EP1075215A4 - Hyaluronan-based imaging agents - Google Patents

Hyaluronan-based imaging agents

Info

Publication number: EP1075215A4
Authority: EP; European Patent Office
Prior art keywords: hyaluronan; imaging agents; based imaging; agents; imaging
Prior art date: 1998-04-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99921503A

Other languages

German (de)

French (fr)

Other versions

EP1075215A1 (en

Inventor

George Harrison Kidd

David John Mikulis

James I Nagy

Eva Anne Turley

Francoise Martine Winnik

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Jagotec AG

Original Assignee

Jagotec AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-28

Filing date

1999-04-27

Publication date

2002-04-17

1999-04-27 Application filed by Jagotec AG filed Critical Jagotec AG

2001-02-14 Publication of EP1075215A1 publication Critical patent/EP1075215A1/en

2002-04-17 Publication of EP1075215A4 publication Critical patent/EP1075215A4/en

Status Withdrawn legal-status Critical Current

Links

KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 title 1
229940099552 hyaluronan Drugs 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
239000012216 imaging agent Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Biodiversity & Conservation Biology (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Oncology (AREA)
Optics & Photonics (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
Materials Engineering (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Dispersion Chemistry (AREA)
Radiology & Medical Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Magnetic Resonance Imaging Apparatus (AREA)

EP99921503A 1998-04-28 1999-04-27 Hyaluronan-based imaging agents Withdrawn EP1075215A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US8331198P	1998-04-28	1998-04-28
US83311P		1998-04-28
PCT/US1999/009177 WO1999055230A1 (en)	1998-04-28	1999-04-27	Hyaluronan-based imaging agents

Publications (2)

Publication Number	Publication Date
EP1075215A1 EP1075215A1 (en)	2001-02-14
EP1075215A4 true EP1075215A4 (en)	2002-04-17

Family

ID=22177514

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99921503A Withdrawn EP1075215A4 (en)	1998-04-28	1999-04-27	Hyaluronan-based imaging agents

Country Status (7)

Country	Link
EP (1)	EP1075215A4 (en)
JP (1)	JP2002512942A (en)
AU (1)	AU3870099A (en)
CA (1)	CA2328698A1 (en)
NZ (1)	NZ507540A (en)
WO (1)	WO1999055230A1 (en)
ZA (1)	ZA200006067B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6875753B1 (en)	1996-03-14	2005-04-05	The Governors Of The University Of Alberta	Methods for cell mobilization using in vivo treatment with hyaluronan (HA)
US6630457B1 (en) *	1998-09-18	2003-10-07	Orthogene Llc	Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6593308B2 (en) *	1999-12-03	2003-07-15	The Regents Of The University Of California	Targeted drug delivery with a hyaluronan ligand
DE10141106A1 (en) *	2001-08-22	2003-03-13	Aventis Pharma Gmbh	Use of heparinoid derivatives for the treatment and diagnosis of heparinoid-treatable diseases
EP1466629A1 (en) *	2003-04-11	2004-10-13	BRACCO IMAGING S.p.A.	Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
WO2005117995A1 (en) *	2004-06-03	2005-12-15	Joji Kitayama	Application of hyaluronic acid to sentinel lymph node identification
EP1846042A2 (en) *	2005-01-05	2007-10-24	Board of Regents, The University of Texas System	Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
CN101549161B (en) *	2009-05-13	2010-12-01	中南大学	A liver-spleen-specific positive nuclear magnetic resonance contrast agent and preparation method thereof
EP2558108A1 (en) *	2010-04-12	2013-02-20	Ramot at Tel-Aviv University Ltd	Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders
CN101862461B (en) *	2010-06-18	2012-01-04	上海纳米技术及应用国家工程研究中心有限公司	Gadolinium-containing macromolecular contrast agent for specific imaging of lymphatic system and preparation method thereof
ES2439167B1 (en) *	2012-06-21	2014-11-17	Consejo Superior De Investigaciones Científicas (Csic)	Compounds with magnetic functionality, implants or gels derived from them, and the use of both to determine the enzymatic activity of an enzyme
KR101939880B1 (en) *	2016-06-29	2019-01-18	서울대학교산학협력단	Hydrogel based nano emulsion for the selective labeling on cancerous lesions and manufacturing method the same
KR101901986B1 (en) *	2016-11-18	2018-09-27	서울대학교산학협력단	Nanocarriers for selective fluorescence labeling of cancer cells and a process for the preparing the same
CN113440626A (en) *	2020-03-30	2021-09-28	复旦大学附属华山医院	Targeting nano magnetic resonance contrast agent for articular cartilage damage and preparation and application thereof
CN112111552B (en) *	2020-08-05	2024-10-01	重庆博视知识产权服务有限公司	Fluorescent imaging method for tumor cells
CN114224846B (en) *	2021-11-18	2023-03-14	东华大学	Drug-loaded fiber microsphere and preparation method and application thereof
CN114409275B (en) *	2022-01-14	2023-03-24	大连理工大学	Hyaluronic acid molecular brush modified surface and preparation method and application thereof
CN115554420B (en) *	2022-10-17	2023-08-08	中国科学院长春应用化学研究所	A kind of paramagnetic magnetic resonance contrast agent and its preparation method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996004922A1 (en) *	1994-08-10	1996-02-22	Davis, Joanne, T.	Method of using hyaluronic acid for the detection, location and diagnosis of tumors

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US5707604A (en) *	1986-11-18	1998-01-13	Access Pharmaceuticals, Inc.	Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
US5368840A (en) *	1990-04-10	1994-11-29	Imarx Pharmaceutical Corp.	Natural polymers as contrast media for magnetic resonance imaging
US5143716A (en) *	1991-02-01	1992-09-01	Unger Evan C	Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
ES2199226T3 (en) *	1992-09-04	2004-02-16	The General Hospital Corporation	BIOCOMPATIBLE POLYMERS CONTAINING DIAGNOSTIC OR THERAPEUTIC HALVES.
US5534241A (en) *	1993-07-23	1996-07-09	Torchilin; Vladimir P.	Amphipathic polychelating compounds and methods of use

1999
- 1999-04-27 JP JP2000545439A patent/JP2002512942A/en active Pending
- 1999-04-27 WO PCT/US1999/009177 patent/WO1999055230A1/en not_active Ceased
- 1999-04-27 EP EP99921503A patent/EP1075215A4/en not_active Withdrawn
- 1999-04-27 CA CA002328698A patent/CA2328698A1/en not_active Abandoned
- 1999-04-27 AU AU38700/99A patent/AU3870099A/en not_active Abandoned
- 1999-04-27 NZ NZ507540A patent/NZ507540A/en unknown
2000
- 2000-10-27 ZA ZA200006067A patent/ZA200006067B/en unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996004922A1 (en) *	1994-08-10	1996-02-22	Davis, Joanne, T.	Method of using hyaluronic acid for the detection, location and diagnosis of tumors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO9955230A1 *
TRUBETSKOY V S ET AL: "NEW APPROACHES IN THE CHEMICAL DESIGN OG GD-CONTAINING LIPOSOMES FOR USE IN MAGNETIC RESONANCE IMAGING OF LYMPH NODES", JOURNAL OF LIPOSOME RESEARCH, MARCEL DEKKER, NEW YORK, US, vol. 4, no. 2, 1994, pages 961 - 980, XP000619021, ISSN: 0898-2104 *
WINNIK F.M. ET AL: "Hyaluronan-stabilized colloidal superparamagnetic iron oxides: preparation and characterization", ROUND TABLE SERIES-ROYAL SOCIETY OF MEDICINE, vol. 45, 1996, pages 10 - 26, XP001055698 *

Also Published As

Publication number	Publication date
EP1075215A1 (en)	2001-02-14
WO1999055230A1 (en)	1999-11-04
AU3870099A (en)	1999-11-16
JP2002512942A (en)	2002-05-08
CA2328698A1 (en)	1999-11-04
ZA200006067B (en)	2001-08-23
NZ507540A (en)	2002-07-26

Legal Events

Date	Code	Title	Description
2000-12-29	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-02-14	17P	Request for examination filed	Effective date: 20001012
2001-02-14	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-04-17	A4	Supplementary search report drawn up and despatched	Effective date: 20020304
2002-04-17	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-10-09	17Q	First examination report despatched	Effective date: 20020821
2003-05-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2003-07-02	18D	Application deemed to be withdrawn	Effective date: 20030103

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