EP0662834A4 - Novel epoxide-containing compounds. - Google Patents

Novel epoxide-containing compounds.

Info

Publication number: EP0662834A4
Authority: EP; European Patent Office
Prior art keywords: containing compounds; novel epoxide; epoxide; novel; compounds
Prior art date: 1992-09-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93922366A

Other languages

German (de)

French (fr)

Other versions

EP0662834A1 (en

Inventor

Gail Underiner

J Peter Klein

John Michnick

Alistair Leigh

Anil Kumar

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CTI Biopharma Corp

Original Assignee

Cell Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-22

Filing date

1993-09-22

Publication date

1996-04-17

1992-09-22 Priority claimed from US07/949,330 external-priority patent/US5288721A/en

1993-09-22 Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc

1995-07-19 Publication of EP0662834A1 publication Critical patent/EP0662834A1/en

1996-04-17 Publication of EP0662834A4 publication Critical patent/EP0662834A4/en

Status Withdrawn legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title 1
150000002118 epoxides Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pulmonology (AREA)
Virology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP93922366A 1992-09-22 1993-09-22 Novel epoxide-containing compounds. Withdrawn EP0662834A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US949330		1992-09-22
US07/949,330 US5288721A (en)	1992-09-22	1992-09-22	Substituted epoxyalkyl xanthines
US99165592A	1992-12-16	1992-12-16
PCT/US1993/009073 WO1994006431A1 (en)	1992-09-22	1993-09-22	Novel epoxide-containing compounds
US991655		1997-12-16

Publications (2)

Publication Number	Publication Date
EP0662834A1 EP0662834A1 (en)	1995-07-19
EP0662834A4 true EP0662834A4 (en)	1996-04-17

Family

ID=27130287

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93922366A Withdrawn EP0662834A4 (en)	1992-09-22	1993-09-22	Novel epoxide-containing compounds.

Country Status (5)

Country	Link
EP (1)	EP0662834A4 (en)
JP (1)	JPH08501564A (en)
AU (1)	AU5138493A (en)
CA (1)	CA2145192A1 (en)
WO (1)	WO1994006431A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0620739A4 (en) *	1992-09-15	1997-01-15	Immunex Corp	Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists.
US5446046A (en) *	1993-10-28	1995-08-29	University Of Florida Research Foundation	A1 adenosine receptor agonists and antagonists as diuretics
WO1995019171A1 (en) *	1994-01-14	1995-07-20	Cell Therapeutics, Inc.	Method for treating diseases mediated by cellular proliferation in response to pdgf, egf, fgf and vegf
AU1967495A (en) *	1994-02-18	1995-09-04	Cell Therapeutics, Inc.	Intracellular signalling mediators
WO1998052919A1 (en) *	1997-05-21	1998-11-26	Japan Tobacco Inc.	Phthalimide derivatives and pharmaceutical containing said derivatives
US7276506B2 (en)	1998-12-28	2007-10-02	4 Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
US6946465B2 (en)	1999-02-02	2005-09-20	4 Aza Bioscience Nv	Immunosuppressive effects of pteridine derivatives
WO2008009078A2 (en)	2006-07-20	2008-01-24	Gilead Sciences, Inc.	4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10144736B2 (en)	2006-07-20	2018-12-04	Gilead Sciences, Inc.	Substituted pteridines useful for the treatment and prevention of viral infections
DK3097102T3 (en)	2015-03-04	2018-01-22	Gilead Sciences Inc	TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO [3,2-D] PYRIMIDINE COMPOUNDS
MA46093A (en)	2016-09-02	2021-05-19	Gilead Sciences Inc	TOLL-TYPE RECEIVER MODULATING COMPOUNDS
WO2018045150A1 (en)	2016-09-02	2018-03-08	Gilead Sciences, Inc.	4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
TW202212339A (en)	2019-04-17	2022-04-01	美商基利科學股份有限公司	Solid forms of a toll-like receptor modulator
TW202210480A (en)	2019-04-17	2022-03-16	美商基利科學股份有限公司	Solid forms of a toll-like receptor modulator
TWI879779B (en)	2019-06-28	2025-04-11	美商基利科學股份有限公司	Processes for preparing toll-like receptor modulator compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE678272A (en) *	1965-03-23	1966-09-23	Ciba Ltd

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5158967A (en) *	1991-06-12	1992-10-27	E. R. Squibb & Sons, Inc.	7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease

1993
- 1993-09-22 WO PCT/US1993/009073 patent/WO1994006431A1/en not_active Ceased
- 1993-09-22 EP EP93922366A patent/EP0662834A4/en not_active Withdrawn
- 1993-09-22 CA CA002145192A patent/CA2145192A1/en not_active Abandoned
- 1993-09-22 AU AU51384/93A patent/AU5138493A/en not_active Abandoned
- 1993-09-22 JP JP6508445A patent/JPH08501564A/en active Pending

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE678272A (en) *	1965-03-23	1966-09-23	Ciba Ltd

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 100, no. 1, 2 January 1984, Columbus, Ohio, US; abstract no. 6860k, page 593; column L; *
INDIAN JOURNAL OF CHEMISTRY., SECTION B, vol. 22B, no. 5, 1983, pages 515 - 516 *
See also references of WO9406431A1 *

Also Published As

Publication number	Publication date
EP0662834A1 (en)	1995-07-19
AU5138493A (en)	1994-04-12
WO1994006431A1 (en)	1994-03-31
CA2145192A1 (en)	1994-03-31
JPH08501564A (en)	1996-02-20

Legal Events

Date	Code	Title	Description
1995-06-02	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-07-19	17P	Request for examination filed	Effective date: 19950407
1995-07-19	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1996-04-17	A4	Supplementary search report drawn up and despatched	Effective date: 19960301
1996-04-17	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1999-09-17	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1999-11-03	18D	Application deemed to be withdrawn	Effective date: 19990401

Publication	Publication Date	Title
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ZA931773B (en)	1993-09-29	Substituted phenylacetamides.
AU5138493A (en)	1994-04-12	Novel epoxide-containing compounds
EP0603314A4 (en)	1994-08-24	Chemical compounds.
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