EP0850057A4 - PHARMACEUTICAL COMPOUNDS - Google Patents

PHARMACEUTICAL COMPOUNDS

Info

Publication number
EP0850057A4
EP0850057A4 EP96929780A EP96929780A EP0850057A4 EP 0850057 A4 EP0850057 A4 EP 0850057A4 EP 96929780 A EP96929780 A EP 96929780A EP 96929780 A EP96929780 A EP 96929780A EP 0850057 A4 EP0850057 A4 EP 0850057A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical compounds
pharmaceutical
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96929780A
Other languages
German (de)
French (fr)
Other versions
EP0850057A1 (en
Inventor
Richard E Moore
Vinod F Patel
James E Ray
John E Toth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii at Manoa
Wayne State University
Original Assignee
University of Hawaii at Manoa
Wayne State University
Eli Lilly and Co
University of Hawaii at Hilo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Hawaii at Manoa, Wayne State University, Eli Lilly and Co, University of Hawaii at Hilo filed Critical University of Hawaii at Manoa
Publication of EP0850057A1 publication Critical patent/EP0850057A1/en
Publication of EP0850057A4 publication Critical patent/EP0850057A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
EP96929780A 1995-08-30 1996-08-30 PHARMACEUTICAL COMPOUNDS Withdrawn EP0850057A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US293595P 1995-08-30 1995-08-30
US2935 1995-08-30
PCT/US1996/013855 WO1997007798A1 (en) 1995-08-30 1996-08-30 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
EP0850057A1 EP0850057A1 (en) 1998-07-01
EP0850057A4 true EP0850057A4 (en) 2001-04-11

Family

ID=21703268

Family Applications (2)

Application Number Title Priority Date Filing Date
EP96929780A Withdrawn EP0850057A4 (en) 1995-08-30 1996-08-30 PHARMACEUTICAL COMPOUNDS
EP96932217A Withdrawn EP0850316A4 (en) 1995-08-30 1996-08-30 CRYPTOPHYCINS OBTAINED FROM AN ABERRANT BIOSYNTHESIS

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP96932217A Withdrawn EP0850316A4 (en) 1995-08-30 1996-08-30 CRYPTOPHYCINS OBTAINED FROM AN ABERRANT BIOSYNTHESIS

Country Status (6)

Country Link
EP (2) EP0850057A4 (en)
JP (2) JP2000501067A (en)
AU (2) AU6904896A (en)
BR (1) BR9610214A (en)
CA (2) CA2230540A1 (en)
WO (2) WO1997008334A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850057A4 (en) * 1995-08-30 2001-04-11 Lilly Co Eli PHARMACEUTICAL COMPOUNDS
ES2194129T3 (en) * 1995-12-22 2003-11-16 Univ Hawaii PHARMACEUTICAL COMPOUNDS.
AU4233997A (en) * 1996-08-30 1998-03-19 Eli Lilly And Company Process for preparing pharmaceutical compounds
US6680311B1 (en) 1996-08-30 2004-01-20 Eli Lilly And Company Cryptophycin compounds
JP2001502297A (en) * 1996-08-30 2001-02-20 イーライ・リリー・アンド・カンパニー Pharmaceutical compounds
CA2264063C (en) * 1996-08-30 2007-03-13 Eli Lilly And Company Cryptophycin compounds
JP2001506970A (en) * 1996-09-06 2001-05-29 イーライ・リリー・アンド・カンパニー Methods and novel intermediates
US6143909A (en) * 1997-02-26 2000-11-07 Eli Lilly And Company Selective epoxidation process for preparing pharmaceutical compounds
CA2281107A1 (en) * 1997-02-26 1998-09-03 Eli Lilly And Company Tripeptide and tetrapeptide pharmaceutical compounds
EP0870501A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Use of specific cryptophycin derivatives for the manufacture of a medicament in the treatment of fungal infections
EP0870506A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer
US6180679B1 (en) * 1998-04-07 2001-01-30 Eli Lilly And Company Method for treating fungal infections
US6376230B1 (en) 1998-10-16 2002-04-23 Eli Lilly And Company Stereoselective process for producing intermediates of cryptophycins
US6103913A (en) * 1998-10-16 2000-08-15 Eli Lilly And Company Process for preparing enollactone derivatives
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AU2002238939A1 (en) * 2002-03-18 2003-09-29 Nihon University Cyclic etheramine derivatives as medicaments for malignant tumors
US7229814B2 (en) * 2004-05-05 2007-06-12 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
US20110098477A1 (en) * 2005-06-28 2011-04-28 Chugai Seiyaku Kabushiki Kaisha Method Of Producing Compound Having Anti-Hcv Activity
CN103724290B (en) * 2013-11-15 2015-04-29 浙江大学 Cyclopeptide compound clavatustide A as well as producing strain, preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
WO1996040184A1 (en) * 1995-03-07 1996-12-19 University Of Hawaii New cryptophycins from synthesis
WO1996039829A1 (en) * 1995-06-07 1996-12-19 University Of Hawaii New cryptophycins
WO1997008334A1 (en) * 1995-08-30 1997-03-06 University Of Hawaii Cryptophycins from aberrant biosynthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
WO1996040184A1 (en) * 1995-03-07 1996-12-19 University Of Hawaii New cryptophycins from synthesis
WO1996039829A1 (en) * 1995-06-07 1996-12-19 University Of Hawaii New cryptophycins
WO1997008334A1 (en) * 1995-08-30 1997-03-06 University Of Hawaii Cryptophycins from aberrant biosynthesis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BARROW, RUSSELL A. ET AL: "Total Synthesis of Cryptophycins. Revision of the Structures of Cryptophycins A and C", J. AM. CHEM. SOC. (1995), 117(9), 2479-90, XP002066281 *
KOBAYASHI, MOTOMASA ET AL: "The absolute stereostructure of arenastatin A, a potent cytotoxic depsipeptide from the Okinawan marine sponge Dysidea arenaria", CHEM. PHARM. BULL. (1994), 42(10), 2196-8, XP002159595 *
See also references of WO9707798A1 *
TRIMURTULU, GOLAKOTI ET AL: "Total Structures of Cryptophycins, Potent Antitumor Depsipeptides from th Blue-Green Alga Nostoc sp. Strain GSV 224", J. AM. CHEM. SOC. (1994), 116(11), 4729-37, XP002159594 *

Also Published As

Publication number Publication date
CA2230540A1 (en) 1997-03-06
AU7109096A (en) 1997-03-19
BR9610214A (en) 1999-06-15
EP0850316A1 (en) 1998-07-01
EP0850316A4 (en) 2000-08-23
AU6904896A (en) 1997-03-19
CA2246117A1 (en) 1997-03-06
WO1997007798A1 (en) 1997-03-06
JP2000507805A (en) 2000-06-27
AU709828B2 (en) 1999-09-09
WO1997008334A1 (en) 1997-03-06
EP0850057A1 (en) 1998-07-01
JP2000501067A (en) 2000-02-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19980226

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

Effective date: 20010222

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: WAYNE STATE UNIVERSITY

Owner name: UNIVERSITY OF HAWAII

17Q First examination report despatched

Effective date: 20030826

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040106