EP0778899A4 - Enrichment of fetal cells from maternal blood - Google Patents

Enrichment of fetal cells from maternal blood

Info

Publication number: EP0778899A4
Authority: EP; European Patent Office
Prior art keywords: enrichment; fetal cells; maternal blood; maternal; fetal
Prior art date: 1994-09-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP95933174A

Other languages

German (de)

French (fr)

Other versions

EP0778899A1 (en

Inventor

Jurgen Busch

Andreas Radbruch

Stefan Miltenyi

Juergen Holtz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Miltenyi Biotec Inc

Original Assignee

Miltenyi Biotec Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-20

Filing date

1995-09-19

Publication date

2001-08-29

1995-09-19 Application filed by Miltenyi Biotec Inc filed Critical Miltenyi Biotec Inc

1997-06-18 Publication of EP0778899A1 publication Critical patent/EP0778899A1/en

2001-08-29 Publication of EP0778899A4 publication Critical patent/EP0778899A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Pathology (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Food Science & Technology (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Virology (AREA)
Biophysics (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Reproductive Health (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP95933174A 1994-09-20 1995-09-19 Enrichment of fetal cells from maternal blood Withdrawn EP0778899A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US30922994A	1994-09-20	1994-09-20
PCT/US1995/011971 WO1996009409A1 (en)	1994-09-20	1995-09-19	Enrichment of fetal cells from maternal blood
US309229		1999-05-10

Publications (2)

Publication Number	Publication Date
EP0778899A1 EP0778899A1 (en)	1997-06-18
EP0778899A4 true EP0778899A4 (en)	2001-08-29

Family

ID=23197274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP95933174A Withdrawn EP0778899A4 (en)	1994-09-20	1995-09-19	Enrichment of fetal cells from maternal blood

Country Status (5)

Country	Link
EP (1)	EP0778899A4 (en)
JP (1)	JPH10507632A (en)
AU (1)	AU691040B2 (en)
CA (1)	CA2200294A1 (en)
WO (1)	WO1996009409A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1294964B1 (en) *	1996-07-12	1999-04-23	Domenico Valerio	INSULATION AND CULTURE OF FETAL CELLS FROM THE MATERNAL PERIPHERAL BLOOD
DK0925494T3 (en)	1996-09-04	2002-07-01	Scandinavian Micro Biodevices	Microfluidic system for particle separation and analysis
FR2758884B1 (en) *	1997-01-30	1999-04-02	Bio Merieux	METHOD FOR ISOLATING, IN PARTICULAR DETECTING OR QUANTIFYING AN ANALYTE IN A MEDIUM
JP2001514751A (en) *	1997-03-08	2001-09-11	ザ・ユニバーシティー・オブ・ダンディー	Fetal diagnostic method
GB0009179D0 (en) *	2000-04-13	2000-05-31	Imp College Innovations Ltd	Non-invasive prenatal diagnosis
GB0616045D0 (en) *	2006-08-11	2006-09-20	Univ Bristol	Blood cell separation
GB2447255A (en) *	2007-03-02	2008-09-10	Oncoprobe Ltd	Preparation of enriched target cell samples for use in a chemosensitivity assay
FR2963108B1 (en) *	2010-07-21	2017-06-23	Diagast	MAGNETIC IMMUNODIAGNOSTIC METHOD AND KIT FOR THE EVIDENCE OF BLOOD GROUP / BLOOD PHENOTYPE ANTIBODY / ANTIGEN COMPLEX
US20140336075A1 (en) *	2011-12-17	2014-11-13	Bgi Diagnosis Co., Ltd.	Method and system for determinining whether genome is abnormal
EP2955521A1 (en) *	2014-06-11	2015-12-16	Centre Hospitalier Universitaire Vaudois (CHUV)	Methods for separating cells
CN109718880A (en) *	2019-02-20	2019-05-07	广州睿辰生物科技有限公司	Based on the specified micro-fluidic chip of dual anti-method sorting fetal nucleated red blood and its method for separating

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991016452A1 (en) *	1990-04-23	1991-10-31	Cellpro Incorporated	A method for enriching fetal cells from maternal blood

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4230685A (en) *	1979-02-28	1980-10-28	Northwestern University	Method of magnetic separation of cells and the like, and microspheres for use therein
US4452773A (en) *	1982-04-05	1984-06-05	Canadian Patents And Development Limited	Magnetic iron-dextran microspheres

1995
- 1995-09-19 EP EP95933174A patent/EP0778899A4/en not_active Withdrawn
- 1995-09-19 JP JP8511058A patent/JPH10507632A/en active Pending
- 1995-09-19 AU AU35935/95A patent/AU691040B2/en not_active Ceased
- 1995-09-19 CA CA002200294A patent/CA2200294A1/en not_active Abandoned
- 1995-09-19 WO PCT/US1995/011971 patent/WO1996009409A1/en not_active Ceased

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991016452A1 (en) *	1990-04-23	1991-10-31	Cellpro Incorporated	A method for enriching fetal cells from maternal blood

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BÜSCH J ET AL.: "Simple and fast 'Double-MACS' sorting of fetal erythroblasts from maternal blood for PCR-based paternity analysis", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 731, 1994, pages 144 - 146, XP001011400 *
CHUEH J AND GOLBUS M S: "Prenatal diagnosis using fetal cells in the maternal circulation", SEMINARS IN PERINATOLOGY, vol. 14, no. 6, 1990, pages 471 - 482, XP001011366 *
GÄNSHIRT-AHLERT D ET AL.: "Magnetic cell sorting and the transferrin receptor as potential means of prenatal diagnosis from maternal blood", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 166, May 1992 (1992-05-01), pages 1350 - 1355, XP001011368 *
HOLZGREVE W ET AL.: "Noninvasive prenatal diagnosis", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 731, 1994, pages 253 - 256, XP001011401 *
MILTENYI S ET AL: "HIGH GRADIENT MAGNETIC CELL SEPERATION WITH MACS", CYTOMETRY,ALAN LISS, NEW YORK,US, vol. 11, no. 11, 1990, pages 231 - 238, XP000999711, ISSN: 0196-4763 *
READING J P ET AL.: "Nucleated erythrocytes in maternal blood: quantity and quality of fetal cells in enriched populations", HUMAN REPRODUCTION, vol. 10, no. 9, September 1995 (1995-09-01), pages 2510 - 2515, XP001011367 *
See also references of WO9609409A1 *

Also Published As

Publication number	Publication date
AU691040B2 (en)	1998-05-07
AU3593595A (en)	1996-04-09
WO1996009409A1 (en)	1996-03-28
JPH10507632A (en)	1998-07-28
CA2200294A1 (en)	1996-03-28
EP0778899A1 (en)	1997-06-18

Legal Events

Date	Code	Title	Description
1997-05-02	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1997-06-18	17P	Request for examination filed	Effective date: 19970409
1997-06-18	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
2001-08-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2001-08-29	A4	Supplementary search report drawn up and despatched	Effective date: 20010712
2001-08-29	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
2001-08-29	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 12Q 1/68 A, 7G 01N 33/569 B
2001-10-10	18W	Application withdrawn	Withdrawal date: 20010816

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