EP0723460A4 - GENE THERAPY FOR THE NERVOUS SYSTEM - Google Patents

GENE THERAPY FOR THE NERVOUS SYSTEM

Info

Publication number: EP0723460A4
Authority: EP; European Patent Office
Prior art keywords: nervous system; gene therapy; therapy; gene; nervous
Prior art date: 1993-10-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP94930498A

Other languages

German (de)

French (fr)

Other versions

EP0723460A1 (en

Inventor

Zvi Ram

R Michael Blaese

Edward H Oldfield

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

United States Department of Health and Human Services

Original Assignee

United States Department of Health and Human Services

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-01

Filing date

1994-09-28

Publication date

1998-09-30

1994-09-28 Application filed by United States Department of Health and Human Services filed Critical United States Department of Health and Human Services

1996-07-31 Publication of EP0723460A1 publication Critical patent/EP0723460A1/en

1998-09-30 Publication of EP0723460A4 publication Critical patent/EP0723460A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Virology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP94930498A 1993-10-01 1994-09-28 GENE THERAPY FOR THE NERVOUS SYSTEM Withdrawn EP0723460A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13108593A	1993-10-01	1993-10-01
US131085		1993-10-01
PCT/US1994/010977 WO1995009654A1 (en)	1993-10-01	1994-09-28	Gene therapy of the nervous system

Publications (2)

Publication Number	Publication Date
EP0723460A1 EP0723460A1 (en)	1996-07-31
EP0723460A4 true EP0723460A4 (en)	1998-09-30

Family

ID=22447805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP94930498A Withdrawn EP0723460A4 (en)	1993-10-01	1994-09-28	GENE THERAPY FOR THE NERVOUS SYSTEM

Country Status (4)

Country	Link
EP (1)	EP0723460A4 (en)
JP (1)	JPH09505561A (en)
CA (1)	CA2171109A1 (en)
WO (1)	WO1995009654A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU711269B2 (en)	1994-08-16	1999-10-07	Crucell Holland B.V.	Recombinant vectors derived from adenovirus for use in gene therapy
US6544523B1 (en)	1996-11-13	2003-04-08	Chiron Corporation	Mutant forms of Fas ligand and uses thereof
EP0961830A1 (en) *	1997-01-29	1999-12-08	Neurosearch A/S	EXPRESSION VECTORS AND METHODS FOR $i(IN VIVO) EXPRESSION OF THERAPEUTIC POLYPEPTIDES
BR9813930A (en)	1997-11-06	2006-12-19	Chiron Spa	neisserial antigen
ATE446368T1 (en)	1998-01-14	2009-11-15	Novartis Vaccines & Diagnostic	ANTIGENS FROM NEISSERIA MENINGITIDIS
EP1061806A4 (en) *	1998-03-12	2001-09-12	Univ Pennsylvania	REPLICATING VIRUS PRODUCING CELLS FOR TREATING MALIGNANCY
MX343752B (en)	1998-05-01	2016-11-22	Novartis Vaccines & Diagnostics Inc	Neisseria meningitidis antigens and compositions.
NZ571167A (en)	1999-04-30	2010-05-28	Novartis Vaccines & Diagnostic	Fragments from Neisseria protein ORF 953 and their use in medicaments and diagnostic reagents
GB9911683D0 (en)	1999-05-19	1999-07-21	Chiron Spa	Antigenic peptides
GB9916529D0 (en)	1999-07-14	1999-09-15	Chiron Spa	Antigenic peptides
GB9924981D0 (en)	1999-10-21	1999-12-22	Univ Manchester	Gene therapy
GB2397063A (en) *	1999-10-21	2004-07-14	Cedars Sinai Medical Center	A medicament comprising a cytotoxic pro drug activated by HSV TK
PT2275551E (en)	1999-10-29	2015-06-29	Novartis Vaccines & Diagnostic	Neisserial antigenic peptides
ES2588917T3 (en)	2000-01-17	2016-11-07	Glaxosmithkline Biologicals Sa	VME supplement supplemented against meningococcus
US7939087B2 (en)	2000-10-27	2011-05-10	Novartis Vaccines And Diagnostics, Inc.	Nucleic acids and proteins from Streptococcus groups A & B
GB0107661D0 (en)	2001-03-27	2001-05-16	Chiron Spa	Staphylococcus aureus
GB0107658D0 (en)	2001-03-27	2001-05-16	Chiron Spa	Streptococcus pneumoniae
ES2386386T3 (en)	2001-12-12	2012-08-20	Novartis Vaccines And Diagnostics S.R.L.	Immunization against Chlamydia trachomatis
GB0308198D0 (en)	2003-04-09	2003-05-14	Chiron Srl	ADP-ribosylating bacterial toxin
KR101222281B1 (en)	2004-03-29	2013-01-28	가르파마 컴퍼니 리미티드	Novel galectin 9 modification protein and use thereof
EP2338524B1 (en)	2004-08-12	2013-05-22	Cedars-Sinai Medical Center	Combined gene therapy for the treatment of macroscopic gliomas
DK2054431T3 (en)	2006-06-09	2012-01-02	Novartis Ag	Conformers of bacterial adhesins
WO2008095027A2 (en)	2007-01-30	2008-08-07	Cedars-Sinai Medical Center	Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene
RU2664471C2 (en) *	2013-07-26	2018-08-17	Юниверсити Оф Айова Рисерч Фаундейшн	Methods and compositions for brain diseases treatment
EP4208718B1 (en)	2020-09-02	2025-04-16	Johansson Swartling, Fredrik	Predicting cancer relapse and treatment of cancer diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2051288C (en) *	1990-09-14	2002-02-05	Robert L. Martuza	Viral targeted destruction of neoplastic cells
US5529774A (en) *	1991-08-13	1996-06-25	The Regents Of The University Of California	In vivo transfer of the HSV-TK gene implanted retroviral producer cells

1994
- 1994-09-28 JP JP7510881A patent/JPH09505561A/en active Pending
- 1994-09-28 WO PCT/US1994/010977 patent/WO1995009654A1/en not_active Ceased
- 1994-09-28 EP EP94930498A patent/EP0723460A4/en not_active Withdrawn
- 1994-09-28 CA CA002171109A patent/CA2171109A1/en not_active Abandoned

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BREAKEFIELD ET AL: "GENE TRANSFER INTO THE NERVOUS SYSTEM", MOLECULAR NEUROBIOLOGY, vol. 1, 1987, pages 339 - 371, XP002072764 *
MURASZKO ET AL: "PHARMACOKINETICS AND TOXICOLOGY OF IMMUNOTOXINS ADMINISTERED INTO THE SUBARACHNOID SPACE IN NONHUMAN PRIMATES AND RODENTS", CANCER RESEARCH, vol. 53, 1993, pages 3752 - 3757, XP002072533 *
RAM ET AL: "INTRATHECAL GENE THERAPY FOR MALIGNANT LEPTOMENINGEAL NEOPLASIA", CANCER RESEARCH, vol. 54, 15 April 1994 (1994-04-15), pages 2141 - 2145, XP002072534 *
See also references of WO9509654A1 *

Also Published As

Publication number	Publication date
WO1995009654A1 (en)	1995-04-13
CA2171109A1 (en)	1995-04-13
EP0723460A1 (en)	1996-07-31
JPH09505561A (en)	1997-06-03

Legal Events

Date	Code	Title	Description
1996-06-14	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1996-07-31	17P	Request for examination filed	Effective date: 19960318
1996-07-31	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1998-09-30	A4	Supplementary search report drawn up and despatched	Effective date: 19980818
1998-09-30	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1999-03-26	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1999-05-12	18D	Application deemed to be withdrawn	Effective date: 19970203

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