EP1017841A4 - Chromatographisches verfahren zur mutations-detektion unter verwendung von enzymen die spezifisch am mutationsort wirken - Google Patents

Chromatographisches verfahren zur mutations-detektion unter verwendung von enzymen die spezifisch am mutationsort wirken

Info

Publication number
EP1017841A4
EP1017841A4 EP98942090A EP98942090A EP1017841A4 EP 1017841 A4 EP1017841 A4 EP 1017841A4 EP 98942090 A EP98942090 A EP 98942090A EP 98942090 A EP98942090 A EP 98942090A EP 1017841 A4 EP1017841 A4 EP 1017841A4
Authority
EP
European Patent Office
Prior art keywords
mutation
chromatographic method
site specifically
acting enzymes
specifically acting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98942090A
Other languages
English (en)
French (fr)
Other versions
EP1017841A1 (de
Inventor
Douglas T Gjerde
Paul D Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Precipio Inc
Original Assignee
Transgenomic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgenomic Inc filed Critical Transgenomic Inc
Publication of EP1017841A1 publication Critical patent/EP1017841A1/de
Publication of EP1017841A4 publication Critical patent/EP1017841A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
EP98942090A 1997-08-18 1998-08-18 Chromatographisches verfahren zur mutations-detektion unter verwendung von enzymen die spezifisch am mutationsort wirken Withdrawn EP1017841A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5567697P 1997-08-18 1997-08-18
US55676P 1997-08-18
US6241397P 1997-10-14 1997-10-14
US62413P 1997-10-14
PCT/US1998/017062 WO1999009203A1 (en) 1997-08-18 1998-08-18 Chromatographic method for mutation detection using mutation site specifically acting enzymes

Publications (2)

Publication Number Publication Date
EP1017841A1 EP1017841A1 (de) 2000-07-12
EP1017841A4 true EP1017841A4 (de) 2002-01-09

Family

ID=26734515

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98942090A Withdrawn EP1017841A4 (de) 1997-08-18 1998-08-18 Chromatographisches verfahren zur mutations-detektion unter verwendung von enzymen die spezifisch am mutationsort wirken

Country Status (5)

Country Link
EP (1) EP1017841A4 (de)
JP (1) JP3345832B2 (de)
AU (1) AU744476B2 (de)
CA (1) CA2298630A1 (de)
WO (1) WO1999009203A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE408026T1 (de) * 1999-10-12 2008-09-15 Transgenomic Inc Nachweis von nukleinsäure-heteroduplex molekülen mittels anionen-austausch-chromatographie
AU2001227679A1 (en) * 2000-02-25 2001-09-03 General Atomics Mutant nucleic binding enzymes and use thereof in diagnostic, detection and purification methods
WO2002057492A1 (en) 2000-12-08 2002-07-25 California Institute Of Technology Methods and compositions for detecting polynucleotide duplex damage

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395486A (en) * 1981-08-19 1983-07-26 Medical College Of Ga. Research Inst., Inc. Method for the direct analysis of sickle cell anemia
AT398973B (de) * 1992-11-18 1995-02-27 Bonn Guenther Dr Verfahren zur trennung von nukleinsäuren
GB9408344D0 (en) * 1994-04-27 1994-06-15 St James S University Hospital Nucleic acid assays
US5824530A (en) * 1995-09-01 1998-10-20 Variagenics, Inc. Overexpression of recombinant bacteriophage T4 endonuclease VII and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COTTON R G H: "Slowly but surely towards better scanning for mutations", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 13, no. 2, 1 February 1997 (1997-02-01), pages 43 - 46, XP004034140, ISSN: 0168-9525 *
See also references of WO9909203A1 *
SMITH J ET AL: "MUTATION DETECTION WITH MUTH, MUTL, AND MUTS MISMATCH REPAIR PROTEINS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 April 1996 (1996-04-01), pages 4374 - 4379, XP002030021, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU9021998A (en) 1999-03-08
JP3345832B2 (ja) 2002-11-18
EP1017841A1 (de) 2000-07-12
AU744476B2 (en) 2002-02-28
JP2001515217A (ja) 2001-09-18
CA2298630A1 (en) 1999-02-25
WO1999009203A1 (en) 1999-02-25

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