EP1085869A4 - SPIRO PIPERID DERIVATIVES AS MELANOCORTIN RECEPTORAGONISTS - Google Patents

SPIRO PIPERID DERIVATIVES AS MELANOCORTIN RECEPTORAGONISTS

Info

Publication number
EP1085869A4
EP1085869A4 EP99930220A EP99930220A EP1085869A4 EP 1085869 A4 EP1085869 A4 EP 1085869A4 EP 99930220 A EP99930220 A EP 99930220A EP 99930220 A EP99930220 A EP 99930220A EP 1085869 A4 EP1085869 A4 EP 1085869A4
Authority
EP
European Patent Office
Prior art keywords
receptoragonists
piperid
melanocortin
spiro
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99930220A
Other languages
German (de)
French (fr)
Other versions
EP1085869A1 (en
Inventor
Ravi P Nargund
Zhixiong Ye
Brenda L Palucki
Raman K Bakshi
Arthur A Patchett
Der Ploeg Leonardus H T Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817179.6A external-priority patent/GB9817179D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1085869A1 publication Critical patent/EP1085869A1/en
Publication of EP1085869A4 publication Critical patent/EP1085869A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
EP99930220A 1998-06-11 1999-06-10 SPIRO PIPERID DERIVATIVES AS MELANOCORTIN RECEPTORAGONISTS Withdrawn EP1085869A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8890898P 1998-06-11 1998-06-11
US88908P 1998-06-11
GBGB9817179.6A GB9817179D0 (en) 1998-08-06 1998-08-06 Spiropiperidine derivatives as melanocortin receptor agonists
GB9817179 1998-08-06
US12326099P 1999-03-08 1999-03-08
US123260P 1999-03-08
PCT/US1999/013252 WO1999064002A1 (en) 1998-06-11 1999-06-10 Spiropiperidine derivatives as melanocortin receptor agonists

Publications (2)

Publication Number Publication Date
EP1085869A1 EP1085869A1 (en) 2001-03-28
EP1085869A4 true EP1085869A4 (en) 2001-10-04

Family

ID=27269429

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99930220A Withdrawn EP1085869A4 (en) 1998-06-11 1999-06-10 SPIRO PIPERID DERIVATIVES AS MELANOCORTIN RECEPTORAGONISTS

Country Status (5)

Country Link
EP (1) EP1085869A4 (en)
JP (1) JP2002517444A (en)
AU (1) AU742425B2 (en)
CA (1) CA2334551A1 (en)
WO (1) WO1999064002A1 (en)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
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