EP0558634A4 - Triplex-forming oligomers containing modified bases - Google Patents

Triplex-forming oligomers containing modified bases

Info

Publication number
EP0558634A4
EP0558634A4 EP92901107A EP92901107A EP0558634A4 EP 0558634 A4 EP0558634 A4 EP 0558634A4 EP 92901107 A EP92901107 A EP 92901107A EP 92901107 A EP92901107 A EP 92901107A EP 0558634 A4 EP0558634 A4 EP 0558634A4
Authority
EP
European Patent Office
Prior art keywords
triplex
modified bases
containing modified
oligomers containing
forming oligomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92901107A
Other versions
EP0558634A1 (en
Inventor
Brian Froehler
Steven Krawczyk
Mark D Matteucci
John Milligan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of EP0558634A1 publication Critical patent/EP0558634A1/en
Publication of EP0558634A4 publication Critical patent/EP0558634A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP92901107A 1990-11-23 1991-11-25 Triplex-forming oligomers containing modified bases Withdrawn EP0558634A4 (en)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US766733 1985-08-16
US61790790A 1990-11-23 1990-11-23
US617907 1990-11-23
US64338291A 1991-01-18 1991-01-18
US68342091A 1991-04-08 1991-04-08
US683420 1991-04-08
US68654691A 1991-04-17 1991-04-17
US68654791A 1991-04-17 1991-04-17
US68654491A 1991-04-17 1991-04-17
US686547 1991-04-17
US686544 1991-04-17
US686546 1991-04-17
US76673391A 1991-09-27 1991-09-27
US643382 2003-08-19

Publications (2)

Publication Number Publication Date
EP0558634A1 EP0558634A1 (en) 1993-09-08
EP0558634A4 true EP0558634A4 (en) 1995-06-28

Family

ID=27569857

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92901107A Withdrawn EP0558634A4 (en) 1990-11-23 1991-11-25 Triplex-forming oligomers containing modified bases

Country Status (3)

Country Link
EP (1) EP0558634A4 (en)
AU (1) AU9094991A (en)
WO (1) WO1992009705A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
EP0637965B1 (en) * 1991-11-26 2002-10-16 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
WO1993012135A1 (en) 1991-12-12 1993-06-24 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US7038026B2 (en) 2000-05-26 2006-05-02 Centelion Purification of a triple heli formation with an immobilized oligonucleotide
FR2728264B1 (en) * 1994-12-16 1997-01-31 Rhone Poulenc Rorer Sa DNA PURIFICATION BY TRIPLE PROPELLER FORMATION WITH A IMMOBILIZED OLIGONUCLEOTIDE
CA2223088A1 (en) 1995-06-07 1996-12-19 Bob Dale Brown Novel carbamate-based cationic lipids
US6426407B1 (en) * 1995-06-07 2002-07-30 Codon Pharm. Residues for binding third strands to complementary nucleic acid duplexes of any base pair sequence
AU2696897A (en) * 1996-04-26 1997-11-19 Novartis Ag Modified oligonucleotides
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US6034135A (en) * 1997-03-06 2000-03-07 Promega Biosciences, Inc. Dimeric cationic lipids
US5877220A (en) * 1997-03-06 1999-03-02 Genta, Incorporated Amide-based oligomeric cationic lipids
KR20030033007A (en) 2001-05-31 2003-04-26 코울터 파머수티컬, 인코포레이티드 Cytotoxins, prodrugs, linkers and stabilizers useful therefor
BRPI0510909A2 (en) 2004-05-19 2008-12-16 Medarex Inc cytotoxic drug-binder binding compound, pharmaceutical formulation, method for killing a cell and method for retarding or stopping tumor growth
EA016577B1 (en) 2005-09-26 2012-06-29 Медарекс, Инк. Antibody-drug conjugates and use thereof
WO2016106050A1 (en) 2014-12-26 2016-06-30 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
RU2020116571A (en) 2017-12-07 2021-11-22 Эмори Юниверсити N4-HYDROXYCYTIDINE AND DERIVATIVES AND RELATED ANTIVIRAL USES
CN112778388B (en) * 2021-01-21 2022-08-23 大连医科大学 Nucleoside analogue and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018997A1 (en) * 1990-05-25 1991-12-12 Gilead Sciences, Inc. Sequence-specific nonphotoactivated crosslinking agents which bind to the major groove of duplex dna
WO1993005180A1 (en) * 1991-08-30 1993-03-18 The Johns Hopkins University Formation of triple helix complexes of double stranded dna using nucleoside oligomers which comprise purine base analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2006008C (en) * 1988-12-20 2000-02-15 Donald J. Kessler Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018997A1 (en) * 1990-05-25 1991-12-12 Gilead Sciences, Inc. Sequence-specific nonphotoactivated crosslinking agents which bind to the major groove of duplex dna
WO1993005180A1 (en) * 1991-08-30 1993-03-18 The Johns Hopkins University Formation of triple helix complexes of double stranded dna using nucleoside oligomers which comprise purine base analogs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GUY ET AL.: "Synthesis and characterisation of DNA fragments bearing an adenine radiation product: 7,8-dihydroadenin-8-one", HELVETICA CHIMICA ACTA, vol. 71, BASEL CH, pages 1566 - 1572 *
KOMATSU ET AL.: "Recognition by EcoRI of octadeoxiribonucleotides containing midified sugar and base moieties", NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 22, 8 November 1990 (1990-11-08), OXFORD UK, pages 95 - 96 *
See also references of WO9209705A1 *

Also Published As

Publication number Publication date
EP0558634A1 (en) 1993-09-08
WO1992009705A1 (en) 1992-06-11
AU9094991A (en) 1992-06-25

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Legal Events

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