active Expired - Lifetime
- 1992-07-03 MX MX9203950A patent/MX9203950A/en unknown
- 1992-07-15 TW TW081105603A patent/TW229157B/zh active
1995
- 1995-06-06 US US08/466,449 patent/US5672603A/en not_active Expired - Fee Related
1997
- 1997-05-09 US US08/854,074 patent/US5872120A/en not_active Expired - Fee Related
- 1997-05-09 US US08/853,746 patent/US5798358A/en not_active Expired - Fee Related
- 1997-05-09 US US08/854,073 patent/US5916890A/en not_active Expired - Fee Related
- 1997-05-09 US US08/853,745 patent/US5925640A/en not_active Expired - Fee Related

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIOMED. PHARMACOTHER. vol. 46, no. 5-7, 1992, page 308 S.NAKAI ET AL. 'DIFFERENTIATION-INDUCING ACTIVITY ...' *
ENDOCRINOLOGY vol. 128, no. 6, June 1991, pages 2709 - 2714 W.LUEPRASITSAKUL ET AL. 'EFFECTS OF THE CARDIAC INOTROPIC DRUG, OPC 8212,...' *
EXP.HEMATOL. vol. 19, no. 6, July 1991, page 490 F.W.BUSH ET AL. 'EFFECTS OF OPC-8212, ...' *
HEART VESSELS vol. 2, no. 1, 1986, pages 23 - 28 S.SASAYAMA ET AL. 'ACUTE HEMODYNAMIC EFFECTS...' *
R.BERKOW, ED. 'THE MERCK MANUAL OF DIAGNOSIS AND THERAPY, 15TH EDITION' 1987 , MERCK SHARP & DOHME RESEARCH LABORATORIES , RAHWAY, N.J., USA *
See also references of WO9300902A1 *

Also Published As

Publication number	Publication date
EP0552373A1 (en)	1993-07-28
DE69230131D1 (en)	1999-11-18
US5672603A (en)	1997-09-30
EP0552373B1 (en)	1999-10-13
ES2138971T3 (en)	2000-02-01
KR930702002A (en)	1993-09-08
TW229157B (en)	1994-09-01
US5925640A (en)	1999-07-20
AU648690B2 (en)	1994-04-28
DE69230131T2 (en)	2000-03-02
US5916890A (en)	1999-06-29
US5798358A (en)	1998-08-25
CA2090876A1 (en)	1993-01-04
US5872120A (en)	1999-02-16
MX9203950A (en)	1993-05-01
WO1993000902A1 (en)	1993-01-21
KR100196368B1 (en)	1999-06-15
HK1004469A1 (en)	1998-11-27
AU2231792A (en)	1993-02-11
DK0552373T3 (en)	1999-12-27

Legal Events

Date	Code	Title	Description
1993-06-10	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1993-07-28	17P	Request for examination filed	Effective date: 19930303
1993-07-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): BE CH DE DK ES FR GB GR IT LI NL SE
1993-08-11	RBV	Designated contracting states (corrected)	Designated state(s): BE CH DE DK ES FR GB IT LI NL SE
1993-09-22	A4	Supplementary search report drawn up and despatched	Effective date: 19930802
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1995-11-08	17Q	First examination report despatched	Effective date: 19950920
1998-11-12	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
1999-02-10	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
1999-02-10	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
1999-05-19	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
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1999-10-29	ITF	It: translation for a ep patent filed
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2000-03-22	RIN2	Information on inventor provided after grant (corrected)	Free format text: NAKAI, SATORU * AIHARA, KOUTOKU * MORI, HITOMI * TOMINAGA, MICHIAKI * ADACHI, MASAKAZU * ICHIKAWA, HIROYUKI * AKAMATSU, SEIJI * SAITO, FUMIO
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Publication	Publication Date	Title
EP0552373A4 (en)	1993-09-22	Apoptosis regulator
HU9600083D0 (en)	1996-03-28	Regulated apoptosis
HU9303393D0 (en)	1994-03-28	Substituted 3-amino-quinuclidines
ZA927153B (en)	1994-03-18	Substituted 3-phenylluracils
GB9126311D0 (en)	1992-02-12	Substituted diphenylsulfides
GB9113899D0 (en)	1991-08-14	Regulating system
DE69221613D1 (en)	1997-09-18	Former
GB9105123D0 (en)	1991-04-24	Relaning unit
ZA924101B (en)	1993-02-24	Substituted imidazolinylpyrimidines
ZA923936B (en)	1993-02-24	Substituted 2-arylpyrroles
HU9201738D0 (en)	1992-08-28	Substituted 4-hetaryl-pyrazoline
CA69416S (en)	1991-10-22	Orgnizer
AU205P (en)	1992-11-17	TARANNA Danthonia richardsonii
AU206P (en)	1992-11-17	BUNDERRA Danthonia linkii
AU213P (en)	1993-01-05	MOONBEAM Galtonia candicans
CA68506S (en)	1991-05-10	Pom-pom
CA68731S (en)	1991-06-18	Moneybox
CA68724S (en)	1991-06-18	Mobilier-jeu pedagogique
AU204P (en)	1992-11-13	NIRIBI Chamelaucium uncinatum
RU1832411C (en)	1993-08-07	Radioelectronic unit
RU1832410C (en)	1993-08-07	Radioelectronic unit
ZA928677B (en)	1993-05-11	Substituted biphenlypryridones
ZA92974B (en)	1992-10-28	Substituted arylsulphonylaminoguanidinotriazines
DE4290190D2 (en)	1993-02-18	Cyclische strukturelemente enthaltende orientierungsschichten
HU9500311V0 (en)	1996-01-29	Case