EP0716614A4 - TREATMENT OF HUMAN TUMORS BY GENETIC TRANSFORMATION OF HUMAN TUMOR CELLS - Google Patents

TREATMENT OF HUMAN TUMORS BY GENETIC TRANSFORMATION OF HUMAN TUMOR CELLS

Info

Publication number: EP0716614A4
Authority: EP; European Patent Office
Prior art keywords: human; treatment; tumor cells; genetic transformation; tumors
Prior art date: 1993-09-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP94926678A

Other languages

German (de)

French (fr)

Other versions

EP0716614A1 (en

Inventor

Edward J Oldfield

Zvi Ram

R Michael Blaese

Kenneth W Culver

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

US Department of Health and Human Services

Original Assignee

US Department of Health and Human Services

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-03

Filing date

1994-09-02

Publication date

1998-02-04

1994-09-02 Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services

1996-06-19 Publication of EP0716614A1 publication Critical patent/EP0716614A1/en

1998-02-04 Publication of EP0716614A4 publication Critical patent/EP0716614A4/en

Status Withdrawn legal-status Critical Current

Links

206010028980 Neoplasm Diseases 0.000 title 1
230000002068 genetic effect Effects 0.000 title 1
230000009466 transformation Effects 0.000 title 1
210000004881 tumor cell Anatomy 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Immunology (AREA)
Virology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Magnetic Resonance Imaging Apparatus (AREA)

EP94926678A 1993-09-03 1994-09-02 TREATMENT OF HUMAN TUMORS BY GENETIC TRANSFORMATION OF HUMAN TUMOR CELLS Withdrawn EP0716614A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11666993A	1993-09-03	1993-09-03
US116669		1993-09-03
PCT/US1994/009961 WO1995006486A1 (en)	1993-09-03	1994-09-02	Treatment of human tumors by genetic transformation of human tumor cells

Publications (2)

Publication Number	Publication Date
EP0716614A1 EP0716614A1 (en)	1996-06-19
EP0716614A4 true EP0716614A4 (en)	1998-02-04

Family

ID=22368537

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP94926678A Withdrawn EP0716614A4 (en)	1993-09-03	1994-09-02	TREATMENT OF HUMAN TUMORS BY GENETIC TRANSFORMATION OF HUMAN TUMOR CELLS

Country Status (4)

Country	Link
EP (1)	EP0716614A4 (en)
JP (1)	JPH09505557A (en)
CA (1)	CA2169557A1 (en)
WO (1)	WO1995006486A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6537541B1 (en)	1990-09-14	2003-03-25	The General Hospital Corporation	Implantation of HSV-TK retrovirus producer cells to destroy glioma
US6555108B1 (en)	1990-09-14	2003-04-29	The General Hospital Corporation	Implanting HSV-TK retrovirus producing cells to treat tumors
AU2434195A (en) *	1994-05-02	1995-11-29	University Of Washington	Thymidine kinase mutants
US6451571B1 (en)	1994-05-02	2002-09-17	University Of Washington	Thymidine kinase mutants
US7087582B1 (en)	1995-09-26	2006-08-08	Regents Of The University Of Michigan	Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21
US6207648B1 (en)	1997-07-24	2001-03-27	Trustees Of Boston University	Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy
GB9801902D0 (en) *	1998-01-29	1998-03-25	Cancer Res Campaign Tech	A gene promoter
EP1153136A2 (en)	1998-12-09	2001-11-14	The General Hospital Corporation	Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors
US6677155B1 (en)	1999-04-22	2004-01-13	The General Hospital Corporation	Triple hybrid amplicon vector systems to generate retroviral packaging lines
US6770632B1 (en)	1999-07-16	2004-08-03	The General Hospital Corporation	Folypolyglutamyl synthetase gene transfer to enhance antifolate
US7214515B2 (en)	2001-01-05	2007-05-08	The General Hospital Corporation	Viral delivery system for infectious transfer of large genomic DNA inserts
EP3777980B1 (en)	2013-10-29	2023-12-06	President and Fellows of Harvard College	Nuclear factor erythroid 2-like 2 (nrf2) for use in treatment of age-related macular degeneration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4583538A (en) *	1984-05-04	1986-04-22	Onik Gary M	Method and apparatus for stereotaxic placement of probes in the body utilizing CT scanner localization
US4813399A (en) *	1986-07-18	1989-03-21	Gordon Robert T	Process for the treatment of neurological or neuromuscular diseases and development
US4892538A (en) *	1987-11-17	1990-01-09	Brown University Research Foundation	In vivo delivery of neurotransmitters by implanted, encapsulated cells

1994
- 1994-09-02 CA CA002169557A patent/CA2169557A1/en not_active Abandoned
- 1994-09-02 EP EP94926678A patent/EP0716614A4/en not_active Withdrawn
- 1994-09-02 WO PCT/US1994/009961 patent/WO1995006486A1/en not_active Ceased
- 1994-09-02 JP JP7508296A patent/JPH09505557A/en active Pending

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BRAIN NERVE (TOKYO), vol. 38, no. 6, 1986, pages 593 - 598 *
CULVER ET AL: "IN VIVO GENE TRANSFER WITH RETROVIRAL VECTOR-PRODUCER CELLS FOR TREATMENT OF EXPERIMENTAL BRAIN TUMORS", SCIENCE, vol. 256, 1992, pages 1550 - 1552, XP002045618 *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; OKAMOTO ET AL: "CLINICAL STUDIES OF ADOPTIVE IMMUNOTHERAPY OF HUMAN DISSEMINATED BRAIN TUMORS WITH LYMPHOKINE-ACTIVATED KILLER CELLS AND RECOMBINANT INTERLEUKIN 2", XP002045621 *
DATABASE MEDLINE FILE SERVER STN KARLSRUHE; PLUNKETT ET AL: "STEROTAXIC IMPLANTATION OF DISPERSED CELL SUSPENSIONS INTO BRAIN. A SYSTEMATIC APPRAISAL OF CELL PLACEMENT AND SURVIVAL", XP002045622 *
GILBERT ET AL: "CELL TRANSPLANTATION OF GENETICALLY ALTERED CELLS ON BIODEGRADABLE POLYMER SCAFFOLDS IN SYNGENEIC RATS", TRANSPLANTATION, vol. 56, August 1993 (1993-08-01), pages 423 - 427, XP002045620 *
JOURNAL OF NEUROSURGERY, vol. 69, no. 2, 1988, pages 228 - 233 *
RAM ET AL: "IN SITU RETROVIRAL-MEDIATED GENE TRANSFER FOR THE TREATMENT OF BRAIN TUMORS IN RATS", CANCER RESEARCH, vol. 53, 1 January 1993 (1993-01-01), pages 83 - 88, XP002045617 *
See also references of WO9506486A1 *
SHORT ET AL: "GENE DELIVERY TO GLIOMA CELLS IN RAT BRAIN BY GRAFTING OF A RETROVIRUS PACKAGING CELL LINE", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 27, 1990, pages 427 - 433, XP002045619 *

Also Published As

Publication number	Publication date
JPH09505557A (en)	1997-06-03
WO1995006486A1 (en)	1995-03-09
EP0716614A1 (en)	1996-06-19
CA2169557A1 (en)	1995-03-09

Legal Events

Date	Code	Title	Description
1996-05-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1996-06-19	17P	Request for examination filed	Effective date: 19960223
1996-06-19	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1998-02-04	A4	Supplementary search report drawn up and despatched	Effective date: 19971218
1998-02-04	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
2000-08-11	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2000-09-27	18D	Application deemed to be withdrawn	Effective date: 20000403

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