EP1011665A4 - Heterocyclic agents - Google Patents

Heterocyclic agents

Info

Publication number
EP1011665A4
EP1011665A4 EP98906687A EP98906687A EP1011665A4 EP 1011665 A4 EP1011665 A4 EP 1011665A4 EP 98906687 A EP98906687 A EP 98906687A EP 98906687 A EP98906687 A EP 98906687A EP 1011665 A4 EP1011665 A4 EP 1011665A4
Authority
EP
European Patent Office
Prior art keywords
heterocyclic agents
heterocyclic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98906687A
Other languages
German (de)
French (fr)
Other versions
EP1011665A1 (en
Inventor
Fariborz Mohamadi
Vinod F Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9706304.4A external-priority patent/GB9706304D0/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP1011665A1 publication Critical patent/EP1011665A1/en
Publication of EP1011665A4 publication Critical patent/EP1011665A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP98906687A 1997-03-10 1998-02-26 Heterocyclic agents Withdrawn EP1011665A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4026597P 1997-03-10 1997-03-10
US40265P 1997-03-10
GB9706304 1997-03-26
GBGB9706304.4A GB9706304D0 (en) 1997-03-26 1997-03-26 Heterocyclic agents
PCT/US1998/003612 WO1998040068A1 (en) 1997-03-10 1998-02-26 Heterocyclic agents

Publications (2)

Publication Number Publication Date
EP1011665A1 EP1011665A1 (en) 2000-06-28
EP1011665A4 true EP1011665A4 (en) 2001-09-12

Family

ID=26311269

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98906687A Withdrawn EP1011665A4 (en) 1997-03-10 1998-02-26 Heterocyclic agents

Country Status (5)

Country Link
EP (1) EP1011665A4 (en)
JP (1) JP2001514653A (en)
AU (1) AU6184898A (en)
CA (1) CA2283127A1 (en)
WO (1) WO1998040068A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136489A0 (en) * 1997-12-08 2001-06-14 Scripps Research Inst Synthesis of cc-1065/duocarmycin analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248691A (en) * 1992-09-03 1993-09-28 Eli Lilly And Company Furanoindolines

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOGER D L ET AL: "DESIGN, SYNTHESIS, AND EVALUATION OF CC-1065 AND DUOCARMYCIN ANALOGS INCORPORATING THE 2,3,10,10A-TETRAHYDRO-1H-CYCLOPROPAUD BENZOUFQUINOL-5-ONE (CBQ) ALKYLATION SUBUNIT: IDENTICATION AND STRUCTURAL ORIGIN OF SUBTLE STEREOELECTRONIC FEATURES THAT GOVERN REACTIVITY AND REGIOSELECTIVITY", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 116, no. 25, 1994, pages 11335 - 11348, XP002914133, ISSN: 0002-7863 *
BOGER D L ET AL: "TOTAL SYNTHESIS AND PRELIMINARY EVVALUATION OF (+)- AND ENT-(-)- DUOCARMYCIN SA", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 115, no. 20, 1993, pages 9025 - 9036, XP002914132, ISSN: 0002-7863 *
MOHAMADI F ET AL: "Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 37, 1994, pages 232 - 239, XP002086068, ISSN: 0022-2623 *
PATEL ET AL: "Total Synthesis of Seco (+)- and ent-(-)-Oxaduocarmycin SA: Construction of the (Chloromethyl)indoline Alkylating Subunit by a Novel Intramolecular Aryl Radical Cyclization onto a Vinyl Chloride", JOURNAL OF ORGANIC CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, vol. 62, no. 25, 1997, pages 8868 - 8874, XP002142466, ISSN: 0022-3263 *
See also references of WO9840068A1 *
TIETZE L F ET AL: "SYNTHESIS OF THE REDUCED A-UNIT (CI) OF THE ANTITUMOR ANTIBIOTIC CC-1065", CHEMISCHE BERICHTE,DE,VERLAG CHEMIE GMBH. WEINHEIM, vol. 126, no. 12, 1 December 1993 (1993-12-01), pages 2733 - 2737, XP002041813, ISSN: 0009-2940 *

Also Published As

Publication number Publication date
WO1998040068A1 (en) 1998-09-17
EP1011665A1 (en) 2000-06-28
AU6184898A (en) 1998-09-29
JP2001514653A (en) 2001-09-11
CA2283127A1 (en) 1998-09-17

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