EP0577775A4 - Anti-thrombotic peptides and pseudopeptides. - Google Patents

Anti-thrombotic peptides and pseudopeptides.

Info

Publication number: EP0577775A4
Authority: EP; European Patent Office
Prior art keywords: pseudopeptides; thrombotic; peptides; thrombotic peptides
Prior art date: 1991-03-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP92912095A

Other languages

German (de)

French (fr)

Other versions

EP0577775A1 (en

Inventor

Scott I Klein

Bruce F Molino

Mark Czekaj

Charles Gardner

Michael R Becker

Jeffrey M Dener

Jeffrey C Pelletier

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Rhone Poulenc Rorer International Holdings Inc

Original Assignee

Rhone Poulenc Rorer International Holdings Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-28

Filing date

1992-03-30

Publication date

1995-01-11

1992-03-30 Application filed by Rhone Poulenc Rorer International Holdings Inc filed Critical Rhone Poulenc Rorer International Holdings Inc

1994-01-12 Publication of EP0577775A1 publication Critical patent/EP0577775A1/en

1995-01-11 Publication of EP0577775A4 publication Critical patent/EP0577775A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
Hematology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

EP92912095A 1991-03-28 1992-03-30 Anti-thrombotic peptides and pseudopeptides. Withdrawn EP0577775A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67700691A	1991-03-28	1991-03-28
US677006		1991-03-28

Publications (2)

Publication Number	Publication Date
EP0577775A1 EP0577775A1 (en)	1994-01-12
EP0577775A4 true EP0577775A4 (en)	1995-01-11

Family

ID=24716920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92912095A Withdrawn EP0577775A4 (en)	1991-03-28	1992-03-30	Anti-thrombotic peptides and pseudopeptides.

Country Status (6)

Country	Link
EP (1)	EP0577775A4 (en)
JP (1)	JPH06506699A (en)
AU (1)	AU673497B2 (en)
CA (1)	CA2107088A1 (en)
MX (1)	MX9201416A (en)
WO (1)	WO1992017196A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5780303A (en) *	1990-04-06	1998-07-14	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5672585A (en) *	1990-04-06	1997-09-30	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US6017877A (en) *	1990-04-06	2000-01-25	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US6521594B1 (en)	1990-04-06	2003-02-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5726192A (en) *	1992-12-29	1998-03-10	Smithkline Beecham Corporation	Platelet aggregation inhibiting compounds
US5753659A (en) *	1993-03-29	1998-05-19	Zeneca Limited	Heterocyclic compouds
US5652242A (en) *	1993-03-29	1997-07-29	Zeneca Limited	Heterocyclic derivatives
EP0690847A1 (en) *	1993-03-29	1996-01-10	Zeneca Limited	Heterocyclic compounds as platelet aggregation inhibitors
US5750754A (en) *	1993-03-29	1998-05-12	Zeneca Limited	Heterocyclic compounds
DK0691959T3 (en) *	1993-03-29	1999-04-26	Zeneca Ltd	Heterocyclic derivatives as platelet aggregation inhibitors
US5516889A (en) *	1993-06-21	1996-05-14	University Technologies International, Inc.	Synthetic thrombin receptor peptides
GB9313268D0 (en) *	1993-06-28	1993-08-11	Zeneca Ltd	Chemical compounds
US5463011A (en) *	1993-06-28	1995-10-31	Zeneca Limited	Acid derivatives
GB9313285D0 (en) *	1993-06-28	1993-08-11	Zeneca Ltd	Acid derivatives
US5780590A (en) *	1993-10-15	1998-07-14	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5639765A (en) *	1995-01-17	1997-06-17	G. D. Searle & Co.	Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss
US5602155A (en) *	1995-01-17	1997-02-11	G. D. Searle & Co.	Platelet aggregation inhibitors
US5681820A (en) *	1995-05-16	1997-10-28	G. D. Searle & Co.	Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis
WO2020092139A1 (en) *	2018-10-29	2020-05-07	Huahai Us Inc.	Novel dipeptide compounds and uses thereof
JP2024510435A (en)	2021-03-18	2024-03-07	シージェンインコーポレイテッド	Selective drug release from internalization complexes of bioactive compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0378432A2 (en) *	1989-01-13	1990-07-18	Richter Gedeon Vegyeszeti Gyar R.T.	Novel peptides, their use to inhibit the maturation of t-lymphocytes and the activity of macrophages, and processes for their preparation
US4952562A (en) *	1989-09-29	1990-08-28	Rorer Pharmaceutical Corporation	Anti-thrombotic peptides and pseudopeptides
WO1991004746A1 (en) *	1989-09-29	1991-04-18	Rhone-Poulenc Rorer International (Holdings) Inc.	Anti-thrombotic peptides and pseudopeptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0136879A3 (en) *	1983-09-30	1987-01-07	Yamanouchi Pharmaceutical Co., Ltd.	Fatty acid derivatives and processes of producing them
US5053393A (en) *	1988-07-20	1991-10-01	Monsanto Company	Novel platelet-aggregation inhibitor
US5037808A (en) *	1988-07-20	1991-08-06	Monsanto Co.	Indolyl platelet-aggregation inhibitors
US4879313A (en) *	1988-07-20	1989-11-07	Mosanto Company	Novel platelet-aggregation inhibitors
US4992463A (en) *	1988-07-20	1991-02-12	Monsanto Company	Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation

1992
- 1992-03-27 MX MX9201416A patent/MX9201416A/en unknown
- 1992-03-30 WO PCT/US1992/002637 patent/WO1992017196A1/en not_active Ceased
- 1992-03-30 JP JP4511653A patent/JPH06506699A/en active Pending
- 1992-03-30 AU AU20143/92A patent/AU673497B2/en not_active Expired - Fee Related
- 1992-03-30 CA CA002107088A patent/CA2107088A1/en not_active Abandoned
- 1992-03-30 EP EP92912095A patent/EP0577775A4/en not_active Withdrawn

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0378432A2 (en) *	1989-01-13	1990-07-18	Richter Gedeon Vegyeszeti Gyar R.T.	Novel peptides, their use to inhibit the maturation of t-lymphocytes and the activity of macrophages, and processes for their preparation
US4952562A (en) *	1989-09-29	1990-08-28	Rorer Pharmaceutical Corporation	Anti-thrombotic peptides and pseudopeptides
WO1991004746A1 (en) *	1989-09-29	1991-04-18	Rhone-Poulenc Rorer International (Holdings) Inc.	Anti-thrombotic peptides and pseudopeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
R E CACHAU ET AL.: "Recognition in cell adhesion. A comparative study of the conformations of RGD-containing peptides by Monte Carlo and NMR methods", J. MOL. RECOGNITION, vol. 2, no. 4, December 1989 (1989-12-01), WASHINGTON, DC, USA, pages 179 - 186 *
See also references of WO9217196A1 *

Also Published As

Publication number	Publication date
AU2014392A (en)	1992-11-02
MX9201416A (en)	1992-10-01
AU673497B2 (en)	1996-11-14
EP0577775A1 (en)	1994-01-12
JPH06506699A (en)	1994-07-28
CA2107088A1 (en)	1992-09-29
WO1992017196A1 (en)	1992-10-15

Legal Events

Date	Code	Title	Description
1993-11-26	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1994-01-12	17P	Request for examination filed	Effective date: 19931021
1994-01-12	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1994-12-28	RHK1	Main classification (correction)	Ipc: C07K 5/02
1995-01-11	A4	Supplementary search report drawn up and despatched	Effective date: 19941123
1995-01-11	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE
1995-12-27	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.
1997-06-04	17Q	First examination report despatched	Effective date: 19970418
1998-01-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1998-03-04	18D	Application deemed to be withdrawn	Effective date: 19970828

Publication	Publication Date	Title
AU645342B2 (en)	1994-01-13	Antimicrobial peptides and an antimicrobial agent
GB2269176B (en)	1997-01-08	Peptides
ZA928511B (en)	1994-05-04	Peptides
ZA971259B (en)	1997-12-04	Antimicrobial peptides and methods of use.
AU6883791A (en)	1991-05-16	Anti-thrombotic peptides and pseudopeptides
MX9201416A (en)	1992-10-01	ANTITHROMBOTIC PEPTIDES AND PSEUDOPEPTIDES.
PL309778A1 (en)	1995-11-13	Novel peptides
EP0578819A4 (en)	1994-10-12	Icam-related protein.
EP0494248A4 (en)	1992-08-26	Anti-thrombotic peptides and pseudopeptides
GB9315303D0 (en)	1993-09-08	Polypeptide
ZA977511B (en)	1998-03-03	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides.
EP0646172A4 (en)	1997-07-02	RECOMBINANT ENTOMOPHILIC VIRUSES.
EP0584066A4 (en)	1994-10-12	Anti-thrombotic peptide and pseudopeptide derivatives.
EP0664115A3 (en)	1996-11-06	Shampoo composition.
GB9325519D0 (en)	1994-02-16	Peptides
IL108353A0 (en)	1994-04-12	Novel peptides
PL302321A1 (en)	1994-09-05	Antimicrobial proteins
AU8228591A (en)	1992-01-07	Antimicrobial peptides
EP0579611A4 (en)	1995-04-19	Peptides.
ZA934353B (en)	1994-01-13	Linear peptides.
GB9324691D0 (en)	1994-01-19	Peptide compounds
EP0651769A4 (en)	1996-05-08	Leukaemia inhibitory factor-binding protein.
EP0672681A4 (en)	1997-02-26	Novel antitumor peptide.
GB9324818D0 (en)	1994-01-19	Peptide
GB9312601D0 (en)	1993-08-04	Peptides