EP1023076A4 - USE OF THE P-TEN TUMOR SUPPRESSOR GENE IN THE DIAGNOSIS AND TREATMENT OF CANCER - Google Patents

USE OF THE P-TEN TUMOR SUPPRESSOR GENE IN THE DIAGNOSIS AND TREATMENT OF CANCER

Info

Publication number
EP1023076A4
EP1023076A4 EP98908523A EP98908523A EP1023076A4 EP 1023076 A4 EP1023076 A4 EP 1023076A4 EP 98908523 A EP98908523 A EP 98908523A EP 98908523 A EP98908523 A EP 98908523A EP 1023076 A4 EP1023076 A4 EP 1023076A4
Authority
EP
European Patent Office
Prior art keywords
diagnosis
cancer
treatment
tumor suppressor
suppressor gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98908523A
Other languages
German (de)
French (fr)
Other versions
EP1023076A1 (en
Inventor
Ramon E Parsons
Michael H Wigler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cold Spring Harbor Laboratory
Columbia University in the City of New York
Original Assignee
Cold Spring Harbor Laboratory
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Laboratory, Columbia University in the City of New York filed Critical Cold Spring Harbor Laboratory
Publication of EP1023076A1 publication Critical patent/EP1023076A1/en
Publication of EP1023076A4 publication Critical patent/EP1023076A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP98908523A 1997-02-07 1998-02-06 USE OF THE P-TEN TUMOR SUPPRESSOR GENE IN THE DIAGNOSIS AND TREATMENT OF CANCER Withdrawn EP1023076A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3694397P 1997-02-07 1997-02-07
US36943P 1997-02-07
PCT/US1998/002615 WO1998034624A1 (en) 1997-02-07 1998-02-06 Use of the p-ten suppressor gene in diagnosis and treatment of cancer

Publications (2)

Publication Number Publication Date
EP1023076A1 EP1023076A1 (en) 2000-08-02
EP1023076A4 true EP1023076A4 (en) 2001-11-21

Family

ID=21891553

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98908523A Withdrawn EP1023076A4 (en) 1997-02-07 1998-02-06 USE OF THE P-TEN TUMOR SUPPRESSOR GENE IN THE DIAGNOSIS AND TREATMENT OF CANCER

Country Status (4)

Country Link
EP (1) EP1023076A4 (en)
AU (1) AU6653698A (en)
CA (1) CA2280097A1 (en)
WO (1) WO1998034624A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287854B1 (en) 1996-10-22 2001-09-11 Imperial Cancer Research Technology Limited Diagnosis of susceptibility to cancer and treatment thereof
WO1999002704A2 (en) * 1997-07-08 1999-01-21 Cold Spring Harbor Laboratory Dual specifically phosphatase and methods of use
AU6513701A (en) * 2000-05-30 2001-12-11 Advanced Res & Tech Inst Compositions and methods for identifying agents which modulate pten function andpi-3 kinase pathways
WO2004074459A2 (en) * 2003-02-19 2004-09-02 Georgetown University Pten-deficient cells and their uses
CN109022461B (en) 2017-06-08 2022-01-14 中山大学附属第一医院 Upstream open reading frame 45aa-uORF nucleotide sequence of PTEN gene and application of encoded polypeptide thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033907A1 (en) * 1997-01-30 1998-08-06 Board Of Regents, The University Of Texas System A tumor suppressor designated ts10q23.3

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033907A1 (en) * 1997-01-30 1998-08-06 Board Of Regents, The University Of Texas System A tumor suppressor designated ts10q23.3

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
LI D-M ET AL: "TEP1, ENCODED BY A CANDIDATE TUMOR SUPPRESSOR LOCUS, IS A NOVEL PROTEIN TYROSINE PHOSPHATASE REGULATED BY TRANSFORMING GROWTH FACTOR BETA1-", CANCER RESEARCH, vol. 57, 1 June 1997 (1997-06-01), pages 2124 - 2129, XP002066157, ISSN: 0008-5472 *
LIAW DANNY ET AL: "Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.", NATURE GENETICS, vol. 16, no. 1, 16 May 1997 (1997-05-16), pages 64 - 67, XP001024445, ISSN: 1061-4036 *
LO SU HAO ET AL: "Molecular cloning of chick cardiac muscle tensin: Full-length cDNA sequence, expression, and characterization.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 35, 1994, pages 22310 - 22319, XP002178161, ISSN: 0021-9258 *
MYERS ET AL: "P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatse", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, 1 August 1997 (1997-08-01), pages 9052 - 9057, XP002088258, ISSN: 0027-8424 *
NELEN M R ET AL: "Localization of the gene for Cowden disease to chromosome 10q22-23.", NATURE GENETICS, vol. 13, no. 1, 1996, pages 114 - 116, XP001024519, ISSN: 1061-4036 *
See also references of WO9834624A1 *

Also Published As

Publication number Publication date
EP1023076A1 (en) 2000-08-02
AU6653698A (en) 1998-08-26
CA2280097A1 (en) 1998-08-13
WO1998034624A1 (en) 1998-08-13

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