EP1075215A4 - Bildgebungsmittel basierend auf hyaluronan - Google Patents

Bildgebungsmittel basierend auf hyaluronan

Info

Publication number
EP1075215A4
EP1075215A4 EP99921503A EP99921503A EP1075215A4 EP 1075215 A4 EP1075215 A4 EP 1075215A4 EP 99921503 A EP99921503 A EP 99921503A EP 99921503 A EP99921503 A EP 99921503A EP 1075215 A4 EP1075215 A4 EP 1075215A4
Authority
EP
European Patent Office
Prior art keywords
hyaluronan
imaging agents
based imaging
agents
imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99921503A
Other languages
English (en)
French (fr)
Other versions
EP1075215A1 (de
Inventor
George Harrison Kidd
David John Mikulis
James I Nagy
Eva Anne Turley
Francoise Martine Winnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jagotec AG
Original Assignee
Jagotec AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jagotec AG filed Critical Jagotec AG
Publication of EP1075215A1 publication Critical patent/EP1075215A1/de
Publication of EP1075215A4 publication Critical patent/EP1075215A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
EP99921503A 1998-04-28 1999-04-27 Bildgebungsmittel basierend auf hyaluronan Withdrawn EP1075215A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8331198P 1998-04-28 1998-04-28
US83311P 1998-04-28
PCT/US1999/009177 WO1999055230A1 (en) 1998-04-28 1999-04-27 Hyaluronan-based imaging agents

Publications (2)

Publication Number Publication Date
EP1075215A1 EP1075215A1 (de) 2001-02-14
EP1075215A4 true EP1075215A4 (de) 2002-04-17

Family

ID=22177514

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99921503A Withdrawn EP1075215A4 (de) 1998-04-28 1999-04-27 Bildgebungsmittel basierend auf hyaluronan

Country Status (7)

Country Link
EP (1) EP1075215A4 (de)
JP (1) JP2002512942A (de)
AU (1) AU3870099A (de)
CA (1) CA2328698A1 (de)
NZ (1) NZ507540A (de)
WO (1) WO1999055230A1 (de)
ZA (1) ZA200006067B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875753B1 (en) 1996-03-14 2005-04-05 The Governors Of The University Of Alberta Methods for cell mobilization using in vivo treatment with hyaluronan (HA)
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6593308B2 (en) * 1999-12-03 2003-07-15 The Regents Of The University Of California Targeted drug delivery with a hyaluronan ligand
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
EP1466629A1 (de) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducte zwischen NMR Vershibungsreagenzen und Substraten mit austauschbaren Protonen für die "CEST" Anwendung
WO2005117995A1 (ja) * 2004-06-03 2005-12-15 Joji Kitayama ヒアルロン酸のセンチネルリンパ節同定への応用
EP1846042A2 (de) * 2005-01-05 2007-10-24 Board of Regents, The University of Texas System Konjugate zur doppelten abbildung und radiochemotherapie: zusammensetzung sowie herstellung und anwendungen davon
CN101549161B (zh) * 2009-05-13 2010-12-01 中南大学 一种肝、脾脏特异性阳性核磁共振对比剂及其制备方法
EP2558108A1 (de) * 2010-04-12 2013-02-20 Ramot at Tel-Aviv University Ltd Eisenoxidnanopartikel zur verwendung bei der behandlung von nicht infektiösen entzündungserkrankungen
CN101862461B (zh) * 2010-06-18 2012-01-04 上海纳米技术及应用国家工程研究中心有限公司 用于淋巴系统特异成像的含钆大分子造影剂及其制备方法
ES2439167B1 (es) * 2012-06-21 2014-11-17 Consejo Superior De Investigaciones Científicas (Csic) Compuestos con funcionalidad magnética, implantes o geles derivados de ellos, y el uso de ambos para determinar la actividad enzimática de una enzima
KR101939880B1 (ko) * 2016-06-29 2019-01-18 서울대학교산학협력단 암병변 선택적 표지를 위한 수화젤 기반 나노 에멀전 및 이의 제조 방법
KR101901986B1 (ko) * 2016-11-18 2018-09-27 서울대학교산학협력단 암세포의 선택적 형광 표지를 위한 나노전달체 및 그 제조방법
CN113440626A (zh) * 2020-03-30 2021-09-28 复旦大学附属华山医院 一种针对关节软骨损伤的靶向纳米磁共振造影剂及其制备和应用
CN112111552B (zh) * 2020-08-05 2024-10-01 重庆博视知识产权服务有限公司 一种肿瘤细胞的荧光成像方法
CN114224846B (zh) * 2021-11-18 2023-03-14 东华大学 一种载药纤维微球及其制备方法和应用
CN114409275B (zh) * 2022-01-14 2023-03-24 大连理工大学 一种透明质酸分子刷修饰表面及其制备方法和应用
CN115554420B (zh) * 2022-10-17 2023-08-08 中国科学院长春应用化学研究所 一种顺磁性磁共振造影剂及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004922A1 (en) * 1994-08-10 1996-02-22 Davis, Joanne, T. Method of using hyaluronic acid for the detection, location and diagnosis of tumors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
US5143716A (en) * 1991-02-01 1992-09-01 Unger Evan C Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
ES2199226T3 (es) * 1992-09-04 2004-02-16 The General Hospital Corporation Polimeros biocompatibles que contienen mitades diagnosticas o terapeuticas.
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004922A1 (en) * 1994-08-10 1996-02-22 Davis, Joanne, T. Method of using hyaluronic acid for the detection, location and diagnosis of tumors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO9955230A1 *
TRUBETSKOY V S ET AL: "NEW APPROACHES IN THE CHEMICAL DESIGN OG GD-CONTAINING LIPOSOMES FOR USE IN MAGNETIC RESONANCE IMAGING OF LYMPH NODES", JOURNAL OF LIPOSOME RESEARCH, MARCEL DEKKER, NEW YORK, US, vol. 4, no. 2, 1994, pages 961 - 980, XP000619021, ISSN: 0898-2104 *
WINNIK F.M. ET AL: "Hyaluronan-stabilized colloidal superparamagnetic iron oxides: preparation and characterization", ROUND TABLE SERIES-ROYAL SOCIETY OF MEDICINE, vol. 45, 1996, pages 10 - 26, XP001055698 *

Also Published As

Publication number Publication date
EP1075215A1 (de) 2001-02-14
WO1999055230A1 (en) 1999-11-04
AU3870099A (en) 1999-11-16
JP2002512942A (ja) 2002-05-08
CA2328698A1 (en) 1999-11-04
ZA200006067B (en) 2001-08-23
NZ507540A (en) 2002-07-26

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