EP0659085A4 - Method of inhibiting cell proliferation using apolipoprotein e. - Google Patents

Method of inhibiting cell proliferation using apolipoprotein e.

Info

Publication number: EP0659085A4
Authority: EP; European Patent Office
Prior art keywords: apolipoprotein; cell proliferation; inhibiting cell; inhibiting; proliferation
Prior art date: 1992-08-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93919995A

Other languages

German (de)

French (fr)

Other versions

EP0659085A1 (en

Inventor

Tikva Vogel

Amos Panet

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Savient Pharmaceuticals Inc

Original Assignee

Savient Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-12

Filing date

1993-08-12

Publication date

1996-06-12

1993-08-12 Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc

1995-06-28 Publication of EP0659085A1 publication Critical patent/EP0659085A1/en

1996-06-12 Publication of EP0659085A4 publication Critical patent/EP0659085A4/en

Status Withdrawn legal-status Critical Current

Links

102100029470 Apolipoprotein E Human genes 0.000 title 1
101710095339 Apolipoprotein E Proteins 0.000 title 1
230000004663 cell proliferation Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Marine Sciences & Fisheries (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP93919995A 1992-08-12 1993-08-12 Method of inhibiting cell proliferation using apolipoprotein e. Withdrawn EP0659085A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US92897992A	1992-08-12	1992-08-12
US928979		1992-08-12
PCT/US1993/007582 WO1994004178A1 (en)	1992-08-12	1993-08-12	Method of inhibiting cell proliferation using apolipoprotein e

Publications (2)

Publication Number	Publication Date
EP0659085A1 EP0659085A1 (en)	1995-06-28
EP0659085A4 true EP0659085A4 (en)	1996-06-12

Family

ID=25457115

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93919995A Withdrawn EP0659085A4 (en)	1992-08-12	1993-08-12	Method of inhibiting cell proliferation using apolipoprotein e.

Country Status (9)

Country	Link
EP (1)	EP0659085A4 (en)
JP (1)	JPH08502730A (en)
KR (1)	KR950702430A (en)
AU (1)	AU673543B2 (en)
CA (1)	CA2141598A1 (en)
IL (1)	IL106664A0 (en)
NZ (1)	NZ255732A (en)
WO (1)	WO1994004178A1 (en)
ZA (1)	ZA935879B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6515009B1 (en)	1991-09-27	2003-02-04	Neorx Corporation	Therapeutic inhibitor of vascular smooth muscle cells
ZA946090B (en) *	1993-08-12	1995-11-22	Bio Technology General Corp	Method of inhibiting kaposi's sarcoma
US7611533B2 (en)	1995-06-07	2009-11-03	Cook Incorporated	Coated implantable medical device
IL120005A (en)	1997-01-14	2000-08-31	Ramot University Authority Of	Pharmaceutical compositions for the treatment of the eye
US6593291B1 (en) *	1997-02-06	2003-07-15	Entremed, Inc.	Compositions and methods of use of ligands that bind components of the blood coagulation/clotting pathway for the treatment of cancer and angiogenic-based disease
EP1161258A1 (en) *	1999-03-17	2001-12-12	EntreMed, Inc.	Compositions and methods of use of ldl-like receptor ligands for the treatment of cancer and angiogenic-based disease
WO2001037853A2 (en) *	1999-11-23	2001-05-31	North Shore - Long Island Jewish Health System	Methods and agents for the inhibition of smooth muscle cell proliferation
US20020182587A1 (en) *	2001-03-02	2002-12-05	Sivaram Pillarisetti	Methods and compositions for the treatment and prevention of smooth muscle cell proliferation
US6613083B2 (en)	2001-05-02	2003-09-02	Eckhard Alt	Stent device and method
CN102137680A (en) *	2008-07-01	2011-07-27	克格诺西有限公司	Methods of treating cancer with APOE peptides
CA2823191A1 (en)	2010-01-06	2011-07-14	Cognosci, Inc.	Apoe peptide dimers and uses thereof
US20140228299A1 (en) *	2011-09-20	2014-08-14	National University Corporation Tokyo Medical And Dental University	Prophylactic and therapeutic agent for neurological diseases using lipoproteins and prophylactic and therapeutic method for neurological diseases
EP4215214A4 (en) *	2020-09-16	2024-07-03	Osaka University	CANCER THERAPEUTICS, IMMUNOSTIMULANT AND SCREENING METHODS FOR AN ANTICANCER SUBSTANCE

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991002751A1 (en) *	1989-08-18	1991-03-07	Scripps Clinic And Research Foundation	Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1992010512A1 (en) *	1990-12-10	1992-06-25	The Scripps Research Institute	Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1995005190A1 (en) *	1993-08-12	1995-02-23	Bio-Technology General Corp.	Method of inhibiting kaposi's sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU658578B2 (en) *	1991-06-26	1995-04-27	Bio-Technology General Corporation	Purification of recombinant apolipoprotein E from bacteria

1993
- 1993-08-12 EP EP93919995A patent/EP0659085A4/en not_active Withdrawn
- 1993-08-12 AU AU50072/93A patent/AU673543B2/en not_active Ceased
- 1993-08-12 IL IL106664A patent/IL106664A0/en unknown
- 1993-08-12 WO PCT/US1993/007582 patent/WO1994004178A1/en not_active Ceased
- 1993-08-12 ZA ZA935879A patent/ZA935879B/en unknown
- 1993-08-12 KR KR1019950700386A patent/KR950702430A/en not_active Withdrawn
- 1993-08-12 JP JP6506399A patent/JPH08502730A/en active Pending
- 1993-08-12 NZ NZ255732A patent/NZ255732A/en unknown
- 1993-08-12 CA CA002141598A patent/CA2141598A1/en not_active Abandoned

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991002751A1 (en) *	1989-08-18	1991-03-07	Scripps Clinic And Research Foundation	Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1992010512A1 (en) *	1990-12-10	1992-06-25	The Scripps Research Institute	Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
WO1995005190A1 (en) *	1993-08-12	1995-02-23	Bio-Technology General Corp.	Method of inhibiting kaposi's sarcoma

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DYER ET AL: "ONLY MULTIMERS OF A SYNTHETIC PEPTIDE OF HUMAN APOLIPOPROTEIN E ARE BIOLOGICALLY ACTIVE", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 23, 15 August 1991 (1991-08-15), pages 15009 - 15015 *
See also references of WO9404178A1 *

Also Published As

Publication number	Publication date
NZ255732A (en)	1997-05-26
ZA935879B (en)	1994-03-11
IL106664A0 (en)	1993-12-08
AU673543B2 (en)	1996-11-14
KR950702430A (en)	1995-07-29
JPH08502730A (en)	1996-03-26
WO1994004178A1 (en)	1994-03-03
AU5007293A (en)	1994-03-15
CA2141598A1 (en)	1994-03-03
EP0659085A1 (en)	1995-06-28

Legal Events

Date	Code	Title	Description
1995-05-12	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-06-28	17P	Request for examination filed	Effective date: 19950310
1995-06-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1996-01-10	RHK1	Main classification (correction)	Ipc: A61K 38/00
1996-05-29	RHK1	Main classification (correction)	Ipc: A61K 37/02
1996-06-12	A4	Supplementary search report drawn up and despatched	Effective date: 19960419
1996-06-12	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1997-06-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1997-08-06	18W	Application withdrawn	Withdrawal date: 19970610

Publication	Publication Date	Title
IL108075A0 (en)	1994-04-12	Enzyme inhibitors
ZA945657B (en)	1996-01-29	Method to inhibit restenosis
ZA939369B (en)	1994-08-08	Method of milling.
EP0612249A4 (en)	1995-11-08	Methods of inhibiting restenosis.
IL101792A0 (en)	1992-12-30	Bioreactor
ZA94102B (en)	1995-07-07	Method of inhibiting viral reproduction
ZA935879B (en)	1994-03-11	Method of inhibiting cell proliferation using apolipoprotein E.
GB9317513D0 (en)	1993-10-06	An improved airlock system
EP0608982A3 (en)	1995-04-19	Process for inhibiting activity of endotoxin.
EP0599514A3 (en)	1994-07-06	Pyranoquinoline derivatives as inhibitors of cell proliferation.
PL313740A1 (en)	1996-07-22	Method of
GB9209175D0 (en)	1992-06-10	Bioreactor system
PL305237A1 (en)	1995-04-03	Method of obtaining 3-aminopyridines from 3-nitropyridines
GB9214720D0 (en)	1992-08-19	Enzyme inhibitors
GB9306292D0 (en)	1993-05-19	Method
GR3022957T3 (en)	1997-06-30	Arrangement for cathodic protection
IL109333A0 (en)	1994-07-31	Genetic stabilizing elements
HU9300927D0 (en)	1993-07-28	Method for hetero-annulation
GB9212261D0 (en)	1992-07-22	Enzyme cloning
ZA939480B (en)	1995-06-19	Enzyme inhibitor
AU2321088A (en)	1989-03-31	Method for preventing or treating thrombocytopenia
PL303627A1 (en)	1994-12-12	Chloroalkaline electrolyzing method
GB9324803D0 (en)	1994-01-19	Enzyme inhibitors
GB9300700D0 (en)	1993-03-10	Evaporating method
ZA938867B (en)	1995-05-26	Enzyme inhibitors