EP1003521A4 - METHODS OF POTENTIALIZING INTRAVENOUS PHOSPHATE ESTRAMUSTINE - Google Patents

METHODS OF POTENTIALIZING INTRAVENOUS PHOSPHATE ESTRAMUSTINE

Info

Publication number: EP1003521A4
Authority: EP; European Patent Office
Prior art keywords: potentializing; methods; intravenous; estramustine; phosphate estramustine
Prior art date: 1998-03-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99914884A

Other languages

German (de)

French (fr)

Other versions

EP1003521A1 (en

Inventor

Michael S Kopreski

Beryl Asp

Bo Fredholm

Per-Olv Gunnarsson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co LLC

Original Assignee

Pharmacia and Upjohn Co

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-27

Filing date

1999-03-26

Publication date

2003-07-23

1999-03-26 Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co

2000-05-31 Publication of EP1003521A1 publication Critical patent/EP1003521A1/en

2003-07-23 Publication of EP1003521A4 publication Critical patent/EP1003521A4/en

Status Withdrawn legal-status Critical Current

Links

229910019142 PO4 Inorganic materials 0.000 title 1
FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 title 1
229960001842 estramustine Drugs 0.000 title 1
238000001990 intravenous administration Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
239000010452 phosphate Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

EP99914884A 1998-03-27 1999-03-26 METHODS OF POTENTIALIZING INTRAVENOUS PHOSPHATE ESTRAMUSTINE Withdrawn EP1003521A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US7954298P	1998-03-27	1998-03-27
US79542P		1998-03-27
PCT/US1999/004275 WO1999049869A1 (en)	1998-03-27	1999-03-26	Methods to potentiate intravenous estramustine phosphate

Publications (2)

Publication Number	Publication Date
EP1003521A1 EP1003521A1 (en)	2000-05-31
EP1003521A4 true EP1003521A4 (en)	2003-07-23

Family

ID=22151209

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99914884A Withdrawn EP1003521A4 (en)	1998-03-27	1999-03-26	METHODS OF POTENTIALIZING INTRAVENOUS PHOSPHATE ESTRAMUSTINE

Country Status (16)

Country	Link
EP (1)	EP1003521A4 (en)
JP (1)	JP2001508810A (en)
KR (1)	KR20010021656A (en)
CN (2)	CN1636598A (en)
AU (1)	AU750010B2 (en)
BR (1)	BR9906425A (en)
CA (1)	CA2295049A1 (en)
EA (1)	EA004647B1 (en)
HU (1)	HUP0200547A3 (en)
ID (1)	ID24504A (en)
IL (1)	IL133612A0 (en)
NO (1)	NO20002343L (en)
NZ (1)	NZ501987A (en)
PL (1)	PL342969A1 (en)
WO (1)	WO1999049869A1 (en)
ZA (1)	ZA997821B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0003201D0 (en) *	2000-02-11	2000-04-05	Pharmacia & Upjohn Spa	Method to potentiate the therapeutic efficacy of taxane and derivatives thereof
US6436913B1 (en) *	2000-07-25	2002-08-20	Pharmacia & Upjohn Company	Use of estramustine phosphate in the treatment of bone metastasis
RU2471511C1 (en) *	2011-05-04	2013-01-10	Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "РНИОИ" Минздравсоцразвития России)	Method of treating colonic liver metastases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4584136A (en) *	1984-06-20	1986-04-22	Japan Atomic Energy Research Institute	Process for preparing Estracyt compounds having a carcinostatic bound thereto
US5728687A (en) *	1992-11-10	1998-03-17	Rhone-Poulenc Rorer, S.A.	Antitumour compositions containing taxane derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5077056A (en) *	1984-08-08	1991-12-31	The Liposome Company, Inc.	Encapsulation of antineoplastic agents in liposomes
MX9203808A (en) *	1987-03-05	1992-07-01	Liposome Co Inc	HIGH DRUG CONTENT FORMULATIONS: LIPID, FROM LIPOSOMIC-ANTINEOPLASTIC AGENTS.
DE69329073T2 (en) *	1992-03-23	2001-01-18	Georgetown University, Washington	TAXOL ENCLOSED IN LIPOSOMES AND METHOD OF USE

1999
- 1999-03-26 IL IL13361299A patent/IL133612A0/en not_active IP Right Cessation
- 1999-03-26 CA CA002295049A patent/CA2295049A1/en not_active Abandoned
- 1999-03-26 EP EP99914884A patent/EP1003521A4/en not_active Withdrawn
- 1999-03-26 KR KR1020007000214A patent/KR20010021656A/en not_active Ceased
- 1999-03-26 CN CNA2004100867183A patent/CN1636598A/en active Pending
- 1999-03-26 PL PL99342969A patent/PL342969A1/en unknown
- 1999-03-26 ID IDW20000105A patent/ID24504A/en unknown
- 1999-03-26 BR BR9906425-1A patent/BR9906425A/en not_active IP Right Cessation
- 1999-03-26 WO PCT/US1999/004275 patent/WO1999049869A1/en not_active Ceased
- 1999-03-26 AU AU33533/99A patent/AU750010B2/en not_active Ceased
- 1999-03-26 NZ NZ501987A patent/NZ501987A/en unknown
- 1999-03-26 EA EA199901081A patent/EA004647B1/en not_active IP Right Cessation
- 1999-03-26 HU HU0200547A patent/HUP0200547A3/en unknown
- 1999-03-26 JP JP54936999A patent/JP2001508810A/en not_active Ceased
- 1999-03-26 CN CN99800823A patent/CN1273530A/en active Pending
- 1999-12-22 ZA ZA9907821A patent/ZA997821B/en unknown
2000
- 2000-05-04 NO NO20002343A patent/NO20002343L/en not_active Application Discontinuation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4584136A (en) *	1984-06-20	1986-04-22	Japan Atomic Energy Research Institute	Process for preparing Estracyt compounds having a carcinostatic bound thereto
US5728687A (en) *	1992-11-10	1998-03-17	Rhone-Poulenc Rorer, S.A.	Antitumour compositions containing taxane derivatives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GARCIA A A ET AL: "PHASE I AND PHARMACOLOGIC STUDY OF ESTRAMUSTINE PHOSPHATE AND SHORTINFUSIONS OF PACLITAXEL IN WOMEN WITH SOLID TUMORS", JOURNAL OF CLINICAL ONCOLOGY, PHILADELPHIA, PA, US, vol. 16, no. 9, September 1998 (1998-09-01), pages 2959 - 2963, XP001000703 *
GUNNARSSON ET AL: "Pharmacokenetics of estramustine phosphate in prostatic cancer patients", EUR.J.PHARMACOL, vol. 26, 1984, pages 113 - 119 *
HUDES G R ET AL: "PACLITAXEL PLUS ESTRAMUSTINE IN METASTATIC HORMONE-REFRACTORY PROSTATE CANCER", SEMINARS IN ONCOLOGY, BETHESDA, MD, US, vol. 22, no. 5, SUPPL 12, October 1995 (1995-10-01), pages 41 - 45, XP001000716 *
NAGEL ET AL: "Treatment of advanced carcinoma of the prostrate with estramustine phopshate", BR.J.UROL., vol. 49, 1977, pages 73 - 79 *
See also references of WO9949869A1 *

Also Published As

Publication number	Publication date
WO1999049869A1 (en)	1999-10-07
HUP0200547A2 (en)	2002-07-29
JP2001508810A (en)	2001-07-03
EA199901081A1 (en)	2000-12-25
CN1636598A (en)	2005-07-13
EP1003521A1 (en)	2000-05-31
AU3353399A (en)	1999-10-18
HUP0200547A3 (en)	2003-07-28
NZ501987A (en)	2002-10-25
CA2295049A1 (en)	1999-10-07
ZA997821B (en)	2000-08-01
AU750010B2 (en)	2002-07-11
EA004647B1 (en)	2004-06-24
ID24504A (en)	2000-07-20
PL342969A1 (en)	2001-07-16
BR9906425A (en)	2000-07-11
CN1273530A (en)	2000-11-15
NO20002343D0 (en)	2000-05-04
KR20010021656A (en)	2001-03-15
NO20002343L (en)	2000-05-04
IL133612A0 (en)	2001-04-30

Legal Events

Date	Code	Title	Description
2000-04-14	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2000-05-31	17P	Request for examination filed	Effective date: 20000120
2000-05-31	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2000-05-31	AX	Request for extension of the european patent	Free format text: SI PAYMENT 20000120
2003-07-23	A4	Supplementary search report drawn up and despatched	Effective date: 20030606
2004-01-07	17Q	First examination report despatched	Effective date: 20031119
2005-04-29	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2005-05-03	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2005-06-01	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: PHARMACIA & UPJOHN COMPANY LLC
2006-02-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2006-03-29	18D	Application deemed to be withdrawn	Effective date: 20050924

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GB9500865D0 (en)	1995-03-08	Trenching plough
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IT244003Y1 (en)	2002-03-07	TREE OF TREE
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