EP0661970A4 - METHOD AND COMPOSITIONS FOR TREATING HIGH PRESSURE, ANGINA AND OTHER DISEASES WITH OPTICALLY PURE (-) AMLODIPINE. - Google Patents

METHOD AND COMPOSITIONS FOR TREATING HIGH PRESSURE, ANGINA AND OTHER DISEASES WITH OPTICALLY PURE (-) AMLODIPINE.

Info

Publication number
EP0661970A4
EP0661970A4 EP19920925405 EP92925405A EP0661970A4 EP 0661970 A4 EP0661970 A4 EP 0661970A4 EP 19920925405 EP19920925405 EP 19920925405 EP 92925405 A EP92925405 A EP 92925405A EP 0661970 A4 EP0661970 A4 EP 0661970A4
Authority
EP
European Patent Office
Prior art keywords
amlodipine
angina
diseases
compositions
high pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19920925405
Other languages
German (de)
French (fr)
Other versions
EP0661970A1 (en
Inventor
James W Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma America Inc
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Priority to EP02019389A priority Critical patent/EP1262182A3/en
Priority to EP05107608A priority patent/EP1614420A3/en
Priority to EP99123828A priority patent/EP1013275A3/en
Publication of EP0661970A4 publication Critical patent/EP0661970A4/en
Publication of EP0661970A1 publication Critical patent/EP0661970A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP92925405A 1991-11-26 1992-11-25 Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine Ceased EP0661970A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02019389A EP1262182A3 (en) 1991-11-26 1992-11-25 Methods and compositions for treating hypertension, angina and other disorders using optically pure(-) amlodipine
EP05107608A EP1614420A3 (en) 1992-11-25 1992-11-25 Treatment of hypertension, angina and other disorders using (-) amlodipine
EP99123828A EP1013275A3 (en) 1991-11-26 1992-11-25 Method and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79846691A 1991-11-26 1991-11-26
US798466 1991-11-26
PCT/US1992/010145 WO1993010779A1 (en) 1991-11-26 1992-11-25 Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP99123828A Division EP1013275A3 (en) 1991-11-26 1992-11-25 Method and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine

Publications (2)

Publication Number Publication Date
EP0661970A4 true EP0661970A4 (en) 1994-12-16
EP0661970A1 EP0661970A1 (en) 1995-07-12

Family

ID=25173478

Family Applications (3)

Application Number Title Priority Date Filing Date
EP02019389A Ceased EP1262182A3 (en) 1991-11-26 1992-11-25 Methods and compositions for treating hypertension, angina and other disorders using optically pure(-) amlodipine
EP99123828A Withdrawn EP1013275A3 (en) 1991-11-26 1992-11-25 Method and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine
EP92925405A Ceased EP0661970A1 (en) 1991-11-26 1992-11-25 Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP02019389A Ceased EP1262182A3 (en) 1991-11-26 1992-11-25 Methods and compositions for treating hypertension, angina and other disorders using optically pure(-) amlodipine
EP99123828A Withdrawn EP1013275A3 (en) 1991-11-26 1992-11-25 Method and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine

Country Status (5)

Country Link
EP (3) EP1262182A3 (en)
JP (1) JPH07501547A (en)
AU (2) AU3147593A (en)
CA (1) CA2124445A1 (en)
WO (1) WO1993010779A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0795327A1 (en) * 1996-03-13 1997-09-17 Pfizer Inc. Use of Amlodipine for the treatment and prophylaxis of congestive cardiac failure of non-ischaemic origin
CA2270022A1 (en) * 1998-05-14 1999-11-14 Rodney H. Falk Combination of dofetilide and a calcium channel blocker
US6333342B1 (en) 1998-11-04 2001-12-25 Isotechnika, Inc Methods of pharmacological treatment using S(−) amlodipine
US6617361B2 (en) * 1999-11-05 2003-09-09 Be Able, Llc Behavior chemotherapy
US6521647B2 (en) 2000-04-04 2003-02-18 Pfizer Inc. Treatment of renal disorders
GB0008332D0 (en) * 2000-04-04 2000-05-24 Pfizer Ltd Treament
GB0020842D0 (en) * 2000-08-23 2000-10-11 Pfizer Ltd Therapeutic compositions
AT5874U1 (en) * 2000-12-29 2003-01-27 Bioorg Bv PHARMACEUTICAL PREPARATIONS CONTAINING AMLODIPINMALEAT
US6680334B2 (en) 2001-08-28 2004-01-20 Pfizer Inc Crystalline material
CN1152013C (en) * 2001-11-22 2004-06-02 张喜田 Levo-amlodipine salt able to generate hydrate and its hydrate and preparation
AU2003260984A1 (en) * 2002-09-11 2004-04-30 Hanlim Pharmaceutical Co., Ltd. S-(-)-amlodipine nicotinate and process for the preparation thereof
RU2239433C1 (en) * 2003-06-09 2004-11-10 Закрытое акционерное общество "Фармацевтическое предприятие "Оболенское" Medicinal formulation eliciting vasodilating, anti-anginal, hypotensive and spasmolytic effect and method for its preparing
US20050187262A1 (en) * 2004-01-12 2005-08-25 Grogan Donna R. Compositions comprising (S)-amlodipine and an angiotensin receptor blocker and methods of their use
US20060035940A1 (en) * 2004-03-16 2006-02-16 Sepracor Inc. (S)-Amlodipine malate
WO2005097191A2 (en) * 2004-04-04 2005-10-20 Sepracor Inc. COMBINATIONS COMPRISING (S)- AMLODIPINE AND A HMG-CoA REDUCTASE INHIBITOR OR CHOLESTEROL ABSORPOTION INHIBITOR OR BOTH, AND METHODS FOR REDUCING HYPERTENSION
WO2005099699A1 (en) * 2004-04-07 2005-10-27 Sepracor Inc. Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension
ATE399154T1 (en) * 2004-10-20 2008-07-15 Emcure Pharmaceuticals Ltd METHOD FOR PRODUCING AN ENANTIOMER OF AMLODIPINE IN HIGH OPTICAL PURITY
WO2008062435A2 (en) * 2006-08-15 2008-05-29 Alkem Laboratories Ltd. Stabilised dosage forms of amlodipine besylate
KR100828883B1 (en) * 2006-10-27 2008-05-09 씨제이제일제당 (주) Separation Method of S-(-)-Amlodipine from Racemic Amlodipine
GB0906868D0 (en) * 2009-04-21 2009-06-03 Rabin Bennie Amlodipine salt compositions
EP2322163A1 (en) * 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
CN110882249B (en) 2019-11-08 2021-04-30 北京吾为尔创科技有限公司 Composition containing levamlodipine besylate hydrate and preparation method thereof
CN113209035B (en) * 2021-05-28 2022-07-08 海南锦瑞制药有限公司 Levamlodipine besylate tablets and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089167A2 (en) * 1982-03-11 1983-09-21 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
EP0244944A2 (en) * 1986-04-04 1987-11-11 Pfizer Limited Salts of amlodipine
EP0331315A2 (en) * 1988-02-27 1989-09-06 Pfizer Limited Preparation of R- and S-amlodipine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4833191U (en) * 1971-08-23 1973-04-21
GB1438268A (en) * 1974-03-25 1976-06-03 Nelson Research Dev Co Antidepressant
JPS50160949A (en) * 1974-06-21 1975-12-26
GR75395B (en) * 1980-11-14 1984-07-13 Lilly Co Eli
FR2528046B1 (en) * 1982-06-08 1985-06-21 Delalande Sa OPTICALLY ACTIVE OXAZOLIDINONE-2 N-ARYLATED DERIVATIVES, SPECIFIC AND REVERSIBLE INHIBITORS OF TYPE B MONOAMINE OXYDASE AND PROCESS FOR THEIR PREPARATION
NL8202810A (en) * 1982-07-12 1984-02-01 Duphar Int Res SPASMOLYTIC EFFICACY (+) - SECOVERINE.
IT1203721B (en) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa OPTICALLY ACTIVE COMPOUNDS WITH ANTITOSSE AND CENTRAL SEDATIVE ACTIVITIES, PROCEDURE FOR PREPARATION AND COMPOSITIONS CONTAINING THEM
DE3928287A1 (en) * 1989-08-26 1991-02-28 Knoll Ag USE OF THE (+) - ENANTIOMER OF ANIPAMIL
WO1991006295A1 (en) * 1989-11-06 1991-05-16 Sepracor, Inc. Analgesic composition containing optically pure s(+) flurbiprofen
JPH05503510A (en) * 1989-11-21 1993-06-10 セプラカー・インコーポレーテツド Compositions and methods containing optically pure (S)-atenolol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089167A2 (en) * 1982-03-11 1983-09-21 Pfizer Limited Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them
EP0244944A2 (en) * 1986-04-04 1987-11-11 Pfizer Limited Salts of amlodipine
EP0331315A2 (en) * 1988-02-27 1989-09-06 Pfizer Limited Preparation of R- and S-amlodipine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
E.J.ARIËNS: "Racemic therapeutics - ethical and regulatory aspects", EUR.J.CLIN.PHARMACOL., vol. 41, no. 2, June 1991 (1991-06-01), pages 89 - 93 *
E.J.ARIËNS: "Stereoselectivity in pharmacodynamics and pharmacokinetics", SCHWEIZ.MED.WOCHENSCHR., vol. 120, no. 5, 3 February 1990 (1990-02-03), pages 131 - 134 *
J.E.ARROWSMITH ET AL.: "Long-Acting Dihydropyridine Calcium Antagonists. 1. 2-Alkoxymethyl Deivatives Incorporating Basic Substituents", J.MED.CHEM., vol. 29, no. 9, 1986, pages 1696 - 1702, XP002070765, DOI: doi:10.1021/jm00159a022 *
S GOLDMANN ET AL.: "Determination of the Absolute Configuration of the Active Amlodipine Enantiomer as (-)-S: A Correction", J.MED.CHEM., vol. 35, no. 18, 4 September 1992 (1992-09-04), pages 3341 - 3344, XP000877422, DOI: doi:10.1021/jm00096a005 *
See also references of WO9310779A1 *
W.G.NAYLER ET AL.: "(-)[3H]Amlodipine Binding to Rat Cardiac Membranes", J.CARDIOVASC.PHARMACOL., vol. 17, no. 4, 1991, pages 587 - 592, XP000900097 *

Also Published As

Publication number Publication date
AU3147593A (en) 1993-06-28
JPH07501547A (en) 1995-02-16
EP1262182A3 (en) 2003-02-26
EP1262182A2 (en) 2002-12-04
AU2221597A (en) 1997-07-31
EP1013275A2 (en) 2000-06-28
CA2124445A1 (en) 1993-06-10
EP1013275A3 (en) 2001-01-10
WO1993010779A1 (en) 1993-06-10
EP0661970A1 (en) 1995-07-12

Similar Documents

Publication Publication Date Title
EP0661970A4 (en) METHOD AND COMPOSITIONS FOR TREATING HIGH PRESSURE, ANGINA AND OTHER DISEASES WITH OPTICALLY PURE (-) AMLODIPINE.
DE69010893D1 (en) METHOD FOR TREATING KOKS AND DELETING THE SAME.
DE69019180D1 (en) Organopolysiloxane-polyurea block copolymer and method for its production.
DE68904986D1 (en) METHOD FOR PRODUCING 1,1,1-TRIFLUOR-2,2-DICHLORETHANE.
DE69002432D1 (en) DIAMOND SEMICONDUCTOR COMPONENT AND METHOD FOR THE PRODUCTION THEREOF.
DE69417550D1 (en) BLOOD FILTER AND METHOD FOR THE PRODUCTION THEREOF
DE68923319D1 (en) Fluorocarbon membranes and process for making fluorocarbon membranes.
FI921425A7 (en) Compositions, products and methods for removing oxygen
ATA253990A (en) CONCENTRATED FUNGICIDE AGENTS AND METHOD FOR PRODUCING SUCH GRANULATED AGENTS
DE69008456D1 (en) Film composition for treating surfaces and process for their manufacture.
DE69415100D1 (en) Nonwoven article for treating surfaces, process for making and using same
DE69231592D1 (en) METHOD AND COMPOSITIONS FOR TREATING MALARIA AND OTHER DISEASES
DE58906239D1 (en) Facility for the treatment of diseases, in particular the visual pathway.
DE69606960D1 (en) Adsorbent, process for its preparation and method for the treatment of fruit juice
DE69422812D1 (en) METHOD FOR PRODUCING 1,1,1,3,3-PENTAFLUORPROPANE AND / OR 1,1,3,3,3-PENTAFLUORPROPANE
DE69005987D1 (en) Seal, device and method for their manufacture.
DE3669507D1 (en) 1-BENZYL-2- (N-SUBSTITUTED) -CARBAMOYLTETRAHYDROISOCHINOLINE AND METHOD FOR THE PRODUCTION THEREOF.
DE59002322D1 (en) METHOD FOR PRODUCING 1,1,1,3,3,3-HEXAFLUORPROPANE AND 2-CHLORINE-1,1,1,3,3,3-HEXAFLUORPROPANE.
DE59001670D1 (en) METHOD AND PLANT FOR PRODUCING DICALCIUMPHOSPHATE.
DE69321848D1 (en) METHOD FOR PRODUCING 1,1,1,2,3,3-HEXAFLUORPROPANE AND TETRAFLUORCHLOROPROPEN
DE68904052D1 (en) METHOD FOR PRODUCING VERY PURE ZIRCONIUM TETRAFLUORIDE AND OTHER FLUORIDS.
DE59510180D1 (en) Process for the preparation of 4-amino-2,2,6,6-tetramethyl-piperidine
DE69017141D1 (en) Method for eliminating multiple frames in token ring networks.
AT399802B (en) PRE-FILLED STONE FRUIT FRUIT, METHOD AND DEVICE FOR THEIR PRODUCTION
DE3669063D1 (en) METHOD FOR DISINFECTING LOCAL AGAINST COCKICIDAL OOCYSTS.

Legal Events

Date Code Title Description
A4 Supplementary search report drawn up and despatched
AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19940627

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 19950920

APAB Appeal dossier modified

Free format text: ORIGINAL CODE: EPIDOS NOAPE

APAD Appeal reference recorded

Free format text: ORIGINAL CODE: EPIDOS REFNE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20030523

APAF Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNE