EP0628035A4 - Retroviral protease inhibitors. - Google Patents

Retroviral protease inhibitors.

Info

Publication number: EP0628035A4
Authority: EP; European Patent Office
Prior art keywords: protease inhibitors; retroviral protease; retroviral; inhibitors; protease
Prior art date: 1992-02-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93906262A

Other languages

German (de)

French (fr)

Other versions

EP0628035A1 (en

Inventor

Geoffrey Bainbridge Dreyer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-26

Filing date

1993-02-26

Publication date

1995-03-29

1993-02-26 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

1994-12-14 Publication of EP0628035A1 publication Critical patent/EP0628035A1/en

1995-03-29 Publication of EP0628035A4 publication Critical patent/EP0628035A4/en

Status Withdrawn legal-status Critical Current

Links

229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
230000001177 retroviral effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP93906262A 1992-02-26 1993-02-26 Retroviral protease inhibitors. Withdrawn EP0628035A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US842295		1986-03-26
US84229592A	1992-02-26	1992-02-26
US84229992A	1992-02-26	1992-02-26
US842299		1992-02-26
PCT/US1993/001785 WO1993017003A1 (en)	1992-02-26	1993-02-26	Retroviral protease inhibitors

Publications (2)

Publication Number	Publication Date
EP0628035A1 EP0628035A1 (en)	1994-12-14
EP0628035A4 true EP0628035A4 (en)	1995-03-29

Family

ID=27126334

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93906262A Withdrawn EP0628035A4 (en)	1992-02-26	1993-02-26	Retroviral protease inhibitors.

Country Status (4)

Country	Link
EP (1)	EP0628035A4 (en)
JP (1)	JPH07504417A (en)
AU (1)	AU3735793A (en)
WO (1)	WO1993017003A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA49803C2 (en) *	1994-06-03	2002-10-15	Дж.Д. Сьорль Енд Ко	METHOD FOR TREATMENT OF RETROVIRAL INFECTIONS
KR100447553B1 (en)	1997-02-26	2004-09-08	화이자 인코포레이티드	Heteroaryl-Hexanoic Acid Amide Derivative, Their Preparation and Their Use as Selective Inhibitor of MIP-1-Alpha Binding to its CCR1 Receptor
EP1252154A1 (en) *	2000-02-04	2002-10-30	Pfizer Products Inc.	Heterocyclic amide derivatives
EP1498417A1 (en) *	2000-02-04	2005-01-19	Pfizer Products Inc.	Heterocyclic amide derivatives
DE60124080T2 (en)	2000-03-23	2007-03-01	Elan Pharmaceuticals, Inc., San Francisco	COMPOUNDS AND METHOD FOR THE TREATMENT OF ALZHEIMER'S DISEASE
EP1666452A2 (en)	2000-06-30	2006-06-07	Elan Pharmaceuticals, Inc.	Compounds to treat Alzheimer's disease
PE20020276A1 (en)	2000-06-30	2002-04-06	Elan Pharm Inc	SUBSTITUTE AMINE COMPOUNDS AS ß-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER
EP1299352B1 (en)	2000-06-30	2005-12-28	Elan Pharmaceuticals, Inc.	Compounds to treat alzheimer's disease
US6846813B2 (en)	2000-06-30	2005-01-25	Pharmacia & Upjohn Company	Compounds to treat alzheimer's disease
EP1401452A1 (en)	2001-06-27	2004-03-31	Elan Pharmaceuticals, Inc.	Beta-hydroxyamine derivatives useful in the treatment of alzheimer's disease
JP2024525589A (en)	2021-07-09	2024-07-12	アリゴスセラピューティクスインコーポレイテッド	Antiviral Compounds
WO2023043816A1 (en)	2021-09-17	2023-03-23	Aligos Therapeutics, Inc.	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3997551A (en) *	1970-12-30	1976-12-14	Argus Chemical Corporation	3-Salicylamido-s-triazoles
US4038406A (en) *	1972-09-26	1977-07-26	Bayer Aktiengesellschaft	1,2,4-triazole antimycotic compositions and use thereof
US4505919A (en) *	1982-10-09	1985-03-19	Pfizer Inc.	Antifungal S-arylmethyl- and S-heterocyclylmethyl ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-yl) propan-2-ols

1993
- 1993-02-26 JP JP5515105A patent/JPH07504417A/en active Pending
- 1993-02-26 WO PCT/US1993/001785 patent/WO1993017003A1/en not_active Ceased
- 1993-02-26 EP EP93906262A patent/EP0628035A4/en not_active Withdrawn
- 1993-02-26 AU AU37357/93A patent/AU3735793A/en not_active Abandoned

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J.P. VACCA ET AL.: "L-687,908, a potent hxdroxyethylene-containing HIV protease inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 34, no. 3, March 1991 (1991-03-01), WASHINGTON US, pages 1225 - 1228 *
See also references of WO9317003A1 *

Also Published As

Publication number	Publication date
WO1993017003A1 (en)	1993-09-02
JPH07504417A (en)	1995-05-18
EP0628035A1 (en)	1994-12-14
AU3735793A (en)	1993-09-13

Legal Events

Date	Code	Title	Description
1994-10-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1994-12-14	17P	Request for examination filed	Effective date: 19940914
1994-12-14	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): BE CH DE FR GB IT LI NL
1995-03-29	A4	Supplementary search report drawn up and despatched	Effective date: 19950210
1995-03-29	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): BE CH DE FR GB IT NL
1997-01-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1997-03-12	18D	Application deemed to be withdrawn	Effective date: 19960903
2000-03-15	RBV	Designated contracting states (corrected)	Designated state(s): BE CH DE FR GB IT LI NL

Publication	Publication Date	Title
ZA915269B (en)	1992-08-26	Retroviral protease inhibitors
IL102534A0 (en)	1993-01-14	Retroviral protease inhibitors
KR100190517B1 (en)	1999-06-01	Hiv protease inhibitors
HU9302080D0 (en)	1993-10-28	Amine-diole protease inhibitors
GR3030719T3 (en)	1999-11-30	Sulfonamide inhibitors of hiv-aspartyl protease.
EP0683772A4 (en)	1995-09-27	Retroviral protease inhibiting compounds.
HU9601508D0 (en)	1996-07-29	Dp-iv-serine protease inhibitors
IL90218A0 (en)	1989-12-15	Retroviral protease inhibitors
EP0601322A3 (en)	1994-10-12	Adenosindeaminase inhibitor.
PH31249A (en)	1998-06-18	Inhibitors of hiv protease.
EP0428849A3 (en)	1991-07-31	Retroviral protease inhibitors
ZA939432B (en)	1994-08-09	Retroviral protease inhibitors
ZA899558B (en)	1990-08-29	Retroviral protease inhibitors
IL100161A0 (en)	1992-08-18	Retroviral protease inhibitors derived from 3-chloro-2-chloro-methyl-1-propene
EP0628035A4 (en)	1995-03-29	Retroviral protease inhibitors.
ZA949259B (en)	1995-11-29	Retroviral protease inhibiting compounds
ZA946325B (en)	1995-08-21	Retroviral protease inhibitors and combinations thereof.
EP0443560A3 (en)	1992-07-01	Hiv protease inhibitors
EP0566237A3 (en)	1994-10-26	Retroviral protease inhibitors.
EP0594586A4 (en)	1994-08-17	Hiv protease inhibitors
EP0575500A4 (en)	1994-06-01	Hiv protease inhibitors
ZA928396B (en)	1993-05-12	HIV protease inhibitors.
ZA925360B (en)	1993-06-14	Retroviral protease inhibitors.
IL105450A0 (en)	1993-08-18	Hydroxy-carbamate retroviral protease inhibitors
MXPA94001311A (en)	2003-11-13	Combinations of retroviral inhibitors.