EP0977567A4 - CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SAID COMPOUNDS AND METHODS OF TREATMENT - Google Patents

CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SAID COMPOUNDS AND METHODS OF TREATMENT

Info

Publication number
EP0977567A4
EP0977567A4 EP97943428A EP97943428A EP0977567A4 EP 0977567 A4 EP0977567 A4 EP 0977567A4 EP 97943428 A EP97943428 A EP 97943428A EP 97943428 A EP97943428 A EP 97943428A EP 0977567 A4 EP0977567 A4 EP 0977567A4
Authority
EP
European Patent Office
Prior art keywords
compounds
treatment
methods
compositions containing
carbapenem antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97943428A
Other languages
German (de)
French (fr)
Other versions
EP0977567A1 (en
Inventor
Lovji D Cama
Robert R Wilkening
Ronald W Ratcliffe
Timothy A Blizzard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9701605.9A external-priority patent/GB9701605D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0977567A4 publication Critical patent/EP0977567A4/en
Publication of EP0977567A1 publication Critical patent/EP0977567A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP97943428A 1996-09-13 1997-09-09 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment Withdrawn EP0977567A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2618296P 1996-09-13 1996-09-13
US26182P 1996-09-13
GBGB9701605.9A GB9701605D0 (en) 1997-01-27 1997-01-27 Carbapenham antibacterial compounds compositions containing such compounds and methods of treatment
GB9701605 1997-01-27
PCT/US1997/016786 WO1998010761A1 (en) 1996-09-13 1997-09-09 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Publications (2)

Publication Number Publication Date
EP0977567A4 true EP0977567A4 (en) 2000-02-09
EP0977567A1 EP0977567A1 (en) 2000-02-09

Family

ID=26310862

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97943428A Withdrawn EP0977567A1 (en) 1996-09-13 1997-09-09 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Country Status (5)

Country Link
EP (1) EP0977567A1 (en)
JP (1) JP2002515882A (en)
AU (1) AU4490597A (en)
CA (1) CA2264605A1 (en)
WO (1) WO1998010761A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002509856A (en) * 1997-10-23 2002-04-02 メルク エンド カムパニー インコーポレーテッド Carbapenem antibacterial compounds, compositions and methods of treatment
CN1968932A (en) 2004-06-18 2007-05-23 惠氏公司 Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines
JP2026507461A (en) * 2023-03-01 2026-03-04 成都先導薬物開発股▲フン▼有限公司 Aromatic ring compounds and their uses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192758A (en) * 1992-02-28 1993-03-09 Merck & Co., Inc. 2-biphenyl-carbapenem antibacterial agents
US5451579A (en) * 1994-02-15 1995-09-19 Merck & Co., Inc. 1-β-methyl-carbapenem, compositions containing same and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578722A (en) * 1994-03-29 1996-11-26 Sumitomo Pharmaceuticals Co., Ltd. Process for preparing carbapenem compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192758A (en) * 1992-02-28 1993-03-09 Merck & Co., Inc. 2-biphenyl-carbapenem antibacterial agents
US5451579A (en) * 1994-02-15 1995-09-19 Merck & Co., Inc. 1-β-methyl-carbapenem, compositions containing same and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9810761A1 *

Also Published As

Publication number Publication date
AU4490597A (en) 1998-04-02
WO1998010761A1 (en) 1998-03-19
JP2002515882A (en) 2002-05-28
CA2264605A1 (en) 1998-03-19
EP0977567A1 (en) 2000-02-09

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