EP0941086A4 - NITROSIC AND NITROSYL COMPOUNDS INHIBITORS OF PHOSPHODIESTERASE, COMPOSITIONS COMPRISING SUCH COMPOUNDS AND USES THEREOF - Google Patents

NITROSIC AND NITROSYL COMPOUNDS INHIBITORS OF PHOSPHODIESTERASE, COMPOSITIONS COMPRISING SUCH COMPOUNDS AND USES THEREOF

Info

Publication number
EP0941086A4
EP0941086A4 EP97946871A EP97946871A EP0941086A4 EP 0941086 A4 EP0941086 A4 EP 0941086A4 EP 97946871 A EP97946871 A EP 97946871A EP 97946871 A EP97946871 A EP 97946871A EP 0941086 A4 EP0941086 A4 EP 0941086A4
Authority
EP
European Patent Office
Prior art keywords
compounds
nitrosic
phosphodiesterase
compositions
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97946871A
Other languages
German (de)
French (fr)
Other versions
EP0941086A1 (en
Inventor
David S Garvey
De Tejada Inigo Saenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitromed Inc
Original Assignee
Nitromed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/740,764 external-priority patent/US5874437A/en
Application filed by Nitromed Inc filed Critical Nitromed Inc
Publication of EP0941086A1 publication Critical patent/EP0941086A1/en
Publication of EP0941086A4 publication Critical patent/EP0941086A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Paper (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP97946871A 1996-11-01 1997-10-31 NITROSIC AND NITROSYL COMPOUNDS INHIBITORS OF PHOSPHODIESTERASE, COMPOSITIONS COMPRISING SUCH COMPOUNDS AND USES THEREOF Withdrawn EP0941086A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/740,764 US5874437A (en) 1996-11-01 1996-11-01 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US740764 1996-11-01
PCT/US1997/019870 WO1998019672A1 (en) 1996-11-01 1997-10-31 Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses

Publications (2)

Publication Number Publication Date
EP0941086A1 EP0941086A1 (en) 1999-09-15
EP0941086A4 true EP0941086A4 (en) 2000-07-12

Family

ID=26792881

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97946871A Withdrawn EP0941086A4 (en) 1996-11-01 1997-10-31 NITROSIC AND NITROSYL COMPOUNDS INHIBITORS OF PHOSPHODIESTERASE, COMPOSITIONS COMPRISING SUCH COMPOUNDS AND USES THEREOF

Country Status (5)

Country Link
EP (1) EP0941086A4 (en)
JP (1) JP2001504457A (en)
AU (1) AU722480B2 (en)
CA (1) CA2270118A1 (en)
WO (1) WO1998019672A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
EP1535611A3 (en) * 1997-06-23 2009-09-16 Strakan International Limited Microdose therapy of vascular conditions by no donors
JP2003525845A (en) * 1997-10-28 2003-09-02 ヴィヴァス・インコーポレイテッド Topical administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6200591B1 (en) 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
BR9916162A (en) * 1998-12-14 2001-09-04 Cellegy Pharma Inc Composition and method for the treatment of an anorectal disorder and for controlling the pain associated with it
US6627632B2 (en) 1998-12-14 2003-09-30 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
US6476037B1 (en) * 2000-03-23 2002-11-05 The Regents Of The University Of California L-arginine and phosphodiesterase (PDE) inhibitor synergism
AU2000270300A1 (en) * 2000-09-13 2002-03-26 Isis Innovation Limited Use of phosphodiesterase inhibitors for the treatment of anorectal disorders
WO2002087508A2 (en) 2001-05-02 2002-11-07 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
DE60230266D1 (en) * 2001-06-15 2009-01-22 Astellas Pharma Inc PHENYLPYRIDINCARBONYL PIPERAZINE DERIVATIVES
NZ532310A (en) 2001-10-05 2007-02-23 Combinatorx Inc Combinations comprising a tetra-substituted pyrimidopyrimidine and a corticosteroid for the treatment of immunoinflammatory disorders
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US7875268B2 (en) 2004-04-06 2011-01-25 L'oreal S.A. Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith
US7067659B2 (en) * 2004-04-23 2006-06-27 Duke University Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
ATE462703T1 (en) 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd BICYCLONONE DERIVATIVES AS RENIN INHIBITORS
WO2006041855A2 (en) 2004-10-04 2006-04-20 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
GEP20115206B (en) 2005-05-27 2011-04-26 Actelion Pharmaceuticals Ltd Novel piperidine carboxylic acid amide derivatives
EP1915157A4 (en) 2005-08-02 2010-09-01 Nicox Sa Nitric oxide enhancing antimicrobial compounds, compositions and methods of use
NZ570828A (en) 2006-02-02 2011-07-29 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
AU2007243765A1 (en) 2006-03-29 2007-11-08 Nicox S.A. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
KR101403311B1 (en) 2008-05-05 2014-06-05 액테리온 파마슈티칼 리미티드 3,4-Substituted piperidine derivatives as renin inhibitors
NO2440239T3 (en) 2009-06-09 2018-02-10
MX2019013626A (en) * 2017-05-22 2020-01-13 Topadur Pharma Ag Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof.
WO2022022669A1 (en) * 2020-07-30 2022-02-03 Biofront Therapeutics (Beijing) Co., Ltd. Dual-functional compounds and methods of use
CA3187693A1 (en) * 2020-07-30 2022-02-03 Zheng Huang Drug conjugates comprising apremilast, and a nitric oxide-releasing moiety and uses thereof
WO2023005180A1 (en) * 2021-07-30 2023-02-02 Biofront Therapeutics (Beijing) Co., Ltd. Dual-functional compounds and methods of use

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252721A1 (en) * 1986-07-07 1988-01-13 Ortho Pharmaceutical Corporation 4-Nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
EP0352960A2 (en) * 1988-07-25 1990-01-31 Smith Kline & French Laboratories Limited Purine compounds, process for their preparation and pharmaceutical compositions
EP0442204A2 (en) * 1989-12-15 1991-08-21 Smith Kline & French Laboratories Limited Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
EP0463756A1 (en) * 1990-06-20 1992-01-02 Pfizer Limited Pyrazolopyrimidinone antianginal agents
EP0506194A1 (en) * 1991-03-25 1992-09-30 Akzo Nobel N.V. 4-aryl-thiazole or imidazole derivatives
WO1993012068A1 (en) * 1991-12-11 1993-06-24 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
WO1995009636A1 (en) * 1993-10-04 1995-04-13 The Trustees Of Columbia University In The City Ofnew York Method of inducing vasorelaxation to treat pulmonary hypertension
WO1996025184A1 (en) * 1995-02-16 1996-08-22 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
WO1997034871A1 (en) * 1996-03-22 1997-09-25 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
WO1997039760A1 (en) * 1996-04-23 1997-10-30 Queen's University At Kingston Combination therapy for treatment of erectile dysfunction

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179019B (en) * 1978-11-01 1982-08-28 Gyogyszekutato Intezet Process for preparing 4-//3,4-dialkoxy-phenyl/-alkyl/- 2imidazolidinone derivatives
US5459145A (en) * 1988-01-19 1995-10-17 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
GB8929208D0 (en) * 1989-12-27 1990-02-28 Almirall Lab New xanthine derivatives
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9212693D0 (en) * 1992-06-15 1992-07-29 Celltech Ltd Chemical compounds
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
DE59410119D1 (en) * 1993-07-02 2002-06-20 Byk Gulden Lomberg Chem Fab FLUORALKOXY SUBSTITUTED BENZAMIDES AND THEIR USE AS CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252721A1 (en) * 1986-07-07 1988-01-13 Ortho Pharmaceutical Corporation 4-Nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
EP0352960A2 (en) * 1988-07-25 1990-01-31 Smith Kline & French Laboratories Limited Purine compounds, process for their preparation and pharmaceutical compositions
EP0442204A2 (en) * 1989-12-15 1991-08-21 Smith Kline & French Laboratories Limited Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
EP0463756A1 (en) * 1990-06-20 1992-01-02 Pfizer Limited Pyrazolopyrimidinone antianginal agents
EP0506194A1 (en) * 1991-03-25 1992-09-30 Akzo Nobel N.V. 4-aryl-thiazole or imidazole derivatives
US5380758A (en) * 1991-03-29 1995-01-10 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
WO1993012068A1 (en) * 1991-12-11 1993-06-24 Brigham And Women's Hospital S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof
WO1995009636A1 (en) * 1993-10-04 1995-04-13 The Trustees Of Columbia University In The City Ofnew York Method of inducing vasorelaxation to treat pulmonary hypertension
WO1996025184A1 (en) * 1995-02-16 1996-08-22 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
WO1997034871A1 (en) * 1996-03-22 1997-09-25 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
WO1997039760A1 (en) * 1996-04-23 1997-10-30 Queen's University At Kingston Combination therapy for treatment of erectile dysfunction

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
A.J.M. BARBIER ET AL., BR. J. PHARMACOL., vol. 111, no. 4, 1994, pages 1280 - 1286 *
AM. J. PHYSIOL., vol. 265, no. 3(1), 1993, pages G418 - G422 *
BOOLELL M ET AL: "SILDENAFIL, A NOVEL EFFECTIVE ORAL THERAPY FOR MALE ERECTILE DYSFUNCTION", BRITISH JOURNAL OF UROLOGY,GB,EDINBURGH, vol. 78, no. 2, 1996, pages 257-261, XP000853934 *
CHEMICAL ABSTRACTS, vol. 116, no. 1, 6 January 1992, Columbus, Ohio, US; abstract no. 4477, XP002127110 *
CHEMICAL ABSTRACTS, vol. 120, no. 1, 3 January 1994, Columbus, Ohio, US; abstract no. 5451d, XP002107375 *
CHEMICAL ABSTRACTS, vol. 120, no. 25, 20 June 1994, Columbus, Ohio, US; abstract no. 315630, XP002127108 *
CHEMICAL ABSTRACTS, vol. 121, no. 7, 15 August 1994, Columbus, Ohio, US; abstract no. 73410, XP002127109 *
CHEMICAL ABSTRACTS, vol. 123, no. 1, 3 July 1995, Columbus, Ohio, US; abstract no. 574, XP002127107 *
CHEMICAL ABSTRACTS, vol. 125, no. 15, 7 October 1996, Columbus, Ohio, US; abstract no. 191382, XP002127106 *
F. ICHINOSE ET AL., J. APPL. PHYSIOL., vol. 78, no. 4, 1995, pages 1288 - 1295 *
J. DE VENTE ET AL., J. CHEM. NEUROANAT., vol. 10, no. 3,4, 1996, pages 241 - 248 *
M.W. RADOMSKI ET AL., CANCER RES., vol. 51, no. 22, 1991, pages 6073 - 6078 *
MARTEL A M ET AL: "Sildenafil", DRUGS OF THE FUTURE,ES,BARCELONA, vol. 22, no. 2, 1997, pages 138-143, XP002090616, ISSN: 0377-8282 *
N.A. ALLEN ET AL., BR. J. PHARMACOL., vol. 112, no. 2, 1994, pages 423 - 428 *
See also references of WO9819672A1 *

Also Published As

Publication number Publication date
AU5196298A (en) 1998-05-29
EP0941086A1 (en) 1999-09-15
JP2001504457A (en) 2001-04-03
AU722480B2 (en) 2000-08-03
WO1998019672A1 (en) 1998-05-14
CA2270118A1 (en) 1998-05-14

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