EP0929218A4 - R2Y RECEPTOR ANTAGONISTS - Google Patents

R2Y RECEPTOR ANTAGONISTS

Info

Publication number
EP0929218A4
EP0929218A4 EP97952172A EP97952172A EP0929218A4 EP 0929218 A4 EP0929218 A4 EP 0929218A4 EP 97952172 A EP97952172 A EP 97952172A EP 97952172 A EP97952172 A EP 97952172A EP 0929218 A4 EP0929218 A4 EP 0929218A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97952172A
Other languages
German (de)
French (fr)
Other versions
EP0929218A2 (en
Inventor
Jose L Boyer
T Kendall Harden
Kenneth A Jacobson
Emidio Camaioni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of EP0929218A2 publication Critical patent/EP0929218A2/en
Publication of EP0929218A4 publication Critical patent/EP0929218A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP97952172A 1996-10-30 1997-10-23 R2Y RECEPTOR ANTAGONISTS Withdrawn EP0929218A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2985596P 1996-10-30 1996-10-30
US29855P 1996-10-30
PCT/US1997/019922 WO1998018430A2 (en) 1996-10-30 1997-10-23 P2y receptor antagonists

Publications (2)

Publication Number Publication Date
EP0929218A2 EP0929218A2 (en) 1999-07-21
EP0929218A4 true EP0929218A4 (en) 2001-05-16

Family

ID=21851254

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97952172A Withdrawn EP0929218A4 (en) 1996-10-30 1997-10-23 R2Y RECEPTOR ANTAGONISTS

Country Status (5)

Country Link
EP (1) EP0929218A4 (en)
JP (1) JP2001504097A (en)
AU (1) AU5584698A (en)
CA (1) CA2241687A1 (en)
WO (1) WO1998018430A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100719606B1 (en) 1998-02-25 2007-05-17 에모리 유니버시티 2'-fluoronucleosides
SE9802574D0 (en) * 1998-07-17 1998-07-17 Astra Pharma Prod Novel compounds
AU6234000A (en) * 1999-07-22 2001-02-13 Supergen, Inc. Methods for treating autoimmune diseases
US7115585B2 (en) * 2000-08-21 2006-10-03 Inspire Pharmaceuticals, Inc. Compositions for treating epithelial and retinal tissue diseases
US20040122223A1 (en) * 2001-02-07 2004-06-24 Davis Jeremy Martin Non-natural nucleotides and dinucleotides
KR20050043761A (en) * 2001-11-06 2005-05-11 인스파이어 파마슈티컬스 인코퍼레이티드 Method for treating or preventing inflammatory diseases
KR20050097971A (en) * 2003-02-03 2005-10-10 씨브이 쎄러퓨틱스, 인코포레이티드 Partial and full agonists of a1 adenosine receptors
ATE460402T1 (en) 2004-05-12 2010-03-15 Bristol Myers Squibb Co UREA ANTAGONISTS OF THE P2Y1 RECEPTOR SUITABLE FOR THE TREATMENT OF THROMBOTIC DISEASES
US7550499B2 (en) * 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
EP1954696B1 (en) 2005-01-19 2011-02-23 Bristol-Myers Squibb Company 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders
AR056867A1 (en) * 2005-06-27 2007-10-31 Bristol Myers Squibb Co HETEROCICLIC ANTAGONISTS N- LINKED TO THE RECEIVER OF P2Y1 USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS. PHARMACEUTICAL COMPOSITIONS.
WO2007002634A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
DE602006020871D1 (en) 2005-06-27 2011-05-05 Bristol Myers Squibb Co LINEAR UREA MIMETIC ANTAGONISTS OF THE P2Y1 RECEPTOR FOR THE TREATMENT OF THROMBOSELEIDES
EP1899299B1 (en) 2005-06-27 2010-10-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
AR064245A1 (en) 2006-11-17 2009-03-25 Epix Delaware Inc ADENOSINE ANALOGS AND ITS USE

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2331223A1 (en) * 1972-06-19 1974-01-17 Kohjin Co S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors
US3846402A (en) * 1971-05-06 1974-11-05 Max Planck Gesellschaft Thiophosphate analogues of the nucleoside diphosphates and triphosphates and a method for the preparation thereof
GB1433507A (en) * 1972-05-15 1976-04-28 Takeda Chemical Industries Ltd Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates
US4266048A (en) * 1977-10-11 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
US4719295A (en) * 1985-12-31 1988-01-12 Warner-Lambert Company Compound 2-iodo-2'-deoxyadenosine
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
WO1992017488A1 (en) * 1991-04-06 1992-10-15 Fisons Plc Atp analogues
WO1994018216A1 (en) * 1993-02-10 1994-08-18 Astra Pharmaceuticals Limited N-alkyl-2-substituted atp analogues
WO1995010287A1 (en) * 1993-10-15 1995-04-20 Wisconsin Alumni Research Foundation Substituted purine nucleoside analogs and method for treating endotoxin shock
WO1996029345A1 (en) * 1995-03-23 1996-09-26 The Trustees Of The University Of Pennsylvania Novel inotropic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788181A (en) * 1986-09-29 1988-11-29 The United States Of America As Represented By The Department Of Health And Human Services 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846402A (en) * 1971-05-06 1974-11-05 Max Planck Gesellschaft Thiophosphate analogues of the nucleoside diphosphates and triphosphates and a method for the preparation thereof
GB1433507A (en) * 1972-05-15 1976-04-28 Takeda Chemical Industries Ltd Pharmaceutically active 2-substituted adenosine-3,5-cyclic monophosphates
DE2331223A1 (en) * 1972-06-19 1974-01-17 Kohjin Co S-substd 2-thioadenosines - as coronary vasodilators and blood platelet aggregation inhibitors
US4266048A (en) * 1977-10-11 1981-05-05 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
US4828979A (en) * 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4719295A (en) * 1985-12-31 1988-01-12 Warner-Lambert Company Compound 2-iodo-2'-deoxyadenosine
WO1992017488A1 (en) * 1991-04-06 1992-10-15 Fisons Plc Atp analogues
WO1994018216A1 (en) * 1993-02-10 1994-08-18 Astra Pharmaceuticals Limited N-alkyl-2-substituted atp analogues
WO1995010287A1 (en) * 1993-10-15 1995-04-20 Wisconsin Alumni Research Foundation Substituted purine nucleoside analogs and method for treating endotoxin shock
WO1996029345A1 (en) * 1995-03-23 1996-09-26 The Trustees Of The University Of Pennsylvania Novel inotropic agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOYER, J.L. ET AL.: "Identification of competitive antagonists of the P2Y1 receptor", MOL. PHARMACOL., vol. 50, 1996, pages 1323 - 9, XP000944991 *
BRENNAN, C.A. AND GUMPORT, R. I.: "T4 RNA ligase catalyzed synthesis of base analogue-containing oligodeoxyribonucleotides and a characterization of thermal stabilities", NUCLEIC ACIDS RES., vol. 13, 1985, pages 8665 - 84, XP000944971 *
FISCHER, B. ET AL.: "Identification of potent, selective P2Y-purinoreceptor antagonists: relationship or 2-thioether derivatives of adenosine 5'-triphosphate", J. MED. CHEM., vol. 36, 1993, pages 3937 - 46, XP002155543 *
See also references of WO9818430A3 *
VAN RHEE, A.M. ET AL.: "Novel competitive antagonists for P2 purinoreceptors", EUR. J. PHARMACOL. MOL. PHARMACOL. SECT., vol. 268, 1994, pages 1 - 7, XP000944973 *

Also Published As

Publication number Publication date
EP0929218A2 (en) 1999-07-21
WO1998018430A2 (en) 1998-05-07
WO1998018430A3 (en) 1998-06-18
JP2001504097A (en) 2001-03-27
CA2241687A1 (en) 1998-05-07
AU5584698A (en) 1998-05-22

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