EP1100947A4 - Method for the production of an antibiotic agent - Google Patents

Method for the production of an antibiotic agent

Info

Publication number
EP1100947A4
EP1100947A4 EP99938933A EP99938933A EP1100947A4 EP 1100947 A4 EP1100947 A4 EP 1100947A4 EP 99938933 A EP99938933 A EP 99938933A EP 99938933 A EP99938933 A EP 99938933A EP 1100947 A4 EP1100947 A4 EP 1100947A4
Authority
EP
European Patent Office
Prior art keywords
production
antibiotic agent
antibiotic
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99938933A
Other languages
German (de)
French (fr)
Other versions
EP1100947A1 (en
Inventor
Neal C Connors
Leslie A Petersen
David L Hughes
Lisa M Dimichele
Thomas J Novak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1100947A1 publication Critical patent/EP1100947A1/en
Publication of EP1100947A4 publication Critical patent/EP1100947A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP99938933A 1998-08-07 1999-08-04 Method for the production of an antibiotic agent Withdrawn EP1100947A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9569198P 1998-08-07 1998-08-07
US95691P 1998-08-07
PCT/US1999/017444 WO2000008197A1 (en) 1998-08-07 1999-08-04 Method for the production of an antibiotic agent

Publications (2)

Publication Number Publication Date
EP1100947A1 EP1100947A1 (en) 2001-05-23
EP1100947A4 true EP1100947A4 (en) 2001-09-05

Family

ID=22253174

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99938933A Withdrawn EP1100947A4 (en) 1998-08-07 1999-08-04 Method for the production of an antibiotic agent

Country Status (4)

Country Link
EP (1) EP1100947A4 (en)
JP (1) JP2003510245A (en)
AU (1) AU5331199A (en)
WO (1) WO2000008197A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
NZ554405A (en) 2000-12-18 2009-04-30 Cubist Pharm Inc Method for preparing crystalline and crystal-like forms of purified lipopeptides
US20090324635A1 (en) * 2008-06-25 2009-12-31 Ferenc Korodi Caspofungin free of caspofungin impurity A
CN101928670B (en) 2009-09-24 2012-02-22 上海天伟生物制药有限公司 High-yield bacterial strain of antibiotic, preparation method and usage thereof
CN102947327B (en) 2010-03-29 2017-06-13 中化帝斯曼制药有限公司荷兰公司 The purifying of Caspofungin intermediate
WO2013104576A1 (en) 2012-01-13 2013-07-18 Dsm Sinochem Pharmaceuticals Netherlands B.V. Cyclopeptide fermentation at increased metal ion concentration
CN105481952B (en) * 2014-12-24 2020-12-29 上海天伟生物制药有限公司 A kind of composition of nitrogen-containing heterocyclic hexapeptide precursor and its preparation method and use
CN106755223A (en) * 2017-01-20 2017-05-31 信泰制药（苏州）有限公司 A kind of fermentation process of Pneumocandin B0
CN107201316B (en) * 2017-07-14 2020-04-07 海正药业(杭州)有限公司 Aspergillus and producing pneumocandin B thereof0Method (2)
CN113046251B (en) * 2019-12-27 2023-01-24 上海医药工业研究院 Genetically engineered bacteria for producing pneumocidine B0, its preparation method and application
CN113046250B (en) * 2019-12-27 2023-01-24 上海医药工业研究院 Genetically engineered bacteria for producing pneumocidine B0 and its preparation method and application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968608A (en) * 1987-10-07 1990-11-06 Merck & Co., Inc. Process for antifungal fermentation product
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO0008197A1 *

Also Published As

Publication number Publication date
JP2003510245A (en) 2003-03-18
AU5331199A (en) 2000-02-28
EP1100947A1 (en) 2001-05-23
WO2000008197A1 (en) 2000-02-17

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