EP0900081A4 - Inhibiteurs de farnesyl-proteine transferase - Google Patents

Inhibiteurs de farnesyl-proteine transferase

Info

Publication number
EP0900081A4
EP0900081A4 EP97917604A EP97917604A EP0900081A4 EP 0900081 A4 EP0900081 A4 EP 0900081A4 EP 97917604 A EP97917604 A EP 97917604A EP 97917604 A EP97917604 A EP 97917604A EP 0900081 A4 EP0900081 A4 EP 0900081A4
Authority
EP
European Patent Office
Prior art keywords
farnesyl
protein transferase
transferase inhibitors
inhibitors
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97917604A
Other languages
German (de)
English (en)
Other versions
EP0900081A1 (fr
Inventor
Christopher J Dinsmore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9610338.7A external-priority patent/GB9610338D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0900081A1 publication Critical patent/EP0900081A1/fr
Publication of EP0900081A4 publication Critical patent/EP0900081A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP97917604A 1996-04-03 1997-03-27 Inhibiteurs de farnesyl-proteine transferase Withdrawn EP0900081A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1479296P 1996-04-03 1996-04-03
US14792P 1996-04-03
GBGB9610338.7A GB9610338D0 (en) 1996-05-17 1996-05-17 Inhibitors of farnesyl-protein transferase
GB9610338 1996-05-17
PCT/US1997/004750 WO1997036591A1 (fr) 1996-04-03 1997-03-27 Inhibiteurs de farnesyl-proteine transferase

Publications (2)

Publication Number Publication Date
EP0900081A1 EP0900081A1 (fr) 1999-03-10
EP0900081A4 true EP0900081A4 (fr) 2002-01-09

Family

ID=26309349

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97917604A Withdrawn EP0900081A4 (fr) 1996-04-03 1997-03-27 Inhibiteurs de farnesyl-proteine transferase

Country Status (5)

Country Link
EP (1) EP0900081A4 (fr)
JP (1) JP2001518067A (fr)
AU (1) AU707347B2 (fr)
CA (1) CA2250587A1 (fr)
WO (1) WO1997036591A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002519428A (ja) 1998-07-02 2002-07-02 メルク エンド カムパニー インコーポレーテッド プレニル−タンパク質トランスフェラーゼの阻害剤
WO2007031791A1 (fr) 2005-09-16 2007-03-22 Arrow Therapeutics Limited Dérivés de biphényle et leur utilisation dans le traitement de l'hépatite c
CA2756870A1 (fr) 2009-03-31 2010-10-07 Arqule, Inc. Composes indolo-pyridinone substitues
AU2011261375B2 (en) 2010-06-04 2016-09-22 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA983495A (en) * 1972-10-11 1976-02-10 Gilbert Regnier Procede de preparation de derives du benzodioxole
US4598079A (en) * 1981-08-20 1986-07-01 Cassella Aktiengesellschaft 2-(aryl substitued)piperazinones and nootropic compositions based thereon
WO1993021186A1 (fr) * 1992-04-13 1993-10-28 Fujisawa Pharmaceutical Co., Ltd. 3-pyrrolidinylthio-carbapenemes substitues, utilises comme agents antimicrobiens
WO1995000497A1 (fr) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibiteurs de farnesyle-proteine transferase
US5382584A (en) * 1992-07-31 1995-01-17 Bristol-Myers Squibb Company Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
EP0670314A1 (fr) * 1993-09-22 1995-09-06 Kyowa Hakko Kogyo Co., Ltd. Inhibiteur de la farnesyl-transferase
WO1996030343A1 (fr) * 1995-03-29 1996-10-03 Merck & Co., Inc. Inhibiteurs de farnesyl-proteine transferase
WO1996037204A1 (fr) * 1995-05-24 1996-11-28 Merck & Co., Inc. Inhibiteurs de la farnesyle-proteine transferase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915981A (en) * 1973-03-16 1975-10-28 Yoshitomi Pharmaceutical 1-{8 2-(2-Chlorobenzoyl)-4-nitrophenyl{9 -2-(diethylaminomethyl)-imidazole
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4835154A (en) * 1987-06-01 1989-05-30 Smithkline Beckman Corporation 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US5219856A (en) * 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
US5478934A (en) * 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
WO1996016057A1 (fr) * 1994-11-23 1996-05-30 Neurogen Corporation Certains derives d'aminoethyl imidazole et pyrrole substitues en 1; nouveaux ligands specifiques d'un sous-type de recepteur dopaminergique

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA983495A (en) * 1972-10-11 1976-02-10 Gilbert Regnier Procede de preparation de derives du benzodioxole
US4598079A (en) * 1981-08-20 1986-07-01 Cassella Aktiengesellschaft 2-(aryl substitued)piperazinones and nootropic compositions based thereon
WO1993021186A1 (fr) * 1992-04-13 1993-10-28 Fujisawa Pharmaceutical Co., Ltd. 3-pyrrolidinylthio-carbapenemes substitues, utilises comme agents antimicrobiens
US5382584A (en) * 1992-07-31 1995-01-17 Bristol-Myers Squibb Company Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
WO1995000497A1 (fr) * 1993-06-18 1995-01-05 Merck & Co., Inc. Inhibiteurs de farnesyle-proteine transferase
EP0670314A1 (fr) * 1993-09-22 1995-09-06 Kyowa Hakko Kogyo Co., Ltd. Inhibiteur de la farnesyl-transferase
WO1996030343A1 (fr) * 1995-03-29 1996-10-03 Merck & Co., Inc. Inhibiteurs de farnesyl-proteine transferase
WO1996037204A1 (fr) * 1995-05-24 1996-11-28 Merck & Co., Inc. Inhibiteurs de la farnesyle-proteine transferase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9736591A1 *

Also Published As

Publication number Publication date
EP0900081A1 (fr) 1999-03-10
AU707347B2 (en) 1999-07-08
WO1997036591A1 (fr) 1997-10-09
JP2001518067A (ja) 2001-10-09
AU2587997A (en) 1997-10-22
CA2250587A1 (fr) 1997-10-09

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